Details of the Drug

General Information of Drug (ID: DMAKXW9)

Drug Name

PLEGRIDY

Synonyms

Peginterferon beta-1a

Indication

Disease Entry	ICD 11	Status	REF
Multiple sclerosis	8A40	Approved	[1]

ATC Code

L03AB13: PLEGRIDY

L03AB: Interferons

L03A: IMMUNOSTIMULANTS

L03: IMMUNOSTIMULANTS

L: ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS

Sequence

>Sequence
MSYNLLGFLQRSSNFQCQKLLWQLNGRLEYCLKDRMNFDIPEEIKQLQQFQKEDAALTIY
EMLQNIFAIFRQDSSSTGWNETIVENLLANVYHQINHLKTVLEEKLEKEDFTRGKLMSSL
HLKRYYGRILHYLKAKEYSHCAWTIVRVEILRNFYFINRLTGYLRN

ADMET Property

Absorption AUC: The area under the plot of plasma concentration (AUC) of drug is 34.8 mcgh/L [2]
Absorption Cmax: The maximum plasma concentration (Cmax) of drug is 280 ng/L [2]
Absorption Tmax: The time to maximum plasma concentration (Tmax) is 1-1.5 days [2]
Clearance: The clearance of drug is 4.1 L/h [3]
Half-life: The concentration or amount of drug in body reduced by one-half in 78 hours [4]
Metabolism: The drug is metabolized via the liver [3]
Vd: The volume of distribution (Vd) of drug is 481 L [3]

Cross-matching ID

UNII: I8309403R0
DrugBank ID: DB09122
TTD ID: D0LW4O

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Interferon-beta (IFNB1)	TT4TZ8J	IFNB_HUMAN	Modulator	[5]

Molecular Interaction Atlas (MIA)

MIA Detail

Jump to Detail Molecular Interaction Atlas of This Drug

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7637).
2	Hu X, Cui Y, White J, Zhu Y, Deykin A, Nestorov I, Hung S: Pharmacokinetics and pharmacodynamics of peginterferon beta-1a in patients with relapsing-remitting multiple sclerosis in the randomized ADVANCE study. Br J Clin Pharmacol. 2015 Mar;79(3):514-22. doi: 10.1111/bcp.12521.
3	FDA Approved Drug Products: PLEGRIDY (peginterferon beta-1a) injection, for subcutaneous or intramuscular use
4	Product monograph: Avonex (interferon beta-1a) injection
5	2014 FDA drug approvals. Nat Rev Drug Discov. 2015 Feb;14(2):77-81.