Details of the Drug

General Information of Drug (ID: DMAJH75)

Drug Name
RSV-604
Synonyms
A-60444; A-60445; RSV therapeutics, Arrow; RSV therapeutics, Novartis; Respiratory syncytial virus therapeutics, Novartis; Respiratory syncytial virus therapeutics, Arrow/Virogen; Antivirals (RSV), Arrow/ Virogen
Indication
Disease Entry ICD 11 Status REF
Virus infection 1A24-1D9Z Phase 2 [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 388.4
Logarithm of the Partition Coefficient (xlogp) 3.3
Rotatable Bond Count (rotbonds) 3
Hydrogen Bond Donor Count (hbonddonor) 3
Hydrogen Bond Acceptor Count (hbondacc) 4
Chemical Identifiers
Formula
C22H17FN4O2
IUPAC Name
1-(2-fluorophenyl)-3-[(3S)-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl]urea
Canonical SMILES
C1=CC=C(C=C1)C2=N[C@@H](C(=O)NC3=CC=CC=C32)NC(=O)NC4=CC=CC=C4F
InChI
InChI=1S/C22H17FN4O2/c23-16-11-5-7-13-18(16)25-22(29)27-20-21(28)24-17-12-6-4-10-15(17)19(26-20)14-8-2-1-3-9-14/h1-13,20H,(H,24,28)(H2,25,27,29)/t20-/m1/s1
InChIKey
MTPVBMVUENFFLL-HXUWFJFHSA-N
Cross-matching ID
PubChem CID
5279172
CAS Number
676128-63-5
DrugBank ID
DB15197
TTD ID
D09KNG

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Respiratory syncytial virus protein N (RSV N) TT25A0I NCAP_HRSVA Inhibitor [1]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

References

1 Mechanism of action for respiratory syncytial virus inhibitor RSV604. Antimicrob Agents Chemother. 2015 Feb;59(2):1080-7.