Details of the Drug

General Information of Drug (ID: DM4Y1SP)

Drug Name
Carisbamate
Synonyms Comfyde; JNJ 10234094; RWJ 333369; YKP 509; Carisbamate (USAN); JNJ-10234094; RWJ-333369; YKP-509; S-2-O-Carbamoyl-1-o-chlorophenyl-ethanol; [(2S)-2-(2-chlorophenyl)-2-hydroxyethyl] carbamate
Indication
Disease Entry ICD 11 Status REF
Epilepsy 8A60-8A68 Phase 3 [1]
Focal dystonia 8A02.1 Phase 3 [1]
Seizure disorder 8A6Z Phase 3 [1]
ATC Code
N03AX19: Carisbamate
N03AX: Other antiepileptics
N03A: ANTIEPILEPTICS
N03: ANTIEPILEPTICS
N: NERVOUS SYSTEM
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 215.63
Logarithm of the Partition Coefficient (xlogp) 1
Rotatable Bond Count (rotbonds) 4
Hydrogen Bond Donor Count (hbonddonor) 2
Hydrogen Bond Acceptor Count (hbondacc) 3
Chemical Identifiers
Formula
C9H10ClNO3
IUPAC Name
[(2S)-2-(2-chlorophenyl)-2-hydroxyethyl] carbamate
Canonical SMILES
C1=CC=C(C(=C1)[C@@H](COC(=O)N)O)Cl
InChI
InChI=1S/C9H10ClNO3/c10-7-4-2-1-3-6(7)8(12)5-14-9(11)13/h1-4,8,12H,5H2,(H2,11,13)/t8-/m1/s1
InChIKey
OLBWFRRUHYQABZ-MRVPVSSYSA-N
Cross-matching ID
PubChem CID
6918474
ChEBI ID
CHEBI:135966
CAS Number
194085-75-1
UNII
P7725I9V3Z
DrugBank ID
DB12338
TTD ID
D0S0FZ
INTEDE ID
DR1891
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Sodium channel unspecific (NaC) TTRK8B9 NOUNIPROTAC Blocker [1]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
UDP-glucuronosyltransferase 1A1 (UGT1A1)
Main DME 		DEYGVN4 UD11_HUMAN Substrate [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

References

1 Progress report on new antiepileptic drugs: a summary of the Ninth Eilat Conference (EILAT IX). Epilepsy Res. 2009 Jan;83(1):1-43.
2 Carisbamate addon therapy for drugresistant partial epilepsy. The Cochrane Library. John Wiley Sons, Ltd, 2016.