Details of the Drug

General Information of Drug (ID: DM1AFPW)

• Drug Name: KC-764
• Synonyms: (2-Methylpyrazolo[1,5-a]pyridin-3-yl)(1,4,5,6-tetrahydro-3-pyridyl)methanone; 2-Methyl-3-(1,4,5,6-tetrahydronicotinoyl)pyrazolo[1,5-a]pyridine; 2-Methyl-3-(1,4,5,6-tetrahydropyridin-3-ylcarbonyl)pyrazolo[1,5-a]pyridine; 94457-09-7

Indication

Disease Entry	ICD 11	Status	REF
Platelet aggregation disorder	3B62	Discontinued in Phase 3	[1]

• Drug Type: Small molecular drug
• #Ro5 Violations (Lipinski): 0:
  Molecular Weight (mw); 241.29
  Logarithm of the Partition Coefficient (xlogp); 1.8
  Rotatable Bond Count (rotbonds); 2
  Hydrogen Bond Donor Count (hbonddonor); 1
  Hydrogen Bond Acceptor Count (hbondacc); 3
• Chemical Identifiers:
  Formula: C14H15N3O
  IUPAC Name: (2-methylpyrazolo[1,5-a]pyridin-3-yl)-(1,2,3,4-tetrahydropyridin-5-yl)methanone
  Canonical SMILES: CC1=NN2C=CC=CC2=C1C(=O)C3=CNCCC3
  InChI: InChI=1S/C14H15N3O/c1-10-13(12-6-2-3-8-17(12)16-10)14(18)11-5-4-7-15-9-11/h2-3,6,8-9,15H,4-5,7H2,1H3
  InChIKey: SLMUMPSLUWOXAO-UHFFFAOYSA-N
• Cross-matching ID:
  PubChem CID: 146826
  CAS Number: 94457-09-7
  TTD ID: D0S6GJ

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Prostaglandin G/H synthase (COX)	TTK0943	PGH1_HUMAN ; PGH2_HUMAN	Modulator	[2]

References

• [1] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001148)
• [2] Clinical and preclinical pharmacology of KC-764, a novel antiplatelet agent. Nihon Rinsho. 1992 Feb;50(2):379-84.