General Information of Drug (ID: DM1JOXY)

Drug Name
Bryostatin-1
Synonyms
Bryostatin 1; 83314-01-6; Bryostatin-1; NSC 339555; CHEMBL449158; CHEBI:88353; 37O2X55Y9E; BRYOSTATIN; NSC-339555; 2,4-Octadienoic acid, (1S,3S,5Z,7R,8E,11S,12S,13E,15S,17R,21R,23R,25S)-25-(acetyloxy)-1,11,21-trihydroxy-17-((1R)-1-hydroxyethyl)-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo(21.3.1.13,7.111,15)nonacos-8-en-12-yl ester, (2E,4E)-; DTXSID8046876; UNII-37O2X55Y9E; BRN 4349157; BRYOSTATIN 1 [MI]; SCHEMBL182960; BRYOSTATIN 1 [WHO-DD]; Bryostatin 1, >=99%, solid; MJQUEDHRCUIRLF-TVIXENOKSA-N; BDBM50258529; BMY-45618; MFCD00893832; Bryostatin 1 - CAS 83314-01-6; (1S-(1R*,3R*,5Z,7S*,8E,11R*,12R*(2E,4E),13E,15R*,17S*(S*),21S*,23S*,25R*))-25-(Acetyloxy)-1,11,21-trihydroxy-17-(1-hydroxyethyl)-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo(21.3.1.13,7.111,15)nonacos-8-en-12-yl 2,4-octadienoate; 2,4-Octadienoic acid, 25-(acetyloxy)-1,11,21-trihydroxy-17-(1-hydroxyethyl)-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo(21.3.1.13,7.111,15)nonacos-8-en-12-yl ester, (1S-(1R*,3R*,5Z,7S*,8E,11R*,12R*(2E,4E),13E,15R*,17S*(S*),21S*,23S*,25R*))-; HY-105231; CS-0025440; Q27095907; (1S,3S,5Z,7R,8E,11S,12S,13E,15S,17R,21R,23R,25S)-25-(acetyloxy)-1,11,21-trihydroxy-17-[(1R)-1-hydroxyethyl]-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo[21.3.1.1(3,7).1(11,15)]nonacos-8-en-12-yl (2E,4E)-octa-2,4-dienoate; (1S,3S,5Z,7R,8E,11S,12S,13E,15S,17R,21R,23R,25S)-25-(Acetyloxy)-1,11,21-trihydroxy-17-[(1R)-1-hydroxyethyl]-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo[21.3.1.13,7.111,15]nonacos-8-en-12-yl-(2E, 4E)-2,4-octadienoic acid ester; [(1S,3S,5Z,7R,8E,11S,12S,13E,15S,17R,21R,23R,25S)-25-acetyloxy-1,11,21-trihydroxy-17-[(1R)-1-hydroxyethyl]-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo[21.3.1.13,7.111,15]nonacos-8-en-12-yl] (2E,4E)-octa-2,4-dienoate
Indication
Disease Entry ICD 11 Status REF
Alzheimer disease 8A20 Phase 2 [1]
Drug Type
Small molecule
Structure
3D MOL is unavailable 2D MOL
Adverse Drug Reaction (ADR)
ADR Term Variation Related DOT DOT ID REF
Apoptosis Not Available TRAF1 OTTLM5RU [2]
Chemical Identifiers
Formula
C47H68O17
Canonical SMILES
CCCC=CC=CC(=O)OC1C(=CC(=O)OC)CC2CC(OC(=O)CC(CC3CC(C(C(O3)(CC4CC(=CC(=O)OC)CC(O4)C=CC(C1(O2)O)(C)C)O)(C)C)OC(=O)C)O)C(C)O
InChI
InChI=1S/C47H68O17/c1-10-11-12-13-14-15-39(51)62-43-31(22-41(53)58-9)21-34-25-37(28(2)48)61-42(54)24-32(50)23-35-26-38(59-29(3)49)45(6,7)46(55,63-35)27-36-19-30(20-40(52)57-8)18-33(60-36)16-17-44(4,5)47(43,56)64-34/h12-17,20,22,28,32-38,43,48,50,55-56H,10-11,18-19,21,23-27H2,1-9H3/b13-12+,15-14+,17-16+,30-20+,31-22+/t28-,32-,33+,34+,35-,36+,37-,38+,43+,46+,47-/m1/s1
InChIKey
MJQUEDHRCUIRLF-TVIXENOKSA-N
Cross-matching ID
PubChem CID
5280757
UNII
37O2X55Y9E
DrugBank ID
DB11752
TTD ID
DD8L0V
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Protein kinase C (PRKC) TTYVX59 NOUNIPROTAC Agonist [3]
Protein kinase C epsilon (PRKCE) TTBZ7OD KPCE_HUMAN Activator [4]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
B-cell receptor CD22 (CD22) OTXDJR9T CD22_HUMAN Gene/Protein Processing [5]
Baculoviral IAP repeat-containing protein 3 (BIRC3) OT3E95KB BIRC3_HUMAN Gene/Protein Processing [6]
Integrin alpha-X (ITGAX) OTOGIMHE ITAX_HUMAN Gene/Protein Processing [5]
Interleukin-10 (IL10) OTIRFRXC IL10_HUMAN Gene/Protein Processing [7]
Interleukin-12 subunit beta (IL12B) OT0JF8A3 IL12B_HUMAN Gene/Protein Processing [7]
Protein kinase C alpha type (PRKCA) OT5UWNRD KPCA_HUMAN Gene/Protein Processing [8]
Protein kinase C beta type (PRKCB) OTYQ0656 KPCB_HUMAN Gene/Protein Processing [8]
Protein kinase C gamma type (PRKCG) OTW52VNZ KPCG_HUMAN Gene/Protein Processing [8]
Tissue factor (F3) OT3MSU3B TF_HUMAN Gene/Protein Processing [9]
TNF receptor-associated factor 1 (TRAF1) OTTLM5RU TRAF1_HUMAN Drug Response [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Alzheimer disease
ICD Disease Classification 8A20
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Protein kinase C epsilon (PRKCE) DTT PRKCE 8.86E-15 -0.17 -0.53
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 36 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RPMI-3460/CS1 GDSC1 -0.1037 2.9745 -7.942 0.1297
HOS GDSC1 -6.7402 -3.4374 -8.5457 11.5878
EW-13 GDSC1 -5.4811 3.0896 -10.8162 21.2877
ES6 GDSC1 -0.4178 10.1525 -10.8806 10.8706
EW-18 GDSC1 -0.3122 5.4387 -8.881 2.3575
G-292 clone A141B1 GDSC1 -0.283 4.9785 -8.698 1.7179
EW-1 GDSC1 -0.2737 3.4062 -8.142 0.3783
NY GDSC1 -0.217 5.4945 -8.8627 2.2249
HuO9 GDSC1 -0.1437 2.9006 -7.9312 0.1251
SJSA-1 GDSC1 -0.1342 8.099 -9.8541 6.1268
EW-24 GDSC1 -0.1072 1.9667 -7.6203 0.0082
EW-11 GDSC1 -0.0257 7.9658 -9.7471 5.5476
MHH-ES-1 GDSC1 -0.007 3.3964 -8.0481 0.2143
ES4 GDSC1 0.0065 2.4755 -7.7458 0.0283
H-EMC-SS GDSC1 0.0267 6.107 -8.9923 2.5061
ES1 GDSC1 0.0387 3.705 -8.1349 0.3085
A-673 GDSC1 0.0671 2.5447 -7.7485 0.0275
CHSA0108 GDSC1 0.0672 3.3579 -8.0107 0.1693
SaOS-2 GDSC1 0.0741 12.9699 -11.8577 13.8748
TC-71 GDSC1 0.0953 4.6823 -8.448 0.8526
EW-3 GDSC1 0.1596 3.1088 -7.8995 0.0826
SK-ES-1 GDSC1 0.1636 8.5939 -9.9133 6.0299
EW-16 GDSC1 0.1671 10.4709 -10.7025 9.3026
NOS-1 [Human HNSCC] GDSC1 0.199 3.7625 -8.0997 0.2413
HuO-3N1 GDSC1 0.2059 4.212 -8.2473 0.4363
EW-7 GDSC1 0.2304 3.7796 -8.0948 0.2316
SK-PN-DW GDSC1 0.2744 2.6708 -7.7225 0.0178
CHSA8926 GDSC1 0.2756 11.3649 -11.0319 10.4711
CAL-78 GDSC1 0.2939 12.3052 -11.4351 11.9957
ES8 GDSC1 0.3169 13.3153 -11.8725 13.5603
CAL-72 GDSC1 0.4434 15.9303 -12.9866 17.029
U2OS GDSC1 0.5038 13.6561 -11.9178 13.4435
CHSA0011 GDSC1 0.5164 3.3015 -7.8461 0.0431
ES5 GDSC1 0.5225 3.4721 -7.8988 0.0631
MG-63 GDSC1 0.6017 4.3979 -8.1741 0.2662
ES7 GDSC1 0.6462 3.8985 -7.9961 0.1073
⏷ Show the Full List of 36 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 146 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JM1 GDSC1 -0.0711 5.3111 -8.736 1.7121
SIG-M5 GDSC1 -9.1644 -7.1918 -9.3075 28.395
NU-DUL-1 GDSC1 -8.14 -6.0355 -8.5823 17.7489
SU-DHL-8 GDSC1 -7.9055 -2.3495 -10.0973 26.445
P30/OHK GDSC1 -7.6277 -6.3851 -7.9007 10.1836
NB4 GDSC1 -7.0468 -4.5722 -8.2307 10.2607
P32/ISH GDSC1 -6.933 -4.2579 -8.2925 10.3245
HEL GDSC1 -6.5585 -4.6575 -7.8006 5.2468
ML-2 GDSC1 -6.4909 -3.6992 -8.2222 8.2963
SU-DHL-1 GDSC1 -6.4554 -1.4487 -9.3114 16.0592
EoL-1 GDSC1 -6.1982 -2.0807 -8.8019 11.7102
KOPN-8 GDSC1 -6.1915 -2.9192 -8.3857 8.6352
697 GDSC1 -6.0838 -3.0284 -8.2567 7.3667
Karpas-45 GDSC1 -5.7067 -0.4151 -9.2603 13.3771
Farage GDSC1 -5.6971 1.9892 -10.4349 20.1088
MY-M12 GDSC1 -5.3025 7.8852 -13.0548 28.6543
OCI-AML-5 GDSC1 -3.9249 3.2942 -9.8371 12.3086
Karpas-422 GDSC1 -1.921 6.5816 -10.1407 9.9859
H9 GDSC1 -1.1324 6.5394 -9.6998 6.7004
GDM-1 GDSC1 -0.9428 7.6801 -10.0876 8.216
OCI-Ly19 GDSC1 -0.8544 11.1486 -11.5788 14.3312
Karpas-231 GDSC1 -0.8066 11.8296 -11.8616 15.3007
LAMA-84 GDSC1 -0.7463 6.4123 -9.457 5.1144
CCRF-CEM GDSC1 -0.6536 6.4493 -9.4281 4.8821
MOLM-13 GDSC1 -0.5886 5.1334 -8.881 2.5675
CTB-1 GDSC1 -0.5472 4.5834 -8.6579 1.7502
WIL2 NS GDSC1 -0.5047 2.8586 -8.038 0.2774
SU-DHL-4 GDSC1 -0.4736 1.9295 -7.7253 0.0361
BE-13 GDSC1 -0.4673 6.0094 -9.1672 3.5868
K-562 GDSC1 -0.4634 1.9146 -7.7173 0.0332
Mono-Mac-6 GDSC1 -0.4624 7.2196 -9.6512 5.6377
BL-41 GDSC1 -0.4378 7.5271 -9.7661 6.1103
BALL-1 GDSC1 -0.4369 3.1303 -8.1056 0.3579
L-428 GDSC1 -0.4287 1.972 -7.7245 0.0344
KE-37 GDSC1 -0.3989 1.6248 -7.6046 0.0092
YT GDSC1 -0.3689 1.6643 -7.6075 0.0093
EJM GDSC1 -0.3186 2.7292 -7.933 0.1428
MHH-PREB-1 GDSC1 -0.3154 5.2581 -8.8146 2.1263
DEL GDSC1 -0.2992 6.0362 -9.1038 3.1822
U-698-M GDSC1 -0.2983 10.4234 -10.9337 10.9089
DND-41 GDSC1 -0.2776 7.1439 -9.5325 4.9178
JVM-3 GDSC1 -0.2387 2.64 -7.8778 0.096
WSU-DLCL2 GDSC1 -0.2268 1.7611 -7.5932 0.0066
CESS GDSC1 -0.2223 2.2165 -7.7364 0.0318
A3/Kawakami GDSC1 -0.2018 5.2725 -8.7739 1.9137
SU-DHL-16 GDSC1 -0.1974 1.6001 -7.5329 0.0026
HL-60 GDSC1 -0.1934 3.5126 -8.15 0.3736
Ramos.2G6.4C10 GDSC1 -0.1836 6.1939 -9.1146 3.1252
ALL-PO GDSC1 -0.1696 3.7533 -8.223 0.4849
ME1 GDSC1 -0.1678 2.0063 -7.6522 0.0128
AMO1 GDSC1 -0.1644 2.8193 -7.9116 0.1127
Loucy GDSC1 -0.1366 6.3615 -9.1591 3.2566
BC-1 GDSC1 -0.1266 2.1887 -7.697 0.02
NK-92MI GDSC1 -0.1243 2.5384 -7.8079 0.0533
RL GDSC1 -0.1136 6.0655 -9.0354 2.7691
ALL-SIL GDSC1 -0.1116 2.0914 -7.6613 0.0134
Reh GDSC1 -0.1077 1.8562 -7.5855 0.0052
RPMI-8402 GDSC1 -0.0978 2.6513 -7.8356 0.0644
LC4-1 GDSC1 -0.0648 2.6482 -7.8239 0.0575
LP-1 GDSC1 -0.0626 3.0753 -7.9614 0.141
ATN-1 GDSC1 -0.0609 4.7815 -8.5409 1.1434
SUP-T1 GDSC1 -0.0582 2.9521 -7.9198 0.11
EB2 GDSC1 -0.0524 2.1162 -7.6503 0.0112
SR GDSC1 -0.0512 2.2259 -7.6848 0.0164
NALM-6 GDSC1 -0.0496 2.4155 -7.7446 0.0294
VAL GDSC1 -0.0483 4.0415 -8.2785 0.5514
JURL-MK1 GDSC1 -0.0452 5.6516 -8.8513 2.0692
HDLM-2 GDSC1 -0.0383 3.4261 -8.0684 0.2405
Sc-1 GDSC1 -0.0304 2.4235 -7.741 0.028
Jiyoye GDSC1 -0.0279 2.275 -7.6929 0.0175
MOLT-16 GDSC1 -0.0141 1.867 -7.5593 0.0032
PF-382 GDSC1 -0.012 4.1983 -8.3192 0.6177
OCI-M1 GDSC1 -0.004 1.6844 -7.4984 0.0011
U266B1 GDSC1 0.0061 2.6058 -7.7876 0.0407
Namalwa GDSC1 0.0076 6.1449 -9.0146 2.6
BV-173 GDSC1 0.0227 6.0941 -8.9891 2.4978
DoHH2 GDSC1 0.023 6.9475 -9.3172 3.7334
EM-2 GDSC1 0.0236 3.0749 -7.9329 0.1124
MEG-01 GDSC1 0.0266 6.0077 -8.9549 2.3746
MOLT-4 GDSC1 0.0292 2.3275 -7.6915 0.0163
MLMA GDSC1 0.0335 3.4056 -8.0376 0.1985
RS4;11 GDSC1 0.0338 14.1929 -12.4373 15.9282
ROS-50 GDSC1 0.05 3.3346 -8.0088 0.1695
ST486 GDSC1 0.061 2.1279 -7.6181 0.0067
MV4-11 GDSC1 0.0706 3.4173 -8.029 0.1857
RPMI-6666 GDSC1 0.0718 2.4665 -7.7221 0.0213
HT GDSC1 0.0718 3.5161 -8.0611 0.2174
KMOE-2 GDSC1 0.0762 3.291 -7.9859 0.1473
TK [Human B-cell lymphoma] GDSC1 0.0807 2.5818 -7.7559 0.0291
P31/FUJ GDSC1 0.0887 2.3712 -7.6864 0.0146
GR-ST GDSC1 0.0961 3.6988 -8.1133 0.2722
Karpas-299 GDSC1 0.0979 2.6931 -7.786 0.0372
KY821 GDSC1 0.1033 2.5585 -7.7413 0.0249
JVM-2 GDSC1 0.1058 4.2778 -8.3047 0.5575
Karpas-620 GDSC1 0.1064 3.2246 -7.9543 0.1207
NOMO-1 GDSC1 0.108 2.2138 -7.6304 0.0075
MN-60 GDSC1 0.1086 2.5971 -7.7519 0.0274
RPMI-8866 GDSC1 0.1087 3.6232 -8.084 0.2368
KCL-22 GDSC1 0.1152 5.4589 -8.7168 1.5484
NKM-1 GDSC1 0.122 3.0513 -7.8931 0.0814
OCI-AML-3 GDSC1 0.1338 3.608 -8.0706 0.2191
L-1236 GDSC1 0.1341 5.2475 -8.6333 1.3008
L-363 GDSC1 0.1386 6.4979 -9.0936 2.7859
Granta-519 GDSC1 0.1496 3.3858 -7.9925 0.1457
SUP-M2 GDSC1 0.1549 2.6915 -7.7672 0.0302
HH [Human lymphoma] GDSC1 0.1627 3.111 -7.8992 0.0823
SK-MM-2 GDSC1 0.1698 2.7652 -7.7859 0.0351
SU-DHL-5 GDSC1 0.1771 1.6878 -7.4423 0.0003
Raji GDSC1 0.1846 2.8673 -7.8138 0.0436
KMS-12-BM GDSC1 0.1858 2.8515 -7.8084 0.0417
PL-21 GDSC1 0.1885 3.577 -8.0421 0.1844
OCI-AML-2 GDSC1 0.1957 2.7344 -7.7678 0.0293
P12-Ichikawa GDSC1 0.2028 3.2613 -7.9347 0.1003
RPMI-8226 GDSC1 0.2051 2.705 -7.7554 0.026
KM-H2 GDSC1 0.2097 2.6959 -7.7511 0.0249
KG-1 GDSC1 0.216 2.6479 -7.7338 0.021
DG-75 GDSC1 0.2191 6.5917 -9.0954 2.7308
TUR GDSC1 0.2265 4.5008 -8.3382 0.5857
SUP-HD1 GDSC1 0.2388 2.9144 -7.8115 0.0409
SU-DHL-6 GDSC1 0.2484 2.7418 -7.7533 0.0245
Ku812 GDSC1 0.2559 15.9683 -13.119 17.7145
OPM-2 GDSC1 0.2617 4.329 -8.2674 0.4555
RC-K8 GDSC1 0.2643 2.3722 -7.631 0.0064
WSU-NHL GDSC1 0.2675 5.2717 -8.5915 1.1292
JJN-3 GDSC1 0.2688 3.3364 -7.9374 0.0974
HAL-01 GDSC1 0.2727 2.54 -7.6815 0.0116
A4/Fukuda GDSC1 0.2866 6.2321 -8.9326 2.1222
JSC-1 GDSC1 0.289 3.2338 -7.8977 0.0743
L-540 GDSC1 0.3208 2.6334 -7.6959 0.0129
MC116 GDSC1 0.3272 3.6841 -8.0312 0.1598
THP-1 GDSC1 0.3443 3.6727 -8.0218 0.1505
ARH-77 GDSC1 0.3573 2.9764 -7.7933 0.0319
IM-9 GDSC1 0.3666 2.9671 -7.7874 0.0301
HC-1 GDSC1 0.3671 4.5426 -8.303 0.4885
SUP-B15 GDSC1 0.3677 4.0259 -8.13 0.2507
BC-3 GDSC1 0.3877 2.5772 -7.6568 0.0078
SCC-3 GDSC1 0.3918 3.4882 -7.9464 0.0946
VL51 GDSC1 0.4173 3.365 -7.8984 0.068
MOLP-8 GDSC1 0.4373 15.8318 -12.945 16.9122
Daudi GDSC1 0.4657 2.5878 -7.6354 0.0055
CA46 GDSC1 0.5465 3.2214 -7.8109 0.0317
DB GDSC1 0.5773 3.615 -7.927 0.0734
EHEB GDSC1 0.6183 3.6168 -7.9143 0.0655
QIMR-WIL GDSC1 0.6915 3.5032 -7.8544 0.0402
Hs 445 GDSC1 0.6988 3.0385 -7.7043 0.0099
CTV-1 GDSC1 1.0235 3.6643 -7.7996 0.0195
⏷ Show the Full List of 146 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 4 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KYSE-50 GDSC1 -0.7161 14.5489 -13.0675 19.1315
HCE-4 GDSC1 -0.4142 8.9822 -10.3688 8.7084
KYSE-220 GDSC1 -0.1597 4.1362 -8.3508 0.7281
TE-12 GDSC1 -0.0761 6.9738 -9.3719 4.0453
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC1 0.3668 4.8314 -8.4015 0.6654
Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SK-N-MC-IXC GDSC1 -0.6668 17.4945 -14.4286 22.709
SK-N-SH GDSC1 -0.3709 13.0366 -12.1517 15.6101
SJNB-7 GDSC1 -0.3459 2.3122 -7.8069 0.0633
CHP-126 GDSC1 -0.1985 2.7264 -7.8926 0.1025
SK-N-DZ GDSC1 -0.1979 8.3515 -9.9903 6.7888
SiMa GDSC1 -0.1825 3.0986 -8.0088 0.1967
GI-ME-N GDSC1 -0.165 9.7913 -10.5855 9.2792
CHP-212 GDSC1 -0.1632 4.6141 -8.5199 1.1343
NB(TU)1 GDSC1 -0.1632 2.6961 -7.8713 0.0869
SJNB-5 GDSC1 -0.1539 3.2921 -8.063 0.2515
SK-N-AS GDSC1 -0.1238 2.7081 -7.8624 0.0794
TGW GDSC1 -0.0792 2.4435 -7.763 0.0356
SJNB-6 GDSC1 -0.0394 2.535 -7.7795 0.0396
SJNB-13 GDSC1 -0.0338 3.3185 -8.0314 0.2007
IMR-5 GDSC1 -0.0283 3.9669 -8.246 0.4891
Kelly GDSC1 -0.0112 2.4349 -7.7385 0.0269
NB69 GDSC1 0.0317 2.6462 -7.7922 0.0414
KP-N-YN GDSC1 0.0324 2.9045 -7.8749 0.0769
MHH-NB-11 GDSC1 0.056 2.2929 -7.6719 0.0128
SK-N-FI GDSC1 0.0877 3.0014 -7.8882 0.0808
NH-12 GDSC1 0.0937 2.6782 -7.7826 0.0363
SK-N-BE(2)-M17 GDSC1 0.134 2.3402 -7.6622 0.0107
GOTO GDSC1 0.1418 2.791 -7.8032 0.0414
LA-N-6 GDSC1 0.1887 2.9597 -7.8421 0.054
SJNB-10 GDSC1 0.1923 2.8159 -7.7949 0.0371
SJNB-12 GDSC1 0.2079 6.4007 -9.0278 2.4995
SJNB-14 GDSC1 0.3088 2.5171 -7.6628 0.009
NB1 GDSC1 0.312 2.5745 -7.68 0.011
KP-N-YS GDSC1 0.4394 2.9986 -7.7741 0.0252
⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuCC-T1 GDSC1 -0.4964 4.2813 -8.5278 1.318
Cancer Drug Sensitivity Data Curated from 50 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CAL-85-1 GDSC1 -7.6827 2.9329 -12.5246 34.4256
HCC1954 GDSC1 -6.9787 -4.0662 -8.4263 11.5256
CAL-51 GDSC1 -6.8805 -3.9194 -8.4185 11.1104
MDA-MB-468 GDSC1 -6.8268 5.4954 -13.0809 32.9724
DU4475 GDSC1 -5.1607 5.0718 -11.5545 23.4645
JIMT-1 GDSC1 -0.6715 10.1489 -11.0214 11.8378
MFM-223 GDSC1 -0.4452 4.7979 -8.6962 1.8121
HCC1569 GDSC1 -0.4112 7.883 -9.901 6.6679
CAMA-1 GDSC1 -0.2469 4.1886 -8.4009 0.8717
MDA-MB-453 GDSC1 -0.2427 3.176 -8.0546 0.2552
HCC38 GDSC1 -0.202 2.515 -7.8255 0.0649
HDQ-P1 GDSC1 -0.1935 4.7195 -8.5691 1.2827
MDA-MB-175-VII GDSC1 -0.1642 3.7579 -8.2227 0.483
ZR-75-30 GDSC1 -0.1384 9.6327 -10.5031 8.8968
HCC70 GDSC1 -0.1275 16.8383 -13.7657 20.1475
MCF-7 GDSC1 -0.0998 9.823 -10.5646 9.1008
MDA-MB-361 GDSC1 -0.0974 2.7227 -7.8585 0.0758
Evsa-T GDSC1 -0.081 2.8501 -7.8943 0.0951
MDA-MB-231 GDSC1 -0.0476 3.1405 -7.9777 0.1529
HCC1419 GDSC1 -0.0191 3.0669 -7.9443 0.124
EFM-19 GDSC1 -0.0161 26.5397 -18.3394 28.9398
HCC202 GDSC1 -0.0147 4.1003 -8.2867 0.5573
HCC1599 GDSC1 0.0026 3.6262 -8.1209 0.2969
EFM-192A GDSC1 0.0223 34.843 -22.3708 33.4069
BT-20 GDSC1 0.0276 2.7851 -7.8381 0.0594
COLO 824 GDSC1 0.0576 3.8951 -8.192 0.3839
BT-549 GDSC1 0.0627 4.1054 -8.2612 0.4923
UACC-812 GDSC1 0.0763 4.3674 -8.3458 0.6432
MDA-MB-157 GDSC1 0.0836 12.0972 -11.4612 12.4041
HCC1806 GDSC1 0.098 9.391 -10.2778 7.6373
BT-483 GDSC1 0.1289 2.5506 -7.7306 0.022
CAL-120 GDSC1 0.1341 2.4731 -7.7043 0.0169
HCC1187 GDSC1 0.1535 5.2909 -8.6414 1.3137
HCC1500 GDSC1 0.1704 2.849 -7.8125 0.0436
MRK-nu-1 GDSC1 0.1718 2.3423 -7.6508 0.009
MDA-MB-415 GDSC1 0.1919 8.8108 -9.9889 6.3126
HCC1428 GDSC1 0.2275 9.9893 -10.4648 8.2481
AU565 GDSC1 0.2405 5.7328 -8.7674 1.6306
OCUB-M GDSC1 0.2406 2.8613 -7.7939 0.0354
HCC2157 GDSC1 0.2583 2.7811 -7.7627 0.0265
MDA-MB-436 GDSC1 0.2634 5.6171 -8.7166 1.4697
HCC2218 GDSC1 0.2876 3.3753 -7.9439 0.1001
MDA-MB-330 GDSC1 0.2908 9.7904 -10.3484 7.6868
HCC1395 GDSC1 0.3002 11.1789 -10.9377 10.0648
BT-474 GDSC1 0.3003 3.819 -8.0844 0.2116
CAL-148 GDSC1 0.3313 3.0703 -7.8316 0.0446
HCC1937 GDSC1 0.3349 3.2075 -7.8745 0.0612
Hs 578T GDSC1 0.4032 3.3655 -7.9031 0.0709
UACC-893 GDSC1 0.6535 5.1606 -8.4124 0.6047
T-47D GDSC1 0.8641 15.4455 -12.5143 14.9249
⏷ Show the Full List of 50 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 52 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
M059J GDSC1 -8.7866 -0.2211 -11.9542 37.3893
MOG-G-UVW GDSC1 -8.0759 -3.6039 -9.6426 24.6604
D-542MG GDSC1 -7.5998 -1.0076 -10.4885 27.0781
YKG-1 GDSC1 -7.2185 -2.2867 -9.5191 20.1962
LN-405 GDSC1 -7.164 -6.2082 -7.5202 5.1479
D-502MG GDSC1 -7.0148 0.986 -10.9826 26.9987
H4 GDSC1 -6.703 5.9565 -13.2092 32.9014
Daoy GDSC1 -6.0843 1.2055 -10.3421 20.8434
LNZTA3WT4 GDSC1 -1.1964 5.2922 -9.2149 4.5465
DBTRG-05MG GDSC1 -1.1696 8.1892 -10.432 10.1074
SW1088 GDSC1 -1.0955 8.8908 -10.7013 11.1704
CAS-1 GDSC1 -0.6871 8.9776 -10.513 9.7247
LN-18 GDSC1 -0.5836 7.3053 -9.7458 6.2
D-392MG GDSC1 -0.5636 8.1654 -10.0973 7.7308
D-263MG GDSC1 -0.5275 2.9116 -8.0634 0.3154
SF295 GDSC1 -0.504 7.4471 -9.7654 6.1885
Onda 11 GDSC1 -0.4611 6.7976 -9.4785 4.8875
SK-MG-1 GDSC1 -0.4238 3.9019 -8.3656 0.8562
U-251MG GDSC1 -0.3713 7.269 -9.6277 5.4297
T98G GDSC1 -0.3217 4.9674 -8.7093 1.7778
D-423MG GDSC1 -0.3138 2.8374 -7.9668 0.172
SF126 GDSC1 -0.2829 6.6892 -9.3527 4.1697
ONS-76 GDSC1 -0.2423 8.716 -10.166 7.6019
SNB-75 GDSC1 -0.235 10.632 -10.9906 11.0448
SW1783 GDSC1 -0.1573 9.5885 -10.494 8.8847
D-566MG GDSC1 -0.1356 6.1029 -9.0591 2.8747
YH-13 GDSC1 -0.0933 9.0243 -10.2203 7.6405
GI-1 GDSC1 -0.056 15.267 -12.9871 17.8085
SF539 GDSC1 -0.0348 3.5636 -8.1128 0.2929
D283 Med GDSC1 -0.0219 2.9781 -7.9164 0.1049
LN-229 GDSC1 -0.0119 11.05 -11.0512 10.9586
KNS-81-FD GDSC1 0.0174 3.7433 -8.1549 0.3391
DK-MG GDSC1 0.0519 14.4973 -12.5659 16.3193
8-MG-BA GDSC1 0.1001 2.6369 -7.7673 0.0317
A-172 GDSC1 0.1199 2.9913 -7.8745 0.0718
SF268 GDSC1 0.1302 2.9678 -7.8636 0.0661
KALS-1 GDSC1 0.2124 10.6276 -10.746 9.4176
AM-38 GDSC1 0.248 3.5417 -8.0109 0.151
U-87MG ATCC GDSC1 0.2529 2.8381 -7.7826 0.0318
Hs 683 GDSC1 0.2928 12.6952 -11.6089 12.6435
U-118MG GDSC1 0.3069 2.6758 -7.7137 0.0158
KNS-42 GDSC1 0.3111 12.579 -11.5469 12.3876
42-MG-BA GDSC1 0.3219 2.6305 -7.6946 0.0128
MOG-G-CCM GDSC1 0.3408 6.6295 -9.0589 2.5124
NMC-G1 GDSC1 0.3596 16.1463 -13.1374 17.6089
PFSK-1 GDSC1 0.4011 2.9631 -7.775 0.0262
Onda 10 GDSC1 0.4051 3.4412 -7.9269 0.0829
KINGS-1 GDSC1 0.41 4.0389 -8.12 0.2341
Becker GDSC1 0.4444 3.4318 -7.9111 0.0727
GaMG GDSC1 0.4748 2.9747 -7.7552 0.0205
GB-1 GDSC1 0.5476 2.6538 -7.6304 0.0047
KS-1 [Human Krukenberg tumour] GDSC1 0.5549 4.0374 -8.0713 0.1704
⏷ Show the Full List of 52 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TGBC24TKB GDSC1 0.0544 2.7361 -7.8137 0.0483
ETK-1 GDSC1 0.0598 5.9347 -8.914 2.2106
TGBC1TKB GDSC1 0.0998 2.5501 -7.7398 0.0247
Cancer Drug Sensitivity Data Curated from 7 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MFE-296 GDSC1 -0.4721 5.8579 -9.11 3.3602
ESS-1 GDSC1 -0.0596 7.9858 -9.7715 5.6888
KLE GDSC1 -0.0295 2.8703 -7.884 0.0856
MFE-319 GDSC1 0.0457 4.5998 -8.4373 0.8465
AN3-CA GDSC1 0.1305 14.9206 -12.7127 16.6649
MFE-280 GDSC1 0.1454 6.5811 -9.1225 2.8859
EN GDSC1 0.3446 9.3405 -10.1334 6.7326
⏷ Show the Full List of 7 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 25 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
786-O GDSC1 -1.4567 9.8532 -11.3482 14.4685
OS-RC-2 GDSC1 -0.9242 11.6366 -11.8442 15.436
BFTC-909 GDSC1 -0.7456 5.4603 -9.0755 3.4729
BB65-RCC GDSC1 -0.4781 9.7119 -10.7202 10.2951
VMRC-RCZ GDSC1 -0.4016 5.5471 -8.9597 2.7148
A-498 GDSC1 -0.3272 15.3347 -13.1884 18.8461
RCC10RGB GDSC1 -0.3063 10.8686 -11.135 11.7301
SN12C GDSC1 -0.2795 9.6875 -10.6018 9.5089
Caki-1 GDSC1 -0.213 8.486 -10.0542 7.0829
SW13 GDSC1 -0.1605 10.4406 -10.8655 10.4282
CAL-54 GDSC1 -0.108 9.8305 -10.5722 9.1438
TK-10 GDSC1 -0.08 13.3325 -12.1126 15.011
RXF 393L GDSC1 -0.0494 6.7227 -9.2614 3.5791
A-704 GDSC1 0.041 6.3078 -9.0624 2.7477
UO-31 GDSC1 0.0521 2.8157 -7.84 0.0591
KMRC-1 GDSC1 0.1472 8.5088 -9.8863 5.936
769-P GDSC1 0.1832 11.1649 -10.9948 10.4548
LB996-RCC GDSC1 0.2041 3.0778 -7.8751 0.0677
LB2241-RCC GDSC1 0.2069 2.8694 -7.8073 0.0406
LB1047-RCC GDSC1 0.3008 3.9206 -8.1177 0.2466
HA7-RCC GDSC1 0.3193 16.1017 -13.1416 17.6834
SW156 GDSC1 0.328 2.9193 -7.7845 0.0303
ACHN GDSC1 0.412 3.8278 -8.0501 0.1671
VMRC-RCW GDSC1 0.4286 17.9185 -13.9178 19.6854
KMRC-20 GDSC1 0.5614 9.9648 -10.2858 7.099
⏷ Show the Full List of 25 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 37 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HT-55 GDSC1 -7.1029 -5.5308 -7.8005 7.0972
LoVo GDSC1 -0.8331 12.8043 -12.3275 16.9769
RKO GDSC1 -0.5839 5.4235 -8.9903 2.9835
CaR-1 GDSC1 -0.432 9.4591 -10.5847 9.6562
HCT 116 GDSC1 -0.3541 1.7814 -7.64 0.0135
COLO 320HSR GDSC1 -0.2716 4.8855 -8.6595 1.5905
SW1417 GDSC1 -0.2443 2.8033 -7.9326 0.1353
NCI-H716 GDSC1 -0.2224 2.3302 -7.7728 0.0436
LS123 GDSC1 -0.2183 2.1939 -7.7279 0.0293
SNU-C2B GDSC1 -0.2141 13.8211 -12.4168 16.2536
CL-11 GDSC1 -0.1058 2.5062 -7.7916 0.0462
GP5d GDSC1 -0.1015 2.5522 -7.805 0.0512
NCI-H747 GDSC1 -0.0659 6.6325 -9.2334 3.4842
HT-29 GDSC1 -0.0432 2.4871 -7.7654 0.0352
C2BBe1 GDSC1 -0.0218 3.4205 -8.061 0.23
SW837 GDSC1 -0.0079 12.6172 -11.7465 13.5994
SW1463 GDSC1 -0.0003 8.6063 -9.9985 6.5813
MDST8 GDSC1 0.0067 4.1377 -8.2919 0.5609
COLO 678 GDSC1 0.0129 4.2282 -8.3206 0.6131
T84 GDSC1 0.0407 3.0961 -7.9341 0.112
SW948 GDSC1 0.0535 8.582 -9.962 6.3624
LS513 GDSC1 0.0661 4.5761 -8.4216 0.8042
HCT 15 GDSC1 0.1011 7.5738 -9.5297 4.5111
CCK-81 GDSC1 0.1316 2.9382 -7.8536 0.0614
LS180 GDSC1 0.1408 2.378 -7.672 0.0118
SW626 GDSC1 0.1493 6.9758 -9.2727 3.4474
RCM-1 [Human ESC] GDSC1 0.1646 3.1119 -7.8988 0.082
SW620 GDSC1 0.1749 2.2484 -7.6201 0.0061
CW-2 GDSC1 0.1774 2.8399 -7.8074 0.0416
COLO205 GDSC1 0.182 8.1485 -9.723 5.2193
LS1034 GDSC1 0.2081 2.3962 -7.6564 0.0093
SNU-C1 GDSC1 0.2312 3.3142 -7.9425 0.1032
LS411N GDSC1 0.2682 4.7483 -8.4082 0.7088
HCC2998 GDSC1 0.3386 3.1657 -7.8598 0.0549
HT115 GDSC1 0.3574 2.8249 -7.745 0.0206
KM12 GDSC1 0.5189 2.8451 -7.7001 0.0112
SW48 GDSC1 0.6023 2.8716 -7.682 0.0085
⏷ Show the Full List of 37 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC1 -0.4185 3.5563 -8.2437 0.5908
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Huh-7 GDSC1 -6.6902 4.6389 -12.5401 31.1765
JHH-6 GDSC1 -0.2933 1.9919 -7.6875 0.0212
SNU-387 GDSC1 -0.2582 2.823 -7.9436 0.1456
JHH-7 GDSC1 -0.2279 2.7435 -7.9078 0.1152
JHH-1 GDSC1 -0.1115 11.8147 -11.4461 12.6415
SNU-423 GDSC1 0.0282 3.594 -8.1015 0.2688
JHH-4 GDSC1 0.0569 4.4522 -8.382 0.7224
SNU-475 GDSC1 0.0782 2.2996 -7.667 0.0119
JHH-2 GDSC1 0.1088 2.8518 -7.8333 0.0538
SNU-449 GDSC1 0.1494 5.1826 -8.6043 1.2153
Hep-G2/C3A GDSC1 0.1688 15.2352 -12.8341 16.9851
SK-HEP-1 GDSC1 0.242 6.0443 -8.881 1.9827
SNU-398 GDSC1 0.251 2.9136 -7.8073 0.0392
Hep 3B2.1-7 GDSC1 0.2598 13.4426 -11.9628 13.965
HuH-1 GDSC1 0.283 9.7658 -10.342 7.67
HLE GDSC1 0.3749 3.3112 -7.8948 0.0684
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 168 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RERF-LC-MS GDSC1 -7.2336 3.788 -12.5675 32.995
SBC-5 GDSC1 -7.1264 2.3551 -11.7607 30.2768
NCI-H727 GDSC1 -6.8047 4.0948 -12.3625 31.0405
LK-2 GDSC1 -6.3592 -1.4766 -9.2227 15.1486
NCI-H1437 GDSC1 -5.6554 0.2094 -9.5286 14.9279
NCI-H1573 GDSC1 -5.269 6.5702 -12.3769 26.6051
NCI-H2030 GDSC1 -4.9607 10.6566 -14.1668 30.4832
NCI-H1648 GDSC1 -3.8469 6.8302 -11.4693 19.816
NCI-H2122 GDSC1 -1.5711 11.7258 -12.2891 18.1458
SBC-3 GDSC1 -0.9233 18.4284 -15.0484 24.5489
DMS 53 GDSC1 -0.7644 9.5121 -10.7908 11.0274
NCI-H2110 GDSC1 -0.7509 5.5022 -9.0943 3.5559
NCI-H3255 GDSC1 -0.6951 4.3887 -8.6453 1.8022
NCI-H513 GDSC1 -0.6703 11.5428 -11.6488 14.2905
NCI-H522 GDSC1 -0.6539 12.3706 -12.0173 15.6041
HCC44 GDSC1 -0.6505 20.2585 -15.7421 25.5474
NCI-H345 GDSC1 -0.6253 6.1246 -9.2842 4.2306
NCI-H1876 GDSC1 -0.5697 2.6804 -8.0009 0.2422
NCI-H1299 GDSC1 -0.5052 18.2095 -14.6617 22.9987
NCI-H2795 GDSC1 -0.4895 19.6182 -15.3246 24.4425
NCI-H292 GDSC1 -0.4761 15.267 -13.2511 19.2736
NCI-H460 GDSC1 -0.461 6.2661 -9.2656 3.9856
COR-L105 GDSC1 -0.4228 11.8567 -11.6452 13.8763
SK-LU-1 GDSC1 -0.4048 8.1952 -10.0288 7.2189
COR-L95 GDSC1 -0.4037 2.2554 -7.8073 0.0666
NCI-H187 GDSC1 -0.3808 1.8752 -7.6783 0.021
NCI-H2342 GDSC1 -0.3769 12.7914 -12.0431 15.2418
NCI-H838 GDSC1 -0.3719 6.305 -9.2408 3.7966
RERF-LC-KJ GDSC1 -0.368 12.7692 -12.0276 15.1727
SK-MES-1 GDSC1 -0.3641 9.1268 -10.4045 8.7919
NCI-H1993 GDSC1 -0.3592 13.1246 -12.1849 15.7054
NCI-H2818 GDSC1 -0.3555 2.7931 -7.9661 0.1762
NCI-H2023 GDSC1 -0.344 2.2873 -7.7982 0.0592
NCI-H196 GDSC1 -0.3399 2.675 -7.9223 0.1362
NCI-H1963 GDSC1 -0.3366 3.3325 -8.139 0.3871
SW1573 GDSC1 -0.3363 7.6788 -9.7791 6.0448
NCI-H2170 GDSC1 -0.3286 9.1468 -10.3945 8.6994
Calu-6 GDSC1 -0.3272 4.6612 -8.5996 1.4399
HOP-62 GDSC1 -0.3252 11.4031 -11.3842 12.734
NCI-H520 GDSC1 -0.3251 7.2507 -9.5982 5.2505
IA-LM GDSC1 -0.3235 1.8723 -7.6591 0.0162
PC-14 GDSC1 -0.3108 10.5775 -11.0086 11.2309
IST-SL1 GDSC1 -0.3026 2.8884 -7.9798 0.183
NCI-H1838 GDSC1 -0.2925 2.2513 -7.7701 0.0453
NCI-H1793 GDSC1 -0.2555 6.6836 -9.338 4.082
NCI-H1755 GDSC1 -0.2384 9.3535 -10.4358 8.7505
NCI-H2595 GDSC1 -0.2374 3.6869 -8.2243 0.5044
NCI-H841 GDSC1 -0.2364 8.0001 -9.8632 6.2881
ABC-1 GDSC1 -0.2272 5.6845 -8.9385 2.5015
NCI-H1563 GDSC1 -0.2222 11.8839 -11.5406 13.1691
NCI-H2804 GDSC1 -0.2093 8.4791 -10.0494 7.0577
HCC78 GDSC1 -0.1868 9.9596 -10.6701 9.6622
Lu-99A GDSC1 -0.1749 19.3099 -14.9663 23.1702
NCI-H69 GDSC1 -0.1583 2.6143 -7.8433 0.0713
NCI-H1944 GDSC1 -0.1546 9.3347 -10.3838 8.4158
NCI-H2373 GDSC1 -0.1507 4.608 -8.5131 1.1107
NCI-H2009 GDSC1 -0.128 11.0731 -11.1258 11.4251
NCI-H1666 GDSC1 -0.1242 3.0013 -7.9575 0.1438
NCI-H1568 GDSC1 -0.1218 13.8829 -12.3891 16.0145
NCI-H1792 GDSC1 -0.1211 10.4697 -10.8567 10.3353
NCI-H1693 GDSC1 -0.1185 11.4336 -11.2802 12.0155
IST-SL2 GDSC1 -0.1144 3.1336 -7.9976 0.1777
LC-2/ad GDSC1 -0.1093 3.0509 -7.9688 0.1517
NCI-H2444 GDSC1 -0.1036 2.3936 -7.7549 0.0338
NCI-H2172 GDSC1 -0.1028 13.0212 -11.9846 14.5996
NCI-H2722 GDSC1 -0.0981 6.5799 -9.2271 3.488
NCI-H226 GDSC1 -0.0919 2.5973 -7.8164 0.0555
LCLC-97TM1 GDSC1 -0.0845 3.0944 -7.9748 0.1542
EPLC-272H GDSC1 -0.0799 3.2726 -8.0317 0.2069
CAL-12T GDSC1 -0.0791 12.6819 -11.817 13.9651
SW1271 GDSC1 -0.0688 11.8155 -11.4221 12.4852
DMS 79 GDSC1 -0.0627 4.8784 -8.5761 1.2387
NCI-H2461 GDSC1 -0.0615 15.6848 -13.1846 18.4072
NCI-H446 GDSC1 -0.0591 4.8444 -8.5626 1.2005
NCI-H1355 GDSC1 -0.056 19.9257 -15.1805 23.4583
NCI-H647 GDSC1 -0.0449 7.1531 -9.4288 4.2459
DMS 273 GDSC1 -0.0272 5.6088 -8.8281 1.9807
CPC-N GDSC1 -0.0209 2.6248 -7.8023 0.0469
NCI-H2081 GDSC1 -0.0156 3.0287 -7.9307 0.1141
LXF 289 GDSC1 -0.0047 10.2965 -10.7185 9.6055
NCI-H2347 GDSC1 -0.0027 3.7923 -8.1782 0.3761
NCI-H847 GDSC1 0.0041 2.3073 -7.693 0.0169
NCI-H2731 GDSC1 0.0081 6.1431 -9.0137 2.5964
NCI-H1092 GDSC1 0.0116 2.0057 -7.5951 0.0052
HCC15 GDSC1 0.0149 5.1126 -8.6305 1.3516
NCI-H1435 GDSC1 0.0391 6.466 -9.1236 2.975
A-549 GDSC1 0.0466 4.8412 -8.5218 1.0474
NCI-H526 GDSC1 0.047 3.0917 -7.9307 0.1091
HARA [Human squamous cell lung carcinoma] GDSC1 0.0475 2.9491 -7.8844 0.0811
NCI-H2803 GDSC1 0.0516 6.2354 -9.0305 2.6239
HCC33 GDSC1 0.0523 4.8445 -8.5208 1.0425
EBC-1 GDSC1 0.0634 2.5597 -7.7544 0.0291
NCI-H1703 GDSC1 0.0645 2.8437 -7.845 0.0607
NCI-H748 GDSC1 0.0747 3.7432 -8.1353 0.3029
NCI-H1304 GDSC1 0.075 7.9296 -9.6847 5.1759
NCI-H1623 GDSC1 0.0755 2.628 -7.7723 0.0338
Lu-134-A GDSC1 0.077 3.6869 -8.1158 0.2783
NCI-H2029 GDSC1 0.0825 2.4047 -7.699 0.0168
Lu-165 GDSC1 0.089 3.0458 -7.9021 0.0885
NCI-H2227 GDSC1 0.0911 3.4251 -8.0248 0.1794
NCI-H1581 GDSC1 0.096 3.3272 -7.9911 0.1497
NCI-H2869 GDSC1 0.0965 7.4459 -9.4809 4.3178
NCI-H358 GDSC1 0.1011 2.4396 -7.7042 0.0174
LB647-SCLC GDSC1 0.1077 2.7116 -7.7887 0.0378
Lu-139 GDSC1 0.1114 3.7783 -8.1345 0.2957
NCI-H1688 GDSC1 0.1146 3.3183 -7.9821 0.1407
COR-L23 GDSC1 0.1148 9.6034 -10.3591 7.9555
NCI-H64 GDSC1 0.1217 1.8852 -7.5221 0.0015
NCI-H1836 GDSC1 0.1338 2.5782 -7.7379 0.0235
NCI-H2085 GDSC1 0.1347 3.3737 -7.9935 0.1479
NCI-H1436 GDSC1 0.1352 2.2129 -7.6215 0.0065
NCI-H720 GDSC1 0.153 2.6046 -7.7401 0.0236
NCI-H2087 GDSC1 0.1617 3.0803 -7.8896 0.0772
PaCa-3 GDSC1 0.1651 5.8616 -8.8443 1.9127
SHP-77 GDSC1 0.1659 2.428 -7.6799 0.0126
NCI-H2196 GDSC1 0.1662 2.8249 -7.8062 0.0416
NCI-H1975 GDSC1 0.1779 2.9508 -7.8427 0.0547
RERF-LC-Sq1 GDSC1 0.1779 2.9126 -7.8305 0.0499
NCI-H1650 GDSC1 0.1807 2.7661 -7.7828 0.0338
NCI-H2228 GDSC1 0.186 3.0378 -7.8681 0.0654
LOU-NH91 GDSC1 0.1957 5.5825 -8.7303 1.5449
NCI-H1694 GDSC1 0.1976 2.4601 -7.68 0.0122
HOP-92 GDSC1 0.1993 8.8428 -9.9985 6.3442
Ms-1 GDSC1 0.2015 3.3054 -7.9494 0.1098
NCI-H524 GDSC1 0.2047 2.4371 -7.6704 0.0109
LC-1/sq GDSC1 0.2077 3.87 -8.1323 0.2774
NCI-H810 GDSC1 0.2113 14.4362 -12.442 15.6677
EKVX GDSC1 0.2179 25.2482 -17.5501 27.4385
NCI-H510A GDSC1 0.2196 2.5192 -7.6918 0.0136
NCI-H82 GDSC1 0.2214 2.534 -7.6959 0.0142
NCI-H3122 GDSC1 0.2351 3.8403 -8.1133 0.2512
NCI-H290 GDSC1 0.237 2.5603 -7.6993 0.0145
A-427 GDSC1 0.239 2.8752 -7.7989 0.0369
NCI-H209 GDSC1 0.3068 4.0365 -8.154 0.2878
UMC-11 GDSC1 0.3145 2.9646 -7.8033 0.036
NCI-H1155 GDSC1 0.332 2.5435 -7.6638 0.0089
NCI-H441 GDSC1 0.333 6.6721 -9.0782 2.5853
COR-L88 GDSC1 0.3351 3.448 -7.9519 0.1017
LCLC-103H GDSC1 0.3369 8.8683 -9.9424 5.9537
NCI-H1770 GDSC1 0.3402 4.7706 -8.3902 0.6513
NCI-H650 GDSC1 0.3467 16.9435 -13.5149 18.7159
NCI-H1651 GDSC1 0.3508 3.8379 -8.0737 0.1952
DMS 114 GDSC1 0.3624 6.1096 -8.857 1.8339
NCI-H1734 GDSC1 0.3659 3.6676 -8.0131 0.1416
NCI-H2171 GDSC1 0.3665 2.468 -7.629 0.0056
ChaGo-K-1 GDSC1 0.3783 11.5076 -11.0384 10.3532
NCI-H596 GDSC1 0.3805 3.3504 -7.9056 0.0733
NCI-H211 GDSC1 0.3818 3.1302 -7.8346 0.0438
Calu-3 GDSC1 0.3819 3.2688 -7.879 0.061
NCI-H2141 GDSC1 0.3902 3.5501 -7.9669 0.1072
NCI-H2291 GDSC1 0.3985 3.4622 -7.9358 0.0881
NCI-H322M GDSC1 0.4216 4.4644 -8.2577 0.4059
NCI-H2591 GDSC1 0.4361 3.2842 -7.8664 0.0535
NCI-H2369 GDSC1 0.4366 4.1613 -8.1515 0.2649
NCI-H1048 GDSC1 0.4423 2.72 -7.6847 0.0102
NCI-H2405 GDSC1 0.4428 4.8086 -8.3668 0.579
Lu-65 GDSC1 0.4839 3.9428 -8.0639 0.1715
NCI-H1781 GDSC1 0.4847 5.4351 -8.5683 0.9835
NCI-H1915 GDSC1 0.5295 2.925 -7.722 0.0141
HCC827 GDSC1 0.5302 15.8138 -12.8805 16.5738
NCI-H661 GDSC1 0.5313 3.1393 -7.7896 0.0268
NCI-H2135 GDSC1 0.5494 3.0995 -7.7712 0.0223
NCI-H23 GDSC1 0.554 4.4031 -8.192 0.2942
COLO 668 GDSC1 0.5727 3.0563 -7.75 0.0179
NCI-H1869 GDSC1 0.6134 3.4166 -7.8518 0.0418
SBC-1 GDSC1 0.6387 2.99 -7.708 0.011
Lu-135 GDSC1 0.654 13.4824 -11.755 12.6478
BEN GDSC1 0.6698 17.3759 -13.5148 18.2244
⏷ Show the Full List of 168 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CBTCi002-A GDSC1 0.0511 3.256 -7.9827 0.1472
Cancer Drug Sensitivity Data Curated from 23 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE-11 GDSC1 -0.7824 4.2653 -8.6347 1.8233
TE-9 GDSC1 -0.4901 6.2298 -9.2644 4.0094
KYSE-450 GDSC1 -0.3626 1.8283 -7.6576 0.0166
TE-6 GDSC1 -0.297 3.0025 -8.0155 0.2189
T.T GDSC1 -0.1885 10.865 -11.0675 11.284
KYSE-180 GDSC1 -0.1861 4.8833 -8.6253 1.4402
OE21 GDSC1 -0.1755 14.0443 -12.4959 16.4523
TE-10 GDSC1 -0.1272 2.7019 -7.8614 0.0791
KYSE-70 GDSC1 -0.1148 4.3225 -8.3993 0.8187
TE-5 GDSC1 -0.0579 7.0567 -9.3965 4.1272
TE-15 GDSC1 -0.051 9.148 -10.251 7.7158
TE-8 GDSC1 -0.0154 7.7118 -9.6391 5.0831
KYSE-270 GDSC1 0.0092 9.5865 -10.4062 8.2909
TE-1 GDSC1 0.0244 3.0512 -7.9249 0.1071
EC-GI-10 GDSC1 0.0266 2.542 -7.7606 0.0318
KYSE-410 GDSC1 0.0737 9.3774 -10.2844 7.696
OE19 GDSC1 0.1653 3.6933 -8.0882 0.2335
KYSE-140 GDSC1 0.3068 3.4969 -7.977 0.1203
OE33 GDSC1 0.3221 3.2738 -7.8999 0.0736
COLO 680N GDSC1 0.3976 10.4441 -10.5705 8.4596
KYSE-510 GDSC1 0.5808 2.7253 -7.6425 0.0053
KYSE-520 GDSC1 0.7661 15.9789 -12.8144 16.0171
KYSE-150 GDSC1 1.044 15.5723 -12.4667 14.5115
⏷ Show the Full List of 23 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 25 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
OV-90 GDSC1 -2.75 5.1179 -9.9609 10.5686
OAW28 GDSC1 -0.4813 9.3445 -10.5614 9.629
TOV-21G GDSC1 -0.305 4.7543 -8.6248 1.5032
A2780 GDSC1 -0.2888 4.2538 -8.4393 0.9817
OVTOKO GDSC1 -0.2511 4.6694 -8.5732 1.323
TYK-nu GDSC1 -0.2282 2.6964 -7.8926 0.1048
OAW42 GDSC1 -0.2165 3.0526 -8.005 0.1973
Kuramochi GDSC1 -0.17 3.4617 -8.125 0.3331
Caov-3 GDSC1 -0.115 2.179 -7.6902 0.0184
EFO-27 GDSC1 -0.0688 2.8121 -7.878 0.0847
OVISE GDSC1 -0.0615 3.0576 -7.9552 0.136
OVCAR-4 GDSC1 -0.0069 6.4682 -9.1442 3.0899
OVCAR-8 GDSC1 0.0535 2.5048 -7.7401 0.0258
EFO-21 GDSC1 0.0599 2.4409 -7.7177 0.0207
OVCAR-5 GDSC1 0.0664 4.3408 -8.3402 0.6352
SK-OV-3 GDSC1 0.1115 3.2313 -7.9548 0.1206
OVKATE GDSC1 0.138 2.4341 -7.6907 0.0146
TOV-112D GDSC1 0.1569 2.6105 -7.7407 0.0237
ES-2 GDSC1 0.2366 3.666 -8.0554 0.1912
Caov-4 GDSC1 0.2671 2.6683 -7.724 0.0182
IGROV-1 GDSC1 0.2753 18.5162 -14.2958 20.8887
OC 314 GDSC1 0.3837 9.0571 -9.9973 6.1267
FU-OV-1 GDSC1 0.4162 2.7074 -7.689 0.011
OVCAR-3 GDSC1 0.4396 8.1917 -9.6212 4.5433
RMG-I GDSC1 0.5326 4.2001 -8.1321 0.2304
⏷ Show the Full List of 25 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 30 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
YAPC GDSC1 -4.7843 2.7026 -10.1248 15.9408
HPAC GDSC1 -0.8985 11.0059 -11.5401 14.2574
BxPC-3 GDSC1 -0.8336 9.8325 -10.9724 11.894
PSN1 GDSC1 -0.4385 12.8212 -12.0937 15.5185
Panc 04.03 GDSC1 -0.3677 6.4138 -9.2819 3.9612
MZ-PC-1 GDSC1 -0.3431 2.5156 -7.8716 0.0996
KP-1N GDSC1 -0.3341 4.0451 -8.3827 0.8622
KP-4 GDSC1 -0.3216 5.841 -9.0381 2.9476
DAN-G GDSC1 -0.2516 8.0424 -9.8882 6.4145
Panc 08.13 GDSC1 -0.1667 4.2083 -8.3784 0.7907
Hs 766T GDSC1 -0.1553 3.5004 -8.1328 0.3412
PL4 GDSC1 -0.0862 2.7623 -7.8676 0.08
PaTu 8902 GDSC1 -0.0742 7.7052 -9.6641 5.2518
HuP-T3 GDSC1 -0.0125 18.5301 -14.489 21.8077
AsPC-1 GDSC1 0.0106 11.2153 -11.1115 11.164
SUIT-2 GDSC1 0.0266 9.7033 -10.447 8.4384
KP-2 GDSC1 0.0366 2.8151 -7.8448 0.062
KP-3 GDSC1 0.1135 2.8055 -7.8169 0.0472
PaTu 8988t GDSC1 0.1476 7.931 -9.6513 4.961
Capan-1 GDSC1 0.1514 3.7174 -8.1008 0.2493
CFPAC-1 GDSC1 0.2179 7.8249 -9.5763 4.5832
Panc 02.03 GDSC1 0.236 6.2547 -8.9615 2.2522
SW1990 GDSC1 0.3506 7.238 -9.2869 3.3293
HuP-T4 GDSC1 0.3895 7.7757 -9.4793 4.0323
Capan-2 GDSC1 0.3989 3.3287 -7.8927 0.0663
Panc 03.27 GDSC1 0.4451 6.2083 -8.8605 1.7963
SU.86.86 GDSC1 0.4495 2.7147 -7.6808 0.0097
HPAF-II GDSC1 0.5152 16.0756 -13.0097 16.9898
Panc 10.05 GDSC1 0.5378 11.7825 -11.072 10.2643
MIA PaCa-2 GDSC1 0.5888 12.286 -11.2638 10.9293
⏷ Show the Full List of 30 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H28 GDSC1 -0.2665 3.3232 -8.1117 0.3329
IST-Mes1 GDSC1 -0.2008 9.1502 -10.3291 8.2455
MSTO-211H GDSC1 -0.0163 3.037 -7.9337 0.1162
NCI-H2052 GDSC1 0.0009 3.5245 -8.0877 0.2568
NCI-H2452 GDSC1 0.2266 13.1233 -11.8383 13.5742
MPP 89 GDSC1 0.2912 2.3547 -7.617 0.0052
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
VCaP GDSC1 -5.6022 3.0289 -10.8772 21.9177
DU145 GDSC1 -0.8118 6.663 -9.5917 5.7933
LNCaP clone FGC GDSC1 -0.0755 4.2516 -8.3604 0.7204
22Rv1 GDSC1 0.0094 4.5485 -8.4327 0.8492
PC-3 GDSC1 0.0443 2.5697 -7.7638 0.0322
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 GDSC1 -6.2669 -1.4644 -9.158 14.4117
Cancer Drug Sensitivity Data Curated from 56 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MeWo GDSC1 -7.3924 -3.6959 -8.9686 17.1794
M14 GDSC1 -7.0024 7.3335 -14.146 35.6722
IGR-1 GDSC1 -6.8412 -3.9146 -8.3888 10.7425
G-mel GDSC1 -6.8386 -3.0336 -8.8269 14.0266
SK-MEL-30 GDSC1 -6.7993 -2.6259 -8.9986 15.1194
G-361 GDSC1 -6.1076 0.5865 -10.0527 19.3848
COLO 829 GDSC1 -5.3117 3.4937 -10.8892 21.131
CP66-MEL GDSC1 -4.6801 8.1283 -12.703 26.0935
HMV-II GDSC1 -1.0998 18.158 -15.039 24.8197
Hs 940.T GDSC1 -0.9349 45.8995 -28.5559 38.4794
MMAc-SF GDSC1 -0.6499 8.0323 -10.0853 7.7951
COLO 792 GDSC1 -0.6226 7.4465 -9.824 6.5963
WM278 GDSC1 -0.57 12.8081 -12.1674 15.9897
MZ-MEL-7 GDSC1 -0.5415 7.8238 -9.9416 7.0134
GAK GDSC1 -0.3967 10.6262 -11.0783 11.6416
RPMI-7951 GDSC1 -0.3719 12.8071 -12.0473 15.2484
IPC-298 GDSC1 -0.3675 13.761 -12.4827 16.7189
CHL-1 GDSC1 -0.2997 6.2042 -9.1693 3.4406
WM1552C GDSC1 -0.2925 3.3131 -8.1172 0.3458
LB2518-MEL GDSC1 -0.2312 12.5021 -11.8249 14.2316
A101D GDSC1 -0.2012 7.0451 -9.4572 4.5207
WM793 GDSC1 -0.1803 13.8542 -12.4115 16.1819
A-388 GDSC1 -0.1689 6.9525 -9.4055 4.2735
UACC-257 GDSC1 -0.1681 6.2445 -9.1275 3.1616
SK-MEL-3 GDSC1 -0.1615 2.9011 -7.9372 0.1312
MZ-MEL-2 GDSC1 -0.1411 6.2707 -9.1259 3.1325
UACC-62 GDSC1 -0.1318 7.0572 -9.4302 4.3382
IGR-37 GDSC1 -0.0793 10.7623 -10.962 10.7003
LB373-MEL-D GDSC1 -0.0527 4.7613 -8.5306 1.1129
Mel JuSo GDSC1 -0.0188 7.0392 -9.3719 3.9906
SH-4 GDSC1 -0.0155 7.1578 -9.4174 4.1706
VMRC-MELG GDSC1 0.0076 2.4076 -7.7238 0.023
CP50-MEL-B GDSC1 0.0493 12.762 -11.7784 13.6275
DJM-1 GDSC1 0.0591 2.4217 -7.7119 0.0195
A-375 GDSC1 0.0624 4.2022 -8.2942 0.5502
SK-MEL-2 GDSC1 0.088 8.6884 -9.9891 6.436
WM115 GDSC1 0.1048 16.2955 -13.3647 18.6667
WM35 GDSC1 0.115 8.5196 -9.9063 6.0564
A-431 GDSC1 0.1177 5.2341 -8.6348 1.3127
A2058 GDSC1 0.135 10.9455 -10.9253 10.2463
SK-MEL-1 GDSC1 0.1683 2.8972 -7.8286 0.0495
WT2-iPS GDSC1 0.1767 8.8689 -10.0204 6.462
IST-MEL1 GDSC1 0.1978 4.0317 -8.1896 0.3529
COLO 800 GDSC1 0.2459 2.6951 -7.7393 0.0216
LOX-IMVI GDSC1 0.2675 2.5238 -7.678 0.0112
Mel Ho GDSC1 0.2741 8.4134 -9.7869 5.3833
Hs 938.T GDSC1 0.2792 2.9125 -7.7979 0.0354
COLO 679 GDSC1 0.3177 3.6456 -8.0218 0.153
SK-MEL-28 GDSC1 0.3393 7.1499 -9.2577 3.2298
COLO 783 GDSC1 0.3541 2.8145 -7.7428 0.0202
HT-144 GDSC1 0.3848 3.6544 -8.0026 0.132
SK-MEL-24 GDSC1 0.393 4.915 -8.4209 0.6956
RVH-421 GDSC1 0.4525 12.0589 -11.2389 11.0247
SK-MEL-5 GDSC1 0.56 10.5567 -10.5349 8.1088
451Lu GDSC1 0.613 2.672 -7.6155 0.0036
EquiPSC Line K2 GDSC1 0.5982 4.1152 -8.0824 0.1754
⏷ Show the Full List of 56 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuTu 80 GDSC1 -0.8048 8.7238 -10.4662 9.6973
Cancer Drug Sensitivity Data Curated from 22 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
G-401 GDSC1 -1.1186 9.7246 -11.0886 12.838
SW684 GDSC1 -0.4433 11.1346 -11.3317 12.7154
Rh30 GDSC1 -0.441 10.4099 -11.0073 11.4231
SK-UT-1 GDSC1 -0.3213 2.0271 -7.7077 0.0266
Rh41 GDSC1 -0.2968 3.2935 -8.1121 0.3394
STS-0421 GDSC1 -0.2622 11.3272 -11.3143 12.3663
GCT GDSC1 -0.2432 1.8541 -7.6278 0.0104
SW872 GDSC1 -0.2254 3.0029 -7.9917 0.1852
SK-LMS-1 GDSC1 -0.2159 3.7104 -8.2247 0.4995
G-402 GDSC1 -0.117 9.1128 -10.2699 7.8821
RD GDSC1 -0.112 8.8582 -10.1598 7.4066
A-204 GDSC1 -0.0153 8.0384 -9.7718 5.6398
SW982 GDSC1 -0.0153 5.6656 -8.8444 2.0268
EW-8 GDSC1 0.0022 2.2936 -7.6893 0.0163
KYM-1 GDSC1 0.0097 2.1419 -7.6388 0.0092
MFH-ino GDSC1 0.0334 8.9416 -10.1215 7.0607
TE 441.T GDSC1 0.0778 2.3369 -7.679 0.0136
VA-ES-BJ GDSC1 0.3183 19.4739 -14.7196 21.846
Hs 633.T GDSC1 0.3852 2.5587 -7.6517 0.0073
HT-1080 GDSC1 0.45 5.8454 -8.727 1.4049
RKN GDSC1 0.4621 14.4429 -12.2964 14.8036
MES-SA GDSC1 0.5518 4.4115 -8.1955 0.2988
⏷ Show the Full List of 22 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 25 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TMK-1 GDSC1 -6.0765 2.0469 -10.7541 22.8122
23132/87 GDSC1 -0.5588 13.2106 -12.3461 16.5794
SCH GDSC1 -0.3767 5.4234 -8.9021 2.4819
ECC10 GDSC1 -0.2905 5.9163 -9.0537 2.9812
MKN45 GDSC1 -0.2091 1.5394 -7.5174 0.002
IM95 GDSC1 -0.1321 2.4822 -7.7924 0.0475
MKN7 GDSC1 -0.0979 2.4816 -7.7812 0.0422
NUGC-4 GDSC1 -0.0713 15.2408 -12.9845 17.825
Fu97 GDSC1 -0.0553 7.0794 -9.4043 4.1563
MKN28 GDSC1 -0.0365 2.6505 -7.8156 0.0527
OCUM-1 GDSC1 -0.0281 24.817 -17.5126 27.7273
HSC-39 GDSC1 0.0002 2.1473 -7.6435 0.0098
GCIY GDSC1 0.0306 8.5548 -9.962 6.3896
AGS GDSC1 0.0953 4.4975 -8.3838 0.7138
RF-48 GDSC1 0.0967 3.0105 -7.8882 0.0803
RERF-GC-1B GDSC1 0.1473 4.8921 -8.5023 0.9589
TGBC11TKB GDSC1 0.1786 2.5237 -7.7063 0.0165
SNU-16 GDSC1 0.1873 1.8606 -7.4937 0.0008
SNU-1 GDSC1 0.1994 3.5491 -8.0294 0.1716
HGC-27 GDSC1 0.2078 11.7459 -11.2361 11.3629
NCI-N87 GDSC1 0.3063 4.2913 -8.2393 0.4026
NUGC-3 GDSC1 0.3718 8.7014 -9.8576 5.5673
SNU-5 GDSC1 0.4101 2.454 -7.6107 0.0042
MKN1 GDSC1 0.4163 4.4578 -8.2573 0.4065
SNG-M GDSC1 0.0595 2.3081 -7.6757 0.0133
⏷ Show the Full List of 25 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TT GDSC1 -6.7933 -2.015 -9.299 17.159
KMH-2 GDSC1 -6.2958 -1.4329 -9.1956 14.7591
8505C GDSC1 -4.7731 2.331 -9.9381 14.8979
CAL-62 GDSC1 -0.4336 8.5828 -10.2079 8.0385
ML-1 [Human leukemia] GDSC1 -0.3338 12.7399 -11.9938 14.9987
CGTH-W-1 GDSC1 -0.2852 3.2217 -8.0842 0.2992
K5 GDSC1 -0.1923 4.8921 -8.6309 1.4601
IHH-4 GDSC1 -0.1659 4.866 -8.6112 1.3887
ASH-3 GDSC1 -0.0477 1.8627 -7.5686 0.0038
B-CPAP GDSC1 -0.0406 11.5478 -11.2871 11.9252
WRO GDSC1 -0.0384 2.4772 -7.7607 0.0337
FTC-133 GDSC1 -0.0189 16.645 -13.6058 19.5395
HTC-C3 GDSC1 0.0692 5.2417 -8.6561 1.3966
BHT-101 GDSC1 0.2082 5.2597 -8.6095 1.2022
TT2609-C02 GDSC1 0.3587 3.5314 -7.9712 0.1123
8305C GDSC1 0.4114 3.1703 -7.8379 0.0439
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 41 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KON GDSC1 -4.5964 5.9776 -11.5848 22.094
BICR 10 GDSC1 -0.5002 6.7073 -9.4604 4.8524
CAL-33 GDSC1 -0.4684 7.9248 -9.9471 6.9433
SCC-25 GDSC1 -0.4313 2.2003 -7.7985 0.0637
HSC-2 GDSC1 -0.4238 3.1563 -8.1098 0.3615
JHU-022 GDSC1 -0.3899 2.932 -8.0234 0.2412
OSC-19 GDSC1 -0.2894 5.0111 -8.7125 1.7684
LB771-HNC GDSC1 -0.283 10.2819 -10.8631 10.5979
HSC-4 GDSC1 -0.261 9.968 -10.7138 9.95
DOK GDSC1 -0.253 11.8494 -11.5429 13.2256
PE/CA-PJ15 GDSC1 -0.1928 2.3671 -7.7751 0.0434
FaDu GDSC1 -0.1806 12.1905 -11.6545 13.5292
HSC-3 GDSC1 -0.1612 2.1402 -7.6926 0.0197
PCI-04B GDSC1 -0.1612 6.1686 -9.0952 3.0321
BICR 31 GDSC1 -0.1448 8.5077 -10.0291 6.8894
JHU-029 GDSC1 -0.1444 6.714 -9.3001 3.8208
BICR 22 GDSC1 -0.1402 12.9224 -11.9619 14.5783
Ca9-22 GDSC1 -0.1032 7.4139 -9.5599 4.8465
SKN-3 GDSC1 -0.0874 14.1005 -12.4682 16.2209
CAL-27 GDSC1 -0.068 3.9306 -8.2477 0.5018
SCC-9 GDSC1 -0.0485 15.2169 -12.9593 17.7122
SCC-15 GDSC1 -0.0456 3.3739 -8.0536 0.2253
BB30-HNC GDSC1 -0.0247 11.4546 -11.2369 11.7068
UPCI-SCC-090 GDSC1 -0.0162 9.6651 -10.453 8.5206
SAT [Human HNSCC] GDSC1 -0.0129 4.2211 -8.3274 0.6339
NCI-H3118 GDSC1 -0.0082 2.6643 -7.8109 0.0497
JHU-011 GDSC1 0.0097 3.7981 -8.1759 0.3702
Detroit 562 GDSC1 0.0318 2.3954 -7.7122 0.0201
BHY GDSC1 0.0336 6.7888 -9.2507 3.4632
HO-1-u-1 GDSC1 0.0859 4.9526 -8.5465 1.093
SCC-4 GDSC1 0.1213 2.2621 -7.6415 0.0084
BICR 78 GDSC1 0.1785 2.5385 -7.711 0.0173
PCI-30 GDSC1 0.2013 6.0279 -8.8913 2.0418
BB49-HNC GDSC1 0.2337 5.7864 -8.7896 1.7013
SAS GDSC1 0.2538 3.0603 -7.8534 0.0558
PCI-38 GDSC1 0.2724 5.3363 -8.6126 1.1812
PCI-06A GDSC1 0.2843 3.8519 -8.1005 0.2304
KOSC-2 GDSC1 0.3213 3.3112 -7.9122 0.0799
PCI-15A GDSC1 0.334 6.0738 -8.8552 1.8449
HO-1-N-1 GDSC1 0.3497 3.2097 -7.8704 0.0587
OSC-20 GDSC1 0.3552 3.061 -7.821 0.0402
⏷ Show the Full List of 41 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
639V GDSC1 -0.5392 8.6655 -10.2985 8.5794
HT-1197 GDSC1 -0.4352 14.331 -12.7886 17.8102
BFTC-905 GDSC1 -0.4184 1.6328 -7.6133 0.0105
J82 GDSC1 -0.3965 6.389 -9.2851 4.0028
RT-112 GDSC1 -0.3586 12.5215 -11.9091 14.737
TCCSUP GDSC1 -0.2438 5.1517 -8.7461 1.8491
CAL-29 GDSC1 0.0077 2.1419 -7.6394 0.0092
SW780 GDSC1 0.0197 2.547 -7.7644 0.0331
647V GDSC1 0.0333 2.3624 -7.7013 0.018
UM-UC-3 GDSC1 0.0695 9.8419 -10.4838 8.5347
RT-4 GDSC1 0.0933 2.6861 -7.7852 0.0371
KU-19-19 GDSC1 0.129 2.4378 -7.6947 0.0153
5637 GDSC1 0.3899 6.5522 -9.0098 2.3105
SW1710 GDSC1 0.5789 2.7441 -7.6491 0.0058
HT-1376 GDSC1 0.7201 3.9881 -8.001 0.1052
T24 GDSC1 0.8087 13.2017 -11.5446 11.669
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
BPH-1 GDSC1 -7.3306 -4.5557 -8.4869 13.3488
SW962 GDSC1 -5.5971 4.8138 -11.7575 25.4351
Ca Ski GDSC1 -1.1049 8.6189 -10.5859 10.6843
HeLa GDSC1 -0.5746 7.5493 -9.843 6.6197
LB831-BLC GDSC1 -0.4928 9.2085 -10.5085 9.4199
DSH1 GDSC1 -0.4886 8.9227 -10.3826 8.8727
NT2-D1 GDSC1 -0.3796 4.8488 -8.6887 1.7469
SKG-IIIa GDSC1 -0.3774 12.0097 -11.6877 13.9618
C-33 A GDSC1 -0.3333 3.0802 -8.0534 0.2682
SW954 GDSC1 -0.322 7.0288 -9.5068 4.8568
MS751 GDSC1 -0.2371 4.163 -8.3883 0.8387
OMC-1 [Human cervical carcinoma] GDSC1 -0.1376 12.0572 -11.5697 13.1471
SW756 GDSC1 -0.1285 12.2315 -11.6427 13.4048
OVMIU GDSC1 -0.0673 4.306 -8.3763 0.7515
HEC-1 GDSC1 -0.0554 2.483 -7.768 0.0364
CAL-39 GDSC1 -0.0343 2.8167 -7.8683 0.0773
DoTc2 4510 GDSC1 -0.0091 8.495 -9.9567 6.4146
HT-3 GDSC1 0.0051 2.3644 -7.7109 0.0203
C-4-I GDSC1 0.0996 2.7066 -7.7897 0.0384
KGN GDSC1 0.1418 3.3139 -7.9717 0.1303
NCC-IT GDSC1 0.2021 2.2384 -7.6084 0.0051
JAR GDSC1 0.2256 3.2206 -7.9141 0.0867
SiSo GDSC1 0.2377 3.7822 -8.0932 0.229
SKN GDSC1 0.2413 3.0331 -7.8487 0.0545
NEC8 GDSC1 0.2586 3.2374 -7.9088 0.0818
PA-1 GDSC1 0.3218 2.5657 -7.6741 0.0102
JEG-3 GDSC1 0.4318 2.7808 -7.7073 0.0132
ME-180 GDSC1 0.5451 3.9186 -8.0358 0.1427
SiHa GDSC1 0.8185 19.1098 -14.228 19.9005
⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug

References

1 ClinicalTrials.gov (NCT03560245) A Randomized, Double-Blind, Placebo-Controlled, Phase 2 Study Assessing the Safety, Tolerability and Efficacy of Bryostatin in the Treatment of Moderately Severe to Severe Alzheimer's Disease Subjects Not Receiving Memantine Treatment. U.S.National Institutes of Health.
2 ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
3 Bryostatin-1: a promising compound for neurological disorders. Front Pharmacol. 2023 Jun 7;14:1187411.
4 Protein kinase epsilon dampens the secretory response of model intestinal epithelia during ischemia. Surgery. 2001 Aug;130(2):310-8.
5 Phase II trial of bryostatin 1 in patients with relapsed low-grade non-Hodgkin's lymphoma and chronic lymphocytic leukemia. Clin Cancer Res. 2000 Mar;6(3):825-8.
6 Induction of cIAP-2 in human colon cancer cells through PKC delta/NF-kappa B. J Biol Chem. 2003 Dec 19;278(51):51091-9. doi: 10.1074/jbc.M306541200. Epub 2003 Oct 3.
7 Effect of serum and antioxidants on the immunogenicity of protein kinase C-activated chronic lymphocytic leukemia cells. J Immunother. 2005 Jan-Feb;28(1):28-39. doi: 10.1097/00002371-200501000-00004.
8 Modulation of protein kinase C activity and calcium-sensitive isoform expression in human myeloid leukemia cells by bryostatin 1: relationship to differentiation and ara-C-induced apoptosis. Exp Cell Res. 1996 Oct 10;228(1):65-75. doi: 10.1006/excr.1996.0300.
9 Elucidating mechanisms of toxicity using phenotypic data from primary human cell systems--a chemical biology approach for thrombosis-related side effects. Int J Mol Sci. 2015 Jan 5;16(1):1008-29. doi: 10.3390/ijms16011008.