Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM0GZTD)

Drug Name

L-ornithine phenylacetate Drug Info

Synonyms

L-ornthine phenylacetate; OCR-002; UCL-L1V; L-ornithine phenylacetate (injectable, acute hepatic encephalopathy); Nitrogen metabolism modulator (injectable, AHE), Ocera; Nitrogen metabolism modulator (injectable, acute hepatic encephalopathy), Ocera; Nitrogen metabolism modulator (injectable, acute hepatic encephalopathy), UCL; Nitrogen metabolism modulator (injectable, hyperammonemia), Ocera; L-ornithine phenylacetate (injectable, AHE), Ocera; L-ornithine phenylacetate (injectable, acute hepatic encephalopathy), Ocera; L-ornithine phenylacetate (injectable, hyperammonemia), Ocera

Indication

Disease Entry	ICD 11	Status	REF
Acute liver failure	DB91	Phase 2	[1]

Cross-matching ID

PubChem CID: 44247677
CAS Number: CAS 952154-79-9
TTD Drug ID: DM0GZTD

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Nuclear factor NF-kappa-B (NFKB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[3]
Triptolide	DMCMDVR	Autoimmune diabetes	5A10	Phase 3	[4]
Laquinimod	DM3IWS8	Lupus	4A40	Phase 3	[5]
Edasalonexent	DMYVBF6	Duchenne dystrophy	8C70	Phase 3	[6]
MD1003	DMVZ57G	Multiple sclerosis	8A40	Phase 3	[6]
Vadimezan	DMK7CYX	Solid tumour/cancer	2A00-2F9Z	Phase 2	[7]
CAT 1004	DMQBP7R	Duchenne dystrophy	8C70	Phase 2	[8]
Parthenolide	DMCQBFT	N. A.	N. A.	Phase 2	[9]
Recoflavone	DMCSR8I	Inflammatory bowel disease	DD72	Phase 2	[10]
CZEN-002	DMUDMHA	Fungal infection	1F29-1F2F	Phase 2	[11]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Nuclear factor NF-kappa-B (NFKB)	TTSXVID	NFKB1_HUMAN; NFKB2_HUMAN; TF65_HUMAN; RELB_HUMAN; REL_HUMAN	Modulator	[2]

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References

1	ClinicalTrials.gov (NCT01634230) Emergency Use of OCR-002 in Acute Liver Failure. U.S. National Institutes of Health.
2	Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
3	Emerging drugs for rheumatoid arthritis. Expert Opin Emerg Drugs. 2008 Mar;13(1):175-96.
4	Functional p53 is required for triptolide-induced apoptosis and AP-1 and nuclear factor-kappaB activation in gastric cancer cells. Oncogene. 2001 Nov 29;20(55):8009-18.
5	Reduced astrocytic NF- B activation by laquinimod protects from cuprizone-induced demyelination. Acta Neuropathol. 2012 Sep;124(3):411-24.
6	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
7	Auckland Cancer Society Research Centre report
8	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
9	Hypoxia-induced neutrophil survival is mediated by HIF-1alpha-dependent NF-kappaB activity. J Exp Med. 2005 Jan 3;201(1):105-15.
10	DA-6034, a derivative of flavonoid, prevents and ameliorates dextran sulfate sodium-induced colitis and inhibits colon carcinogenesis. Exp Biol Med (Maywood). 2008 Feb;233(2):180-91.
11	US patent application no. US20100278784 A1.