Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT25A0I)

• DTT Name: Respiratory syncytial virus protein N (RSV N)
• Synonyms: RSV Protein N; RSV Nucleoprotein; RSV Nucleocapsid protein; N
• Gene Name: RSV N
• DTT Type: Clinical trial target; [1]
• BioChemical Class: Paramyxoviruses nucleocapsid
• UniProt ID: NCAP_HRSVA
• TTD ID: T88360
• Sequence:
  MALSKVKLNDTLNKDQLLSSSKYTIQRSTGDSIDTPNYDVQKHINKLCGMLLITEDANHK
  FTGLIGMLYAMSRLGREDTIKILRDAGYHVKANGVDVTTHRQDINGKEMKFEVLTLASLT
  TEIQINIEIESRKSYKKMLKEMGEVAPEYRHDSPDCGMIILCIAALVITKLAAGDRSGLT
  AVIRRANNVLKNEMKRYKGLLPKDIANSFYEVFEKHPHFIDVFVHFGIAQSSTRGGSRVE
  GIFAGLFMNAYGAGQVMLRWGVLAKSVKNIMLGHASVQAEMEQVVEVYEYAQKLGGEAGF
  YHILNNPKASLLSLTQFPHFSSVVLGNAAGLGIMGEYRGTPRNQDLYDAAKAYAEQLKEN
  GVINYSVLDLTAEELEAIKHQLNPKDNDVEL
• Function: Encapsidates the genome, protecting it from nucleases. The nucleocapsid (NC) has a helical structure. The encapsidated genomic RNA is termed the NC and serves as template for transcription and replication. During replication, encapsidation by protein N is coupled to RNA synthesis and all replicative products are resistant to nucleases.

Molecular Interaction Atlas (MIA) of This DTT

2 Clinical Trial Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
EDP-938	DM32UOC	Respiratory syncytial virus infection	1C80	Phase 2	[2]
RSV-604	DMAJH75	Virus infection	1A24-1D9Z	Phase 2	[1]

References

• [1] Mechanism of action for respiratory syncytial virus inhibitor RSV604. Antimicrob Agents Chemother. 2015 Feb;59(2):1080-7.
• [2] EDP-938, a novel nucleoprotein inhibitor of respiratory syncytial virus, demonstrates potent antiviral activities in vitro and in a non-human primate model. PLoS Pathog. 2021 Mar 15;17(3):e1009428.