Details of the Drug

General Information of Drug (ID: DMC8UPL)

Drug Name

ION532

Synonyms

AZD2373

Indication

Disease Entry	ICD 11	Status	REF
Chronic kidney disease	GB61	Phase 1	[1]
Nephropathy	GC2Z	Phase 1	[2]
------------------------------------------------------------------------------------

Drug Type

Antisense oligonucleotide

Cross-matching ID

Repurposed Drugs (RPD)

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Apolipoprotein L1 messenger RNA (APOL1 mRNA)	TTDB8PW	APOL1_HUMAN	Not Available	[3]

------------------------------------------------------------------------------------

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This Drug

References

1	ClinicalTrials.gov (NCT05351047) A Phase I, Randomized, Single-blind, Placebo-controlled Study to Assess the Safety, Tolerability and Pharmacokinetics of AZD2373 Following Multiple Ascending Dose Administration to Healthy Male Participants of Sub-Saharan West African Ancestry. U.S.National Institutes of Health.
2	ClinicalTrials.gov (NCT04269031) A Phase I, First-in-Human, Randomized, Single-blind, Placebo-controlled Study to Assess the Safety, Tolerability and Pharmacokinetics of AZD2373 Following Single Ascending Dose Administrations to Healthy Male Subjects of African Ancestry. U.S.National Institutes of Health.
3	Clinical pipeline report, company report or official report of Ionis