Details of the Drug

General Information of Drug (ID: DMAG6BV)

Drug Name
LGK974
Synonyms
1243244-14-5; LGK974; LGK-974; 2-(2',3-Dimethyl-[2,4'-bipyridin]-5-yl)-N-(5-(pyrazin-2-yl)pyridin-2-yl)acetamide; WNT-974; LGK 974; UNII-U27F40013Q; CHEBI:78030; CHEMBL3188386; U27F40013Q; AK165831; 2-(2',3-dimethyl-2,4'-bipyridin-5-yl)-N-[5-(pyrazin-2-yl)pyridin-2-yl]acetamide; MLS006011002; SCHEMBL1723611; KS-00000SUI; MolPort-029-945-290; HMS3653G11; BCP08495; EX-A1402; ZINC95930187; STL556617; BDBM50133870; BBL102809; 2140AH; s7143; AKOS025211913; SB19314; CS-2807; DB12561; NCGC00347950-07; NCGC00347950-01; OR302651; QC-11701
Indication
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Phase 1 [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 396.4
Logarithm of the Partition Coefficient (xlogp) 1.8
Rotatable Bond Count (rotbonds) 5
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 6
Chemical Identifiers
Formula
C23H20N6O
IUPAC Name
2-[5-methyl-6-(2-methylpyridin-4-yl)pyridin-3-yl]-N-(5-pyrazin-2-ylpyridin-2-yl)acetamide
Canonical SMILES
CC1=CC(=CN=C1C2=CC(=NC=C2)C)CC(=O)NC3=NC=C(C=C3)C4=NC=CN=C4
InChI
InChI=1S/C23H20N6O/c1-15-9-17(12-28-23(15)18-5-6-25-16(2)10-18)11-22(30)29-21-4-3-19(13-27-21)20-14-24-7-8-26-20/h3-10,12-14H,11H2,1-2H3,(H,27,29,30)
InChIKey
XXYGTCZJJLTAGH-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
46926973
ChEBI ID
CHEBI:78030
CAS Number
1243244-14-5
UNII
U27F40013Q
DrugBank ID
DB12561
TTD ID
D0J5HR
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Protein-serine O-palmitoleoyltransferase porcupine (PORCN) TTNFBTO PORCN_HUMAN Inhibitor [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 40 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RPMI-3460/CS1 GDSC1; GDSC2 6.5551 8.3451 2.7496 0.1391
CADO-ES1 GDSC1; GDSC2 3.7925 6.3967 2.1569 5.5573
EW-13 GDSC1; GDSC2 3.9812 7.0181 1.9903 6.0832
ES1 GDSC1; GDSC2 4.0829 7.3495 1.9017 6.3621
HOS GDSC1; GDSC2 4.2751 7.7314 1.8521 6.2388
TC-71 GDSC1; GDSC2 4.3594 8.1193 1.7232 6.779
A-673 GDSC1; GDSC2 4.3885 7.5737 2.0058 4.6171
EW-18 GDSC1; GDSC2 4.3899 8.7773 1.4249 8.3526
EW-3 GDSC1; GDSC2 4.3979 6.6179 2.4609 2.7293
EW-1 GDSC1; GDSC2 4.6482 11.1848 0.4336 12.9945
SK-PN-DW GDSC1; GDSC2 4.6999 8.2213 1.9034 5.1517
CAL-72 GDSC1; GDSC2 4.7035 7.1544 2.3978 2.5887
ES5 GDSC1; GDSC2 4.8501 9.0578 1.6058 7.0952
EW-7 GDSC1; GDSC2 4.8704 8.7812 1.7497 5.6658
EW-24 GDSC1; GDSC2 5.1575 10.4276 1.1578 8.2508
ES6 GDSC1; GDSC2 5.1817 7.4291 2.5331 1.4031
SK-ES-1 GDSC1; GDSC2 5.1859 7.038 2.6927 0.7993
CHSA0108 GDSC2 5.1983 9.4664 1.6371 6.2435
ES8 GDSC1; GDSC2 5.2051 11.075 0.8803 9.5855
EW-22 GDSC1; GDSC2 5.2057 9.6282 1.5663 6.0433
ES7 GDSC1; GDSC2 5.4052 10.6723 1.2041 7.5615
EW-11 GDSC2 5.4166 10.0564 1.499 6.035
CHSA0011 GDSC2 5.4474 7.9287 2.4563 1.6059
ES4 GDSC1; GDSC2 5.4957 8.9508 2.0461 3.2078
G-292 clone A141B1 GDSC1; GDSC2 5.6029 9.2508 1.9733 3.4111
CHSA8926 GDSC1; GDSC2 5.6305 7.5084 2.7013 0.5065
HuO-3N1 GDSC1; GDSC2 5.7012 10.2822 1.5678 5.2393
EW-12 GDSC2 5.7165 7.6426 2.6862 0.5549
NY GDSC1; GDSC2 5.7255 10.624 1.4264 5.9035
NOS-1 [Human HNSCC] GDSC1; GDSC2 5.7967 19.1271 -2.625 22.4792
SJSA-1 GDSC1; GDSC2 5.8496 8.688 2.3383 1.557
CAL-78 GDSC1; GDSC2 5.9322 11.0446 1.3581 5.9204
U-CH2 GDSC2 5.9602 8.3039 2.5385 0.8663
H-EMC-SS GDSC1; GDSC2 6.3099 14.443 0.0109 11.6826
HuO9 GDSC1; GDSC2 7.0142 14.9854 0.2047 9.6305
U2OS GDSC1; GDSC2 7.292 15.8222 -0.0111 9.2308
MHH-ES-1 GDSC1; GDSC2 7.3428 14.4666 0.6366 7.2246
SaOS-2 GDSC1; GDSC2 8.1538 16.822 0.0467 8.6178
MG-63 GDSC1; GDSC2 8.5258 17.0747 0.1452 7.7192
EW-16 GDSC1; GDSC2 8.5332 22.7697 -2.4772 17.1732
⏷ Show the Full List of 40 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 167 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JM1 GDSC1; GDSC2 3.8223 7.2756 1.7451 8.5996
MOLM-13 GDSC1; GDSC2 0.9881 3.7414 0.6492 22.9218
MV4-11 GDSC1; GDSC2 1.1463 3.6703 0.8441 19.0143
EoL-1 GDSC1; GDSC2 1.4859 3.5311 1.2574 17.8496
EHEB GDSC1 2.4102 5.2896 0.1833 6.0403
MOLT-4 GDSC1; GDSC2 2.7536 4.2415 2.3319 6.6037
AMO1 GDSC1; GDSC2 2.7944 4.6456 2.1817 8.1022
Sc-1 GDSC1 2.9313 7.4602 -0.5041 9.6048
GDM-1 GDSC1; GDSC2 3.2763 9.2228 0.3334 16.884
LP-1 GDSC1; GDSC2 3.2941 5.6446 2.1373 7.5799
HL-60 GDSC1; GDSC2 3.3273 7.6087 1.183 10.9409
Kasumi-1 GDSC2 3.3463 6.0689 1.9687 8.4933
DoHH2 GDSC1; GDSC2 3.3764 5.2142 2.4208 5.5486
MHH-CALL-2 GDSC2 3.3851 5.3338 2.3681 5.3236
Ku812 GDSC1; GDSC2 3.43 5.4992 2.322 4.8853
SIG-M5 GDSC1; GDSC2 3.4944 6.2872 1.9805 7.9997
ATN-1 GDSC1; GDSC2 3.4947 6.5675 1.8408 8.0722
WSU-DLCL2 GDSC1; GDSC2 3.5336 4.6521 2.824 2.352
WSU-NHL GDSC1; GDSC2 3.535 5.0891 2.609 3.5725
SUP-B8 GDSC2 3.538 6.7477 1.7856 9.1033
L-540 GDSC1; GDSC2 3.5456 5.8402 2.244 5.636
ALL-PO GDSC1; GDSC2 3.5483 6.9193 1.7083 8.6945
Jurkat GDSC1; GDSC2 3.5504 8.2186 1.0613 12.3169
MM1.S GDSC2 3.5834 7.6793 1.3571 10.5923
NOMO-1 GDSC1; GDSC2 3.5926 6.2964 2.0538 5.9001
MOLT-13 GDSC1; GDSC2 3.5953 5.7917 2.3068 5.1576
OCI-M1 GDSC1; GDSC2 3.5965 5.62 2.3929 4.6624
RPMI-8402 GDSC1; GDSC2 3.6062 7.7017 1.3642 9.3841
MOLM-16 GDSC2 3.6325 5.9724 2.2458 5.962
SUP-M2 GDSC1; GDSC2 3.633 6.8506 1.8097 7.9074
SUP-HD1 GDSC1; GDSC2 3.6409 5.3312 2.5691 3.5586
BC-3 GDSC1; GDSC2 3.6409 5.7995 2.3379 5.3615
MOLP-8 GDSC1; GDSC2 3.6412 5.5183 2.4771 4.0801
Mono-Mac-6 GDSC1; GDSC2 3.6487 7.4524 1.5223 9.5002
A4/Fukuda GDSC2 3.6814 6.5482 1.9977 6.7191
BALL-1 GDSC1; GDSC2 3.6997 5.5789 2.4907 3.4557
OCI-AML-3 GDSC1; GDSC2 3.7085 8.4631 1.066 11.8912
A3/Kawakami GDSC1; GDSC2 3.71 5.5151 2.5295 3.6307
TALL-1 [Human adult T-ALL] GDSC2 3.7148 6.8049 1.8961 7.9392
HAL-01 GDSC1; GDSC2 3.7263 7.6602 1.4799 9.5497
DEL GDSC1; GDSC2 3.7968 5.0213 2.8279 1.8054
L-1236 GDSC1; GDSC2 3.7974 7.3996 1.6645 8.3383
RCH-ACV GDSC1; GDSC2 3.8211 6.5046 2.125 6.2419
P12-Ichikawa GDSC1; GDSC2 3.8373 6.651 2.065 5.3354
BC-1 GDSC1; GDSC2 3.8443 7.1125 1.8425 7.2225
MHH-PREB-1 GDSC1; GDSC2 3.8518 6.0634 2.3638 4.2607
OCI-AML-2 GDSC1; GDSC2 3.8526 6.8025 2.0016 6.3025
LAMA-84 GDSC1; GDSC2 3.8556 7.8529 1.4844 9.2148
JeKo-1 GDSC2 3.8688 7.0182 1.9074 7.477
NKM-1 GDSC1; GDSC2 3.8737 6.1628 2.331 3.9254
P30/OHK GDSC1; GDSC2 3.8781 6.7682 2.0375 5.3936
CML-T1 GDSC2 3.8834 6.0573 2.3892 4.0522
MHH-CALL-4 GDSC2 3.9059 6.612 2.1346 5.9782
SU-DHL-6 GDSC1; GDSC2 3.9134 7.2606 1.8212 7.1859
Jiyoye GDSC1; GDSC2 3.9317 5.5655 2.6585 2.4748
MY-M12 GDSC1; GDSC2 3.9391 7.9804 1.4849 8.0601
BL-41 GDSC1; GDSC2 3.9495 5.7799 2.5684 2.9311
NK-92MI GDSC2 3.9618 6.5075 2.2258 5.2848
DG-75 GDSC1; GDSC2 3.964 7.3846 1.7977 7.205
VAL GDSC1; GDSC2 3.9652 6.9766 1.999 6.0693
ARH-77 GDSC1; GDSC2 3.9673 5.7363 2.601 2.721
SU-DHL-4 GDSC1; GDSC2 3.9804 5.7217 2.6164 2.8759
JVM-3 GDSC1; GDSC2 3.9868 6.4601 2.2665 4.5248
EJM GDSC1; GDSC2 3.988 6.3344 2.3282 4.1793
KMS-12-BM GDSC1; GDSC2 4.0149 7.6157 1.7216 7.5193
SUP-T1 GDSC1; GDSC2 4.0178 6.0149 2.5019 2.8249
U-698-M GDSC1; GDSC2 4.0271 7.7541 1.6625 6.9887
SU-DHL-5 GDSC1; GDSC2 4.0304 9.1257 0.9873 11.5369
MOLT-16 GDSC1; GDSC2 4.0306 8.8853 1.1065 10.8915
EM-2 GDSC1; GDSC2 4.032 6.6371 2.2123 4.7344
SK-MM-2 GDSC1; GDSC2 4.0532 7.5692 1.7726 7.1491
GA-10 GDSC1; GDSC2 4.0549 8.3617 1.3838 9.3134
P32/ISH GDSC1; GDSC2 4.0588 6.2984 2.394 3.6776
JVM-2 GDSC1; GDSC2 4.0687 6.1086 2.491 3.1307
NCI-H929 GDSC2 4.0722 7.7763 1.6849 7.5981
L-428 GDSC1; GDSC2 4.0793 6.3418 2.387 3.6769
Raji GDSC1; GDSC2 4.0827 6.1781 2.4672 3.2336
THP-1 GDSC1; GDSC2 4.084 11.4216 -0.1116 18.2983
SR GDSC1; GDSC2 4.0957 8.2916 1.4488 8.861
IM-9 GDSC1; GDSC2 4.0984 6.1594 2.4864 3.1017
Granta-519 GDSC1; GDSC2 4.1183 6.7888 2.1989 4.6356
K-562 GDSC1; GDSC2 4.1213 9.2463 0.9967 10.113
Ramos.2G6.4C10 GDSC1; GDSC2 4.1415 8.7621 1.251 9.8478
MN-60 GDSC1; GDSC2 4.1485 7.8034 1.7271 7.1969
Reh GDSC1; GDSC2 4.1494 6.6416 2.2908 3.6318
CCRF-CEM GDSC1; GDSC2 4.1523 7.4085 1.9225 5.4465
Farage GDSC1; GDSC2 4.1536 8.5059 1.3862 9.9543
RS4;11 GDSC1; GDSC2 4.1778 7.0879 2.0957 5.0881
697 GDSC1; GDSC2 4.1865 6.3741 2.4422 3.1813
NB4 GDSC1; GDSC2 4.197 8.7197 1.313 10.2832
MC116 GDSC1; GDSC2 4.226 7.3609 1.9972 6.0875
MEG-01 GDSC1; GDSC2 4.2346 7.5549 1.9094 5.3608
SU-DHL-8 GDSC1; GDSC2 4.2477 6.1036 2.606 2.2209
TK [Human B-cell lymphoma] GDSC1; GDSC2 4.2519 6.0737 2.6221 2.1322
SCC-3 GDSC1; GDSC2 4.2631 5.5234 2.8713 0.9268
HH [Human lymphoma] GDSC1; GDSC2 4.2641 8.3337 1.5513 7.9254
HT GDSC1; GDSC2 4.2721 8.0694 1.6859 7.8691
Daudi GDSC1; GDSC2 4.3097 6.5588 2.4339 3.0134
OCI-Ly7 GDSC2 4.3144 6.2893 2.5611 2.5823
VL51 GDSC1; GDSC2 4.3222 7.7608 1.8707 6.0414
KM-H2 GDSC1; GDSC2 4.3962 9.0556 1.2936 9.0545
SU-DHL-1 GDSC1; GDSC2 4.3978 10.3276 0.6703 13.4581
LC4-1 GDSC1; GDSC2 4.4008 6.6704 2.4385 2.5347
Karpas-299 GDSC1; GDSC2 4.4141 9.105 1.2823 9.0774
KY821 GDSC1; GDSC2 4.4204 6.6089 2.4786 2.3233
QIMR-WIL GDSC1; GDSC2 4.4226 7.3269 2.1457 3.8836
JURL-MK1 GDSC1; GDSC2 4.4232 7.4132 2.1052 4.0776
RPMI-8866 GDSC1; GDSC2 4.4268 7.7709 1.9372 4.8864
Loucy GDSC1; GDSC2 4.4287 8.1643 1.7495 6.4952
Karpas-45 GDSC1; GDSC2 4.46 8.7564 1.4848 7.8795
KE-37 GDSC1; GDSC2 4.4669 11.0413 0.3699 13.7175
JJN-3 GDSC1; GDSC2 4.472 9.4193 1.1704 9.5574
OPM-2 GDSC1; GDSC2 4.4723 10.2522 0.7625 11.7134
Karpas-422 GDSC1; GDSC2 4.4756 8.3913 1.6724 6.8238
Karpas-231 GDSC1; GDSC2 4.4821 5.7912 2.8679 0.7246
H9 GDSC1; GDSC2 4.5025 9.3812 1.2109 9.2751
GR-ST GDSC1; GDSC2 4.5418 9.3892 1.235 9.0628
ALL-SIL GDSC1; GDSC2 4.5471 7.5599 2.1162 4.288
SU-DHL-16 GDSC1; GDSC2 4.5484 6.472 2.6134 1.9344
SU-DHL-10 GDSC1; GDSC2 4.6665 5.5625 3.0318 0.1351
P31/FUJ GDSC1; GDSC2 4.6753 9.7154 1.1707 8.1848
MLMA GDSC1; GDSC2 4.6773 9.003 1.5162 6.5057
Karpas-1106P GDSC2 4.6845 9.9829 1.0473 9.7646
SKM-1 GDSC1; GDSC2 4.6864 9.3321 1.364 8.8464
RL GDSC1; GDSC2 4.6873 10.5315 0.782 12.1449
HC-1 GDSC1; GDSC2 4.6954 10.0717 1.0119 9.9287
BE-13 GDSC1; GDSC2 4.7213 7.018 2.4687 2.2193
PF-382 GDSC1; GDSC2 4.7267 7.6621 2.1808 3.2579
CTV-1 GDSC1; GDSC2 4.738 6.8921 2.5331 1.8936
WIL2 NS GDSC1; GDSC2 4.7384 9.7612 1.1927 8.8839
RPMI-8226 GDSC1; GDSC2 4.7488 8.6109 1.7511 5.8767
CRO-AP2 GDSC2 4.7759 6.9355 2.5346 2.0242
DB GDSC1; GDSC2 4.7966 9.9736 1.1304 9.0962
U266B1 GDSC1; GDSC2 4.8943 6.75 2.6733 0.9928
CA46 GDSC1; GDSC2 4.8996 9.2036 1.5691 6.57
DND-41 GDSC1; GDSC2 4.9082 10.4676 0.9692 9.7154
RC-K8 GDSC1; GDSC2 4.9405 8.3627 1.9887 4.2978
CTB-1 GDSC1; GDSC2 4.949 8.7602 1.8096 5.7272
KMS-11 GDSC1; GDSC2 5.076 8.0592 2.2061 3.3045
HEL GDSC1; GDSC2 5.1062 6.8916 2.7147 0.8603
ML-2 GDSC1; GDSC2 5.1583 10.4545 1.1455 8.3131
ST486 GDSC1; GDSC2 5.1824 10.0982 1.3305 7.3084
HDLM-2 GDSC1; GDSC2 5.1995 10.8861 0.9671 9.1538
YT GDSC1; GDSC2 5.2025 10.0852 1.3497 7.1724
CESS GDSC1; GDSC2 5.2104 7.4892 2.5223 1.2664
NU-DUL-1 GDSC1; GDSC2 5.25 6.6312 2.8717 0.2871
BONNA-12 GDSC2 5.2827 7.6722 2.482 1.6646
RPMI-6666 GDSC1; GDSC2 5.3151 10.584 1.1873 7.8084
ROS-50 GDSC1; GDSC2 5.3627 7.8813 2.4346 1.7916
Hs 445 GDSC1; GDSC2 5.4084 6.9823 2.8062 0.3455
EB2 GDSC1; GDSC2 5.4112 10.1581 1.4485 6.3016
ME1 GDSC1; GDSC2 5.4179 7.7975 2.4958 1.3319
OCI-Ly19 GDSC1; GDSC2 5.5131 7.4311 2.6821 0.6844
Karpas-620 GDSC1; GDSC2 5.5141 12.5285 0.3926 11.3994
L-363 GDSC1; GDSC2 5.5471 10.9648 1.1575 7.5494
TUR GDSC1; GDSC2 5.6809 13.7539 -0.083 13.2868
SUP-B15 GDSC1; GDSC2 5.7256 7.681 2.6757 0.5275
Namalwa GDSC2 5.7826 16.4291 -1.3113 18.1355
JSC-1 GDSC1; GDSC2 5.8163 12.4059 0.6525 9.5784
KG-1 GDSC1; GDSC2 5.8362 12.6459 0.552 10.0281
OCI-AML-5 GDSC1; GDSC2 6.0459 12.3401 0.8303 9.0506
PL-21 GDSC1; GDSC2 6.0579 13.2696 0.4017 11.2031
KMOE-2 GDSC1; GDSC2 6.1001 16.1567 -0.9536 16.1356
NALM-6 GDSC1; GDSC2 6.3423 16.6108 -1.0049 15.8716
BV-173 GDSC1; GDSC2 6.5413 16.193 -0.6687 14.1638
KCL-22 GDSC1; GDSC2 6.5761 15.1967 -0.1718 12.0137
KOPN-8 GDSC1; GDSC2 6.8423 18.182 -1.4184 16.4974
⏷ Show the Full List of 167 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 11 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HCE-4 GDSC1; GDSC2 4.3178 8.5611 1.4788 9.0061
OACM5.1 C GDSC1; GDSC2 4.6543 10.0373 0.9994 9.0502
ESO-26 GDSC1; GDSC2 4.7062 10.7571 0.6853 11.5996
KYSE-220 GDSC1; GDSC2 4.84 9.6391 1.3214 7.1643
FLO-1 GDSC1; GDSC2 5.0232 11.419 0.5887 10.3018
OACP4 C GDSC1; GDSC2 5.2061 8.6306 2.0248 3.312
KYSE-50 GDSC1; GDSC2 5.4376 12.3555 0.4235 10.3087
SK-GT-4 GDSC1; GDSC2 5.9073 9.9642 1.8275 3.3066
TE-12 GDSC1; GDSC2 6.275 12.5903 0.8565 7.0405
ESO-51 GDSC2 6.5566 19.2717 -2.1444 19.514
KYAE-1 GDSC1; GDSC2 7.5559 16.541 -0.1809 9.5321
⏷ Show the Full List of 11 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC1; GDSC2 4.5905 9.8405 1.0498 9.949
Cancer Drug Sensitivity Data Curated from 32 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SJNB-14 GDSC1; GDSC2 3.6984 6.9496 1.8115 7.7393
IMR-5 GDSC1; GDSC2 3.9811 9.0657 0.9792 11.6973
NB(TU)1 GDSC1; GDSC2 4.1564 5.9137 2.6378 2.2011
TGW GDSC1; GDSC2 4.2366 7.233 2.0662 5.1346
GOTO GDSC1; GDSC2 4.2456 7.9081 1.7456 6.1537
CHP-134 GDSC1; GDSC2 4.2808 6.1321 2.6127 2.1358
SJNB-6 GDSC1; GDSC2 4.4697 6.8645 2.3912 3.2725
Kelly GDSC1; GDSC2 4.4722 8.0637 1.8276 5.983
SiMa GDSC1; GDSC2 4.4814 7.408 2.1455 4.2473
MHH-NB-11 GDSC2 4.622 6.4735 2.6523 1.638
SK-N-DZ GDSC1; GDSC2 4.6493 6.1134 2.8161 0.777
NB69 GDSC1; GDSC2 4.6966 10.4933 0.8073 10.9933
SJNB-10 GDSC1; GDSC2 4.7436 9.1589 1.4864 7.305
SJNB-12 GDSC1; GDSC2 4.7862 12.1313 0.07 14.4491
CHP-126 GDSC2 4.8244 7.6041 2.2655 3.3774
KP-N-RT-BM-1 GDSC2 4.8317 7.4693 2.3303 3.0134
SJNB-7 GDSC1; GDSC2 4.8661 9.589 1.3632 7.7264
SJNB-17 GDSC1; GDSC2 4.8745 6.9953 2.5608 1.4333
NH-12 GDSC1; GDSC2 5.079 8.3301 2.0863 3.2044
SK-N-BE(2)-M17 GDSC1; GDSC2 5.2824 7.5091 2.5488 1.2474
SK-N-FI GDSC1; GDSC2 5.3045 10.2816 1.3231 7.1288
KP-N-YN GDSC1; GDSC2 5.3546 12.255 0.4149 11.6051
SK-N-SH GDSC1; GDSC2 5.5469 11.3588 0.972 8.4846
LA-N-6 GDSC1; GDSC2 6.0422 7.6797 2.7958 0.1918
SJNB-13 GDSC1; GDSC2 6.1346 14.2742 -0.0247 12.1605
KP-N-YS GDSC1; GDSC2 6.2074 8.3931 2.6054 0.5343
SK-N-MC-IXC GDSC1; GDSC2 6.5073 15.303 -0.2672 13.4835
SJNB-5 GDSC1; GDSC2 6.9865 16.4576 -0.5006 13.5969
SK-N-AS GDSC1; GDSC2 7.4588 17.8513 -0.8523 13.2997
GI-ME-N GDSC1; GDSC2 7.4881 15.032 0.4665 7.7674
NB1 GDSC1; GDSC2 7.6087 19.2748 -1.4272 15.1952
CHP-212 GDSC1; GDSC2 8.6819 21.5562 -1.8092 14.8058
⏷ Show the Full List of 32 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuCC-T1 GDSC1; GDSC2 4.4371 9.8724 0.9232 10.9504
Cancer Drug Sensitivity Data Curated from 52 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HCC202 GDSC1 2.7712 15.2382 -4.4437 28.5138
MDA-MB-453 GDSC1; GDSC2 2.9432 6.6683 1.3236 11.1779
OCUB-M GDSC1; GDSC2 3.0967 5.1594 2.2094 6.2665
MDA-MB-468 GDSC1; GDSC2 3.1758 5.8981 1.9101 7.6005
MRK-nu-1 GDSC1; GDSC2 3.2574 6.3424 1.7576 8.1839
HCC1954 GDSC1; GDSC2 3.3292 5.5174 2.2302 5.5883
HCC2218 GDSC1; GDSC2 3.5195 7.6918 1.2994 9.907
UACC-893 GDSC1; GDSC2 3.6551 8.561 0.9746 13.6988
DU4475 GDSC1; GDSC2 3.8102 7.6928 1.5289 8.1075
HCC2157 GDSC1; GDSC2 3.8578 5.9595 2.4187 3.5167
HCC70 GDSC1; GDSC2 3.8832 8.74 1.0652 10.2761
MDA-MB-157 GDSC1; GDSC2 3.9171 8.9077 1.0082 11.6941
UACC-812 GDSC1; GDSC2 4.051 6.7665 2.1629 4.9702
MDA-MB-175-VII GDSC1; GDSC2 4.0547 7.3399 1.8861 5.812
MDA-MB-415 GDSC1; GDSC2 4.0821 6.7117 2.2111 4.1406
MDA-MB-361 GDSC1; GDSC2 4.1551 7.7021 1.7814 6.1449
HCC1569 GDSC1; GDSC2 4.2557 9.9667 0.742 11.0718
EFM-19 GDSC1; GDSC2 4.2712 8.4591 1.495 7.3503
BT-20 GDSC1; GDSC2 4.3 8.9217 1.2894 8.3131
Evsa-T GDSC1; GDSC2 4.3448 7.6635 1.9331 5.0478
COLO 824 GDSC1; GDSC2 4.3474 8.0849 1.7315 6.0366
EFM-192A GDSC1; GDSC2 4.3669 8.3382 1.6223 6.5407
CAL-85-1 GDSC1; GDSC2 4.6238 9.2435 1.3634 8.203
MFM-223 GDSC1; GDSC2 4.6408 7.6703 2.1239 3.6478
JIMT-1 GDSC2 4.6458 6.4163 2.689 1.2993
MCF-7 GDSC1; GDSC2 4.6578 8.9055 1.5497 6.3768
CAL-51 GDSC1; GDSC2 4.6983 10.333 0.8867 9.5072
YMB-1-E GDSC1; GDSC2 4.7028 10.5315 0.7931 9.9441
ZR-75-30 GDSC1; GDSC2 4.8039 10.0646 1.0915 8.3326
HCC1419 GDSC1; GDSC2 4.8716 12.6482 -0.1212 13.7721
HCC1143 GDSC2 4.8964 9.4855 1.4329 7.2985
HCC1395 GDSC1; GDSC2 4.9114 8.4398 1.9351 4.1276
BT-474 GDSC1; GDSC2 4.9496 11.3814 0.5549 10.594
CAL-148 GDSC1; GDSC2 5.0508 6.4967 2.8424 0.3738
MDA-MB-231 GDSC1; GDSC2 5.0966 7.7847 2.3383 2.0968
Hs 578T GDSC1; GDSC2 5.1882 7.75 2.4017 1.7439
MDA-MB-330 GDSC1; GDSC2 5.2689 10.2046 1.3364 6.3824
CAL-120 GDSC1; GDSC2 5.3252 7.3025 2.6509 0.7507
CAMA-1 GDSC1; GDSC2 5.4347 11.953 0.6149 9.4494
HDQ-P1 GDSC1; GDSC2 5.4572 10.9492 1.1072 7.1494
HCC1599 GDSC1; GDSC2 5.9442 8.162 2.5854 0.5897
BT-549 GDSC1; GDSC2 5.9457 8.6363 2.4033 1.1057
T-47D GDSC1; GDSC2 6.0165 12.3856 0.7906 8.5587
HCC1428 GDSC1; GDSC2 6.3102 12.3797 0.9747 6.4734
HCC38 GDSC1; GDSC2 6.4256 15.5366 -0.4326 13.3981
MDA-MB-436 GDSC1; GDSC2 6.8722 19.6844 -2.1227 17.5736
HCC1187 GDSC1; GDSC2 6.9599 17.6573 -1.0875 13.8871
HCC1500 GDSC1; GDSC2 7.1954 18.3162 -1.2448 15.2349
HCC1937 GDSC1; GDSC2 7.7613 19.3925 -1.3832 13.6877
AU565 GDSC1; GDSC2 7.9889 18.9173 -1.0143 12.0494
BT-483 GDSC1; GDSC2 9.1793 19.6818 -0.646 9.9506
HCC1806 GDSC1; GDSC2 11.3688 25.4046 -1.9534 10.8739
⏷ Show the Full List of 52 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 55 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
AM-38 GDSC1; GDSC2 3.9226 8.1755 1.3758 9.6632
LN-405 GDSC1; GDSC2 4.0075 7.4954 1.7753 7.2344
YH-13 GDSC1; GDSC2 4.0256 9.5978 0.7494 12.8132
H4 GDSC1; GDSC2 4.0587 7.875 1.6264 7.9547
D283 Med GDSC1; GDSC2 4.0776 6.5664 2.2781 4.2787
CAS-1 GDSC1; GDSC2 4.1281 7.0272 2.0905 5.2161
A-172 GDSC1; GDSC2 4.1794 7.6968 1.8014 6.7179
42-MG-BA GDSC1; GDSC2 4.2378 8.1188 1.6374 7.5052
U-118MG GDSC1; GDSC2 4.2763 7.4081 2.0091 5.3703
Onda 11 GDSC1; GDSC2 4.3081 8.1142 1.6896 7.7641
T98G GDSC1; GDSC2 4.3178 6.7013 2.3726 3.3236
SF126 GDSC1; GDSC2 4.3491 9.1556 1.2106 10.517
SW1088 GDSC1; GDSC2 4.3726 8.0983 1.7425 6.6457
D-247MG GDSC1; GDSC2 4.3811 6.9019 2.3188 3.8501
U-251MG GDSC1; GDSC2 4.4013 10.0391 0.8149 11.5989
D-502MG GDSC1; GDSC2 4.5539 8.1307 1.8505 6.2669
D-423MG GDSC1; GDSC2 4.5555 6.9916 2.3847 3.1614
LN-18 GDSC1; GDSC2 4.6188 6.1067 2.8044 0.8488
SF539 GDSC1; GDSC2 4.6335 10.1666 0.9215 10.5336
KINGS-1 GDSC1; GDSC2 4.6911 8.5106 1.7607 5.9314
GI-1 GDSC1; GDSC2 4.7705 8.627 1.7577 5.8022
KNS-81-FD GDSC1; GDSC2 4.8939 6.7527 2.672 1.2304
ONS-76 GDSC1; GDSC2 4.9162 8.2481 2.0266 4.1417
NMC-G1 GDSC1; GDSC2 5.0329 6.3446 2.8914 0.3315
Hs 683 GDSC1; GDSC2 5.0561 6.4578 2.859 0.409
SK-MG-1 GDSC1; GDSC2 5.0617 10.6122 1.005 9.2252
KNS-42 GDSC1; GDSC2 5.0742 6.5156 2.8449 0.4404
D-263MG GDSC1; GDSC2 5.1714 11.5847 0.6118 11.004
D-245MG GDSC2 5.2836 9.2191 1.8035 5.1629
SF295 GDSC1; GDSC2 5.3023 6.9063 2.7921 0.4705
YKG-1 GDSC1; GDSC2 5.3102 6.7738 2.8436 0.3296
M059J GDSC1; GDSC2 5.3708 7.3444 2.6546 0.7969
MOG-G-UVW GDSC1; GDSC2 5.3756 7.4653 2.6094 0.9472
8-MG-BA GDSC1; GDSC2 5.3833 14.843 -0.824 17.0697
LNZTA3WT4 GDSC1 5.4952 15.7358 -2.7464 15.9215
D-542MG GDSC1; GDSC2 5.504 6.9041 2.87 0.2049
KS-1 [Human Krukenberg tumour] GDSC1; GDSC2 5.5269 9.0835 2.0049 3.3614
MOG-G-CCM GDSC1; GDSC2 5.5296 7.4036 2.6993 0.5634
D-566MG GDSC1; GDSC2 5.6098 7.5932 2.6611 0.6913
SNB-75 GDSC1; GDSC2 5.6392 8.0212 2.5084 1.2127
KALS-1 GDSC1; GDSC2 5.7713 10.5272 1.498 5.4779
DK-MG GDSC1; GDSC2 5.7751 12.0474 0.795 8.9565
SW1783 GDSC1; GDSC2 5.9112 8.1947 2.5594 0.7538
D-336MG GDSC1; GDSC2 5.9214 9.8802 1.8719 3.8176
Onda 10 GDSC1; GDSC2 6.1005 8.2013 2.6334 0.5108
Becker GDSC1; GDSC2 6.2658 13.4492 0.4511 9.7475
D-392MG GDSC1; GDSC2 6.2914 14.2745 0.0787 11.4116
SF268 GDSC1; GDSC2 6.3836 14.2366 0.1565 10.8974
GaMG GDSC1; GDSC2 6.4755 13.8918 0.377 9.734
Daoy GDSC1; GDSC2 6.4783 12.7779 0.8936 7.3181
GB-1 GDSC1; GDSC2 6.8811 13.2966 0.8957 6.7113
PFSK-1 GDSC1; GDSC2 7.7429 17.9854 -0.7345 12.3803
U-87MG ATCC GDSC1; GDSC2 8.3637 18.2529 -0.4778 10.4335
DBTRG-05MG GDSC1; GDSC2 8.4761 18.8588 -0.6872 11.0836
LN-229 GDSC1; GDSC2 8.5373 20.2398 -1.2864 13.2153
⏷ Show the Full List of 55 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TGBC24TKB GDSC1; GDSC2 3.92 8.377 1.2739 10.2339
TGBC1TKB GDSC1; GDSC2 5.651 12.3413 0.5744 10.2604
ETK-1 GDSC1; GDSC2 8.4717 21.1003 -1.7295 13.813
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
EN GDSC1; GDSC2 3.918 7.0505 1.9281 6.572
MFE-280 GDSC1; GDSC2 4.4997 9.5844 1.1097 9.8237
RL95-2 GDSC1; GDSC2 5.2493 9.6757 1.5716 5.3156
MFE-319 GDSC1; GDSC2 5.7249 15.6184 -0.9569 16.8943
KLE GDSC1; GDSC2 5.9576 8.5933 2.4256 1.0286
AN3-CA GDSC1; GDSC2 6.3085 15.5329 -0.5096 13.937
MFE-296 GDSC1; GDSC2 6.9109 15.9619 -0.3159 12.0499
ESS-1 GDSC1; GDSC2 7.5608 15.6939 0.2098 8.7746
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 33 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KTCTL-140 GDSC1; GDSC2 3.5649 6.0566 2.1515 6.7319
SW13 GDSC1; GDSC2 3.7037 8.1016 1.2423 10.9321
A-498 GDSC1; GDSC2 4.2368 10.1265 0.6487 12.8384
ACHN GDSC1; GDSC2 4.2759 6.7749 2.311 3.7259
Caki-1 GDSC1; GDSC2 4.7528 6.9771 2.504 2.2118
RCC10RGB GDSC1; GDSC2 4.8481 8.1918 2.0109 4.3328
KTCTL-1M GDSC1; GDSC2 4.9923 8.054 2.1603 3.6822
HA7-RCC GDSC1; GDSC2 4.9939 7.3865 2.4558 2.131
CAL-54 GDSC1; GDSC2 5.0892 11.5958 0.5492 11.4816
KTCTL-195 GDSC1; GDSC2 5.4665 7.5183 2.6288 0.8163
BFTC-909 GDSC1; GDSC2 5.4786 12.0306 0.6073 10.4249
LB2241-RCC GDSC1; GDSC2 5.5324 9.8893 1.6464 5.6011
BB65-RCC GDSC1; GDSC2 5.5337 12.7784 0.2859 12.8496
KTCTL-13 GDSC1; GDSC2 5.6147 7.7066 2.6201 0.8231
A-704 GDSC1; GDSC2 5.6149 12.7588 0.3506 11.4056
LB996-RCC GDSC1; GDSC2 5.6231 11.6471 0.8854 8.7806
SN12C GDSC1; GDSC2 5.6422 11.3205 1.0514 7.9178
769-P GDSC1; GDSC2 5.6625 12.1389 0.6782 9.7326
RXF 393L GDSC1; GDSC2 5.7731 8.9932 2.1746 2.5276
NCC010 GDSC2 5.8678 14.6064 -0.3653 15.2183
UO-31 GDSC1; GDSC2 5.8697 7.9109 2.6485 0.582
VMRC-RCW GDSC1; GDSC2 5.8962 7.5175 2.7993 0.2227
KTCTL-26A GDSC1; GDSC2 5.9052 7.8666 2.6788 0.4827
LB1047-RCC GDSC1; GDSC2 6.0322 10.2793 1.7578 4.2395
NCC021 GDSC1; GDSC2 6.0393 7.9662 2.6945 0.3882
786-O GDSC1; GDSC2 6.1198 11.547 1.2409 6.2055
TK-10 GDSC1; GDSC2 6.1262 11.3797 1.3206 5.8106
KTCTL-21 GDSC1; GDSC2 6.2685 12.0693 1.0916 7.3074
VMRC-RCZ GDSC1; GDSC2 6.4681 12.559 0.9873 6.8914
KMRC-1 GDSC1; GDSC2 6.509 12.9496 0.8335 7.5537
SW156 GDSC1; GDSC2 6.5931 14.5261 0.1549 11.3816
OS-RC-2 GDSC1; GDSC2 6.8728 13.6177 0.7458 7.4096
KMRC-20 GDSC1; GDSC2 7.554 14.9761 0.5295 7.4008
⏷ Show the Full List of 33 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 48 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CCK-81 GDSC1; GDSC2 3.6072 6.6229 1.9027 7.4394
SW1417 GDSC1; GDSC2 3.9913 6.2174 2.387 3.8471
RKO GDSC1; GDSC2 4.0422 6.5249 2.2737 4.3727
KM12 GDSC1; GDSC2 4.0514 6.6944 2.1981 4.774
SW1463 GDSC1; GDSC2 4.102 7.4636 1.8597 6.5566
CaR-1 GDSC1; GDSC2 4.1549 6.5917 2.3183 3.9093
SNU-C1 GDSC1; GDSC2 4.197 7.9858 1.673 7.3944
HT-55 GDSC1; GDSC2 4.2302 7.4668 1.949 5.7943
SW48 GDSC1; GDSC2 4.2889 8.0562 1.7043 7.0278
NCI-H508 GDSC2 4.2984 6.5641 2.4244 3.3798
T84 GDSC1; GDSC2 4.328 7.9086 1.8033 6.4013
LoVo GDSC1; GDSC2 4.3424 7.4452 2.0362 5.0938
DiFi GDSC2 4.3875 8.0539 1.7743 6.4411
C2BBe1 GDSC2 4.3917 9.365 1.139 9.8999
GP5d GDSC1; GDSC2 4.3958 6.9836 2.2899 3.6277
SW948 GDSC1; GDSC2 4.4784 9.2642 1.2508 9.1113
SK-CO-1 GDSC2 4.4908 8.7695 1.5001 7.7326
LS411N GDSC1; GDSC2 4.5792 8.6136 1.6364 6.8152
NCI-H716 GDSC1; GDSC2 4.5976 6.9286 2.4381 2.5417
SW1116 GDSC1; GDSC2 4.6619 6.4268 2.6928 1.2657
SNU-1040 GDSC1; GDSC2 4.6806 9.2306 1.4089 8.5696
SNU-61 GDSC1; GDSC2 4.713 7.0356 2.4562 2.2905
COLO 320HSR GDSC1; GDSC2 4.7452 8.1165 1.9816 4.6588
SNU-283 GDSC2 4.8224 6.5713 2.712 1.129
LS123 GDSC1; GDSC2 4.8517 9.2802 1.501 7.021
RCM-1 [Human ESC] GDSC1; GDSC2 4.9834 10.2375 1.1317 8.7191
SNU-81 GDSC1; GDSC2 4.9889 10.1841 1.161 9.3243
HCC2998 GDSC1; GDSC2 4.998 7.0592 2.5962 1.3249
LS1034 GDSC1; GDSC2 5.0864 6.5737 2.8282 0.4394
NCI-H747 GDSC1; GDSC2 5.2626 8.1898 2.2517 2.5442
COLO205 GDSC1; GDSC2 5.2725 11.4053 0.7675 10.0255
CL-11 GDSC1; GDSC2 5.3086 9.6491 1.6208 5.5908
MDST8 GDSC1; GDSC2 5.3307 9.9986 1.4723 6.3158
SW620 GDSC1; GDSC2 5.3538 10.4763 1.2632 7.3499
SNU-407 GDSC1; GDSC2 5.381 11.7513 0.6752 10.2768
SNU-175 GDSC1; GDSC2 5.3978 10.6831 1.1942 7.6248
COLO 678 GDSC1; GDSC2 5.5353 9.5529 1.8005 4.3377
HT115 GDSC1; GDSC2 5.6504 12.6445 0.4293 11.8496
HCT 15 GDSC1; GDSC2 5.732 10.874 1.3154 6.4463
HCT 116 GDSC1; GDSC2 5.7428 13.4759 0.0934 12.3631
SW837 GDSC1; GDSC2 5.7522 11.2455 1.1559 7.2084
LS513 GDSC1; GDSC2 5.8614 11.5736 1.0715 8.0993
CW-2 GDSC1; GDSC2 6.4077 14.207 0.186 10.7218
SNU-C2B GDSC1; GDSC2 6.5596 11.6694 1.4376 4.6604
HT-29 GDSC1; GDSC2 6.9183 14.4817 0.3782 9.0087
LS180 GDSC1; GDSC2 7.6967 16.3935 -0.028 9.5836
SNU-C5 GDSC1; GDSC2 7.9916 16.4068 0.1395 8.4573
SW626 GDSC1; GDSC2 8.2975 17.7031 -0.2672 9.6925
⏷ Show the Full List of 48 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC1; GDSC2 3.904 7.6755 1.6092 8.4017
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-475 GDSC1 2.9466 4.4141 0.863 0.7381
Huh-7 GDSC1; GDSC2 3.42 6.6502 1.7388 7.8981
Hep 3B2.1-7 GDSC1; GDSC2 4.57 12.4725 -0.2594 17.7315
Hep-G2/C3A GDSC1; GDSC2 4.5768 10.0824 0.9219 10.6531
SNU-398 GDSC1; GDSC2 4.7955 9.7836 1.2215 8.6168
SK-HEP-1 GDSC1; GDSC2 5.2583 11.1208 0.8943 9.4122
HLE GDSC1; GDSC2 5.3485 10.3288 1.3291 7.0208
SNU-387 GDSC1; GDSC2 5.4487 8.4226 2.25 2.3294
HuH-1 GDSC1; GDSC2 5.5536 13.2289 0.0824 12.7835
SNU-449 GDSC1; GDSC2 6.1635 11.2677 1.3928 5.4096
SNU-423 GDSC1; GDSC2 6.2074 14.647 -0.154 12.5994
JHH-4 GDSC1; GDSC2 6.4364 15.5458 -0.4299 13.3668
JHH-7 GDSC1; GDSC2 6.6722 16.5897 -0.7704 14.3366
JHH-2 GDSC1; GDSC2 6.8088 13.7377 0.6532 7.9297
JHH-6 GDSC1; GDSC2 6.8616 16.6011 -0.6501 13.5156
JHH-1 GDSC1; GDSC2 8.1991 16.7582 0.1013 8.3305
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 185 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H1304 GDSC1 2.6513 6.2566 -0.117 7.6088
DMS 53 GDSC1; GDSC2 2.7409 7.2231 0.8682 15.6189
NCI-H23 GDSC1; GDSC2 2.8169 4.6831 2.1853 8.0091
NCI-H526 GDSC1; GDSC2 3.1452 7.9571 0.8555 14.5215
NCI-H1581 GDSC1; GDSC2 3.2112 8.494 0.6431 15.4704
NCI-H187 GDSC1 3.3868 10.1241 -1.4726 14.5115
NCI-H1703 GDSC1; GDSC2 3.3871 7.2732 1.4003 10.8544
NCI-H510A GDSC1; GDSC2 3.5285 5.6419 2.3293 5.7088
NCI-H2342 GDSC1; GDSC2 3.5481 5.6067 2.3621 4.9532
NCI-H810 GDSC1; GDSC2 3.6855 7.6897 1.4331 9.9117
VMRC-LCD GDSC2 3.859 6.3917 2.2084 5.1199
SHP-77 GDSC1; GDSC2 3.8781 6.6573 2.092 5.7352
NCI-H250 GDSC2 3.8861 6.9804 1.939 7.2382
NCI-H1694 GDSC1; GDSC2 3.9171 7.6317 1.6407 8.1944
BEN GDSC1; GDSC2 3.9189 8.4963 1.2139 11.5772
COR-L311 GDSC1; GDSC2 3.9496 6.6933 2.1264 5.3863
LK-2 GDSC1; GDSC2 3.9518 6.7584 2.0961 5.5518
NCI-H1048 GDSC1; GDSC2 4.0014 7.775 1.6331 8.0454
NCI-H2081 GDSC1; GDSC2 4.0113 7.4787 1.7864 7.8734
A-427 GDSC1; GDSC2 4.0195 10.1907 0.4502 15.626
COR-L279 GDSC2 4.0473 6.6131 2.2346 4.5797
NCI-H2196 GDSC1; GDSC2 4.072 6.2646 2.419 3.8683
NCI-H1993 GDSC1; GDSC2 4.1219 6.4035 2.386 3.602
NCI-H2141 GDSC1; GDSC2 4.1241 6.573 2.3066 4.0316
Lu-65 GDSC1; GDSC2 4.1445 6.7989 2.212 4.5118
CAL-12T GDSC1; GDSC2 4.1455 8.2296 1.5161 9.1939
Calu-3 GDSC1; GDSC2 4.1461 8.5146 1.3763 9.1487
NCI-H1651 GDSC1; GDSC2 4.1607 7.8664 1.7051 7.2934
HCC15 GDSC1; GDSC2 4.2201 7.2466 2.0483 5.2654
HCC78 GDSC1; GDSC2 4.2479 7.0772 2.1487 4.6596
COR-L303 GDSC1; GDSC2 4.2486 8.7892 1.3169 10.1346
NCI-H1105 GDSC1; GDSC2 4.2829 9.2409 1.1202 11.2044
NCI-H1944 GDSC1; GDSC2 4.3199 9.3469 1.0952 10.2931
NCI-H211 GDSC1; GDSC2 4.3239 7.9166 1.7965 6.4468
Lu-165 GDSC1; GDSC2 4.3389 8.7959 1.3792 8.7106
NCI-H1437 GDSC1; GDSC2 4.3395 7.1118 2.1932 4.6707
NCI-H720 GDSC1; GDSC2 4.3414 9.1891 1.1885 9.7427
NCI-H1876 GDSC1; GDSC2 4.3439 6.3627 2.5452 2.3822
DMS 273 GDSC1; GDSC2 4.3542 8.4476 1.5601 7.6863
LCLC-97TM1 GDSC1; GDSC2 4.3727 8.7806 1.4111 8.4644
Lu-139 GDSC1; GDSC2 4.3775 7.0767 2.2345 4.351
HOP-92 GDSC2 4.4109 7.5863 2.0148 5.0807
NCI-H1688 GDSC1; GDSC2 4.417 7.2755 2.1663 4.2507
NCI-H1355 GDSC1; GDSC2 4.4189 9.4056 1.1388 9.8416
NCI-H847 GDSC1; GDSC2 4.4212 6.987 2.3045 3.5072
ABC-1 GDSC1; GDSC2 4.4276 8.3907 1.6394 7.7958
COLO 668 GDSC1; GDSC2 4.4343 8.3375 1.6698 6.9206
NCI-H2444 GDSC1; GDSC2 4.4413 9.9387 0.8937 12.1116
SBC-5 GDSC1; GDSC2 4.4434 9.1456 1.2836 9.0079
NCI-H69 GDSC1; GDSC2 4.4635 7.0531 2.3002 3.4583
Lu-135 GDSC1; GDSC2 4.4661 6.6178 2.5017 2.4175
NCI-H2171 GDSC1; GDSC2 4.4803 6.26 2.669 1.7436
CPC-N GDSC1; GDSC2 4.4868 7.4039 2.1509 4.2088
NCI-H2795 GDSC1; GDSC2 4.4982 10.2245 0.7952 11.4865
NCI-H82 GDSC1; GDSC2 4.5077 8.5736 1.6066 7.1185
DMS 114 GDSC1; GDSC2 4.5084 7.5774 2.0831 4.5331
NCI-H2029 GDSC1; GDSC2 4.5187 7.7297 2.0179 5.3492
NCI-H524 GDSC1; GDSC2 4.547 8.589 1.6262 6.9339
DMS 79 GDSC2 4.551 6.7442 2.494 2.5656
NCI-H727 GDSC1; GDSC2 4.5574 8.5619 1.6463 6.8041
IST-SL1 GDSC1; GDSC2 4.5866 8.7361 1.5826 7.7834
NCI-H358 GDSC1; GDSC2 4.6128 7.9063 1.9956 4.8154
IST-SL2 GDSC1; GDSC2 4.6317 9.1413 1.4183 7.8916
Lu-99A GDSC1; GDSC2 4.6402 9.4237 1.2875 8.5774
Lu-134-A GDSC1; GDSC2 4.6427 11.5015 0.2739 14.9491
SW1271 GDSC1; GDSC2 4.6516 7.8401 2.0515 4.45
NCI-H1963 GDSC2 4.6558 10.9912 0.5341 12.4753
NCI-H345 GDSC1; GDSC2 4.6863 5.854 2.9335 0.3943
NCI-H1781 GDSC1; GDSC2 4.6902 8.8159 1.6146 6.719
NCI-H1755 GDSC1; GDSC2 4.7284 7.9279 2.0589 4.2807
NCI-H1836 GDSC1; GDSC2 4.7445 7.1194 2.4367 2.5765
NCI-H1436 GDSC1; GDSC2 4.779 9.0348 1.5695 7.4518
HCC366 GDSC2 4.8064 8.5027 1.8395 5.8267
HCC33 GDSC1; GDSC2 4.8225 7.2481 2.4234 2.5318
NCI-H835 GDSC2 4.8227 10.6022 0.844 10.5386
NCI-H1435 GDSC1; GDSC2 4.8405 11.1677 0.5813 11.8394
SBC-1 GDSC1; GDSC2 4.8439 6.6107 2.7062 1.1323
NCI-H2227 GDSC2 4.8478 8.7465 1.7514 6.2564
COR-L88 GDSC1; GDSC2 4.8542 8.4181 1.9095 4.8517
NCI-H1770 GDSC1; GDSC2 4.9111 11.3481 0.5438 12.9073
NCI-H1734 GDSC1; GDSC2 4.9132 7.2021 2.4925 2.0533
COR-L23 GDSC1; GDSC2 4.9177 7.0834 2.5456 1.6248
NCI-H64 GDSC1; GDSC2 4.9338 11.9017 0.2899 13.0779
NCI-H1573 GDSC1; GDSC2 4.9623 8.5119 1.9333 4.5483
NCI-H2369 GDSC1; GDSC2 4.9629 8.3206 2.0216 4.0929
HCC827 GDSC1; GDSC2 4.9635 9.2978 1.5663 6.4686
NCI-H748 GDSC2 4.9803 7.5181 2.3915 2.4732
NCI-H841 GDSC1; GDSC2 4.9804 9.7832 1.347 7.5946
NCI-H520 GDSC1; GDSC2 4.9823 7.4241 2.4334 2.0522
NCI-H146 GDSC1; GDSC2 5.0244 8.2353 2.0972 3.976
Ms-1 GDSC1; GDSC2 5.025 9.5552 1.4847 6.7872
PC-14 GDSC1; GDSC2 5.041 10.0768 1.2474 8.0034
RERF-LC-KJ GDSC1; GDSC2 5.0656 9.7728 1.4082 7.1149
NCI-H290 GDSC1; GDSC2 5.0712 7.1742 2.5845 1.4318
NCI-H2170 GDSC1; GDSC2 5.0774 8.9758 1.7896 5.1027
NCI-H3255 GDSC1; GDSC2 5.0912 8.8428 1.8596 5.1846
UMC-11 GDSC1; GDSC2 5.1299 14.1691 -0.6786 17.0146
NCI-H2135 GDSC1; GDSC2 5.1354 8.3871 2.0934 3.818
NCI-H2722 GDSC1; GDSC2 5.1361 7.7995 2.3531 2.2331
NCI-H2085 GDSC1; GDSC2 5.1365 10.8104 0.9607 9.3079
NCI-H2030 GDSC1; GDSC2 5.1539 8.35 2.1207 3.6422
EMC-BAC-1 GDSC1; GDSC2 5.1562 9.2318 1.7198 5.8547
NCI-H2803 GDSC1; GDSC2 5.1616 7.5773 2.4612 1.897
NCI-H2373 GDSC1; GDSC2 5.1728 8.9274 1.8703 4.535
COR-L105 GDSC1; GDSC2 5.2061 11.2852 0.7801 10.0914
NCI-H460 GDSC1; GDSC2 5.2099 6.5038 2.9019 0.2347
COR-L321 GDSC1; GDSC2 5.2264 6.7318 2.8261 0.414
NCI-H2731 GDSC1; GDSC2 5.24 8.0749 2.2894 2.3983
NCI-H1693 GDSC2 5.2958 14.427 -0.6838 16.6805
LC-1/sq GDSC2 5.3023 12.1007 0.4532 11.5232
NCI-H1092 GDSC1; GDSC2 5.3196 7.6619 2.5042 1.3884
NCI-H1648 GDSC1; GDSC2 5.3287 12.9837 0.0441 13.4142
NCI-H1155 GDSC1; GDSC2 5.3525 11.7128 0.6744 10.336
NCI-H3122 GDSC1; GDSC2 5.3551 8.93 1.9763 3.7341
NCI-H2804 GDSC1; GDSC2 5.3903 9.7727 1.6139 6.0251
EKVX GDSC1; GDSC2 5.3929 11.1106 0.9888 9.4694
SBC-3 GDSC1; GDSC2 5.4343 11.5046 0.8288 9.4095
NCI-H2818 GDSC1; GDSC2 5.4416 10.5217 1.298 7.0183
NCI-H2172 GDSC1; GDSC2 5.446 8.3748 2.269 2.4729
NCI-H838 GDSC1; GDSC2 5.4571 6.8688 2.8651 0.2282
NCI-H522 GDSC1; GDSC2 5.4807 13.2188 0.0367 13.1399
RERF-LC-Sq1 GDSC1; GDSC2 5.5396 10.6038 1.3214 6.7325
SK-MES-1 GDSC1; GDSC2 5.5786 10.0868 1.5839 5.3473
COR-L32 GDSC2 5.591 7.4725 2.6986 0.5333
NCI-H196 GDSC1; GDSC2 5.6187 10.2535 1.5317 5.5455
EMC-BAC-2 GDSC1; GDSC2 5.6379 9.9772 1.6688 4.8356
HOP-62 GDSC1; GDSC2 5.6383 11.2321 1.0904 7.729
NCI-H2810 GDSC1; GDSC2 5.6503 8.3816 2.3683 1.7824
Calu-6 GDSC1; GDSC2 5.6599 11.7158 0.8768 8.7575
SK-LU-1 GDSC1; GDSC2 5.661 12.6315 0.4426 10.8781
PaCa-3 GDSC1; GDSC2 5.6695 10.1712 1.5995 5.1305
NCI-H661 GDSC1; GDSC2 5.6779 10.8098 1.3118 6.5521
NCI-H2291 GDSC1; GDSC2 5.702 7.7693 2.633 0.7238
NCI-H226 GDSC1; GDSC2 5.7216 11.3973 1.0659 7.7085
A-549 GDSC1; GDSC2 5.7232 11.0314 1.2372 6.851
LB647-SCLC GDSC1; GDSC2 5.7394 7.617 2.7047 0.4921
NCI-H1650 GDSC1; GDSC2 5.7569 10.1549 1.658 4.7144
SW1573 GDSC1; GDSC2 5.8075 11.1132 1.2513 6.6428
NCI-H2023 GDSC1; GDSC2 5.8081 13.0947 0.3199 11.1845
NCI-H2066 GDSC1; GDSC2 5.8115 12.3058 0.6968 9.3718
NCI-H2347 GDSC1; GDSC2 5.8208 8.1058 2.5551 0.8214
NCI-H1975 GDSC1; GDSC2 5.829 12.4211 0.6537 9.5499
RERF-LC-MS GDSC1; GDSC2 5.9064 8.3142 2.5117 0.9934
NCI-H650 GDSC1; GDSC2 5.914 8.356 2.4989 0.939
HARA [Human squamous cell lung carcinoma] GDSC1; GDSC2 5.9252 12.69 0.5892 9.6894
ChaGo-K-1 GDSC1; GDSC2 5.9304 9.9603 1.8418 3.957
NCI-H513 GDSC1; GDSC2 5.9322 11.0266 1.3663 5.8801
NCI-H1341 GDSC1; GDSC2 6.0454 11.7711 1.0936 7.037
HCC44 GDSC1; GDSC2 6.0917 12.6655 0.7074 8.8317
NCI-H292 GDSC1; GDSC2 6.0919 12.4918 0.7886 9.1812
NCI-H2405 GDSC1; GDSC2 6.0919 11.5443 1.2255 6.3224
EPLC-272H GDSC1; GDSC2 6.1125 13.841 0.1667 11.3344
NCI-H2087 GDSC1; GDSC2 6.1553 12.6586 0.7506 8.5171
NCI-H2009 GDSC1; GDSC2 6.1622 12.12 1.0042 7.2848
NCI-H647 GDSC1; GDSC2 6.1717 8.455 2.5687 0.6509
NCI-H2869 GDSC1; GDSC2 6.2337 8.9406 2.4114 1.1111
NCI-H1915 GDSC1; GDSC2 6.2507 12.3923 0.9329 7.4872
NCI-H1666 GDSC1; GDSC2 6.2704 14.7441 -0.1583 12.5029
NCI-H2595 GDSC1; GDSC2 6.2798 8.2391 2.6878 0.2897
LC-2/ad GDSC1; GDSC2 6.2933 8.3577 2.651 0.3907
EBC-1 GDSC1; GDSC2 6.3165 12.905 0.7366 8.3175
NCI-H740 GDSC2 6.3384 8.2771 2.696 0.2854
NCI-H1568 GDSC1; GDSC2 6.3669 14.3919 0.0724 11.3056
NCI-H1838 GDSC1; GDSC2 6.4031 8.2109 2.742 0.1753
KNS-62 GDSC1; GDSC2 6.6287 14.9489 -0.0209 11.2631
NCI-H2110 GDSC1; GDSC2 6.8123 16.1404 -0.4641 13.765
NCI-H2461 GDSC1; GDSC2 6.8197 14.3417 0.3824 9.1462
IA-LM GDSC1; GDSC2 6.8634 14.6029 0.2886 9.4979
NCI-H1869 GDSC1; GDSC2 6.9124 13.5175 0.8144 7.038
NCI-H2591 GDSC1; GDSC2 6.9509 14.5168 0.3819 8.9415
LCLC-103H GDSC1; GDSC2 6.9637 14.6333 0.3361 9.1261
NCI-H209 GDSC1; GDSC2 6.9947 18.1972 -1.3223 15.8733
NCI-H2228 GDSC1; GDSC2 7.004 14.7439 0.3098 9.1802
NCI-H446 GDSC1; GDSC2 7.0338 13.91 0.708 7.3456
NCI-H1299 GDSC1; GDSC2 7.0793 16.291 -0.3625 11.9609
LOU-NH91 GDSC1; GDSC2 7.1515 15.2457 0.1688 9.5719
NCI-H1623 GDSC1; GDSC2 7.1814 15.3805 0.125 9.7161
NCI-H2122 GDSC1; GDSC2 7.5784 17.2721 -0.5055 11.7326
LXF 289 GDSC1; GDSC2 7.6984 16.7315 -0.1818 10.2223
NCI-H441 GDSC1; GDSC2 8.2613 17.9187 -0.3866 10.2208
NCI-H596 GDSC1; GDSC2 8.3053 17.0532 0.0301 8.4784
NCI-H1563 GDSC1; GDSC2 8.6646 19.6481 -0.9351 11.7455
NCI-H1793 GDSC1; GDSC2 8.6858 19.1218 -0.6818 10.7625
NCI-H1792 GDSC1; GDSC2 8.8042 17.4881 0.1173 7.4796
NCI-H322M GDSC1; GDSC2 9.533 20.3938 -0.762 9.9166
⏷ Show the Full List of 185 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CBTCi002-A GDSC1; GDSC2 4.0921 7.1277 2.0164 5.7025
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE-11 GDSC1; GDSC2 4.0807 7.1669 1.9892 6.4637
T.T GDSC1; GDSC2 4.1941 7.1267 2.0882 4.5491
OE33 GDSC1; GDSC2 4.5088 7.201 2.2597 3.5952
KYSE-270 GDSC1; GDSC2 4.5636 10.556 0.6802 10.7474
COLO 680N GDSC1; GDSC2 4.6353 8.3139 1.8173 5.1183
TE-4 GDSC1; GDSC2 4.7 10.667 0.7249 10.2719
OE21 GDSC1; GDSC2 4.7236 7.9793 2.032 4.43
KYSE-450 GDSC1; GDSC2 5.1156 8.6123 1.9799 3.6329
TE-15 GDSC1; GDSC2 5.2425 14.9422 -0.9756 16.5209
TE-8 GDSC1; GDSC2 5.3389 7.5969 2.5398 1.0995
TE-6 GDSC1; GDSC2 5.4199 11.4754 0.8331 9.415
TE-5 GDSC1; GDSC2 5.536 11.7155 0.7959 8.4531
KYSE-410 GDSC1; GDSC2 5.5785 9.5336 1.834 3.6745
KYSE-70 GDSC1; GDSC2 5.5893 10.4553 1.4211 5.5062
KYSE-140 GDSC1; GDSC2 5.662 10.3957 1.4927 5.0788
TE-10 GDSC1; GDSC2 5.7096 7.7643 2.638 0.7032
EC-GI-10 GDSC1; GDSC2 5.7374 10.7614 1.3705 6.1629
KYSE-520 GDSC1; GDSC2 5.7486 8.2054 2.4848 0.9835
TE-9 GDSC1; GDSC2 6.0682 12.4032 0.8149 8.3534
KYSE-510 GDSC1; GDSC2 6.1969 13.0739 0.583 8.3543
TE-1 GDSC1; GDSC2 6.8059 14.6798 0.2173 9.0005
KYSE-180 GDSC1; GDSC2 7.2097 15.4674 0.1022 8.8906
OE19 GDSC1; GDSC2 7.5155 16.1305 -0.0166 9.8082
KYSE-150 GDSC1; GDSC2 11.0113 26.1477 -2.4979 12.8805
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 30 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
OV56 GDSC1; GDSC2 3.5945 5.3004 2.5497 3.7733
OVK18 GDSC1; GDSC2 3.8465 7.1346 1.8331 7.9929
OVCAR-5 GDSC1; GDSC2 3.9566 8.7373 1.1233 10.9747
Caov-4 GDSC1; GDSC2 4.2851 7.0496 2.1868 4.3811
JHOS-4 GDSC1; GDSC2 4.3109 10.2549 0.6412 13.8354
Caov-3 GDSC1; GDSC2 4.6036 11.0348 0.4745 14.0027
OVCAR-3 GDSC1; GDSC2 4.6105 8.0525 1.925 5.1968
OV-90 GDSC1; GDSC2 4.6319 8.573 1.6916 6.4147
OC 314 GDSC1; GDSC2 4.7707 6.7247 2.6223 1.4524
A2780 GDSC1; GDSC2 4.9308 10.4459 0.9953 9.5345
OVISE GDSC1; GDSC2 4.9618 12.3582 0.0868 13.9864
TOV-21G GDSC1; GDSC2 4.9743 8.4616 1.9638 4.3715
DOV13 GDSC1; GDSC2 5.1379 10.1705 1.2672 7.7192
RMG-I GDSC1; GDSC2 5.374 8.5132 2.1711 2.7784
FU-OV-1 GDSC1; GDSC2 5.5562 8.3703 2.3269 1.8805
ES-2 GDSC1; GDSC2 5.6298 10.121 1.5988 5.1941
TOV-112D GDSC1; GDSC2 5.6513 12.5988 0.4517 10.8526
JHOS-2 GDSC1; GDSC2 5.6767 7.4572 2.7384 0.4331
OAW28 GDSC1; GDSC2 5.6968 11.4832 1.01 8.0301
OVKATE GDSC1; GDSC2 5.9687 10.7908 1.4946 5.2012
Kuramochi GDSC1; GDSC2 6.0015 12.0364 0.9438 7.839
SK-OV-3 GDSC1; GDSC2 6.1568 13.5739 0.3222 10.5379
IGROV-1 GDSC1; GDSC2 6.5942 13.6007 0.586 8.5746
OVCAR-8 GDSC1; GDSC2 6.5994 12.0967 1.2711 5.3738
EFO-21 GDSC1; GDSC2 6.8267 12.5958 1.1774 5.4981
EFO-27 GDSC1; GDSC2 7.5623 15.3524 0.3652 8.758
OVCAR-4 GDSC1; GDSC2 7.7484 18.4272 -0.9374 13.1545
OAW42 GDSC1; GDSC2 7.7492 14.46 0.866 5.6921
TYK-nu GDSC1; GDSC2 7.9607 18.6654 -0.9146 12.7302
OVTOKO GDSC1; GDSC2 8.6935 17.7669 -0.0675 8.3561
⏷ Show the Full List of 30 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 31 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
QGP-1 GDSC1; GDSC2 4.2653 6.8905 2.2494 4.4864
PSN1 GDSC1; GDSC2 4.2707 7.1258 2.1407 4.6595
MIA PaCa-2 GDSC1; GDSC2 4.2856 6.9483 2.2353 4.1171
SW1990 GDSC1; GDSC2 4.3555 8.6218 1.4762 8.1445
SU.86.86 GDSC1; GDSC2 4.3873 8.2954 1.6574 7.0838
KP-4 GDSC1; GDSC2 4.5656 6.904 2.4305 2.6265
Hs 766T GDSC1; GDSC2 4.6176 7.9394 1.9831 4.8734
PL4 GDSC1; GDSC2 4.635 7.661 2.1247 4.0926
HuP-T4 GDSC1; GDSC2 4.7035 9.5795 1.2563 8.6163
MZ-PC-1 GDSC1; GDSC2 4.7168 8.0052 2.0156 4.9616
Capan-1 GDSC1; GDSC2 4.7952 11.3716 0.4491 12.5961
HuP-T3 GDSC1; GDSC2 4.9491 7.0985 2.5553 1.5482
HPAC GDSC1; GDSC2 4.9681 17.226 -2.3104 23.2641
Panc 08.13 GDSC1; GDSC2 5.3418 10.4722 1.2574 7.4009
PaTu 8902 GDSC1; GDSC2 5.583 10.872 1.2237 7.153
Panc 10.05 GDSC1; GDSC2 5.6096 10.041 1.6232 5.1039
KP-3 GDSC1; GDSC2 5.6559 10.9591 1.2289 7.0043
PaTu 8988t GDSC1; GDSC2 5.7696 11.607 0.9983 7.9624
SUIT-2 GDSC1; GDSC2 6.0927 14.3174 -0.0734 12.4552
DAN-G GDSC1; GDSC2 6.1112 12.4207 0.8337 8.1912
BxPC-3 GDSC1; GDSC2 6.3885 14.0576 0.244 10.4916
KP-2 GDSC2 6.5963 14.1713 0.3227 9.7806
HPAF-II GDSC1; GDSC2 6.8653 24.4459 -4.4523 25.1701
Panc 02.03 GDSC1; GDSC2 7.0779 14.0704 0.6613 7.4925
KP-1N GDSC1; GDSC2 7.1326 15.397 0.0873 9.9569
Panc 03.27 GDSC1; GDSC2 7.6511 18.7365 -1.1451 14.0948
Panc 04.03 GDSC1; GDSC2 8.4413 16.8358 0.2037 7.5902
YAPC GDSC1; GDSC2 8.8794 18.3693 -0.2305 8.7561
Capan-2 GDSC1; GDSC2 9.4239 20.2122 -0.7432 9.9893
CFPAC-1 GDSC1; GDSC2 11.3805 25.3028 -1.9012 11.4785
AsPC-1 GDSC1; GDSC2 11.4642 25.1591 -1.7898 11.0319
⏷ Show the Full List of 31 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MSTO-211H GDSC1; GDSC2 4.6892 8.2177 1.8982 5.199
NCI-H28 GDSC1; GDSC2 4.9819 9.2155 1.6171 6.1678
MPP 89 GDSC1; GDSC2 5.1062 10.9212 0.8869 9.745
IST-Mes1 GDSC1; GDSC2 5.7613 13.9997 -0.1462 13.4121
NCI-H2452 GDSC1; GDSC2 6.119 8.4977 2.5314 0.7185
NCI-H2052 GDSC1; GDSC2 6.2502 12.7071 0.7872 8.1848
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
DU145 GDSC1; GDSC2 4.2614 7.4217 1.9923 5.4924
PC-3 GDSC1; GDSC2 4.3175 7.8838 1.8079 6.3969
VCaP GDSC1; GDSC2 4.6841 8.1261 1.938 4.9956
LNCaP clone FGC GDSC1; GDSC2 5.03 11.3243 0.6393 11.1532
NCI-H660 GDSC2 5.1418 6.5065 2.875 0.3243
22Rv1 GDSC1; GDSC2 5.8939 10.3533 1.6478 4.569
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 GDSC1; GDSC2 11.5707 26.3 -2.2386 12.2853
Cancer Drug Sensitivity Data Curated from 57 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
UACC-62 GDSC1; GDSC2 3.9278 12.05 -0.548 19.2755
SK-MEL-2 GDSC1; GDSC2 4.2675 5.4225 2.9158 0.6551
GAK GDSC1; GDSC2 4.2779 8.2656 1.5944 7.6575
SH-4 GDSC1; GDSC2 4.4076 6.9558 2.3105 3.4986
G-mel GDSC1; GDSC2 4.5387 8.6498 1.5912 7.8368
WM35 GDSC2 4.5995 8.9953 1.4665 7.6954
COLO 783 GDSC1; GDSC2 4.6454 5.9729 2.8703 0.6426
SK-MEL-31 GDSC2 4.7344 9.4745 1.3283 8.9482
LB2518-MEL GDSC1; GDSC2 4.8333 6.5297 2.7341 1.0231
A2058 GDSC1; GDSC2 4.8994 6.1265 2.9185 0.2936
MMAc-SF GDSC1; GDSC2 4.9638 7.7242 2.2917 3.0184
CP50-MEL-B GDSC1; GDSC2 5.0262 9.581 1.4733 7.5028
MZ-MEL-7 GDSC1; GDSC2 5.0264 6.8287 2.7036 0.9706
WT2-iPS GDSC1; GDSC2 5.0291 6.3772 2.878 0.336
SK-MEL-1 GDSC1; GDSC2 5.1008 10.2831 1.1889 8.1957
RPMI-7951 GDSC1; GDSC2 5.1549 7.2687 2.5861 1.2169
WM115 GDSC1; GDSC2 5.1578 7.2088 2.6118 1.1147
SK-MEL-3 GDSC1; GDSC2 5.1683 13.3365 -0.2425 16.208
WM1552C GDSC1; GDSC2 5.1858 7.004 2.706 0.7543
Hs 940.T GDSC2 5.2791 7.5573 2.5275 1.4671
SK-MEL-30 GDSC1; GDSC2 5.2824 15.3472 -1.1454 19.7868
COLO 679 GDSC1; GDSC2 5.3819 7.3093 2.673 0.7299
MZ-MEL-2 GDSC1; GDSC2 5.3981 11.0057 1.042 9.1691
LB373-MEL-D GDSC1; GDSC2 5.4057 11.8763 0.632 11.35
HMV-II GDSC1; GDSC2 5.4105 12.2422 0.4595 11.2785
RVH-421 GDSC1; GDSC2 5.4587 10.439 1.3474 7.3737
IGR-37 GDSC1; GDSC2 5.5125 11.6657 0.8041 9.3877
DJM-1 GDSC1; GDSC2 5.516 12.0612 0.6178 11.1934
IPC-298 GDSC1; GDSC2 5.5309 7.3546 2.7181 0.5624
CP66-MEL GDSC1; GDSC2 5.531 6.8012 2.9149 0.1257
451Lu GDSC1; GDSC2 5.5491 9.8223 1.6867 5.3542
A-431 GDSC1; GDSC2 5.6024 7.905 2.5377 1.1302
COLO 800 GDSC1; GDSC2 5.6432 7.5242 2.7006 0.5526
G-361 GDSC1; GDSC2 5.7382 14.5127 -0.4101 14.6133
VMRC-MELG GDSC2 5.8252 7.0874 2.9201 0.0734
SK-MEL-5 GDSC1; GDSC2 5.8586 12.2349 0.7606 9.7646
IST-MEL1 GDSC1; GDSC2 5.9357 8.0256 2.6327 0.5385
MeWo GDSC1; GDSC2 5.947 12.7755 0.5629 9.7764
A-375 GDSC1; GDSC2 5.9587 14.2752 -0.1436 13.0194
COLO 792 GDSC2 6.0369 16.531 -1.1795 17.1319
CHL-1 GDSC1; GDSC2 6.2623 14.1046 0.14 11.1863
UACC-257 GDSC1; GDSC2 6.2818 12.9588 0.6901 8.5951
A-388 GDSC1; GDSC2 6.311 8.517 2.6008 0.4059
SK-MEL-24 GDSC1; GDSC2 6.7054 14.1884 0.3828 9.3278
Hs 938.T GDSC1; GDSC2 6.7774 15.6808 -0.2696 12.9807
WM278 GDSC1; GDSC2 7.2593 15.9253 -0.0789 10.4714
M14 GDSC1; GDSC2 7.3805 17.0603 -0.5312 12.1557
SK-MEL-28 GDSC1; GDSC2 7.4161 20.3517 -2.0698 18.7196
LOX-IMVI GDSC1; GDSC2 7.5433 15.1169 0.4602 7.7171
HT-144 GDSC1; GDSC2 7.5721 15.9609 0.0949 9.2491
IGR-1 GDSC1; GDSC2 7.8405 18.7279 -1.0197 13.3181
Mel Ho GDSC1; GDSC2 8.9563 19.488 -0.6884 11.1169
A101D GDSC1; GDSC2 9.3357 20.7818 -1.0514 11.2273
Mel JuSo GDSC1; GDSC2 9.4763 21.8894 -1.4723 12.5108
COLO 829 GDSC1; GDSC2 10.1747 23.4411 -1.763 12.5409
WM793 GDSC1; GDSC2 12.2288 27.9125 -2.5833 12.5285
EquiPSC Line K2 GDSC2 5.1161 8.0524 2.2316 3.1097
⏷ Show the Full List of 57 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuTu 80 GDSC1; GDSC2 3.4278 5.5504 2.2946 6.2023
Cancer Drug Sensitivity Data Curated from 23 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Rh18 GDSC1 3.3009 5.2694 0.6855 1.2096
SW684 GDSC1; GDSC2 4.2824 5.7467 2.7854 1.2912
SK-LMS-1 GDSC1; GDSC2 4.3928 7.3412 2.1194 4.5472
Rh41 GDSC1; GDSC2 4.414 8.5367 1.559 6.7662
G-402 GDSC1; GDSC2 4.6815 11.1795 0.4606 12.7866
MES-SA GDSC1; GDSC2 4.779 8.7227 1.7179 5.9988
G-401 GDSC1; GDSC2 4.9477 10.6029 0.9311 9.8331
MFH-ino GDSC1; GDSC2 5.1014 9.0945 1.7494 4.7104
A-204 GDSC1; GDSC2 5.1274 11.5246 0.6103 10.0119
STS-0421 GDSC2 5.2543 7.7406 2.4394 1.8914
RKN GDSC1; GDSC2 5.2983 8.8205 1.9927 3.7347
HT-1080 GDSC1; GDSC2 5.3403 12.2646 0.4005 10.5846
TE 441.T GDSC1; GDSC2 5.377 6.7034 2.8935 0.198
Hs 633.T GDSC1; GDSC2 5.3934 7.0136 2.7889 0.3935
SW872 GDSC1; GDSC2 5.4333 10.4809 1.3118 6.962
SW982 GDSC1; GDSC2 5.4396 6.7141 2.9124 0.1356
EW-8 GDSC1; GDSC2 6.1871 13.6501 0.3059 9.5728
VA-ES-BJ GDSC1; GDSC2 6.2242 12.4968 0.8684 7.8387
KYM-1 GDSC1; GDSC2 6.5245 15.6904 -0.44 12.1237
GCT GDSC1; GDSC2 8.3874 20.6296 -1.5626 14.4182
RD GDSC1; GDSC2 8.5692 17.1861 0.1202 7.0733
Rh30 GDSC1; GDSC2 8.6305 20.5366 -1.3662 12.3751
SK-UT-1 GDSC1; GDSC2 8.6981 18.386 -0.3417 9.4323
⏷ Show the Full List of 23 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-16 GDSC1; GDSC2 3.6314 5.623 2.418 4.4385
TGBC11TKB GDSC1; GDSC2 3.791 8.8815 0.9227 12.4635
ECC12 GDSC2 3.8101 8.0525 1.3501 11.0495
KATO III GDSC1; GDSC2 3.8378 8.9281 0.9363 12.2751
RF-48 GDSC1; GDSC2 3.9772 6.6585 2.1632 5.1215
23132/87 GDSC1; GDSC2 4.0229 11.0344 0.0332 16.4085
MKN1 GDSC2 4.0625 6.6554 2.2247 4.6037
OCUM-1 GDSC1; GDSC2 4.0796 8.9686 1.1025 10.7992
TMK-1 GDSC2 4.2038 9.7068 0.8313 13.0553
SNU-5 GDSC1; GDSC2 4.5803 11.9203 0.0211 15.1417
GCIY GDSC1; GDSC2 4.884 10.1794 1.0915 9.1255
SNU-1 GDSC1; GDSC2 4.9439 9.0339 1.6781 5.9138
SK-GT-2 GDSC2 4.9671 10.7159 0.89 10.0059
HSC-39 GDSC1; GDSC2 5.0004 11.0328 0.7599 10.6044
MKN45 GDSC1; GDSC2 5.0677 9.8555 1.3704 7.3094
NUGC-4 GDSC1; GDSC2 5.072 8.6641 1.9301 4.389
NCI-N87 GDSC1; GDSC2 5.3175 12.2788 0.3778 11.8587
Hs 746.T GDSC1; GDSC2 5.3402 14.3938 -0.6354 15.001
IM95 GDSC1; GDSC2 5.5624 12.722 0.3326 11.5922
SCH GDSC1; GDSC2 5.7577 12.6931 0.4777 11.4179
MKN7 GDSC1; GDSC2 6.0391 9.5737 2.0648 2.2175
Fu97 GDSC1; GDSC2 6.647 16.196 -0.5995 13.6903
AGS GDSC1; GDSC2 6.9372 14.4199 0.4181 8.8
MKN28 GDSC1; GDSC2 6.9566 14.8875 0.2145 9.6789
ECC10 GDSC1; GDSC2 7.4902 17.1322 -0.4957 11.8341
HGC-27 GDSC1; GDSC2 8.1268 18.6765 -0.8163 12.0981
NUGC-3 GDSC1; GDSC2 8.7293 17.926 -0.1181 8.5102
RERF-GC-1B GDSC1; GDSC2 9.5248 28.6085 -4.6002 21.2887
SNG-M GDSC1; GDSC2 4.9983 9.0726 1.6947 5.1226
⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TT GDSC1; GDSC2 3.9659 6.3916 2.2851 4.464
IHH-4 GDSC1; GDSC2 3.9733 8.1458 1.429 9.2493
K5 GDSC1; GDSC2 4.1839 6.5526 2.3561 3.6498
CGTH-W-1 GDSC1; GDSC2 4.2064 7.4173 1.9563 5.8016
WRO GDSC2 4.3897 7.2623 2.1548 4.3618
ASH-3 GDSC1; GDSC2 5.0723 6.8337 2.7223 0.7804
8305C GDSC1; GDSC2 5.0762 6.3473 2.9072 0.2484
FTC-133 GDSC2 5.1259 10.9405 0.891 9.6851
CAL-62 GDSC1; GDSC2 5.2487 11.4087 0.7498 10.161
B-CPAP GDSC1; GDSC2 5.2823 7.268 2.6453 0.8918
ML-1 [Human leukemia] GDSC1; GDSC2 5.6342 7.4811 2.7129 0.5222
HTC-C3 GDSC1; GDSC2 5.7837 12.9572 0.3692 10.9974
KMH-2 GDSC1; GDSC2 5.8366 11.5414 1.071 8.1724
BHT-101 GDSC1; GDSC2 6.899 14.3667 0.4194 8.8539
8505C GDSC1; GDSC2 8.8259 19.5007 -0.7711 10.9026
TT2609-C02 GDSC1; GDSC2 10.2325 22.0204 -1.0898 10.1998
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 41 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
PCI-38 GDSC1 3.3596 8.993 -0.9494 11.4378
UPCI-SCC-090 GDSC2 4.3023 7.4247 2.0189 5.2662
HO-1-u-1 GDSC1; GDSC2 4.5567 7.1734 2.3021 3.2959
Ca9-22 GDSC1; GDSC2 4.573 11.5268 0.2097 14.2596
JHU-029 GDSC2 4.6186 8.72 1.6121 7.5406
CAL-27 GDSC1; GDSC2 4.711 12.3836 -0.1098 15.4534
SCC-25 GDSC1; GDSC2 4.7465 9.9995 1.083 10.3265
CAL-33 GDSC1; GDSC2 4.7704 10.326 0.9413 10.1421
KOSC-2 GDSC1; GDSC2 4.7937 10.4802 0.8828 11.3414
PE/CA-PJ15 GDSC1; GDSC2 4.9404 13.1235 -0.3041 17.0286
PCI-06A GDSC1; GDSC2 5.029 8.6048 1.9312 4.8918
HO-1-N-1 GDSC1; GDSC2 5.2288 11.0575 0.9047 9.4159
PCI-15A GDSC1; GDSC2 5.234 6.9789 2.7365 0.6868
BHY GDSC1; GDSC2 5.2445 11.1063 0.892 10.3019
BB30-HNC GDSC1; GDSC2 5.2848 10.7011 1.112 9.013
SAS GDSC1; GDSC2 5.4205 12.5171 0.334 11.8639
DOK GDSC1; GDSC2 5.7754 12.3845 0.636 9.7323
PCI-30 GDSC1; GDSC2 5.8507 7.7132 2.7132 0.3407
OSC-19 GDSC1; GDSC2 5.8887 10.2583 1.6872 4.8127
NCI-H3118 GDSC1; GDSC2 6.0413 13.7976 0.1403 11.5855
HSC-2 GDSC1; GDSC2 6.0612 13.5494 0.2713 10.9453
BICR 31 GDSC1; GDSC2 6.1206 14.0832 0.0569 12.7521
Detroit 562 GDSC1; GDSC2 6.1779 15.1375 -0.4085 13.7554
LB771-HNC GDSC1; GDSC2 6.1963 18.1461 -1.8527 19.2365
JHU-011 GDSC1; GDSC2 6.2663 15.0973 -0.3296 14.237
BICR 10 GDSC1; GDSC2 6.2968 15.0164 -0.2705 12.9426
BICR 78 GDSC1; GDSC2 6.5314 16.1278 -0.6442 14.0822
SCC-4 GDSC2 6.6358 14.2977 0.2886 9.8696
SCC-15 GDSC1; GDSC2 6.74 13.4394 0.7481 7.5976
OSC-20 GDSC1; GDSC2 6.7712 15.7101 -0.2875 12.1697
BICR 22 GDSC1; GDSC2 6.8731 14.6532 0.2713 9.5598
FaDu GDSC1; GDSC2 7.0712 16.4078 -0.4226 12.2239
SAT [Human HNSCC] GDSC1; GDSC2 7.28 16.7317 -0.4413 11.9539
SKN-3 GDSC1; GDSC2 7.4213 16.9493 -0.4537 11.7746
KON GDSC1; GDSC2 7.5975 18.2227 -0.9378 14.2898
PCI-04B GDSC1; GDSC2 7.7362 19.0351 -1.2309 15.1763
HSC-4 GDSC1; GDSC2 7.7529 19.7318 -1.5492 15.388
HSC-3 GDSC1; GDSC2 7.8722 15.7961 0.3447 7.7577
SCC-9 GDSC1; GDSC2 8.079 18.061 -0.5615 11.1815
JHU-022 GDSC1; GDSC2 9.2723 21.2683 -1.3108 12.2352
BB49-HNC GDSC1; GDSC2 9.7536 21.8127 -1.2726 11.4474
⏷ Show the Full List of 41 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RT-4 GDSC1; GDSC2 4.1664 10.7157 0.3031 14.751
SW780 GDSC1; GDSC2 4.1825 6.523 2.3693 3.5811
CAL-29 GDSC1; GDSC2 4.3834 7.5162 2.0298 5.051
SW1710 GDSC1; GDSC2 4.4032 6.8299 2.3663 3.2123
KU-19-19 GDSC1; GDSC2 4.4549 8.5187 1.5965 7.2799
T24 GDSC1; GDSC2 4.6742 7.6934 2.1341 4.3748
5637 GDSC1; GDSC2 5.0064 8.5148 1.9589 4.3455
647V GDSC1; GDSC2 5.2812 11.7625 0.6018 10.8354
HT-1376 GDSC1; GDSC2 5.4708 11.4113 0.8974 8.9976
BFTC-905 GDSC1; GDSC2 5.989 13.4244 0.2831 11.022
UM-UC-3 GDSC1; GDSC2 6.3357 9.7341 2.1434 1.8771
RT-112 GDSC1; GDSC2 7.0919 14.857 0.3112 9.0373
639V GDSC1; GDSC2 7.2074 15.2232 0.2131 9.2912
J82 GDSC1; GDSC2 7.358 15.3824 0.2309 8.9842
HT-1197 GDSC1; GDSC2 8.7722 21.1659 -1.5703 13.8594
TCCSUP GDSC1; GDSC2 8.8558 16.6575 0.5055 5.8755
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 39 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
C-33 A GDSC1; GDSC2 3.2114 9.2237 0.2784 15.6315
DSH1 GDSC1; GDSC2 3.564 7.916 1.2234 11.3879
HT-3 GDSC1; GDSC2 3.8824 7.9115 1.4759 9.1992
TC-YIK GDSC1; GDSC2 4.1407 9.35 0.9601 11.425
NCC-IT GDSC1; GDSC2 4.1734 8.9399 1.1871 10.1239
ME-180 GDSC1; GDSC2 4.2374 9.9594 0.7318 12.4063
UWB1.289 GDSC1; GDSC2 4.2584 6.6395 2.3636 3.8235
CAL-39 GDSC1; GDSC2 4.3736 6.093 2.6836 1.654
OVCA420 GDSC1; GDSC2 4.4093 9.0764 1.2929 9.0301
SiSo GDSC1; GDSC2 4.4983 10.0008 0.9049 9.8028
PEO1 GDSC1; GDSC2 4.7387 8.2517 1.9141 5.0267
SKG-IIIa GDSC1; GDSC2 4.7984 11.4222 0.4267 11.4718
DoTc2 4510 GDSC1; GDSC2 4.9245 10.9377 0.7528 10.7958
JEG-3 GDSC1; GDSC2 4.9384 13.4047 -0.4439 15.0048
PA-1 GDSC1; GDSC2 4.9975 12.1162 0.2309 13.2262
HeLa GDSC1; GDSC2 5.0264 13.2979 -0.3267 15.7311
OVMIU GDSC1; GDSC2 5.1784 10.77 1.0083 8.9827
JAR GDSC1; GDSC2 5.2136 7.1546 2.6592 0.7985
OV17R GDSC1; GDSC2 5.2159 8.1637 2.2377 2.9344
HEY GDSC1; GDSC2 5.2547 10.4972 1.189 7.9097
NT2-D1 GDSC1; GDSC2 5.3433 9.395 1.7589 4.8334
NEC8 GDSC1; GDSC2 5.3635 6.7902 2.858 0.25
SW954 GDSC1; GDSC2 5.4831 7.2897 2.7228 0.5751
SW962 GDSC1; GDSC2 5.554 7.725 2.5868 0.985
SKN GDSC1; GDSC2 5.6384 10.4074 1.4731 5.8079
OMC-1 [Human cervical carcinoma] GDSC1; GDSC2 5.6583 7.47 2.7265 0.4728
OVCA433 GDSC1; GDSC2 5.8779 8.3947 2.468 1.1721
BPH-1 GDSC1; GDSC2 5.9431 14.7825 -0.3983 14.1602
SW756 GDSC1; GDSC2 6.0285 14.1136 -0.0191 12.3321
JHOS-3 GDSC1; GDSC2 6.0628 7.9079 2.7239 0.3162
HEC-1 GDSC1; GDSC2 6.0939 12.7821 0.6542 9.0828
KGN GDSC1; GDSC2 6.2552 8.396 2.6229 0.4273
MS751 GDSC1; GDSC2 6.3794 14.6621 -0.0473 11.8168
Ca Ski GDSC1; GDSC2 6.5449 9.6257 2.2814 1.2228
LB831-BLC GDSC1; GDSC2 6.7693 14.8931 0.0949 9.5627
ACC-OV7 GDSC1; GDSC2 6.8205 13.5407 0.7499 8.1139
C-4-I GDSC1; GDSC2 7.0844 15.1426 0.1752 9.6492
SiHa GDSC1; GDSC2 7.6077 17.2449 -0.4746 11.5614
PWR-1E GDSC1; GDSC2 7.7937 18.0574 -0.7362 12.3061
⏷ Show the Full List of 39 Cancer Drug Sensitivity Data of This Drug

References

1 Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974. Proc Natl Acad Sci U S A. 2013 Dec 10;110(50):20224-9.
2 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)