Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTNFBTO)

DTT Name Protein-serine O-palmitoleoyltransferase porcupine (PORCN)
Synonyms Protein-cysteine N-palmitoyltransferase porcupine; Protein MG61; PORCN
Gene Name PORCN
DTT Type
Clinical trial target
 [1]
BioChemical Class
Acyltransferase
UniProt ID
PORCN_HUMAN
TTD ID
T79747
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
EC Number
EC 2.3.1.250
Sequence
MATFSRQEFFQQLLQGCLLPTAQQGLDQIWLLLAICLACRLLWRLGLPSYLKHASTVAGG
FFSLYHFFQLHMVWVVLLSLLCYLVLFLCRHSSHRGVFLSVTILIYLLMGEMHMVDTVTW
HKMRGAQMIVAMKAVSLGFDLDRGEVGTVPSPVEFMGYLYFVGTIVFGPWISFHSYLQAV
QGRPLSCRWLQKVARSLALALLCLVLSTCVGPYLFPYFIPLNGDRLLRNKKRKARGTMVR
WLRAYESAVSFHFSNYFVGFLSEATATLAGAGFTEEKDHLEWDLTVSKPLNVELPRSMVE
VVTSWNLPMSYWLNNYVFKNALRLGTFSAVLVTYAASALLHGFSFHLAAVLLSLAFITYV
EHVLRKRLARILSACVLSKRCPPDCSHQHRLGLGVRALNLLFGALAIFHLAYLGSLFDVD
VDDTTEEQGYGMAYTVHKWSELSWASHWVTFGCWIFYRLIG
Function protein-cysteine N-palmitoyltransferase that modulates the processingof Wnt proteins by mediating serine palmitoylation of Wnt family members.
KEGG Pathway
Wnt signaling pathway (hsa04310 )
Reactome Pathway
LGK974 inhibits PORCN (R-HSA-5340573 )
WNT ligand biogenesis and trafficking (R-HSA-3238698 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
3 Clinical Trial Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
ETC-1922159 DMY0HU6 Solid tumour/cancer 2A00-2F9Z Phase 1 [1]
LGK974 DMAG6BV Solid tumour/cancer 2A00-2F9Z Phase 1 [1]
RXC006 DM9LUTV Idiopathic pulmonary fibrosis CB03.4 Phase 1 [2]
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References

1 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2 Clinical pipeline report, company report or official report of Redx