Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM5LY1H)

• Drug Name: Leptin Drug Info
• Synonyms: Leptin (Alzheimer's disease)

Indication

Disease Entry	ICD 11	Status	REF
Alzheimer disease	8A20	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 157010069
  TTD Drug ID: DM5LY1H

Molecule-Related Drug Atlas

Drug(s) Targeting Leptin receptor (LEPR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Metreleptin	DM1NOEK	Acquired generalized lipodystrophy		Approved	[4]
AMPE4L	DM64X25	Diabetic complication	5A2Y	Investigative	[2]
PEGylated leptin	DMZ01PS	Obesity	5B81	Investigative	[2]
BL-5040	DMGULNZ	Cachexia	MG20	Investigative	[2]
ANG-2004	DMK1IMC	Obesity	5B81	Investigative	[2]
AMPSL	DMXRIUT	Diabetic complication	5A2Y	Investigative	[2]
EDP-21	DMMN0GO	Obesity	5B81	Investigative	[2]
AMPPL	DMVHOQE	Diabetic complication	5A2Y	Investigative	[2]
PEG-LPA-2	DMY293M	Solid tumour/cancer	2A00-2F9Z	Investigative	[2]

Drug(s) Affected By Tyrosine-protein kinase JAK2 (JAK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Momelotinib	DMF98Q0	Myelofibrosis	2A20.2	Approved	[5]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[6]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[7]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[9]
Paroxetine	DM5PVQE	Anxiety disorder	6B00-6B0Z	Approved	[10]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[6]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[12]
Amlodipine	DMBDAZV	Angina pectoris	BA40	Approved	[13]

Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 2 (SLC2A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[14]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[15]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[16]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[17]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[18]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[19]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[12]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[21]

Drug(s) Affected By Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (PIK3CB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[22]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[23]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[25]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[27]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[28]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[29]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[3]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[24]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Leptin receptor (LEPR)	TT0HD6V	LEPR_HUMAN	Modulator	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (PIK3CB)	OTO8JQJA	PK3CB_HUMAN	Drug Response	[3]
Solute carrier family 2, facilitated glucose transporter member 2 (SLC2A2)	OTBL2W7R	GTR2_HUMAN	Drug Response	[3]
Tyrosine-protein kinase JAK2 (JAK2)	OTBIDOOR	JAK2_HUMAN	Drug Response	[3]

References

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