Details of the Drug

General Information of Drug (ID: DM3TABW)

Drug Name
Oxyphencyclimine
Synonyms
Antulcus; Caridan; Daricol; Manir; Naridan; Oxifencicliminum; Oxiphencycliminum; Oxyphencycliminum; Zamanil; Oxifencicliminum [INN-Spanish]; Oxyphencyclimine (INN); Oxyphencyclimine [INN:BAN]; Oxyphencycliminum [INN-Latin]; Benzeneacetic acid, .alpha.-cyclohexyl-.alpha.-hydroxy-, (1,4,5,6-tetrahydro-1-methyl-2-pyrimidinyl)methyl ester; (1-methyl-1,4,5,6-tetrahydropyrimidin-2-yl)methyl cyclohexyl(hydroxy)phenylacetate; (1-methyl-5,6-dihydro-4H-pyrimidin-2-yl)methyl 2-cyclohexyl-2-hydroxy-2-phenylacetate; 1,4,5,6-Tetrahydro-1-methyl-2-pyrimidinemethanol-alpha-phenylcyclohexaneglycolate; 1,4,5,6-Tetrahydro-1-methyl-2-pyrimidinylmethyl alpha-cyclohexyl-alpha-phenylglycolat; 1-Methyl-1,4,5,6-tetrahydro-2-pyrimidinylmethyl-alpha-cyclohexylmandelat
Indication
Disease Entry ICD 11 Status REF
Peptic ulcer DA61 Approved [1]
Therapeutic Class
Anticholinergic Agents
Affected Organisms
Humans and other mammals
ATC Code
: Oxyphencyclimine
:
A02X: OTHER DRUGS FOR ACID RELATED DISORDERS
A02: DRUGS FOR ACID RELATED DISORDERS
A: ALIMENTARY TRACT AND METABOLISM
A03AA01: Oxyphencyclimine
A03AA: Synthetic anticholinergics, esters with tertiary amino group
A03A: DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS
A03: DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS
A: ALIMENTARY TRACT AND METABOLISM
: Oxyphencyclimine
:
A05C: DRUGS FOR BILE THERAPY AND LIPOTROPICS IN COMBINATION
A05: BILE AND LIVER THERAPY
A: ALIMENTARY TRACT AND METABOLISM
: Oxyphencyclimine
:
A13A: TONICS
A13: TONICS
A: ALIMENTARY TRACT AND METABOLISM
: Oxyphencyclimine
:
A14B: OTHER ANABOLIC AGENTS
A14: ANABOLIC AGENTS FOR SYSTEMIC USE
A: ALIMENTARY TRACT AND METABOLISM
: Oxyphencyclimine
:
:
A15: APPETITE STIMULANTS
A: ALIMENTARY TRACT AND METABOLISM
: Oxyphencyclimine
:
C02N: COMBINATIONS OF ANTIHYPERTENSIVES IN ATC-GR. C02
C02: ANTIHYPERTENSIVES
C: CARDIOVASCULAR SYSTEM
: Oxyphencyclimine
:
D06C: ANTIBIOTICS AND CHEMOTHERAPEUTICS, COMBINATIONS
D06: ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE
D: DERMATOLOGICALS
: Oxyphencyclimine
:
R05X: OTHER COLD PREPARATIONS
R05: COUGH AND COLD PREPARATIONS
R: RESPIRATORY SYSTEM
: Oxyphencyclimine
:
S03D: OTHER OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
S03: OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
S: SENSORY ORGANS
: Oxyphencyclimine
:
V04B: URINE TESTS
V04: DIAGNOSTIC AGENTS
V: VARIOUS
: Oxyphencyclimine
:
V06B: PROTEIN SUPPLEMENTS
V06: GENERAL NUTRIENTS
V: VARIOUS
: Oxyphencyclimine
:
V09B: SKELETON
V09: DIAGNOSTIC RADIOPHARMACEUTICALS
V: VARIOUS
: Oxyphencyclimine
:
:
V20: SURGICAL DRESSINGS
V: VARIOUS
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 344.4
Logarithm of the Partition Coefficient (xlogp) 2.9
Rotatable Bond Count (rotbonds) 6
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 4
Chemical Identifiers
Formula
C20H28N2O3
IUPAC Name
(1-methyl-5,6-dihydro-4H-pyrimidin-2-yl)methyl 2-cyclohexyl-2-hydroxy-2-phenylacetate
Canonical SMILES
CN1CCCN=C1COC(=O)C(C2CCCCC2)(C3=CC=CC=C3)O
InChI
InChI=1S/C20H28N2O3/c1-22-14-8-13-21-18(22)15-25-19(23)20(24,16-9-4-2-5-10-16)17-11-6-3-7-12-17/h2,4-5,9-10,17,24H,3,6-8,11-15H2,1H3
InChIKey
DUDKAZCAISNGQN-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
4642
ChEBI ID
CHEBI:7868
CAS Number
125-53-1
UNII
4V44H1O8XI
DrugBank ID
DB00383
TTD ID
D0H5DU

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Muscarinic acetylcholine receptor M5 (CHRM5) TTH18TF ACM5_HUMAN Binder [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Potassium voltage-gated channel subfamily H member 2 (KCNH2) OTZX881H KCNH2_HUMAN Gene/Protein Processing [3]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7256).
2 Stereoselective interaction of procyclidine, hexahydro-difenidol, hexbutinol and oxyphencyclimine, and of related antagonists, with four muscarinic receptors. Eur J Pharmacol. 1992 Sep 1;227(1):33-42.
3 Why are most phospholipidosis inducers also hERG blockers?. Arch Toxicol. 2017 Dec;91(12):3885-3895. doi: 10.1007/s00204-017-1995-9. Epub 2017 May 27.