Details of the Drug-Related molecule(s) Interaction Atlas

Selenious acid Drug Info

Monohydrated selenium dioxide; SELENIOUS ACID; Selenious acid (H2SeO3); Selenious acid (USP); Selenious acid [USP]; Selenious acid, 98%; Selenite (SeO32-); Selenite ion(2-); Selenium dioxide, monohydrated; Selenous acid; Selenous acid, 98%; dihydroxidooxidoselenium; selenige Saeure; selenige Saure; 7783-00-8; AC1L1APE; CCRIS 5530; CHEBI:26642; DSSTox_CID_4300; EINECS 231-974-7; F6A27P4Q4R; HSDB 6065; MFCD00011331; Selenium, Reference Standard Solution; UNII-F6A27P4Q4R; selenious acid,selenous acid,monohydrated selenium dioxide

Cross-matching ID

PubChem CID

1091

ChEBI ID

CHEMBL26642

CAS Number

CAS 7783-00-8

TTD Drug ID

DMB7GPA

INTEDE Drug ID

DR1468

General Information of Drug (ID: DMB7GPA)

Molecule-Related Drug Atlas

Molecule Type:

DME

DOT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Investigative Drug(s)

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Drug(s) Metabolized By Thioredoxin reductase TR1 (TXNRD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[1]
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Drug(s) Affected By Band 3 anion transport protein (SLC4A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[3]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[4]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[5]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[6]
Adefovir	DMM278X	N. A.	N. A.	Approved	[7]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[8]
CHLORIDE	DM1TJXA	Solid tumour/cancer	2A00-2F9Z	Phase 3	[9]
AMG 386	DMQJXL4	Breast cancer	2C60-2C65	Phase 3	[10]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[11]
D-glucose	DMMG2TO	Discovery agent	N.A.	Investigative	[12]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Thioredoxin reductase TR1 (TXNRD1)^{Main DME}	DEUP4DA	TRXR1_HUMAN	Substrate	[1]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Band 3 anion transport protein (SLC4A1)	OT3EFUK8	B3AT_HUMAN	Regulation of Drug Effects	[2]

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References

1	Selenium metabolism, selenoproteins and mechanisms of cancer prevention: complexities with thioredoxin reductase. Carcinogenesis. 1999 Sep;20(9):1657-66.
2	Human red blood cell uptake and sequestration of arsenite and selenite: Evidence of seleno-bis(S-glutathionyl) arsinium ion formation in human cells. Biochem Pharmacol. 2020 Oct;180:114141. doi: 10.1016/j.bcp.2020.114141. Epub 2020 Jul 8.
3	Phenotypic characterization of retinoic acid differentiated SH-SY5Y cells by transcriptional profiling. PLoS One. 2013 May 28;8(5):e63862.
4	Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
5	Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics. 2009 Aug 7;38(3):386-401.
6	Blood transcript immune signatures distinguish a subset of people with elevated serum ALT from others given acetaminophen. Clin Pharmacol Ther. 2016 Apr;99(4):432-41.
7	ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
8	Resveratrol induces human K562 cell apoptosis, erythroid differentiation, and autophagy. Tumour Biol. 2014 Jun;35(6):5381-8. doi: 10.1007/s13277-014-1701-y. Epub 2014 Feb 15.
9	Lysine 539 of human band 3 is not essential for ion transport or inhibition by stilbene disulfonates. J Biol Chem. 1989 Nov 25;264(33):19607-13.
10	Monovalent cation leaks in human red cells caused by single amino-acid substitutions in the transport domain of the band 3 chloride-bicarbonate exchanger, AE1. Nat Genet. 2005 Nov;37(11):1258-63. doi: 10.1038/ng1656. Epub 2005 Oct 9.
11	Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.
12	Novel oxolane derivative DMTD mitigates high glucose-induced erythrocyte apoptosis by regulating oxidative stress. Toxicol Appl Pharmacol. 2017 Nov 1;334:167-179.