Details of the Drug

General Information of Drug (ID: DM6JYUO)

Drug Name

Tinlarebant

Synonyms

Tinlarebant; Tinlarebant [USAN]; LBS-008; BPN-14967; 63WI9S8P1M; UNII-63WI9S8P1M; WHO 11058; 1-(3-(4-(3,4-Difluoro-2-(trifluoromethyl)phenyl)piperidine-1-carbonyl)-1H,4H,5H,6H,7H-pyrazolo(3,4-C)pyridin-6-yl)ethan-1-one; 1821327-95-0; Ethanone, 1-(3-((4-(3,4-difluoro-2-(trifluoromethyl)phenyl)-1-piperidinyl)carbonyl)-1,4,5,7-tetrahydro-6H-pyrazolo(3,4-C)pyridin-6-yl); TINLAREBANT [INN]; CHEMBL3967849; SCHEMBL17223028; BDBM249482; US9434727, 80; US9434727, 81; 1-(3-(4-(3,4-difluoro-2-(trifluoromethyl)phenyl)piperidine-1-carbonyl)-4,5-dihydro-1H-pyrazolo[3,4-c]pyridin-6(7H)-yl)ethanone

Indication

Disease Entry	ICD 11	Status	REF
Stargardt disease	9B70	Phase 3	[1]
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Drug Type

Small molecule

Structure

3D MOL

2D MOL

Chemical Identifiers

Formula: C21H21F5N4O2
Canonical SMILES: CC(=O)N1CCC2=C(C1)NN=C2C(=O)N3CCC(CC3)C4=C(C(=C(C=C4)F)F)C(F)(F)F
InChI: InChI=1S/C21H21F5N4O2/c1-11(31)30-9-6-14-16(10-30)27-28-19(14)20(32)29-7-4-12(5-8-29)13-2-3-15(22)18(23)17(13)21(24,25)26/h2-3,12H,4-10H2,1H3,(H,27,28)
InChIKey: HAGSLCBZFRRBLS-UHFFFAOYSA-N

Cross-matching ID

PubChem CID: 92044505
UNII: 63WI9S8P1M
DrugBank ID: DB17832
TTD ID: DCD0M4

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Plasma retinol-binding protein (RBP4)	TT0C8BY	RET4_HUMAN	Antagonist	[2]

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Molecular Interaction Atlas (MIA)

MIA Detail

Jump to Detail Molecular Interaction Atlas of This Drug

References

1	ClinicalTrials.gov (NCT05244304) Phase 3, Multicenter, Randomized, Double-Masked, Placebo-Controlled Study to Evaluate the Safety and Efficacy of Tinlarebant in the Treatment of Stargardt Disease in Adolescent Subjects. U.S.National Institutes of Health.
2	Retinol binding protein 4 antagonists and protein synthesis inhibitors: Potential for therapeutic development. Eur J Med Chem. 2021 Dec 15;226:113856.