Details of the Drug

General Information of Drug (ID: DM6WPIS)

Drug Name
L-serine
Synonyms
L-serine; serine; 56-45-1; (S)-2-Amino-3-hydroxypropanoic acid; H-Ser-OH; (S)-Serine; beta-Hydroxyalanine; L-ser; L-(-)-Serine; Polyserine; Serine, L-; (2S)-2-amino-3-hydroxypropanoic acid; L-3-Hydroxy-alanine; Poly-L-serine; 2-Amino-3-hydroxypropionic acid; beta-Hydroxy-L-alanine; Serinum [Latin]; Serina [Spanish]; L-2-Amino-3-hydroxypropionic acid; Serine (VAN); L-3-Hydroxy-2-aminopropionic acid; Serine [USAN:INN]; SER (IUPAC abbrev); 3-Hydroxyalanine; L-Serin; (S)-(-)-Serine; (-)-Serine; alpha-Amino-beta-hydroxypropionic acid
Indication
Disease Entry ICD 11 Status REF
Pulmonary tuberculosis 1B10.Z Approved [1]
Discovery agent N.A. Investigative [2]
Affected Organisms
Humans and other mammals
Drug Type
Small molecular drug
Structure
3D MOL is unavailable 2D MOL
#Ro5 Violations (Lipinski): 1 Molecular Weight (mw) 105.09
Logarithm of the Partition Coefficient (xlogp) -3.1
Rotatable Bond Count (rotbonds) 2
Hydrogen Bond Donor Count (hbonddonor) 3
Hydrogen Bond Acceptor Count (hbondacc) 4
Chemical Identifiers
Formula
C3H7NO3
IUPAC Name
(2S)-2-amino-3-hydroxypropanoic acid
Canonical SMILES
C([C@@H](C(=O)O)N)O
InChI
InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1
InChIKey
MTCFGRXMJLQNBG-REOHCLBHSA-N
Cross-matching ID
PubChem CID
5951
ChEBI ID
CHEMBL11298
CAS Number
56-45-1
UNII
452VLY9402
DrugBank ID
DB00133
TTD ID
D0T6GM
VARIDT ID
DR01005
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Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
G-protein coupled receptor GPCR33 (GPRC6A) TTI1PRE GPC6A_HUMAN Agonist [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Ataxin-3 (ATXN3) OTJVVGKT ATX3_HUMAN Gene/Protein Processing [4]
Calnexin (CANX) OTYP1F6J CALX_HUMAN Gene/Protein Processing [4]
Cyclic AMP-dependent transcription factor ATF-4 (ATF4) OTRFV19J ATF4_HUMAN Gene/Protein Processing [4]
Cyclic AMP-dependent transcription factor ATF-6 alpha (ATF6) OTAFHAVI ATF6A_HUMAN Gene/Protein Processing [4]
Cyclic AMP-dependent transcription factor ATF-6 beta (ATF6B) OTT2ZGSR ATF6B_HUMAN Gene/Protein Processing [4]
Derlin-2 (DERL2) OTI3TUUZ DERL2_HUMAN Gene/Protein Processing [4]
DnaJ homolog subfamily B member 2 (DNAJB2) OTZHPV5M DNJB2_HUMAN Gene/Protein Processing [4]
DnaJ homolog subfamily B member 9 (DNAJB9) OT38EQT6 DNJB9_HUMAN Gene/Protein Processing [4]
DnaJ homolog subfamily C member 3 (DNAJC3) OT7ROIJF DNJC3_HUMAN Gene/Protein Processing [4]
DnaJ homolog subfamily C member 4 (DNAJC4) OT4BUBQU DNJC4_HUMAN Gene/Protein Processing [4]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

References

1 Heterologous production of the D-cycloserine intermediate O-acetyl-L-serine in a human type II pulmonary cell model. Sci Rep. 2023 May 26;13(1):8551.
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 726).
3 Deorphanization of GPRC6A: a promiscuous L-alpha-amino acid receptor with preference for basic amino acids. Mol Pharmacol. 2005 Mar;67(3):589-97.
4 Mechanisms of L-Serine Neuroprotection in vitro Include ER Proteostasis Regulation. Neurotox Res. 2018 Jan;33(1):123-132. doi: 10.1007/s12640-017-9829-3. Epub 2017 Nov 2.