Details of the Drug

General Information of Drug (ID: DM95IPS)

Drug Name
Tivanisiran
Indication
Disease Entry ICD 11 Status REF
Dry eye disease 9E1Z Phase 3 [1]
Drug Type
Small interfering RNA
Sequence
>Subunit 1
AAGCGCAUCUUCUACUUCA
>Subunit 2
UGAAGUAGAAGAUGCGCUU
Cross-matching ID
TTD ID
DRA84P

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
TRPV1 messenger RNA (TRPV1 mRNA) TT50OG3 TRPV1_HUMAN Inhibitor [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

References

1 ClinicalTrials.gov (NCT04819269) Tivanisiran for Dry Eye in Subjects With Sjogren's Syndrome. U.S. National Institutes of Health.
2 Tivanisiran, a novel siRNA for the treatment of dry eye disease. Expert Opin Investig Drugs. 2018 Apr;27(4):421-426.