Details of the Drug

General Information of Drug (ID: DM5LY1H)

Drug Name
Leptin
Synonyms Leptin (Alzheimer's disease)
Indication
Disease Entry ICD 11 Status REF
Alzheimer disease 8A20 Investigative [1]
ADMET Property
Half-life
The concentration or amount of drug in body reduced by one-half in 24.9 +/- 4.4 minutes [2]
Adverse Drug Reaction (ADR)
ADR Term Variation Related DOT DOT ID REF
Ovarian cancer Not Available JAK2 OTBIDOOR [3]
Ovarian cancer Not Available PIK3CB PIK3C1 OTO8JQJA [3]
Reproductive tract disorder Not Available SLC2A2 OTBL2W7R [3]
Cross-matching ID
PubChem CID
157010069
UNII
Q09SXY6BFI
DrugBank ID
DB05098
TTD ID
D0C6TL

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Leptin receptor (LEPR) TT0HD6V LEPR_HUMAN Modulator [4]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (PIK3CB) OTO8JQJA PK3CB_HUMAN Drug Response [3]
Solute carrier family 2, facilitated glucose transporter member 2 (SLC2A2) OTBL2W7R GTR2_HUMAN Drug Response [3]
Tyrosine-protein kinase JAK2 (JAK2) OTBIDOOR JAK2_HUMAN Drug Response [3]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Alzheimer disease
ICD Disease Classification 8A20
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Leptin receptor (LEPR) DTT LEPR 5.82E-02 0.05 0.15
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5015).
2 Trend Analysis of a Database of Intravenous Pharmacokinetic Parameters in Humans for 1352 Drug Compounds
3 ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
4 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1712).