Details of the Drug

General Information of Drug (ID: DMB7GPA)

Drug Name
Selenious acid
Synonyms
Monohydrated selenium dioxide; SELENIOUS ACID; Selenious acid (H2SeO3); Selenious acid (USP); Selenious acid [USP]; Selenious acid, 98%; Selenite (SeO32-); Selenite ion(2-); Selenium dioxide, monohydrated; Selenous acid; Selenous acid, 98%; dihydroxidooxidoselenium; selenige Saeure; selenige Saure; 7783-00-8; AC1L1APE; CCRIS 5530; CHEBI:26642; DSSTox_CID_4300; EINECS 231-974-7; F6A27P4Q4R; HSDB 6065; MFCD00011331; Selenium, Reference Standard Solution; UNII-F6A27P4Q4R; selenious acid,selenous acid,monohydrated selenium dioxide
Affected Organisms
Humans and other mammals
Structure
3D MOL is unavailable 2D MOL
#Ro5 Violations (Lipinski):
0		 Molecular Weight 128.99
Logarithm of the Partition Coefficient Not Available
Rotatable Bond Count 0
Hydrogen Bond Donor Count 2
Hydrogen Bond Acceptor Count 3
ADMET Property
Elimination
Analysis of 72-hour urine sampling from a study of 48 Norwegian women given a 200 g supplement of selenium in the form of selenite indicated approximately 50% absorption of selenite [1]
Half-life
The concentration or amount of drug in body reduced by one-half in 30 days (in beagle dogs) [2]
Metabolism
The drug is metabolized via the exert cancer-selective cytotoxicity [3]
Chemical Identifiers
Formula
H2O3Se
IUPAC Name
selenous acid
Canonical SMILES
O[Se](=O)O
InChI
InChI=1S/H2O3Se/c1-4(2)3/h(H2,1,2,3)
InChIKey
MCAHWIHFGHIESP-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
1091
ChEBI ID
CHEMBL26642
CAS Number
7783-00-8
UNII
F6A27P4Q4R
DrugBank ID
DB11127
INTEDE ID
DR1468
Drug ADMET Endpoint Profile (DAE)NEW Click to Jump to the Detailed DAE Information of This Drug

Molecular Interaction Atlas of This Drug


Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Thioredoxin reductase TR1 (TXNRD1)
Main DME 		DEUP4DA TRXR1_HUMAN Substrate [4]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Band 3 anion transport protein (SLC4A1) OT3EFUK8 B3AT_HUMAN Regulation of Drug Effects [5]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

References

1 Selenious Acid Injection
2 Selenious Acid PubChem
3 Selenious acid as a source of selenium added for nutritional purposes to food supplements
4 Selenium metabolism, selenoproteins and mechanisms of cancer prevention: complexities with thioredoxin reductase. Carcinogenesis. 1999 Sep;20(9):1657-66.
5 Human red blood cell uptake and sequestration of arsenite and selenite: Evidence of seleno-bis(S-glutathionyl) arsinium ion formation in human cells. Biochem Pharmacol. 2020 Oct;180:114141. doi: 10.1016/j.bcp.2020.114141. Epub 2020 Jul 8.