Details of Disease

General Information of Disease (ID: DISRQJRM)

• Disease Name: Seizure disorder
• Disease Class: 8A61-8A6Z: Epilepsy/seizure
• Disease Hierarchy:
  DIS01GPL: Grass pollen hypersensitivity
  DISRQJRM: Seizure disorder
• ICD Code:
  ICD-11: ICD-11: 8A6Z
  ICD-9: ICD-9: 345.9, 780.3
  Expand ICD-11: '8A6Z
  Expand ICD-10: 'G40-G47; 'G40; 'G40.1; 'G40.2; 'G40.5; 'G40.8; 'G40.9
  Expand ICD-9: 345.9,780.3
• Disease Identifiers:
  MONDO ID: MONDO_0005027
  MESH ID: D004827
  UMLS CUI: C0014544
  MedGen ID: 4506
  SNOMED CT ID: 128613002

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 9 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Clonazepam	DMTO13J	Approved	Small molecular drug	[1]
Divalproex sodium	DM4RK0G	Approved	Small molecular drug	[2]
Eslicarbazepine	DMZREFQ	Approved	Small molecular drug	[3]
Eterobarb	DM70E0U	Approved	Small molecular drug	[4]
Paramethadione	DMR5ZUP	Approved	Small molecular drug	[5]
Phenobarbital	DMXZOCG	Approved	Small molecular drug	[6]
Phensuximide	DMFGLXB	Approved	Small molecular drug	[7]
Rufinamide	DMWE60C	Approved	Small molecular drug	[8]
Topiramate	DM82Z30	Approved	Small molecular drug	[9]

This Disease is Treated as An Indication in 4 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Carisbamate	DM4Y1SP	Phase 3	Small molecular drug	[10]
SHP615	DM67VWS	Phase 2	NA	[11]
UCB-0942	DMXZVQH	Phase 2	NA	[11]
ZYN002-CBD	DMNHXDF	Phase 2	NA	[11]

Molecular Interaction Atlas (MIA) of This Disease

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6963).
• [2] FDA approved drugs (1996) in CenterWatch
• [3] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7350).
• [4] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
• [5] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7261).
• [6] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2804).
• [7] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7612).
• [8] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7470).
• [9] The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
• [10] Progress report on new antiepileptic drugs: a summary of the Ninth Eilat Conference (EILAT IX). Epilepsy Res. 2009 Jan;83(1):1-43.
• [11] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)