General Information of Disease (ID: DISW82R7)

Disease Name Chronic kidney disease
Synonyms chronic renal insufficiency; chronic renal failure syndrome; chronic kidney disease; renal failure - chronic; chronic renal disease; kidney disease, chronic; CKD - chronic kidney disease; CKD
Disease Class GB61: Chronic kidney disease
Definition Impairment of the renal function secondary to chronic kidney damage persisting for three or more months.
Disease Hierarchy
DISXWP4P: Nephropathy
DISW82R7: Chronic kidney disease
ICD Code
ICD-11
ICD-11: GB61
ICD-10
ICD-10: N18, N18.9
Expand ICD-11
'GB61
Expand ICD-10
'N18; 'N18.9
Expand ICD-9
403585585.9
Disease Identifiers
MONDO ID
MONDO_0005300
MESH ID
D051436
UMLS CUI
C1561643
MedGen ID
473458
HPO ID
HP:0012622
SNOMED CT ID
709044004

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)
This Disease is Treated as An Indication in 7 Approved Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
Darbepoetin alfa DMMJTYW Approved NA [1]
Doxercalciferol DM6FG1P Approved Small molecular drug [2]
Ferric citrate DM85PUZ Approved Small molecular drug [3]
Ferumoxytol DMRX668 Approved Small molecular drug [4]
Finerenone DMM4FJ3 Approved NA [5]
Flucloxacillin DMNUWST Approved Small molecular drug [6]
Rosiglitazone DMILWZR Approved NA []
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⏷ Show the Full List of 7 Drug(s)
This Disease is Treated as An Indication in 11 Clinical Trial Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
REACT DM6QZ5R Phase 3 Cell therapy [7]
US-APR2020 DMPFJOP Phase 2/3 Live biotherapeutic [8]
ALLN-346 DMZMG96 Phase 2 Enzyme replacement [9]
AZD1772//RDX5791 DMX5SG7 Phase 2 NA [10]
GCS-100 DMYS6MW Phase 2 NA [11]
LY-2623091 DMFGNB4 Phase 2 NA [12]
Neo-Kidney Augment DMS7N5S Phase 2 NA [13]
Runcaciguat DMCFTTN Phase 2 Small molecule [14]
LY3016859 DM7T1CR Phase 1/2 NA [15]
ION532 DMC8UPL Phase 1 Antisense oligonucleotide [16]
MEDI8367 DM7L053 Phase 1 Antibody [17]
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⏷ Show the Full List of 11 Drug(s)

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 189 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
ACVR2A TTX2DRI Limited Biomarker [18]
AGRP TT4DE1O Limited Biomarker [19]
APOL1 TTDB8PW Limited Biomarker [20]
ARSA TTYQANR Limited Genetic Variation [21]
ATF4 TTQCKWT Limited Altered Expression [22]
AVP TTJ8EWH Limited Altered Expression [23]
CALCR TTLWS2O Limited Biomarker [24]
CCR6 TTFDB30 Limited Altered Expression [25]
CD36 TTPJMCU Limited Altered Expression [26]
CDK12 TTJ21A9 Limited Genetic Variation [27]
CFD TT8D13I Limited Genetic Variation [28]
CMKLR1 TT4UGZL Limited Altered Expression [29]
CTSS TTUMQVO Limited Biomarker [30]
CUBN TT9YLCR Limited Genetic Variation [31]
CYP11B2 TT9MNE2 Limited Genetic Variation [32]
CYP2C19 TTZ58XG Limited Biomarker [33]
DPP4 TTDIGC1 Limited Biomarker [34]
EHMT1 TTOFXD7 Limited Biomarker [35]
FGFR4 TT1KX2S Limited Biomarker [36]
GCG TT6Y4PN Limited Biomarker [37]
GCK TTDLNGZ Limited Biomarker [38]
GH1 TTT3YKH Limited Altered Expression [39]
GHR TTHJWYD Limited Altered Expression [39]
GLA TTIS03D Limited Biomarker [40]
HIPK2 TTOB49C Limited Biomarker [41]
HLA-G TTLKFB3 Limited Genetic Variation [42]
LEP TTBJEZ5 Limited Biomarker [43]
LGALS3 TTFPQV7 Limited Biomarker [44]
LPA TTU9LGY Limited Biomarker [45]
MTTP TTUS1RD Limited Altered Expression [46]
NLRP3 TT4EN8X Limited Biomarker [47]
NPPB TTY63XT Limited Biomarker [48]
NPPC TTRK0B9 Limited Biomarker [49]
NR3C2 TT26PHO Limited Biomarker [50]
NRG4 TTWAGKJ Limited Biomarker [51]
PDZK1 TTDTBLM Limited Biomarker [52]
PECAM1 TT4EZB2 Limited Biomarker [53]
PIN1 TTJNTSI Limited Biomarker [54]
PTH1R TTFPD47 Limited Altered Expression [55]
RHBDF2 TTH1ZOP Limited Biomarker [56]
S100A12 TTQ4ESF Limited Biomarker [57]
SCGB1A1 TTONPVW Limited Biomarker [58]
SETD7 TTJ0FSU Limited Altered Expression [59]
SLC17A5 TTFSUIA Limited Biomarker [60]
SLC22A1 TTM5Q4V Limited Genetic Variation [61]
SLC22A2 TT0XOJN Limited Biomarker [62]
SLC22A6 TTTYH7A Limited Biomarker [63]
SLC2A4 TTP6MT5 Limited Biomarker [64]
SLC47A1 TTMHCGA Limited Genetic Variation [27]
TFF1 TTNOJIZ Limited Altered Expression [65]
THBD TTAPV67 Limited Biomarker [66]
TMSB4X TTMVAIU Limited Biomarker [67]
TNFRSF11B TT2CJ75 Limited Biomarker [68]
TRPC5 TT32NQ1 Limited Biomarker [69]
ADAMTS13 TTUREBK Disputed Biomarker [70]
AMD1 TTBFROQ Disputed Genetic Variation [71]
ABCA1 TTJW1GN moderate Altered Expression [72]
ACR TTAHE2N moderate Biomarker [73]
APLN TT87D3J moderate Biomarker [74]
ATP4A TTF1QVM moderate Biomarker [75]
BMP1 TT0L58T moderate Biomarker [76]
CETP TTFQAYR moderate Biomarker [77]
CYP3A4 TTWP7HQ moderate Altered Expression [78]
DDR1 TTI1FPZ moderate Biomarker [79]
F10 TTCIHJA moderate Biomarker [80]
G6PC TTBQMJ8 moderate Biomarker [81]
KCNJ1 TTJ13ST moderate Genetic Variation [82]
LCAT TTGZ91P moderate Altered Expression [83]
MSTN TTM8I2X moderate Biomarker [84]
PDE4D TTSKMI8 moderate Genetic Variation [85]
PLA2R1 TTHKW7D moderate Genetic Variation [86]
PLIN1 TTIV27N moderate Altered Expression [87]
PNPLA3 TTEUAEH moderate Genetic Variation [88]
SELE TT1PL7M moderate Biomarker [89]
SGK1 TTTV8EJ moderate Biomarker [90]
TNFSF11 TT9E8HR moderate Biomarker [91]
UCP2 TTSC2YM moderate Genetic Variation [92]
UTS2 TTERU0T moderate Altered Expression [93]
XDH TT7RJY8 moderate Biomarker [94]
ABCG2 TTIMJ02 Strong Biomarker [95]
ACE2 TTUI5H7 Strong Altered Expression [96]
ACLY TT0Z6Y2 Strong Biomarker [97]
ADAM17 TT6AZXG Strong Biomarker [98]
ADGRL3 TTQST3U Strong Genetic Variation [99]
ADM2 TTM642F Strong Biomarker [100]
AGER TTMO9HF Strong Biomarker [101]
AGXT TTF5NVW Strong Genetic Variation [102]
AHSG TTKF4WV Strong Biomarker [103]
AMACR TTLN1AP Strong Biomarker [104]
APLNR TTJ8E43 Strong Biomarker [105]
APOA4 TTNC3WS Strong Biomarker [106]
ATF3 TTCE793 Strong Altered Expression [107]
AVPR2 TTK8R02 Strong Biomarker [108]
B2M TTY7FKA Strong Biomarker [109]
BDKRB2 TTGY8IW Strong Genetic Variation [110]
BMP2 TTP3IGX Strong Biomarker [111]
BMP7 TTKOBRA Strong Biomarker [112]
CD14 TT6I7DC Strong Biomarker [113]
CD200 TT0BE68 Strong Altered Expression [114]
CD59 TTBGTEJ Strong Genetic Variation [115]
CDA TTQ12RK Strong Biomarker [116]
CFH TTUW6OP Strong Biomarker [117]
CLCNKB TTR68GQ Strong Genetic Variation [118]
CPS1 TT42M75 Strong Genetic Variation [119]
CRY1 TT5MLZR Strong Biomarker [120]
CTF1 TTXGTZU Strong Biomarker [121]
CYP24A1 TT82UI1 Strong Altered Expression [122]
DLG4 TT9PB26 Strong Biomarker [123]
EIF2AK4 TT9U4EP Strong Biomarker [124]
EPHX2 TT7WVHI Strong Genetic Variation [125]
EPOR TTAUX24 Strong Biomarker [126]
EPX TTCIO0M Strong Biomarker [127]
ESRRG TT9ZRHB Strong Altered Expression [128]
F8 TT1290U Strong Biomarker [129]
FABP3 TT3TGLR Strong Altered Expression [130]
FABP4 TTHWMFZ Strong Altered Expression [87]
FCGR3A TTIFOC0 Strong Biomarker [113]
FGF19 TTGCH11 Strong Biomarker [131]
FGF8 TTIUF3J Strong Genetic Variation [132]
FLT1 TT1VAUK Strong Biomarker [133]
FSTL3 TTWRPM8 Strong Altered Expression [134]
GDF15 TT4MXVG Strong Biomarker [135]
GGCX TT76OLR Strong Altered Expression [136]
GLP1R TTVIMDE Strong Altered Expression [137]
HP TTLC8E1 Strong Biomarker [138]
IL19 TT87RWS Strong Biomarker [139]
IL20 TTNZMY2 Strong Biomarker [140]
IRAK3 TTBPJOK Strong Biomarker [141]
KEAP1 TT3Z6Y9 Strong Altered Expression [142]
KLK1 TT5T3P6 Strong Altered Expression [143]
KLK4 TT4319X Strong Genetic Variation [144]
KLKB1 TTN0PCX Strong Biomarker [145]
LHCGR TT2O4W9 Strong Biomarker [146]
LRP2 TTPH1AJ Strong Biomarker [147]
LTB TTHQ6US Strong Altered Expression [148]
LY96 TT8S9AV Strong Biomarker [149]
MUC17 TTVO0JU Strong Biomarker [99]
NAGLU TTDM6HZ Strong Altered Expression [150]
NCF1 TTZ4JC3 Strong Biomarker [151]
NGF TTDN3LF Strong Biomarker [152]
NOX4 TTQRBSJ Strong Altered Expression [153]
NPR3 TTWVLS6 Strong Biomarker [154]
P2RY12 TTZ1DT0 Strong Biomarker [155]
PLD1 TT3T17P Strong Biomarker [156]
PLD2 TTRLMKF Strong Altered Expression [156]
POSTN TT8ALTZ Strong Biomarker [157]
RPS6KA1 TTIXKA4 Strong Altered Expression [158]
SCN8A TT54ERL Strong Altered Expression [159]
SLC11A2 TT2IS7P Strong Biomarker [160]
SLC33A1 TTL69WB Strong Biomarker [161]
SLCO2B1 TTDL3UZ Strong Biomarker [162]
SLCO4C1 TTACFNR Strong Biomarker [163]
SOAT2 TTAK0IN Strong Altered Expression [164]
SPHK2 TTCN0M9 Strong Biomarker [165]
ST8SIA4 TTDP8YM Strong Genetic Variation [166]
THRA TTTSEPU Strong Biomarker [167]
TM6SF2 TTE1OHM Strong Genetic Variation [168]
TNFSF12 TTBTDM1 Strong Biomarker [169]
TPH1 TTZSJHV Strong Biomarker [46]
ADORA2B TTNE7KG Definitive Altered Expression [170]
ALOX5AP TTDMBF5 Definitive Genetic Variation [171]
AOC1 TTM3B5R Definitive Genetic Variation [119]
ATXN2 TTPQJ7P Definitive Genetic Variation [172]
CD248 TTYJWT7 Definitive Biomarker [173]
DRD4 TTE0A2F Definitive Biomarker [174]
FABP2 TTS4YLO Definitive Genetic Variation [171]
FADS2 TTT2VDU Definitive Genetic Variation [119]
GLRX TTRJCNG Definitive Biomarker [175]
HNF1A TT01M3K Definitive Altered Expression [176]
IGF2R TTPNE41 Definitive Genetic Variation [119]
KCNJ11 TT329V4 Definitive Genetic Variation [177]
MYH2 TTBIL13 Definitive Genetic Variation [178]
PGRMC1 TTY3LAZ Definitive Biomarker [179]
PKD2L1 TTAHD89 Definitive Genetic Variation [119]
SCAP TTL6U2P Definitive Genetic Variation [180]
SCT TTOBVIN Definitive Genetic Variation [181]
SELP TTE5VG0 Definitive Altered Expression [182]
SIRPA TTBRJS9 Definitive Biomarker [183]
SLC22A16 TTITAVR Definitive Genetic Variation [119]
SLC2A9 TTIF3GB Definitive Genetic Variation [184]
SLC9A3 TTFZVPO Definitive Biomarker [185]
SSRP1 TTETDKQ Definitive Biomarker [186]
TKT TT04R7I Definitive Altered Expression [187]
TRPC3 TTNVC34 Definitive Altered Expression [188]
TRPC6 TTRBT3W Definitive Biomarker [189]
TYRO3 TTIEMFN Definitive Biomarker [190]
UCP1 TTI12YJ Definitive Genetic Variation [191]
UCP3 TT12RJK Definitive Genetic Variation [92]
VKORC1 TTEUC8H Definitive Genetic Variation [192]
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⏷ Show the Full List of 189 DTT(s)
This Disease Is Related to 11 DTP Molecule(s)
Gene Name DTP ID Evidence Level Mode of Inheritance REF
SLC20A2 DTFD4VB Limited Biomarker [193]
SLC3A1 DTBCKVM Limited Genetic Variation [194]
ATP12A DT5NLZA moderate Biomarker [75]
SLC6A13 DTX8KP0 moderate Genetic Variation [27]
ABCC6 DT582KR Strong Biomarker [195]
SLC39A14 DTZ6IJW Strong Biomarker [196]
SLC4A1 DTB0Q3P Strong Genetic Variation [102]
SLC7A9 DTP7AEQ Strong Genetic Variation [119]
SLC13A3 DTKXTPW Definitive Genetic Variation [197]
SLC16A9 DTQK5O9 Definitive Genetic Variation [119]
SLC20A1 DTMULXV Definitive Biomarker [198]
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⏷ Show the Full List of 11 DTP(s)
This Disease Is Related to 14 DME Molecule(s)
Gene Name DME ID Evidence Level Mode of Inheritance REF
CYP2C8 DES5XRU Limited Altered Expression [199]
DDAH1 DEY0TQC Limited Altered Expression [200]
NAT8 DEA742Z Limited Genetic Variation [27]
APRT DE2MV1R moderate Altered Expression [201]
ACP5 DESITDW Strong Genetic Variation [202]
CHDH DEAHED0 Strong Biomarker [203]
DCXR DE3FEV8 Strong Altered Expression [204]
FMO3 DEP76YL Strong Genetic Variation [205]
MANBA DEMH6UB Strong Biomarker [206]
MT2A DEFKGT7 Strong Biomarker [207]
PER1 DE9HF0I Strong Biomarker [208]
FADS1 DE05S8C Definitive Genetic Variation [119]
GFPT2 DERQCJM Definitive Genetic Variation [209]
PRODH DEVJIHS Definitive Genetic Variation [119]
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⏷ Show the Full List of 14 DME(s)
This Disease Is Related to 288 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
ACACA OT5CQPZY Limited Genetic Variation [210]
ACAT2 OTZ092ZJ Limited Genetic Variation [211]
AHRR OTSJ12W6 Limited Altered Expression [212]
ALPK1 OTBW6SGD Limited Biomarker [213]
AQP2 OTQLBKK6 Limited Altered Expression [214]
ARTN OTWIWGL6 Limited Biomarker [19]
AZIN2 OT8OB7CG Limited Biomarker [215]
B3GAT1 OTXFP98E Limited Biomarker [216]
BCAS3 OTDVAX6B Limited Genetic Variation [217]
BGLAP OTK1YLWQ Limited Biomarker [218]
BMS1 OTEGQ8ZO Limited Genetic Variation [210]
C9 OT7I5FDX Limited Genetic Variation [27]
CABIN1 OT4G5CIK Limited Biomarker [219]
CAP1 OTYM8A2N Limited Biomarker [220]
CCHCR1 OT22C116 Limited Biomarker [221]
CHGA OTXYX5JH Limited Biomarker [222]
CLCN5 OT9YXZSO Limited Biomarker [223]
CMAS OTFQJG3C Limited Biomarker [224]
DAB2 OTRMQTMZ Limited Biomarker [225]
DACH1 OTMKNAGG Limited Genetic Variation [27]
DBP OTE0W7LN Limited Genetic Variation [226]
DDT OTF5HTYL Limited Biomarker [227]
DECR1 OTCDIR6X Limited Biomarker [228]
DMP1 OTBWBWW7 Limited Biomarker [229]
DNAJC16 OTA1F9IN Limited Genetic Variation [27]
DNER OT2GH2E5 Limited Biomarker [230]
DOK6 OTX55OIF Limited Genetic Variation [85]
ESS2 OTZ08VCZ Limited Biomarker [231]
EXOSC3 OTNCF906 Limited Biomarker [182]
FBL OTRODIE5 Limited Biomarker [232]
FBXL20 OTVTR1KY Limited Genetic Variation [85]
FGF13 OTHNNVSG Limited Biomarker [233]
FLOT2 OTZ0QR5L Limited Altered Expression [234]
FLVCR1 OT9XCFOC Limited Biomarker [235]
FNDC5 OT5CSK9X Limited Altered Expression [236]
GADL1 OTJM4A0R Limited Biomarker [215]
GLIS2 OTOUUV1X Limited Genetic Variation [237]
GRIP1 OT958HK1 Limited Genetic Variation [27]
GRP OT8JDFNI Limited Biomarker [238]
INF2 OT8ZM13C Limited Biomarker [239]
INO80 OTJBMS8T Limited Genetic Variation [27]
KLF15 OTGMQMVR Limited Biomarker [240]
LECT2 OTSFZ9JD Limited Biomarker [241]
MSX2 OT1WDKE1 Limited Biomarker [242]
OCLN OTSUTVWL Limited Altered Expression [243]
PINK1 OT50NR57 Limited Altered Expression [244]
PIP5K1B OT8JQ1F7 Limited Genetic Variation [27]
PPARGC1A OTHCDQ22 Limited Altered Expression [245]
PRKAG2 OTHTAM54 Limited Genetic Variation [246]
RARRES2 OT1BJE8K Limited Biomarker [247]
RASAL1 OTAHUNN7 Limited Biomarker [248]
REG1A OTMHUH1D Limited Biomarker [249]
SELENBP1 OT3NZNTR Limited Biomarker [250]
SHBG OTPWU5IW Limited Biomarker [250]
SHROOM3 OTQKC5X2 Limited Genetic Variation [251]
SOSTDC1 OTAKDNSM Limited Biomarker [252]
STEAP4 OTFTLAEZ Limited Altered Expression [253]
TEAD1 OTK6971C Limited Biomarker [254]
TFDP2 OTKQFX5H Limited Genetic Variation [27]
TFF3 OTJJDRTU Limited Biomarker [255]
TNXB OTVBWAV5 Limited Genetic Variation [256]
ALMS1 OTW66JKS moderate Genetic Variation [257]
AMH OT5FH4BD moderate Altered Expression [258]
AQP5 OT77GBY8 moderate Biomarker [259]
BTN2A1 OTUYPMZJ moderate Biomarker [260]
C1QL1 OTNQ0G3E moderate Biomarker [261]
C1QTNF1 OT7I7KHC moderate Altered Expression [262]
CERS2 OTRAHYYP moderate Genetic Variation [172]
CLDN16 OTTHAIKR moderate Genetic Variation [263]
COL4A4 OT9G0MCT moderate Genetic Variation [264]
COL4A5 OTHG60RE moderate Genetic Variation [265]
COQ8B OTBY50BD moderate Genetic Variation [266]
FBXO32 OTUE978R moderate Genetic Variation [267]
GC OTWS63BY moderate Biomarker [268]
ILF3 OTKMZ5K5 moderate Genetic Variation [260]
MEFV OTRJ6S6K moderate Biomarker [269]
MOK OTQK7M9V moderate Biomarker [270]
MRGPRF OT74OZ2Z moderate Biomarker [271]
MYH14 OT1TZEJK moderate Genetic Variation [272]
OCRL OTQ3L42N moderate Genetic Variation [273]
PENK OT8P3HMP moderate Biomarker [274]
PKD1 OT5ALRZ5 moderate Biomarker [275]
RBFOX2 OTXY1WVH moderate Biomarker [271]
SMAD2 OTC6VB4K moderate Posttranslational Modification [276]
STAT5A OTBSJGN3 moderate Biomarker [277]
STAT5B OTZVPEBT moderate Biomarker [277]
TFE3 OTM99ZWH moderate Biomarker [278]
TINAG OTY7BSD7 moderate Genetic Variation [279]
TMEM60 OTRJU667 moderate Genetic Variation [172]
TRIM63 OTUSWA74 moderate Altered Expression [280]
ACCS OTHIHI9D Strong Biomarker [281]
ACKR2 OTWYY14H Strong Biomarker [282]
ACSBG1 OTM040MW Strong Altered Expression [283]
ACSM3 OT0AE1IV Strong Biomarker [284]
AGXT2 OTO6QUTM Strong Altered Expression [285]
AMBRA1 OTY0YGT9 Strong Altered Expression [286]
AMELX OTIN26MM Strong Biomarker [287]
APOM OTI3FQQC Strong Biomarker [288]
AQP11 OT1IQMHV Strong Genetic Variation [289]
ARID4B OTYLPILE Strong Biomarker [290]
ATG2A OTGYDDSV Strong Genetic Variation [291]
ATL1 OTR2788Y Strong Altered Expression [53]
ATP2A3 OTFYDEES Strong Altered Expression [292]
ATP6AP2 OT0IABVV Strong Biomarker [293]
BRAP OTB7BAFQ Strong Genetic Variation [294]
C1QTNF3 OTOJMWW0 Strong Altered Expression [295]
CCL14 OT8QETQU Strong Biomarker [296]
CCNT1 OTDYVGCP Strong Biomarker [297]
CCNT2 OTBDRH1J Strong Altered Expression [297]
CDK20 OTOLNN68 Strong Biomarker [298]
CENPC OTVJ6VE9 Strong Biomarker [299]
CENPV OTPQ0KT9 Strong Biomarker [300]
CFAP298 OTTDRT2N Strong Genetic Variation [291]
CFAP97 OT0RSQO4 Strong Genetic Variation [301]
CFHR5 OT7BMOYE Strong Genetic Variation [302]
CKM OTME0KO7 Strong Biomarker [303]
COL4A3 OT6SB8X5 Strong Biomarker [304]
COL6A5 OTJT8O80 Strong Genetic Variation [99]
COL9A1 OTWBR27Y Strong Altered Expression [159]
COL9A2 OT1ZBDBV Strong Altered Expression [159]
COL9A3 OTCUJOEK Strong Altered Expression [159]
CREBRF OT2GK1HI Strong Genetic Variation [305]
CST3 OTNZ6AO4 Strong Biomarker [306]
CYBRD1 OTUTVBES Strong Biomarker [160]
DSPP OT1TYNDN Strong Genetic Variation [307]
DYM OTQ670WI Strong Biomarker [308]
EDA OTAKS5WS Strong Biomarker [309]
ENHO OT91QASK Strong Biomarker [310]
ESAM OTF518AI Strong Biomarker [311]
EXTL2 OT8U672K Strong Biomarker [312]
FAN1 OT1LM1HZ Strong Genetic Variation [313]
FAR2 OTRYY709 Strong Biomarker [314]
FCGR3B OTSLSPZG Strong Biomarker [113]
FETUB OT7V07NI Strong Biomarker [315]
FOXO3 OTHXQG4P Strong Biomarker [201]
GABPA OT9YB2SA Strong Biomarker [316]
GALNT3 OT7M67WT Strong Biomarker [317]
GCKR OTSIWXGG Strong Biomarker [318]
GOLGA6A OTHU9MRX Strong Biomarker [319]
GSDMD OTH39BKI Strong Biomarker [320]
GUCA2A OTUSF75G Strong Biomarker [321]
GUCA2B OTZERX04 Strong Biomarker [322]
HCP5 OTV0YRI8 Strong Biomarker [323]
HJV OT4235J2 Strong Altered Expression [324]
IFI35 OTV9RZ53 Strong Altered Expression [325]
IL17B OTS86H50 Strong Biomarker [140]
INSRR OT3F75WA Strong Biomarker [326]
KCNIP2 OTY4BLOJ Strong Altered Expression [327]
KCNMB1 OTO4KNJ4 Strong Genetic Variation [328]
KLK15 OT7BVG17 Strong Biomarker [329]
KRT18 OTVLQFIP Strong Biomarker [330]
LAMC1 OTIG527N Strong Altered Expression [331]
LEFTY1 OT51HVC4 Strong Biomarker [332]
LITAF OTT5JX1F Strong Biomarker [333]
LRG1 OTLD0KWA Strong Altered Expression [334]
LRPAP1 OT6DVD2Q Strong Biomarker [18]
LRSAM1 OTOKWR6C Strong Genetic Variation [335]
LXN OTZQ2M6Y Strong Genetic Variation [336]
LZTR1 OTIDM6XO Strong Biomarker [337]
MAGI2 OTXDDKZS Strong Biomarker [338]
MARCHF1 OTI2EYO6 Strong Genetic Variation [339]
MARCHF5 OTBK6BBM Strong Biomarker [340]
MARCHF6 OTBTA03N Strong Biomarker [341]
MBOAT7 OTHRCBLK Strong Genetic Variation [168]
MCIDAS OTK1JVAH Strong Biomarker [342]
MEGF8 OT5G38CH Strong Biomarker [343]
MEST OT8Q4U8Y Strong Genetic Variation [344]
MGP OTZWU3FU Strong Biomarker [345]
MLC1 OTCNZLSP Strong Biomarker [130]
MLKL OTDSLC81 Strong Biomarker [346]
MMP19 OTLSTT2B Strong Biomarker [347]
MMRN1 OT7ZNYHT Strong Genetic Variation [348]
MOB3C OT2OFNGF Strong Biomarker [99]
MPI OTBH6ZK1 Strong Biomarker [349]
MT1B OTUA4FFH Strong Altered Expression [46]
MUC7 OTSTMP0X Strong Biomarker [350]
MXRA5 OTXZBWCU Strong Biomarker [351]
NBAS OTW9IBRI Strong Altered Expression [150]
NBEAL2 OTMCAXWR Strong Biomarker [352]
NKX6-2 OT7FI94W Strong Altered Expression [353]
NPHS1 OT21JD3P Strong Genetic Variation [119]
NPHS2 OTLCNUII Strong Biomarker [354]
OGA OT7ZBWT1 Strong Biomarker [150]
OGN OTKP5S4L Strong Biomarker [355]
OR10A4 OTYYB8SY Strong Biomarker [356]
P4HTM OTKELL7F Strong Biomarker [357]
PAPPA OTTTG9PG Strong Altered Expression [130]
PCOLCE OTJXOAN4 Strong Altered Expression [358]
PDC OT1UUVYY Strong Biomarker [359]
PDK4 OTCMHMBZ Strong Altered Expression [360]
PFN1 OTHTGA1H Strong Altered Expression [361]
PGLYRP1 OTBTPR2T Strong Biomarker [362]
PIK3C3 OTLUM9L7 Strong Altered Expression [363]
PKD2 OTIXBU8H Strong Biomarker [364]
PKHD1 OTAH8SMF Strong Biomarker [365]
PLA2G15 OT6VJTPA Strong Biomarker [281]
PLCB2 OTPAHDGO Strong Biomarker [99]
POLI OTBA4DCE Strong Genetic Variation [89]
POU2F1 OTK7ELJ0 Strong Genetic Variation [61]
POU2F2 OTPV0J0C Strong Biomarker [62]
PRDX3 OTLB2WEU Strong Biomarker [366]
PTRH1 OTOAOS93 Strong Biomarker [367]
PTX3 OTPXHRKU Strong Biomarker [368]
PXDN OTFGGM9R Strong Biomarker [127]
RAC2 OTAOHFNH Strong Altered Expression [323]
RAPH1 OTMQXW7S Strong Altered Expression [283]
RASL12 OTNAK9X4 Strong Biomarker [369]
RBM39 OTCMPTF9 Strong Biomarker [296]
RCBTB1 OTAYELI8 Strong Biomarker [319]
RGS14 OTYN79AG Strong Altered Expression [370]
RMDN1 OTE1NB6U Strong Altered Expression [371]
RMDN2 OTK5WSFI Strong Altered Expression [371]
RMDN3 OTKO7AUM Strong Altered Expression [371]
RNLS OTVP2WJM Strong Genetic Variation [372]
RPL41 OTFW5IFO Strong Altered Expression [373]
RSC1A1 OT54EM29 Strong Biomarker [374]
RTN1 OTCX1SMK Strong Altered Expression [375]
SARNP OTE0OVK5 Strong Biomarker [296]
SCN7A OTK05PXY Strong Altered Expression [150]
SDS OT5WTJ2M Strong Biomarker [376]
SEC61A1 OTLBE3CB Strong Biomarker [377]
SFRP5 OTLCVVSH Strong Altered Expression [378]
SFTPA1 OT87XL1U Strong Genetic Variation [379]
SHMT1 OTIINA3J Strong Biomarker [380]
SMPD3 OTHQBETH Strong Altered Expression [381]
SPON1 OTC06MY4 Strong Biomarker [202]
STUB1 OTSUYI9A Strong Biomarker [382]
SYBU OT3FQV7N Strong Altered Expression [371]
TALDO1 OTDKV2S2 Strong Biomarker [383]
TCN1 OTW6A49Y Strong Genetic Variation [336]
TFF2 OTRXB19X Strong Altered Expression [384]
THEMIS OTXODBXJ Strong Biomarker [385]
TJP1 OTBDCUPK Strong Biomarker [386]
TMEM126B OT8JJ5TP Strong Biomarker [387]
TNFRSF10D OTOSRDJT Strong Biomarker [388]
TNFSF9 OTV9L89D Strong Altered Expression [148]
TRIB3 OTG5OS7X Strong Genetic Variation [389]
TRIM72 OTFAFXPC Strong Biomarker [286]
TRPV5 OTWF4L0U Strong Biomarker [390]
ACADL OTP7Y0UF Definitive Genetic Variation [119]
ACADS OTGFANYQ Definitive Genetic Variation [119]
ADD1 OTTF68DC Definitive Biomarker [391]
ADI1 OT8IOD03 Definitive Biomarker [392]
AKAP12 OTCVRDDX Definitive Biomarker [393]
APOA5 OTEVKLVA Definitive Biomarker [77]
ASPG OT5E2EKR Definitive Genetic Variation [119]
C4A OTXMOYXU Definitive Biomarker [394]
CCN3 OTOW5YL4 Definitive Altered Expression [395]
CDC73 OT6JASZ1 Definitive Biomarker [396]
CERS4 OTV5ENAX Definitive Genetic Variation [119]
CITED2 OT812TV7 Definitive Altered Expression [397]
CLDN19 OTVD6IBL Definitive Genetic Variation [398]
CLEC16A OTLGV5SV Definitive Biomarker [399]
CYBA OT16N9ZO Definitive Genetic Variation [400]
DDOST OT39PDMS Definitive Biomarker [401]
DNAH17 OT4G6E70 Definitive Genetic Variation [119]
ELMO1 OTY2ORXK Definitive Posttranslational Modification [402]
ELOVL2 OTDAF6U3 Definitive Genetic Variation [119]
ERAL1 OTSH78HD Definitive Biomarker [403]
ERFE OTSES1HA Definitive Biomarker [404]
EYA1 OTHU807A Definitive Genetic Variation [405]
FAM78B OTIY35CP Definitive Biomarker [406]
GNB3 OTA6HYBA Definitive Genetic Variation [407]
GOT2 OT6XBWN0 Definitive Altered Expression [408]
IL34 OTZ15VVK Definitive Biomarker [409]
KIRREL2 OTSLTR4Y Definitive Genetic Variation [119]
LAMA3 OTFME7HT Definitive Genetic Variation [399]
LYST OTIUB1B3 Definitive Biomarker [410]
MMP20 OT16S5S3 Definitive Genetic Variation [119]
MTHFS OTZ39JNR Definitive Genetic Variation [405]
MYO7B OTOQ6S1H Definitive Biomarker [393]
MYOCD OTSJNHTH Definitive Altered Expression [411]
MYRF OTKF6AEB Definitive Genetic Variation [119]
NPS OTEG25A2 Definitive Genetic Variation [412]
NRK OTGR01FF Definitive Biomarker [413]
NT5C1A OTS7UF36 Definitive Biomarker [414]
NTAN1 OTJF0U48 Definitive Genetic Variation [119]
PAX2 OTKP1N8F Definitive Genetic Variation [415]
PDXDC1 OTKH7U5Q Definitive Genetic Variation [119]
PLXDC2 OTS1FUV6 Definitive Genetic Variation [261]
POU1F1 OTXT8A5C Definitive Biomarker [198]
PTPRN2 OTL6SH28 Definitive Genetic Variation [119]
SOD3 OTIOZQAB Definitive Altered Expression [416]
SYNE2 OTBUXGQ0 Definitive Genetic Variation [119]
THEM4 OTSIZU8Y Definitive Genetic Variation [119]
TMEM229B OT50LI46 Definitive Genetic Variation [119]
TMEM258 OTXSDU14 Definitive Genetic Variation [119]
TOMM40 OTZDQ29F Definitive Genetic Variation [77]
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⏷ Show the Full List of 288 DOT(s)

References

1 A trial of darbepoetin alfa in type 2 diabetes and chronic kidney disease. N Engl J Med. 2009 Nov 19;361(21):2019-32.
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2790).
3 ClinicalTrials.gov (NCT02268994) KRX-0502 (Ferric Citrate) for the Treatment of IDA in Adult Subjects With NDD-CKD. U.S. National Institutes of Health.
4 ClinicalTrials.gov (NCT01942460) Ferumoxytol for Iron-Deficiency Anemia in Chronic Kidney Disease and Peritoneal Dialysis Patients. U.S. National Institutes of Health.
5 FDA Approved Drug Products from FDA Official Website. 2022. Application Number: 215341.
6 Flucloxacillin and paracetamol induced pyroglutamic acidosis. BMJ Case Rep. 2021 Jan 8;14(1):e237536.
7 ClinicalTrials.gov (NCT05099770) A Phase 3 Randomized Controlled Study of Renal Autologous Cell Therapy (REACT) in Subjects With Type 2 Diabetes and Chronic Kidney Disease (REGEN-006). U.S.National Institutes of Health.
8 ClinicalTrials.gov (NCT05407389) An Open-Label Rollover Extension Phase 2 Clinical Trial To Evaluate The Long-Term Safety And Efficacy Of KT-301 (Formerly US-APR2020) In Subjects With CKD IV Completing The US-APR2020-01 Study. U.S.National Institutes of Health.
9 ClinicalTrials.gov (NCT04987294) A Randomized, Double-Blind, Placebo-Controlled Study of ALLN-346 (Engineered Urate Oxidase) in Hyperuricemic Subjects With Gout and Mild to Moderate Chronic Kidney Disease. U.S.National Institutes of Health.
10 Clinical pipeline report, company report or official report of Ardelyx.
11 ClinicalTrials.gov (NCT01843790) A Phase 2a Study of Weekly Doses of GCS-100 in Patients With Chronic Kidney Disease. U.S. National Institutes of Health.
12 ClinicalTrials.gov (NCT02194465) A Study of LY2623091 in Participants With High Blood Pressure. U.S. National Institutes of Health.
13 ClinicalTrials.gov (NCT02525263) Autologous Neo-Kidney Augment (NKA) in Patients With Type 2 Diabetes and Chronic Kidney Disease (CKD) (RMCL-CL001). U.S. National Institutes of Health.
14 ClinicalTrials.gov (NCT04507061) A Randomized, Double-blind, Placebo-controlled, Multi-center Study to Assess the Safety and Efficacy of Individually Titrated Oral Doses of Runcaciguat in Subjects With Clinical Diagnosis of Chronic Kidney Disease With Diabetes and/or Hypertension and at Least One Cardiovascular Comorbidity. U.S.National Institutes of Health.
15 ClinicalTrials.gov (NCT01774981) Study of LY3016859 in Participants With Diabetic Nephropathy. U.S. National Institutes of Health.
16 ClinicalTrials.gov (NCT05351047) A Phase I, Randomized, Single-blind, Placebo-controlled Study to Assess the Safety, Tolerability and Pharmacokinetics of AZD2373 Following Multiple Ascending Dose Administration to Healthy Male Participants of Sub-Saharan West African Ancestry. U.S.National Institutes of Health.
17 ClinicalTrials.gov (NCT04365218) A Phase I Randomized, Blinded, Placebo-controlled Study to Evaluate the Safety and Pharmacokinetics of MEDI8367 Administered as Single Ascending Doses in Healthy Subjects, and as a Single Dose in Healthy Subjects of Japanese-descent and in Subjects With Chronic Kidney Disease. U.S.National Institutes of Health.
18 The activin receptor is stimulated in the skeleton, vasculature, heart, and kidney during chronic kidney disease.Kidney Int. 2018 Jan;93(1):147-158. doi: 10.1016/j.kint.2017.06.016. Epub 2017 Aug 23.
19 Direct-acting Antivirals for HIV/HCV Co-infected Individuals: As Good as it Gets?.Curr HIV Res. 2017;15(6):422-433. doi: 10.2174/1570162X15666171108125255.
20 Practical Considerations for APOL1 Genotyping in the Living Kidney Donor Evaluation.Transplantation. 2020 Jan;104(1):27-32. doi: 10.1097/TP.0000000000002933.
21 Re-admissions treble the risk of late mortality after primary total hiparthroplasty.Int Orthop. 2018 Sep;42(9):2015-2023. doi: 10.1007/s00264-018-3876-0. Epub 2018 Mar 10.
22 Erythropoietin attenuates vascular calcification by inhibiting endoplasmic reticulum stress in rats with chronic kidney disease.Peptides. 2020 Jan;123:170181. doi: 10.1016/j.peptides.2019.170181. Epub 2019 Nov 2.
23 Plasma copeptin as a predictor of kidney disease.Nephrol Dial Transplant. 2019 Jan 1;34(1):74-82. doi: 10.1093/ndt/gfy017.
24 Effect of cardiac resynchronization therapy on the risk of ventricular tachyarrhythmias in patients with chronic kidney disease.Ann Noninvasive Electrocardiol. 2017 May;22(3):e12404. doi: 10.1111/anec.12404. Epub 2016 Sep 15.
25 A randomized trial of serological and cellular responses to hepatitis B vaccination in chronic kidney disease.PLoS One. 2018 Oct 10;13(10):e0204477. doi: 10.1371/journal.pone.0204477. eCollection 2018.
26 CD36 in chronic kidney disease: novel insights and therapeutic opportunities.Nat Rev Nephrol. 2017 Dec;13(12):769-781. doi: 10.1038/nrneph.2017.126. Epub 2017 Sep 18.
27 Genome-wide association and functional follow-up reveals new loci for kidney function.PLoS Genet. 2012;8(3):e1002584. doi: 10.1371/journal.pgen.1002584. Epub 2012 Mar 29.
28 Accumulation of uraemic toxins is reflected only partially by estimated GFR in paediatric patients with chronic kidney disease.Pediatr Nephrol. 2018 Feb;33(2):315-323. doi: 10.1007/s00467-017-3802-5. Epub 2017 Sep 22.
29 The G-protein coupled receptor ChemR23 determines smooth muscle cell phenotypic switching to enhance high phosphate-induced vascular calcification.Cardiovasc Res. 2019 Aug 1;115(10):1557-1566. doi: 10.1093/cvr/cvy316.
30 Circulating cathepsin-S levels correlate with GFR decline and sTNFR1 and sTNFR2 levels in mice and humans.Sci Rep. 2017 Feb 27;7:43538. doi: 10.1038/srep43538.
31 CUBN as a novel locus for end-stage renal disease: insights from renal transplantation.PLoS One. 2012;7(5):e36512. doi: 10.1371/journal.pone.0036512. Epub 2012 May 4.
32 Modulation of aldosterone levels by aldosterone synthase promoter polymorphism and association with eGFR decline in patients with chronic kidney disease.Discov Med. 2018 Dec;26(145):251-260.
33 Effect of Chronic Kidney Disease on Nonrenal Elimination Pathways: A Systematic Assessment of CYP1A2, CYP2C8, CYP2C9, CYP2C19, and OATP.Clin Pharmacol Ther. 2018 May;103(5):854-867. doi: 10.1002/cpt.807. Epub 2017 Oct 9.
34 Outcomes for Inappropriate Renal Dose Adjustment of Dipeptidyl Peptidase-4 Inhibitors in Patients With Type 2 Diabetes Mellitus: Population-Based Study.Mayo Clin Proc. 2020 Jan;95(1):101-112. doi: 10.1016/j.mayocp.2019.06.010. Epub 2019 Dec 4.
35 Mechanism of Glucagon-Like Peptide 1 Improvements in Type 2 Diabetes Mellitus and Obesity.Curr Obes Rep. 2019 Sep;8(3):284-291. doi: 10.1007/s13679-019-00350-4.
36 FGFR4 does not contribute to progression of chronic kidney disease.Sci Rep. 2019 Oct 1;9(1):14023. doi: 10.1038/s41598-019-50669-0.
37 SGLT-2 inhibitors and GLP-1 receptor agonists for nephroprotection and cardioprotection in patients with diabetes mellitus and chronic kidney disease. A consensus statement by the EURECA-m and the DIABESITY working groups of the ERA-EDTA.Nephrol Dial Transplant. 2019 Feb 1;34(2):208-230. doi: 10.1093/ndt/gfy407.
38 Effect of Hepatic Organic Anion-Transporting Polypeptide 1B Inhibition and Chronic Kidney Disease on the Pharmacokinetics of a Liver-Targeted Glucokinase Activator: A Model-Based Evaluation.Clin Pharmacol Ther. 2019 Oct;106(4):792-802. doi: 10.1002/cpt.1419. Epub 2019 Apr 8.
39 A review of renal GH/IGF1 family gene expression in chronic kidney diseases.Growth Horm IGF Res. 2019 Oct-Dec;48-49:1-4. doi: 10.1016/j.ghir.2019.07.001. Epub 2019 Jul 16.
40 Identification of a novel loss-of-function mutation of the GLA gene in a Chinese Han family with Fabry disease.BMC Med Genet. 2018 Dec 27;19(1):219. doi: 10.1186/s12881-018-0734-2.
41 EGFR drives the progression of AKI to CKD through HIPK2 overexpression.Theranostics. 2019 Apr 13;9(9):2712-2726. doi: 10.7150/thno.31424. eCollection 2019.
42 The association of HLA-G polymorphisms and the synergistic effect of sMICA and sHLA-G with chronic kidney disease and allograft acceptance.PLoS One. 2019 Feb 22;14(2):e0212750. doi: 10.1371/journal.pone.0212750. eCollection 2019.
43 Fu Brick Tea Alleviates Chronic Kidney Disease of Rats with High Fat Diet Consumption through Attenuating Insulin Resistance in Skeletal Muscle.J Agric Food Chem. 2019 Mar 13;67(10):2839-2847. doi: 10.1021/acs.jafc.8b06927. Epub 2019 Mar 4.
44 Utility of Cardiac Biomarkers in the Setting of Kidney Disease.Nephron. 2019;141(4):227-235. doi: 10.1159/000495946. Epub 2019 Feb 6.
45 Association of lipoprotein(a) and coronary artery disease in 1003 patients with stage 3-5 chronic kidney disease undergoing coronary angiography.Coron Artery Dis. 2019 Mar;30(2):137-142. doi: 10.1097/MCA.0000000000000692.
46 Identification of serum metabolites associating with chronic kidney disease progression and anti-fibrotic effect of 5-methoxytryptophan.Nat Commun. 2019 Apr 1;10(1):1476. doi: 10.1038/s41467-019-09329-0.
47 The interplay between microbiota-dependent metabolite trimethylamine N-oxide, Transforming growth factor /SMAD signaling and inflammasome activation in chronic kidney disease patients: A new mechanistic perspective.J Cell Biochem. 2019 Sep;120(9):14476-14485. doi: 10.1002/jcb.28707. Epub 2019 Apr 19.
48 Relation of multi-marker panel to incident chronic kidney disease and rapid kidney function decline in African Americans: the Jackson Heart Study.BMC Nephrol. 2018 Sep 20;19(1):239. doi: 10.1186/s12882-018-1026-y.
49 Urinary Amino-Terminal Pro-C-Type Natriuretic Peptide: A Novel Marker of Chronic Kidney Disease in Diabetes.Clin Chem. 2019 Oct;65(10):1248-1257. doi: 10.1373/clinchem.2019.306910. Epub 2019 Aug 20.
50 Mineralocorticoid Receptor Antagonists and Renal Outcomes in Heart Failure Patients with and without Chronic Kidney Disease.Cardiorenal Med. 2020;10(1):32-41. doi: 10.1159/000503223. Epub 2019 Oct 30.
51 The brown fat-secreted adipokine neuregulin 4 is decreased in human and murine chronic kidney disease.Eur J Endocrinol. 2019 Aug;181(2):151-159. doi: 10.1530/EJE-19-0017.
52 Adaptor protein is a new therapeutic target in chronic kidney disease.Kidney Int. 2017 Dec;92(6):1312-1314. doi: 10.1016/j.kint.2017.06.012.
53 Cinacalcet attenuated bone loss via inhibiting parathyroid hormone-induced endothelial-to-adipocyte transition in chronic kidney disease rats.Ann Transl Med. 2019 Jul;7(14):312. doi: 10.21037/atm.2019.06.44.
54 Pin1 and secondary hyperparathyroidism of chronic kidney disease: gene polymorphisms and protein levels.Ren Fail. 2017 Nov;39(1):159-165. doi: 10.1080/0886022X.2016.1256310. Epub 2016 Nov 23.
55 RANKL/OPG system regulation by endogenous PTH and PTH1R/ATF4 axis in bone: Implications for bone accrual and strength in growing rats with mild uremia.Cytokine. 2018 Jun;106:19-28. doi: 10.1016/j.cyto.2018.03.002. Epub 2018 Mar 9.
56 iRhom2 promotes lupus nephritis through TNF- and EGFR signaling.J Clin Invest. 2018 Apr 2;128(4):1397-1412. doi: 10.1172/JCI97650. Epub 2018 Mar 5.
57 S100/Calgranulin-mediated inflammation accelerates left ventricular hypertrophy and aortic valve sclerosis in chronic kidney disease in a receptor for advanced glycation end products-dependent manner.Arterioscler Thromb Vasc Biol. 2014 Jul;34(7):1399-411. doi: 10.1161/ATVBAHA.114.303508. Epub 2014 May 22.
58 High prevalence of chronic kidney disease among patients with diabetic foot: A cross-sectional study at a tertiary hospital in China.Nephrology (Carlton). 2020 Feb;25(2):150-155. doi: 10.1111/nep.13596. Epub 2019 May 20.
59 Amelioration of Uremic Toxin Indoxyl Sulfate-Induced Osteoblastic Calcification by SET Domain Containing Lysine Methyltransferase 7/9 Protein.Nephron. 2019;141(4):287-294. doi: 10.1159/000495885. Epub 2019 Feb 15.
60 Review of the efficacy of AST-120 (KREMEZIN()) on renal function in chronic kidney disease patients.Ren Fail. 2019 Nov;41(1):47-56. doi: 10.1080/0886022X.2018.1561376.
61 Vitamin D-regulated osteocytic sclerostin and BMP2 modulate uremic extraskeletal calcification.JCI Insight. 2019 Jul 11;4(13):e126467. doi: 10.1172/jci.insight.126467. eCollection 2019 Jul 11.
62 The Effect of Uremic Solutes on the Organic Cation Transporter 2.J Pharm Sci. 2017 Sep;106(9):2551-2557. doi: 10.1016/j.xphs.2017.04.076. Epub 2017 May 5.
63 Quantitative Translation of Microfluidic Transporter in Vitro Data to in Vivo Reveals Impaired Albumin-Facilitated Indoxyl Sulfate Secretion in Chronic Kidney Disease.Mol Pharm. 2019 Nov 4;16(11):4551-4562. doi: 10.1021/acs.molpharmaceut.9b00681. Epub 2019 Sep 27.
64 A renal-cerebral-peripheral sympathetic reflex mediates insulin resistance in chronic kidney disease.EBioMedicine. 2018 Nov;37:281-293. doi: 10.1016/j.ebiom.2018.10.054. Epub 2018 Nov 11.
65 Urine Trefoil Factors as Prognostic Biomarkers in Chronic Kidney Disease.Biomed Res Int. 2018 Apr 3;2018:3024698. doi: 10.1155/2018/3024698. eCollection 2018.
66 Vitamin D receptor activation raises soluble thrombomodulin levels in chronic kidney disease patients: a double blind, randomized trial.Nephrol Dial Transplant. 2019 May 1;34(5):819-824. doi: 10.1093/ndt/gfy085.
67 Thymosin-4: A key modifier of renal disease.Expert Opin Biol Ther. 2018 Jul;18(sup1):185-192. doi: 10.1080/14712598.2018.1473371. Epub 2018 May 9.
68 Expression of bone-related proteins in vascular calcification and its serum correlations with coronary artery calcification score.J Biol Regul Homeost Agents. 2019 Jan-Feb,;33(1):29-38.
69 Design, synthesis and characterization of novel N-heterocyclic-1-benzyl-1H-benzo[d]imidazole-2-amines as selective TRPC5 inhibitors leading to the identification of the selective compound, AC1903.Bioorg Med Chem Lett. 2019 Jan 15;29(2):155-159. doi: 10.1016/j.bmcl.2018.12.007. Epub 2018 Dec 4.
70 Predictive value of ADAMTS-13 on concealed chronic renal failure in COPD patients.Int J Chron Obstruct Pulmon Dis. 2017 Dec 5;12:3495-3501. doi: 10.2147/COPD.S151983. eCollection 2017.
71 Publisher Correction: Predictors of chronic kidney disease in type 1 diabetes: a longitudinal study from the AMD Annals initiative.Sci Rep. 2018 Apr 12;8(1):5999. doi: 10.1038/s41598-018-23163-2.
72 Chronic kidney disease alters lipid trafficking and inflammatory responses in macrophages: effects of liver X receptor agonism.BMC Nephrol. 2018 Jan 27;19(1):17. doi: 10.1186/s12882-018-0814-8.
73 Greater aortic stiffness is associated with renal dysfunction in participants of the ELSA-Brasil cohort with and without hypertension and diabetes.PLoS One. 2019 Feb 4;14(2):e0210522. doi: 10.1371/journal.pone.0210522. eCollection 2019.
74 Apelin affects the mouse aging urinary peptidome with minimal effects on kidney.Sci Rep. 2019 Jul 23;9(1):10647. doi: 10.1038/s41598-019-47109-4.
75 Associations of Proton-Pump Inhibitors and H2 Receptor Antagonists with Chronic Kidney Disease: A Meta-Analysis.Dig Dis Sci. 2017 Oct;62(10):2821-2827. doi: 10.1007/s10620-017-4725-5. Epub 2017 Aug 23.
76 BMP1 inhibitor UK383,367 attenuates renal fibrosis and inflammation in CKD.Am J Physiol Renal Physiol. 2019 Dec 1;317(6):F1430-F1438. doi: 10.1152/ajprenal.00230.2019. Epub 2019 Sep 23.
77 Polymorphisms of genes involved in lipid metabolism and risk of chronic kidney disease in Japanese - cross-sectional data from the J-MICC study.Lipids Health Dis. 2014 Oct 14;13:162. doi: 10.1186/1476-511X-13-162.
78 Effect of Serum Parathyroid Hormone on Tacrolimus Therapy in Kidney Transplant Patients: A Possible Biomarker for a Tacrolimus Dosage Schedule.Biol Pharm Bull. 2019;42(5):786-791. doi: 10.1248/bpb.b18-00976.
79 DDR1: A major player in renal diseases.Cell Adh Migr. 2018;12(4):299-304. doi: 10.1080/19336918.2018.1441661. Epub 2018 Feb 27.
80 Edoxaban Exerts Antioxidant Effects Through FXa Inhibition and Direct Radical-Scavenging Activity.Int J Mol Sci. 2019 Aug 24;20(17):4140. doi: 10.3390/ijms20174140.
81 Polycystic kidney features of the renal pathology in glycogen storage disease type I: possible evolution to renal neoplasia.J Inherit Metab Dis. 2018 Nov;41(6):955-963. doi: 10.1007/s10545-018-0207-y. Epub 2018 Jun 4.
82 Phenotype-genotype correlation in antenatal and neonatal variants of Bartter syndrome.Nephrol Dial Transplant. 2009 May;24(5):1455-64. doi: 10.1093/ndt/gfn689. Epub 2008 Dec 18.
83 Plasma Levels of Pre1-HDL Are Significantly Elevated in Non-Dialyzed Patients with Advanced Stages of Chronic Kidney Disease.Int J Mol Sci. 2019 Mar 9;20(5):1202. doi: 10.3390/ijms20051202.
84 Emerging role of myostatin and its inhibition in the setting of chronic kidney disease.Kidney Int. 2019 Mar;95(3):506-517. doi: 10.1016/j.kint.2018.10.010. Epub 2018 Dec 28.
85 Genetic association for renal traits among participants of African ancestry reveals new loci for renal function.PLoS Genet. 2011 Sep;7(9):e1002264. doi: 10.1371/journal.pgen.1002264. Epub 2011 Sep 8.
86 Genetic risk variants for membranous nephropathy: extension of and association with other chronic kidney disease aetiologies.Nephrol Dial Transplant. 2017 Feb 1;32(2):325-332. doi: 10.1093/ndt/gfw001. Epub 2016 Feb 4.
87 CCN1 induces adipogenic differentiation of fibro/adipogenic progenitors in a chronic kidney disease model.Biochem Biophys Res Commun. 2019 Dec 3;520(2):385-391. doi: 10.1016/j.bbrc.2019.10.047. Epub 2019 Oct 9.
88 PNPLA3 rs738409 is associated with renal glomerular and tubular injury in NAFLD patients with persistently normal ALT levels.Liver Int. 2020 Jan;40(1):107-119. doi: 10.1111/liv.14251. Epub 2019 Oct 7.
89 The impact of antihypertensive pharmacotherapy on interplay between protein-bound uremic toxin (indoxyl sulfate) and markers of inflammation in patients with chronic kidney disease.Int Urol Nephrol. 2019 Mar;51(3):491-502. doi: 10.1007/s11255-018-02064-3. Epub 2019 Jan 7.
90 SGK1 induces vascular smooth muscle cell calcification through NF-B signaling.J Clin Invest. 2018 Jul 2;128(7):3024-3040. doi: 10.1172/JCI96477. Epub 2018 Jun 11.
91 Elevations in Cortical Porosity Occur Prior to Significant Rise in Serum Parathyroid Hormone in Young Female Mice with Adenine-Induced CKD.Calcif Tissue Int. 2020 Apr;106(4):392-400. doi: 10.1007/s00223-019-00642-w. Epub 2019 Dec 12.
92 Association of genetic variants with chronic kidney disease in Japanese individuals.Clin J Am Soc Nephrol. 2009 May;4(5):883-90. doi: 10.2215/CJN.04350808. Epub 2009 Apr 30.
93 Urotensin II in the development and progression of chronic kidney disease following ?nephrectomy in the rat.Exp Physiol. 2019 Mar;104(3):421-433. doi: 10.1113/EP087366. Epub 2019 Jan 15.
94 Relationship between Xanthine Oxidoreductase Redox and Oxidative Stress among Chronic Kidney Disease Patients.Oxid Med Cell Longev. 2018 Jul 8;2018:9714710. doi: 10.1155/2018/9714710. eCollection 2018.
95 Time to Target Uric Acid to Retard Chronic Kidney Disease Progression.Contrib Nephrol. 2018;192:56-68. doi: 10.1159/000484279. Epub 2018 Jan 23.
96 Circulating miR-421 Targeting Leucocytic Angiotensin Converting Enzyme 2 Is Elevated in Patients with Chronic Kidney Disease.Nephron. 2019;141(1):61-74. doi: 10.1159/000493805. Epub 2018 Oct 16.
97 ATP-citrate lyase is an epigenetic regulator to promote obesity-related kidney injury.FASEB J. 2019 Aug;33(8):9602-9615. doi: 10.1096/fj.201900213R. Epub 2019 May 31.
98 Circulating ADAMs are associated with renal and cardiovascular outcomes in chronic kidney disease patients.Nephrol Dial Transplant. 2020 Jan 1;35(1):130-138. doi: 10.1093/ndt/gfy240.
99 Identification of 13 novel susceptibility loci for early-onset myocardial infarction, hypertension, or chronic kidney disease.Int J Mol Med. 2018 Nov;42(5):2415-2436. doi: 10.3892/ijmm.2018.3852. Epub 2018 Sep 4.
100 Intermedin1-53 attenuates vascular calcification in rats with chronic kidney disease by upregulation of -Klotho.Kidney Int. 2016 Mar;89(3):586-600. doi: 10.1016/j.kint.2015.12.029. Epub 2016 Jan 28.
101 Receptor for advanced glycation end products: a key molecule in the genesis of chronic kidney disease vascular calcification and a potential modulator of sodium phosphate co-transporter PIT-1 expression.Nephrol Dial Transplant. 2019 Dec 1;34(12):2018-2030. doi: 10.1093/ndt/gfz012.
102 Whole-exome resequencing distinguishes cystic kidney diseases from phenocopies in renal ciliopathies.Kidney Int. 2014 Apr;85(4):880-7. doi: 10.1038/ki.2013.450. Epub 2013 Nov 20.
103 The importance of fetuin-A in vascular calcification in children with chronic kidney disease.Adv Clin Exp Med. 2019 Apr;28(4):499-505. doi: 10.17219/acem/82517.
104 Prevalence and correlates of chronic kidney disease (CKD) among ART-naive HIV patients in the Niger-Delta region of Nigeria.Medicine (Baltimore). 2018 Apr;97(16):e0380. doi: 10.1097/MD.0000000000010380.
105 Apelin/APJ system: A critical regulator of vascular smooth muscle cell.J Cell Physiol. 2018 Jul;233(7):5180-5188. doi: 10.1002/jcp.26339. Epub 2018 Jan 23.
106 Apolipoprotein A-IV predicts progression of chronic kidney disease: the mild to moderate kidney disease study.J Am Soc Nephrol. 2006 Feb;17(2):528-36. doi: 10.1681/ASN.2005070733. Epub 2005 Dec 28.
107 Indoxyl sulfate upregulates the cannabinoid type 1 receptor gene via an ATF3/c-Jun complex-mediated signaling pathway in the model of uremic cardiomyopathy.Int J Cardiol. 2018 Feb 1;252:128-135. doi: 10.1016/j.ijcard.2017.11.086. Epub 2017 Dec 2.
108 Recommendations for the use of tolvaptan in autosomal dominant polycystic kidney disease: a position statement on behalf of the ERA-EDTA Working Groups on Inherited Kidney Disorders and European Renal Best Practice.Nephrol Dial Transplant. 2016 Mar;31(3):337-48. doi: 10.1093/ndt/gfv456. Epub 2016 Jan 29.
109 Markers of kidney tubule function and risk of cardiovascular disease events and mortality in the SPRINT trial.Eur Heart J. 2019 Nov 1;40(42):3486-3493. doi: 10.1093/eurheartj/ehz392.
110 Association of the human bradykinin B2 receptor gene with chronic renal failure.Mol Diagn. 2004;8(3):157-61. doi: 10.1007/BF03260059.
111 Incremental effects of diabetes mellitus and chronic kidney disease in medial arterial calcification: Synergistic pathways for peripheral artery disease progression.Vasc Med. 2019 Oct;24(5):383-394. doi: 10.1177/1358863X19842276. Epub 2019 May 15.
112 Inflammation and renal fibrosis: Recent developments on key signaling molecules as potential therapeutic targets.Eur J Pharmacol. 2018 Feb 5;820:65-76. doi: 10.1016/j.ejphar.2017.12.016. Epub 2017 Dec 8.
113 Inflammation induces osteoclast differentiation from peripheral mononuclear cells in chronic kidney disease patients: crosstalk between the immune and bone systems.Nephrol Dial Transplant. 2018 Jan 1;33(1):65-75. doi: 10.1093/ndt/gfx222.
114 High serum soluble CD200 levels in patients with autosomal dominant polycystic kidney disease.J Investig Med. 2017 Apr;65(4):784-786. doi: 10.1136/jim-2016-000326. Epub 2017 Feb 8.
115 Can we predict when to start renal replacement therapy in patients with chronic kidney disease using 6 months of clinical data?.PLoS One. 2018 Oct 4;13(10):e0204586. doi: 10.1371/journal.pone.0204586. eCollection 2018.
116 Implementation of a scalable, web-based, automated clinical decision support risk-prediction tool for chronic kidney disease using C-CDA and application programming interfaces.J Am Med Inform Assoc. 2017 Nov 1;24(6):1111-1115. doi: 10.1093/jamia/ocx065.
117 High levels of urinary complement proteins are associated with chronic renal damage and proximal tubule dysfunction in immunoglobulin A nephropathy.Nephrology (Carlton). 2019 Jul;24(7):703-710. doi: 10.1111/nep.13477. Epub 2019 Apr 23.
118 Chronic renal failure in a boy with classic Bartter's syndrome due to a novel mutation in CLCNKB coding for the chloride channel.Eur J Pediatr. 2009 Sep;168(9):1129-33. doi: 10.1007/s00431-008-0883-y. Epub 2008 Dec 3.
119 Genome-Wide Association Studies of Metabolites in Patients with CKD Identify Multiple Loci and Illuminate Tubular Transport Mechanisms.J Am Soc Nephrol. 2018 May;29(5):1513-1524. doi: 10.1681/ASN.2017101099. Epub 2018 Mar 15.
120 Over-expressed microRNA-181a reduces glomerular sclerosis and renal tubular epithelial injury in rats with chronic kidney disease via down-regulation of the TLR/NF-B pathway by binding to CRY1.Mol Med. 2018 Sep 18;24(1):49. doi: 10.1186/s10020-018-0045-2.
121 Cardiotrophin-1 opposes renal fibrosis in mice: Potential prevention of chronic kidney disease.Acta Physiol (Oxf). 2019 Jun;226(2):e13247. doi: 10.1111/apha.13247. Epub 2019 Jan 18.
122 In silico identification and screening of CYP24A1 inhibitors: 3D QSAR pharmacophore mapping and molecular dynamics analysis.J Biomol Struct Dyn. 2019 Apr;37(7):1700-1714. doi: 10.1080/07391102.2018.1464958. Epub 2018 May 4.
123 Impairment of the carnitine/organic cation transporter 1-ergothioneine axis is mediated by intestinal transporter dysfunction in chronic kidney disease.Kidney Int. 2017 Dec;92(6):1356-1369. doi: 10.1016/j.kint.2017.04.032. Epub 2017 Jul 26.
124 D-serine, a novel uremic toxin, induces senescence in human renal tubular cells via GCN2 activation.Sci Rep. 2017 Sep 11;7(1):11168. doi: 10.1038/s41598-017-11049-8.
125 Association of gain-of-function EPHX2 polymorphism Lys55Arg with acute kidney injury following cardiac surgery.PLoS One. 2017 May 26;12(5):e0175292. doi: 10.1371/journal.pone.0175292. eCollection 2017.
126 Model-based approach for methoxy polyethylene glycol-epoetin beta drug development in paediatric patients with anaemia of chronic kidney disease.Br J Clin Pharmacol. 2020 Apr;86(4):801-811. doi: 10.1111/bcp.14186. Epub 2020 Jan 21.
127 Peroxidasin and eosinophil peroxidase, but not myeloperoxidase, contribute to renal fibrosis in the murine unilateral ureteral obstruction model.Am J Physiol Renal Physiol. 2019 Feb 1;316(2):F360-F371. doi: 10.1152/ajprenal.00291.2018. Epub 2018 Dec 19.
128 Genomic integration of ERR-HNF1 regulates renal bioenergetics and prevents chronic kidney disease.Proc Natl Acad Sci U S A. 2018 May 22;115(21):E4910-E4919. doi: 10.1073/pnas.1804965115. Epub 2018 May 7.
129 Blood coagulation system in patients with chronic kidney disease: a prospective observational study.BMJ Open. 2017 Jun 1;7(5):e014294. doi: 10.1136/bmjopen-2016-014294.
130 Cardiac Biomarkers and Cardiovascular Outcome in Children with Chronic Kidney Disease.Iran J Kidney Dis. 2019 Mar;13(2):120-128.
131 Chronic Kidney Disease Is Associated with Increased Plasma Levels of Fibroblast Growth Factors 19 and 21.Kidney Blood Press Res. 2019;44(5):1207-1218. doi: 10.1159/000502647. Epub 2019 Oct 15.
132 Variants in genes belonging to the fibroblast growth factor family are associated with lower extremity amputation in non-Hispanic whites: Findings from the chronic renal insufficiency cohort study.Wound Repair Regen. 2016 Jul;24(4):705-11. doi: 10.1111/wrr.12447. Epub 2016 Jun 20.
133 Endogenous Antiangiogenic Factors in Chronic Kidney Disease: Potential Biomarkers of Progression.Int J Mol Sci. 2018 Jun 24;19(7):1859. doi: 10.3390/ijms19071859.
134 FSTL3 is increased in renal dysfunction.Nephrol Dial Transplant. 2017 Oct 1;32(10):1637-1644. doi: 10.1093/ndt/gfw472.
135 The Role of GDF-15 in Heart Failure Patients With Chronic Kidney Disease.Can J Cardiol. 2019 Apr;35(4):462-470. doi: 10.1016/j.cjca.2018.12.027. Epub 2018 Dec 26.
136 Vitamin K Metabolism in a Rat Model of Chronic Kidney Disease.Am J Nephrol. 2017;45(1):4-13. doi: 10.1159/000451068. Epub 2016 Nov 16.
137 DPP-4 inhibition enhanced renal tubular and myocardial GLP-1 receptor expression decreased in CKD with myocardial infarction.BMC Nephrol. 2019 Mar 1;20(1):75. doi: 10.1186/s12882-019-1243-z.
138 Proteomics analysis of blood plasma in HIV-infected patients with chronic kidney disease.Clin Biochem. 2019 Nov;73:90-97. doi: 10.1016/j.clinbiochem.2019.08.006. Epub 2019 Aug 8.
139 Interleukin-19 as a translational indicator of renal injury. Arch Toxicol. 2015 Jan;89(1):101-6.
140 The role of IL-20 in chronic kidney disease and diabetic nephropathy: Pathogenic and therapeutic implications.J Leukoc Biol. 2018 Nov;104(5):919-923. doi: 10.1002/JLB.MR1217-489R. Epub 2018 Jul 12.
141 Immunomodulatory Molecule IRAK-M Balances Macrophage Polarization and Determines Macrophage Responses during Renal Fibrosis.J Immunol. 2017 Aug 15;199(4):1440-1452. doi: 10.4049/jimmunol.1601982. Epub 2017 Jul 12.
142 GSK3-mediated Keap1-independent regulation of Nrf2 antioxidant response: A molecular rheostat of acute kidney injury to chronic kidney disease transition.Redox Biol. 2019 Sep;26:101275. doi: 10.1016/j.redox.2019.101275. Epub 2019 Jul 17.
143 Blockade of endogenous tissue kallikrein aggravates renal injury by enhancing oxidative stress and inhibiting matrix degradation.Am J Physiol Renal Physiol. 2010 Apr;298(4):F1033-40. doi: 10.1152/ajprenal.00518.2009. Epub 2010 Jan 20.
144 Human tissue kallikrein gene delivery attenuates hypertension, renal injury, and cardiac remodeling in chronic renal failure.Kidney Int. 2000 Aug;58(2):730-9. doi: 10.1046/j.1523-1755.2000.00219.x.
145 Plasma kallikrein activates the epithelial sodium channel invitro but is not essential for volume retention in nephrotic mice.Acta Physiol (Oxf). 2018 Sep;224(1):e13060. doi: 10.1111/apha.13060. Epub 2018 Mar 25.
146 Circulating luteinizing hormone receptor inhibitor(s) in boys with chronic renal failure.Kidney Int. 1997 Mar;51(3):777-84. doi: 10.1038/ki.1997.109.
147 Significance of urinary C-megalin excretion in vitamin D metabolism in pre-dialysis CKD patients.Sci Rep. 2019 Feb 18;9(1):2207. doi: 10.1038/s41598-019-38613-8.
148 Tumor necrosis factor superfamily ligand mRNA expression profiles differ between humans and mice during homeostasis and between various murine kidney injuries.J Biomed Sci. 2017 Sep 19;24(1):77. doi: 10.1186/s12929-017-0383-3.
149 Angiotensin II induces kidney inflammatory injury and fibrosis through binding to myeloid differentiation protein-2 (MD2).Sci Rep. 2017 Mar 21;7:44911. doi: 10.1038/srep44911.
150 Performance of urinary kidney injury molecule-1, neutrophil gelatinase-associated lipocalin, and N-acetyl--D-glucosaminidase to predict chronic kidney disease progression and adverse outcomes.Braz J Med Biol Res. 2017 Mar 30;50(5):e6106. doi: 10.1590/1414-431X20176106.
151 Superoxide and hydrogen peroxide counterregulate myogenic contractions in renal afferent arterioles from a mouse model of chronic kidney disease.Kidney Int. 2017 Sep;92(3):625-633. doi: 10.1016/j.kint.2017.02.009. Epub 2017 Apr 7.
152 Exposure to nerve growth factor worsens nephrotoxic effect induced by Cyclosporine A in HK-2 cells. PLoS One. 2013 Nov 7;8(11):e80113. doi: 10.1371/journal.pone.0080113. eCollection 2013.
153 Tubular NOX4 expression decreases in chronic kidney disease but does not modify fibrosis evolution.Redox Biol. 2019 Sep;26:101234. doi: 10.1016/j.redox.2019.101234. Epub 2019 Jun 5.
154 The guanylate cyclase C agonist linaclotide ameliorates the gut-cardio-renal axis in an adenine-induced mouse model of chronic kidney disease.Nephrol Dial Transplant. 2020 Feb 1;35(2):250-264. doi: 10.1093/ndt/gfz126.
155 P2Y12 inhibitors in acute coronary syndrome patients with renal dysfunction: an analysis from the RENAMI and BleeMACS projects.Eur Heart J Cardiovasc Pharmacother. 2020 Jan 1;6(1):31-42. doi: 10.1093/ehjcvp/pvz048.
156 Phospholipase D: A new mediator during high phosphate-induced vascular calcification associated with chronic kidney disease.J Cell Physiol. 2019 Apr;234(4):4825-4839. doi: 10.1002/jcp.27281. Epub 2018 Sep 12.
157 Periostin contributes to renal and cardiac dysfunction in rats with chronic kidney disease: Reduction of PPAR.Biochimie. 2019 May;160:172-182. doi: 10.1016/j.biochi.2019.03.003. Epub 2019 Mar 16.
158 The Ser/Thr kinase p90RSK promotes kidney fibrosis by modulating fibroblast-epithelial crosstalk.J Biol Chem. 2019 Jun 21;294(25):9901-9910. doi: 10.1074/jbc.RA119.007904. Epub 2019 May 10.
159 Serum protease activity in chronic kidney disease patients: The GANI_MED renal cohort.Exp Biol Med (Maywood). 2017 Mar;242(5):554-563. doi: 10.1177/1535370216684040. Epub 2016 Dec 30.
160 Altered expression of intestinal duodenal cytochrome b and divalent metal transporter 1 might be associated with cardio-renal anemia syndrome.Heart Vessels. 2017 Nov;32(11):1410-1414. doi: 10.1007/s00380-017-1013-4. Epub 2017 Jul 1.
161 AT1 Receptor Antagonism Improves Structural, Functional, and Biomechanical Properties in Resistance Arteries in a Rodent Chronic Kidney Disease Model.Am J Hypertens. 2018 May 7;31(6):696-705. doi: 10.1093/ajh/hpy021.
162 Uremic Toxin Indoxyl Sulfate Promotes Proinflammatory Macrophage Activation Via the Interplay of OATP2B1 and Dll4-Notch Signaling.Circulation. 2019 Jan 2;139(1):78-96. doi: 10.1161/CIRCULATIONAHA.118.034588.
163 SLCO4C1 transporter eliminates uremic toxins and attenuates hypertension and renal inflammation. J Am Soc Nephrol. 2009 Dec;20(12):2546-55.
164 Atorvastatin Improves Hepatic Lipid Metabolism and Protects Renal Damage in Adenine-Induced Chronic Kidney Disease in Sprague-Dawley Rats.Biomed Res Int. 2019 Nov 5;2019:8714363. doi: 10.1155/2019/8714363. eCollection 2019.
165 Sphingosine Kinase-2 Deficiency Ameliorates Kidney Fibrosis by Up-Regulating Smad7 in a Mouse Model of Unilateral Ureteral Obstruction.Am J Pathol. 2017 Nov;187(11):2413-2429. doi: 10.1016/j.ajpath.2017.06.017. Epub 2017 Aug 12.
166 Human SA gene Pst1 polymorphism and chronic renal failure: results of the family-based study.Nephrol Dial Transplant. 2001 Feb;16(2):387-90. doi: 10.1093/ndt/16.2.387.
167 The ligand-bound thyroid hormone receptor in macrophages ameliorates kidney injury via inhibition of nuclear factor-B activities.Sci Rep. 2017 Mar 8;7:43960. doi: 10.1038/srep43960.
168 Association Between a Polymorphism in MBOAT7 and Chronic Kidney Disease in Patients With Biopsy-Confirmed Nonalcoholic Fatty Liver Disease.Clin Gastroenterol Hepatol. 2020 Nov;18(12):2837-2839.e2. doi: 10.1016/j.cgh.2019.09.017. Epub 2019 Sep 20.
169 Soluble TWEAK and atheromatosis progression in patients with chronic kidney disease.Atherosclerosis. 2017 May;260:130-137. doi: 10.1016/j.atherosclerosis.2017.03.043. Epub 2017 Mar 31.
170 Elevated ecto-5'-nucleotidase-mediated increased renal adenosine signaling via A2B adenosine receptor contributes to chronic hypertension.Circ Res. 2013 May 24;112(11):1466-78. doi: 10.1161/CIRCRESAHA.111.300166. Epub 2013 Apr 12.
171 Association of genetic variants with chronic kidney disease in Japanese individuals with type 2 diabetes mellitus.Int J Mol Med. 2009 Apr;23(4):529-37. doi: 10.3892/ijmm_00000161.
172 New loci associated with kidney function and chronic kidney disease.Nat Genet. 2010 May;42(5):376-84. doi: 10.1038/ng.568. Epub 2010 Apr 11.
173 CD248+ stromal cells are associated with progressive chronic kidney disease.Kidney Int. 2011 Jul;80(2):199-207. doi: 10.1038/ki.2011.103. Epub 2011 Apr 13.
174 Association of dopaminergic pathway gene polymorphisms with chronic renal insufficiency among Asian Indians with type-2 diabetes.BMC Genet. 2008 Mar 22;9:26. doi: 10.1186/1471-2156-9-26.
175 Serum Glutaredoxin Activity as a Marker of Oxidative Stress in Chronic Kidney Disease: A Pilot Study.Nephron. 2018;140(4):249-256. doi: 10.1159/000492500. Epub 2018 Sep 25.
176 Hepatocyte nuclear factors as possible C-reactive protein transcriptional inducer in the liver and white adipose tissue of rats with experimental chronic renal failure.Mol Cell Biochem. 2018 Sep;446(1-2):11-23. doi: 10.1007/s11010-018-3268-1. Epub 2018 Jan 12.
177 Association of genetic variants with chronic kidney disease in individuals with different lipid profiles.Int J Mol Med. 2009 Aug;24(2):233-46. doi: 10.3892/ijmm_00000226.
178 CKD in MYH9-related disorders.Am J Kidney Dis. 2009 Oct;54(4):732-40. doi: 10.1053/j.ajkd.2009.06.023. Epub 2009 Sep 2.
179 Changes in FGF-23, Neutrophil/Platelet Activation Markers, and Angiogenin in Advanced Chronic Kidney Disease and Their Effect on Arterial Stiffness.Kidney Blood Press Res. 2019;44(5):1166-1178. doi: 10.1159/000502526. Epub 2019 Sep 25.
180 Association of gene polymorphisms with chronic kidney disease in high- or low-risk subjects defined by conventional risk factors.Int J Mol Med. 2009 Jun;23(6):785-92. doi: 10.3892/ijmm_00000193.
181 Common -globin variants modify hematologic and other clinical phenotypes in sickle cell trait and disease.PLoS Genet. 2018 Mar 28;14(3):e1007293. doi: 10.1371/journal.pgen.1007293. eCollection 2018 Mar.
182 Efficacy of different hemodialysis methods on dendritic cell marker CD40 and CD80 and platelet activation marker CD62P and P10 in patients with chronic renal failure.J Clin Lab Anal. 2019 Mar;33(3):e22713. doi: 10.1002/jcla.22713. Epub 2018 Nov 29.
183 Signal regulatory protein alpha initiates cachexia through muscle to adipose tissue crosstalk.J Cachexia Sarcopenia Muscle. 2019 Dec;10(6):1210-1227. doi: 10.1002/jcsm.12459. Epub 2019 Sep 11.
184 Genetics of serum urate concentrations and gout in a high-risk population, patients with chronic kidney disease.Sci Rep. 2018 Sep 4;8(1):13184. doi: 10.1038/s41598-018-31282-z.
185 Tenapanor: First Approval.Drugs. 2019 Nov;79(17):1897-1903. doi: 10.1007/s40265-019-01215-9.
186 High Mobility Group Box Protein-1 correlates with renal function in chronic kidney disease (CKD).Mol Med. 2008 Mar-Apr;14(3-4):109-15. doi: 10.2119/2007-00107.Bruchfeld.
187 Transketolase Activity but not Thiamine Membrane Transport Change in Response to Hyperglycaemia and Kidney Dysfunction.Exp Clin Endocrinol Diabetes. 2018 Apr;126(4):255-262. doi: 10.1055/s-0043-115009. Epub 2017 Sep 26.
188 Calcium-dependent expression of transient receptor potential canonical type 3 channels in patients with chronic kidney disease.Arch Biochem Biophys. 2011 Oct;514(1-2):44-9. doi: 10.1016/j.abb.2011.07.011. Epub 2011 Jul 23.
189 Renal Fibrosis, Immune Cell Infiltration and Changes of TRPC Channel Expression after Unilateral Ureteral Obstruction in Trpc6-/- Mice.Cell Physiol Biochem. 2019;52(6):1484-1502. doi: 10.33594/000000103.
190 Dual effect of chemokine CCL7/MCP-3 in the development of renal tubulointerstitial fibrosis.Biochem Biophys Res Commun. 2013 Aug 23;438(2):257-63. doi: 10.1016/j.bbrc.2013.07.025. Epub 2013 Jul 19.
191 Oxidative stress pathway genes and chronic renal insufficiency in Asian Indians with Type 2 diabetes.J Diabetes Complications. 2009 Mar-Apr;23(2):102-11. doi: 10.1016/j.jdiacomp.2007.10.003. Epub 2008 Apr 16.
192 Clinical and genetic factors influencing acenocoumarol dosing: a cross-sectional study.Blood Coagul Fibrinolysis. 2018 Sep;29(6):496-500. doi: 10.1097/MBC.0000000000000746.
193 Phosphate-dependent FGF23 secretion is modulated by PiT2/Slc20a2.Mol Metab. 2018 May;11:197-204. doi: 10.1016/j.molmet.2018.02.007. Epub 2018 Feb 26.
194 Low renin-angiotensin system activity gene polymorphism and dysplasia associated with posterior urethral valves.J Urol. 2005 Aug;174(2):713-7. doi: 10.1097/01.ju.0000164739.13408.e2.
195 The ABCC6 Transporter as a Paradigm for Networking from an Orphan Disease to Complex Disorders.Biomed Res Int. 2015;2015:648569. doi: 10.1155/2015/648569. Epub 2015 Aug 18.
196 Tubular iron deposition and iron handling proteins in human healthy kidney and chronic kidney disease.Sci Rep. 2018 Jun 19;8(1):9353. doi: 10.1038/s41598-018-27107-8.
197 An integrative study of the genetic, social and environmental determinants of chronic kidney disease characterized by tubulointerstitial damages in the North Central Region of Sri Lanka.J Occup Health. 2014;56(1):28-38. doi: 10.1539/joh.13-0172-oa. Epub 2013 Dec 18.
198 Sodium-dependent phosphate cotransporters and phosphate-induced calcification of vascular smooth muscle cells: redundant roles for PiT-1 and PiT-2.Arterioscler Thromb Vasc Biol. 2013 Nov;33(11):2625-32. doi: 10.1161/ATVBAHA.113.302249. Epub 2013 Aug 22.
199 Use of Physiologically Based Pharmacokinetic Modeling to Evaluate the Effect of Chronic Kidney Disease on the Disposition of Hepatic CYP2C8 and OATP1B Drug Substrates.Clin Pharmacol Ther. 2019 Mar;105(3):719-729. doi: 10.1002/cpt.1205. Epub 2018 Oct 26.
200 Dimethylarginine Dimethylaminohydrolase 1 Deficiency Induces the Epithelial to Mesenchymal Transition in Renal Proximal Tubular Epithelial Cells and Exacerbates Kidney Damage in Aged and Diabetic Mice.Antioxid Redox Signal. 2017 Dec 1;27(16):1347-1360. doi: 10.1089/ars.2017.7022. Epub 2017 Jul 7.
201 Chronic kidney disease induces left ventricular overexpression of the pro-hypertrophic microRNA-212.Sci Rep. 2019 Feb 4;9(1):1302. doi: 10.1038/s41598-018-37690-5.
202 Proteomic analysis of heart failure hospitalization among patients with chronic kidney disease: The Heart and Soul Study.PLoS One. 2018 Dec 17;13(12):e0208042. doi: 10.1371/journal.pone.0208042. eCollection 2018.
203 Candidate gene association study of coronary artery calcification in chronic kidney disease: findings from the CRIC study (Chronic Renal Insufficiency Cohort).J Am Coll Cardiol. 2013 Aug 27;62(9):789-98. doi: 10.1016/j.jacc.2013.01.103. Epub 2013 May 30.
204 Identification of dicarbonyl and L-xylulose reductase as a therapeutic target in human chronic kidney disease.JCI Insight. 2019 Jun 20;4(12):e128120. doi: 10.1172/jci.insight.128120. eCollection 2019 Jun 20.
205 Association of FMO3 Variants and Trimethylamine N-Oxide Concentration, Disease Progression, and Mortality in CKD Patients.PLoS One. 2016 Aug 11;11(8):e0161074. doi: 10.1371/journal.pone.0161074. eCollection 2016.
206 Genetic-Variation-Driven Gene-Expression Changes Highlight Genes with Important Functions for Kidney Disease.Am J Hum Genet. 2017 Jun 1;100(6):940-953. doi: 10.1016/j.ajhg.2017.05.004.
207 Metallothionein MT2A A-5G Polymorphism as a Risk Factor for Chronic Kidney Disease and Diabetes: Cross-Sectional and Cohort Studies.Toxicol Sci. 2016 Jul;152(1):181-93. doi: 10.1093/toxsci/kfw080. Epub 2016 Apr 27.
208 Subclinical hypothyroidism and the risk of chronic kidney disease in T2D subjects: A case-control and dose-response analysis.Medicine (Baltimore). 2017 Apr;96(15):e6519. doi: 10.1097/MD.0000000000006519.
209 Association analysis of ADPRT1, AKR1B1, RAGE, GFPT2 and PAI-1 gene polymorphisms with chronic renal insufficiency among Asian Indians with type-2 diabetes.BMC Med Genet. 2010 Mar 31;11:52. doi: 10.1186/1471-2350-11-52.
210 KDOQI US Commentary on the 2017 ACC/AHA Hypertension Guideline.Am J Kidney Dis. 2019 Apr;73(4):437-458. doi: 10.1053/j.ajkd.2019.01.007.
211 Association of candidate gene polymorphisms with chronic kidney disease in Japanese individuals with hypertension.Hypertens Res. 2009 May;32(5):411-8. doi: 10.1038/hr.2009.22. Epub 2009 Mar 13.
212 Aryl hydrocarbon receptor is activated in patients and mice with chronic kidney disease.Kidney Int. 2018 Apr;93(4):986-999. doi: 10.1016/j.kint.2017.11.010. Epub 2018 Feb 1.
213 ALPK1 regulates streptozotocin-induced nephropathy through CCL2 and CCL5 expressions.J Cell Mol Med. 2019 Nov;23(11):7699-7708. doi: 10.1111/jcmm.14643. Epub 2019 Sep 26.
214 Integrin linked kinase regulates the transcription of AQP2 by NFATC3.Biochim Biophys Acta Gene Regul Mech. 2017 Sep;1860(9):922-935. doi: 10.1016/j.bbagrm.2017.07.006. Epub 2017 Jul 20.
215 Comparison of readout-segmented and conventional single-shot for echo-planar diffusion-weighted imaging in the assessment of kidney interstitial fibrosis.J Magn Reson Imaging. 2017 Dec;46(6):1631-1640. doi: 10.1002/jmri.25687. Epub 2017 Mar 10.
216 Uraemia-induced immune senescence and clinical outcomes in chronic kidney disease patients.Nephrol Dial Transplant. 2020 Apr 1;35(4):624-632. doi: 10.1093/ndt/gfy276.
217 Genome-Wide Association Study of Renal Function Traits: Results from the Japan Multi-Institutional Collaborative Cohort Study.Am J Nephrol. 2018;47(5):304-316. doi: 10.1159/000488946. Epub 2018 May 18.
218 Vitamin K role in mineral and bone disorder of chronic kidney disease.Clin Chim Acta. 2020 Mar;502:66-72. doi: 10.1016/j.cca.2019.11.040. Epub 2019 Dec 11.
219 Early Postoperative Neutrophil Gelatinase-Associated Lipocalin Predicts the Development of Chronic Kidney Disease After Liver Transplantation.Transplantation. 2018 May;102(5):809-815. doi: 10.1097/TP.0000000000002075.
220 Serum Resistin, Adenylate Cyclase-Associated Protein 1 Gene Expression, and Carotid Intima-Media Thickness in Patients with End-Stage Renal Disease and Healthy Controls.Cardiorenal Med. 2020;10(1):51-60. doi: 10.1159/000503416. Epub 2019 Nov 13.
221 Difference in SBP between arms is a predictor of chronic kidney disease development in the general Korean population.J Hypertens. 2019 Apr;37(4):790-794. doi: 10.1097/HJH.0000000000001931.
222 Chromogranin A pathway: from pathogenic molecule to renal disease.J Hypertens. 2020 Mar;38(3):456-466. doi: 10.1097/HJH.0000000000002295.
223 ClC-5 alleviates renal fibrosis in unilateral ureteral obstruction mice.Hum Cell. 2019 Jul;32(3):297-305. doi: 10.1007/s13577-019-00253-5. Epub 2019 May 3.
224 Preoperative chronic kidney disease predicts poor oncological outcomes after radical cystectomy in patients with muscle-invasive bladder cancer.Oncotarget. 2017 May 29;8(37):61404-61414. doi: 10.18632/oncotarget.18248. eCollection 2017 Sep 22.
225 Getting a Notch closer to renal dysfunction: activated Notch suppresses expression of the adaptor protein Disabled-2 in tubular epithelial cells.FASEB J. 2019 Jan;33(1):821-832. doi: 10.1096/fj.201800392RR. Epub 2018 Jul 27.
226 Validity of self blood pressure measurement in the control of the hypertensive patient: factors involved.BMC Cardiovasc Disord. 2019 Jul 17;19(1):171. doi: 10.1186/s12872-019-1145-9.
227 High serum levels of p,p'-DDE are associated with an accelerated decline in GFR during 10years follow-up.Sci Total Environ. 2018 Dec 10;644:371-374. doi: 10.1016/j.scitotenv.2018.07.020. Epub 2018 Jul 5.
228 Protective effects of Salvia miltiorrhiza on adenine-induced chronic renal failure by regulating the metabolic profiling and modulating the NADPH oxidase/ROS/ERK and TGF-/Smad signaling pathways.J Ethnopharmacol. 2018 Feb 15;212:153-165. doi: 10.1016/j.jep.2017.09.021. Epub 2017 Oct 12.
229 Increased FGF23 protects against detrimental cardio-renal consequences during elevated blood phosphate in CKD.JCI Insight. 2019 Feb 21;4(4):e123817. doi: 10.1172/jci.insight.123817. eCollection 2019 Feb 21.
230 Bromodomain and Extraterminal Proteins as Novel Epigenetic Targets for Renal Diseases.Front Pharmacol. 2019 Nov 8;10:1315. doi: 10.3389/fphar.2019.01315. eCollection 2019.
231 Analysis of chronic kidney disease staging with different estimated glomerular filtration rate equations in Chinese centenarians.Chin Med J (Engl). 2019 Mar 5;132(5):512-518. doi: 10.1097/CM9.0000000000000079.
232 Liver stiffness assessed by transient elastography as a potential indicator of chronic kidney disease in patients with nonalcoholic fatty liver disease.J Clin Lab Anal. 2019 Feb;33(2):e22657. doi: 10.1002/jcla.22657. Epub 2018 Sep 21.
233 Arterial tissue transcriptional profiles associate with tissue remodeling and cardiovascular phenotype in children with end-stage kidney disease.Sci Rep. 2019 Jul 16;9(1):10316. doi: 10.1038/s41598-019-46805-5.
234 Effect of achieved hemoglobin level on renal outcome in non-dialysis chronic kidney disease (CKD) patients receiving epoetin beta pegol: MIRcerA CLinical Evidence on Renal Survival in CKD patients with renal anemia (MIRACLE-CKD Study).Clin Exp Nephrol. 2019 Mar;23(3):349-361. doi: 10.1007/s10157-018-1649-0. Epub 2018 Oct 5.
235 A risk prediction model for renal damage in a hypertensive Chinese Han population.Clin Exp Hypertens. 2019;41(6):552-557. doi: 10.1080/10641963.2018.1523913. Epub 2018 Oct 9.
236 Urotensin II Induces Mice Skeletal Muscle Atrophy Associated with Enhanced Autophagy and Inhibited Irisin Precursor (Fibronectin Type III Domain Containing 5) Expression in Chronic Renal Failure.Kidney Blood Press Res. 2019;44(4):479-495. doi: 10.1159/000499880. Epub 2019 Jun 25.
237 Identification of nuclear localization, DNA binding, and transactivating mechanisms of Kruppel-like zinc finger protein Gli-similar 2 (Glis2).J Biol Chem. 2011 Feb 11;286(6):4749-59. doi: 10.1074/jbc.M110.165951. Epub 2010 Dec 2.
238 Expression and clinical value of gastrin-releasing peptide precursor in nephropathy and chronic kidney disease.Nephrology (Carlton). 2020 May;25(5):398-405. doi: 10.1111/nep.13642. Epub 2019 Aug 29.
239 Mutational screening of inverted formin 2 in adult-onset focal segmental glomerulosclerosis or minimal change patients from the Czech Republic.BMC Med Genet. 2018 Aug 20;19(1):147. doi: 10.1186/s12881-018-0667-9.
240 Krppel-like Factor 15: A Potential Therapeutic Target For Kidney Disease.Int J Biol Sci. 2019 Jul 21;15(9):1955-1961. doi: 10.7150/ijbs.34838. eCollection 2019.
241 Prevalence and organ distribution of leukocyte chemotactic factor 2 amyloidosis (ALECT2) among decedents in New Mexico.Amyloid. 2016 Jun;23(2):119-23. doi: 10.3109/13506129.2016.1145110. Epub 2016 Feb 25.
242 Arterial calcification: a tumor necrosis factor-alpha mediated vascular Wnt-opathy.Transl Res. 2008 May;151(5):233-9. doi: 10.1016/j.trsl.2007.12.005. Epub 2008 Jan 22.
243 Dietary Fermentable Fibers Attenuate Chronic Kidney Disease in Mice by Protecting the Intestinal Barrier.J Nutr. 2018 Apr 1;148(4):552-561. doi: 10.1093/jn/nxy008.
244 TUDCA-treated chronic kidney disease-derived hMSCs improve therapeutic efficacy in ischemic disease via PrP(C).Redox Biol. 2019 Apr;22:101144. doi: 10.1016/j.redox.2019.101144. Epub 2019 Feb 16.
245 Peroxisome Proliferator-Activated Receptor- Coactivator-1 Inhibits Vascular Calcification Through Sirtuin 3-Mediated Reduction of Mitochondrial Oxidative Stress.Antioxid Redox Signal. 2019 Jul 1;31(1):75-91. doi: 10.1089/ars.2018.7620. Epub 2019 Apr 2.
246 Functional Prediction of Chronic Kidney Disease Susceptibility Gene PRKAG2 by Comprehensively Bioinformatics Analysis.Front Genet. 2018 Dec 3;9:573. doi: 10.3389/fgene.2018.00573. eCollection 2018.
247 Chemerin inhibits vascular calcification through ChemR23 and is associated with lower coronary calcium in chronic kidney disease.J Intern Med. 2019 Oct;286(4):449-457. doi: 10.1111/joim.12940. Epub 2019 Jul 7.
248 Low-dose hydralazine prevents fibrosis in a murine model of acute kidney injury-to-chronic kidney disease progression.Kidney Int. 2017 Jan;91(1):157-176. doi: 10.1016/j.kint.2016.07.042. Epub 2016 Sep 28.
249 Mechanisms of Protective Effects of SGLT2 Inhibitors in Cardiovascular Disease and Renal Dysfunction.Curr Top Med Chem. 2019;19(20):1818-1849. doi: 10.2174/1568026619666190828161409.
250 Long-term blood pressure variability and development of chronic kidney disease in type 2 diabetes.J Hypertens. 2019 Apr;37(4):805-813. doi: 10.1097/HJH.0000000000001950.
251 Shroom3 contributes to the maintenance of the glomerular filtration barrier integrity.Genome Res. 2015 Jan;25(1):57-65. doi: 10.1101/gr.182881.114. Epub 2014 Oct 1.
252 Febuxostat inhibits TGF?induced epithelialmesenchymal transition via downregulation of USAG? expression in MadinDarby canine kidney cells invitro.Mol Med Rep. 2019 Mar;19(3):1694-1704. doi: 10.3892/mmr.2019.9806. Epub 2019 Jan 2.
253 Effect of Omega-3 Fatty Acid on STAMP2 Expression in the Heart and Kidney of 5/6 Nephrectomy Rat Model.Mar Drugs. 2018 Oct 23;16(11):398. doi: 10.3390/md16110398.
254 Economic Issues of Chronic Kidney Disease and End-Stage Renal Disease.Contrib Nephrol. 2019;198:87-93. doi: 10.1159/000496533. Epub 2019 Apr 16.
255 A Mendelian Randomization-Based Approach to Identify Early and Sensitive Diagnostic Biomarkers of Disease.Clin Chem. 2019 Mar;65(3):427-436. doi: 10.1373/clinchem.2018.291104. Epub 2018 Oct 18.
256 Associations between genetic risk variants for kidney diseases and kidney disease etiology.Sci Rep. 2017 Oct 24;7(1):13944. doi: 10.1038/s41598-017-13356-6.
257 Role of Alstrm syndrome 1 in the regulation of blood pressure and renal function.JCI Insight. 2018 Nov 2;3(21):e95076. doi: 10.1172/jci.insight.95076.
258 Circulating 25-hydroxy vitamin D correlates with serum level of anti-Mllerian hormone in male patients with chronic kidney disease.Andrologia. 2018 Feb 14. doi: 10.1111/and.12972. Online ahead of print.
259 AQP5 promotes hepatocellular carcinoma metastasis via NF-B-regulated epithelial-mesenchymal transition.Biochem Biophys Res Commun. 2017 Aug 19;490(2):343-348. doi: 10.1016/j.bbrc.2017.06.046. Epub 2017 Jun 12.
260 Association of genetic variants with dyslipidemia and chronic kidney disease in a longitudinal population-based genetic epidemiological study.Int J Mol Med. 2015 May;35(5):1290-300. doi: 10.3892/ijmm.2015.2152. Epub 2015 Mar 20.
261 Genetic loci associated with renal function measures and chronic kidney disease in children: the Pediatric Investigation for Genetic Factors Linked with Renal Progression Consortium.Nephrol Dial Transplant. 2016 Feb;31(2):262-9. doi: 10.1093/ndt/gfv342. Epub 2015 Sep 28.
262 Obesity and chronic kidney disease progression-the role of a new adipocytokine: C1q/tumour necrosis factor-related protein-1.Clin Kidney J. 2018 Oct 11;12(3):420-426. doi: 10.1093/ckj/sfy095. eCollection 2019 Jun.
263 Identification of the first large deletion in the CLDN16 gene in a patient with FHHNC and late-onset of chronic kidney disease: case report.BMC Nephrol. 2015 Jul 2;16:92. doi: 10.1186/s12882-015-0079-4.
264 The role of molecular genetics in diagnosing familial hematuria(s).Pediatr Nephrol. 2012 Aug;27(8):1221-31. doi: 10.1007/s00467-011-1935-5. Epub 2011 Jun 19.
265 A novel Cys1638Tyr NC1 domain substitution in alpha5(IV) collagen causes Alport syndrome with late onset renal failure without hearing loss or eye abnormalities.Nephrol Dial Transplant. 2007 May;22(5):1338-46. doi: 10.1093/ndt/gfl793. Epub 2007 Feb 3.
266 Follow-up results of patients with ADCK4 mutations and the efficacy of CoQ10 treatment.Pediatr Nephrol. 2017 Aug;32(8):1369-1375. doi: 10.1007/s00467-017-3634-3. Epub 2017 Mar 24.
267 Systemic inflammation is associated with exaggerated skeletal muscle protein catabolism in maintenance hemodialysis patients.JCI Insight. 2017 Nov 16;2(22):e95185. doi: 10.1172/jci.insight.95185. eCollection 2017 Nov 16.
268 Fractional excretion as a new marker of tubular damage in children with chronic kidney disease.Clin Chim Acta. 2018 May;480:99-106. doi: 10.1016/j.cca.2018.02.001. Epub 2018 Feb 6.
269 NLRP3 inflammasome inhibition attenuates cisplatin-induced renal fibrosis by decreasing oxidative stress and inflammation.Exp Cell Res. 2019 Oct 1;383(1):111488. doi: 10.1016/j.yexcr.2019.07.001. Epub 2019 Jul 2.
270 Advanced glycation end products in the pathogenesis of chronic kidney disease.Kidney Int. 2018 Apr;93(4):803-813. doi: 10.1016/j.kint.2017.11.034. Epub 2018 Feb 22.
271 A novel SLC4A1 variant in an autosomal dominant distal renal tubular acidosis family with a severe phenotype.Endocrine. 2010 Jun;37(3):473-8. doi: 10.1007/s12020-010-9340-6. Epub 2010 Apr 17.
272 Polymorphisms in the non-muscle myosin heavy chain gene (MYH9) are associated with lower glomerular filtration rate in mixed ancestry diabetic subjects from South Africa.PLoS One. 2012;7(12):e52529. doi: 10.1371/journal.pone.0052529. Epub 2012 Dec 20.
273 Long-term renal outcome in children with OCRL mutations: retrospective analysis of a large international cohort.Nephrol Dial Transplant. 2018 Jan 1;33(1):85-94. doi: 10.1093/ndt/gfw350.
274 Proenkephalin and risk of developing chronic kidney disease: the Prevention of Renal and Vascular End-stage Disease study.Biomarkers. 2018 Jul;23(5):474-482. doi: 10.1080/1354750X.2018.1443514. Epub 2018 Mar 8.
275 Alternative splicing events is not a key event for gene expression regulation in uremia.PLoS One. 2013 Dec 16;8(12):e82702. doi: 10.1371/journal.pone.0082702. eCollection 2013.
276 Nucleotide-Binding Oligomerization Domain-Like Receptor Protein 3 Deficiency in Vascular Smooth Muscle Cells Prevents Arteriovenous Fistula Failure Despite Chronic Kidney Disease.J Am Heart Assoc. 2019 Jan 8;8(1):e011211. doi: 10.1161/JAHA.118.011211.
277 You-Gui-Yin improved the reproductive dysfunction of male rats with chronic kidney disease via regulating the HIF1-STAT5 pathway.J Ethnopharmacol. 2020 Jan 10;246:112240. doi: 10.1016/j.jep.2019.112240. Epub 2019 Sep 14.
278 RBM10-TFE3 renal cell carcinoma characterised by paracentric inversion with consistent closely split signals in break-apart fluorescence in-situ hybridisation: study of 10 cases and a literature review.Histopathology. 2019 Aug;75(2):254-265. doi: 10.1111/his.13866. Epub 2019 Jun 25.
279 A tubulointerstitial nephritis antigen gene defect causes childhood-onset chronic renal failure.Pediatr Nephrol. 2010 Jul;25(7):1349-53. doi: 10.1007/s00467-010-1463-8. Epub 2010 Feb 16.
280 Long-noncoding RNA Atrolnc-1 promotes muscle wasting in mice with chronic kidney disease.J Cachexia Sarcopenia Muscle. 2018 Oct;9(5):962-974. doi: 10.1002/jcsm.12321. Epub 2018 Jul 24.
281 Impact of serum albumin levels on long-term outcomes in patients undergoing percutaneous coronary intervention.Heart Vessels. 2017 Sep;32(9):1085-1092. doi: 10.1007/s00380-017-0981-8. Epub 2017 Apr 20.
282 The Atypical Chemokine Receptor 2 Limits Progressive Fibrosis after Acute Ischemic Kidney Injury.Am J Pathol. 2019 Feb;189(2):231-247. doi: 10.1016/j.ajpath.2018.09.016. Epub 2018 Nov 16.
283 Dietary supplementation with ketoacids protects against CKD-induced oxidative damage and mitochondrial dysfunction in skeletal muscle of 5/6 nephrectomised rats.Skelet Muscle. 2018 May 31;8(1):18. doi: 10.1186/s13395-018-0164-z.
284 Descriptive Study of Aneurysmal and Nonaneurysmal Subarachnoid Hemorrhage and the Role of Confirmative Digital Subtraction Angiography in Patients with Nonaneurysmal Subarachnoid in Puerto Rico.World Neurosurg. 2020 Feb;134:e481-e486. doi: 10.1016/j.wneu.2019.10.104. Epub 2019 Oct 28.
285 L-Homoarginine and its AGXT2-metabolite GOCA in chronic kidney disease as markers for clinical status and prognosis.Amino Acids. 2018 Oct;50(10):1347-1356. doi: 10.1007/s00726-018-2610-y. Epub 2018 Jul 7.
286 Mitsugumin 53 promotes mitochondrial autophagy through regulating Ambra1 expression in C2C12 myoblast cells.Cell Biol Int. 2019 Mar;43(3):290-298. doi: 10.1002/cbin.11097. Epub 2019 Feb 7.
287 Drug disposition model of radiolabeled etelcalcetide in patients with chronic kidney disease and secondary hyperparathyroidism on hemodialysis.J Pharmacokinet Pharmacodyn. 2017 Feb;44(1):43-53. doi: 10.1007/s10928-016-9503-z. Epub 2017 Jan 6.
288 Apolipoprotein M in patients with chronic kidney disease.Atherosclerosis. 2018 Aug;275:304-311. doi: 10.1016/j.atherosclerosis.2018.06.815. Epub 2018 Jun 15.
289 Aquaporin 11 rs2276415 variant and progression of chronic kidney disease.Nephrol Dial Transplant. 2019 Jun 1;34(6):970-973. doi: 10.1093/ndt/gfy219.
290 Branched-chain amino acids in health and disease: metabolism, alterations in blood plasma, and as supplements.Nutr Metab (Lond). 2018 May 3;15:33. doi: 10.1186/s12986-018-0271-1. eCollection 2018.
291 Identification of C21orf59 and ATG2A as novel determinants of renal function-related traits in Japanese by exome-wide association studies.Oncotarget. 2017 Jul 11;8(28):45259-45273. doi: 10.18632/oncotarget.16696.
292 Intracellular calcium increases in vascular smooth muscle cells with progression of chronic kidney disease in a rat model.Nephrol Dial Transplant. 2017 Mar 1;32(3):450-458. doi: 10.1093/ndt/gfw274.
293 (Pro)renin Receptor Blockade Ameliorates Heart Failure Caused by Chronic Kidney Disease.J Card Fail. 2019 Apr;25(4):286-300. doi: 10.1016/j.cardfail.2019.02.009. Epub 2019 Feb 13.
294 Association between kidney function and genetic polymorphisms in atherosclerotic and chronic kidney diseases: A cross-sectional study in Japanese male workers.PLoS One. 2017 Oct 10;12(10):e0185476. doi: 10.1371/journal.pone.0185476. eCollection 2017.
295 The cartonectin levels at different stages of chronic kidney disease and related factors.Ren Fail. 2019 Feb 7;41(1):42-46. doi: 10.1080/0886022X.2018.1561373. eCollection 2019.
296 HCC-1, a novel chemokine from human plasma.J Exp Med. 1996 Jan 1;183(1):295-9. doi: 10.1084/jem.183.1.295.
297 The CDK9-cyclin T1 complex mediates saturated fatty acid-induced vascular calcification by inducing expression of the transcription factor CHOP.J Biol Chem. 2018 Nov 2;293(44):17008-17020. doi: 10.1074/jbc.RA118.004706. Epub 2018 Sep 12.
298 Mutations in six nephrosis genes delineate a pathogenic pathway amenable to treatment. Nat Commun. 2018 May 17;9(1):1960. doi: 10.1038/s41467-018-04193-w.
299 Elevated MIF-2 levels predict mortality in critically ill patients.J Crit Care. 2017 Aug;40:52-57. doi: 10.1016/j.jcrc.2017.03.012. Epub 2017 Mar 16.
300 Revised Equations to Estimate Glomerular Filtration Rate from Serum Creatinine and Cystatin C in China.Kidney Blood Press Res. 2019;44(4):553-564. doi: 10.1159/000500460. Epub 2019 Jun 28.
301 Electrophoretic patterns of proteinuria in feline spontaneous chronic kidney disease.J Feline Med Surg. 2020 Feb;22(2):114-121. doi: 10.1177/1098612X19827597. Epub 2019 Feb 6.
302 A miR-1207-5p binding site polymorphism abolishes regulation of HBEGF and is associated with disease severity in CFHR5 nephropathy.PLoS One. 2012;7(2):e31021. doi: 10.1371/journal.pone.0031021. Epub 2012 Feb 2.
303 Role of Cardio-Specific Micro-RibonucleicAcids and Correlation with Cardiac Biomarkers in Acute Coronary Syndrome: A Comprehensive Systematic Review.Cureus. 2019 Oct 9;11(10):e5878. doi: 10.7759/cureus.5878.
304 Ferric citrate reduces fibroblast growth factor 23 levels and improves renal and cardiac function inamouse model of chronic kidney disease.Kidney Int. 2019 Dec;96(6):1346-1358. doi: 10.1016/j.kint.2019.07.026. Epub 2019 Aug 30.
305 Discordant association of the CREBRF rs373863828 A allele with increased BMI and protection from type 2 diabetes in Mori and Pacific (Polynesian) people living in Aotearoa/New Zealand.Diabetologia. 2018 Jul;61(7):1603-1613. doi: 10.1007/s00125-018-4623-1. Epub 2018 May 2.
306 Incidence, Risk Factors, and Outcomes of Transition of Acute Kidney Injury to Chronic Kidney Disease in Cirrhosis: A Prospective Cohort Study.Hepatology. 2020 Mar;71(3):1009-1022. doi: 10.1002/hep.30859. Epub 2019 Oct 24.
307 Acute renal outcomes with sodium-glucose co-transporter-2 inhibitors: Real-world data analysis.Diabetes Obes Metab. 2019 Feb;21(2):340-348. doi: 10.1111/dom.13532. Epub 2018 Oct 15.
308 Activating transcription factor-4 promotes mineralization in vascular smooth muscle cells.JCI Insight. 2016 Nov 3;1(18):e88646. doi: 10.1172/jci.insight.88646.
309 Activated NF-B/Nrf2 and Wnt/-catenin pathways are associated with lipid metabolism in CKD patients with microalbuminuria and macroalbuminuria.Biochim Biophys Acta Mol Basis Dis. 2019 Sep 1;1865(9):2317-2332. doi: 10.1016/j.bbadis.2019.05.010. Epub 2019 May 16.
310 Adropin and irisin in arterial hypertension, diabetes mellitus and chronic kidney disease.Adv Clin Exp Med. 2019 Nov;28(11):1571-1575. doi: 10.17219/acem/104551.
311 Adiponectin is related to markers of endothelial dysfunction and neoangiogenesis in diabetic patients.Int Urol Nephrol. 2018 Sep;50(9):1661-1666. doi: 10.1007/s11255-018-1890-1. Epub 2018 May 26.
312 EXTL2 controls liver regeneration and aortic calcification through xylose kinase-dependent regulation of glycosaminoglycan biosynthesis.Matrix Biol. 2014 Apr;35:18-24. doi: 10.1016/j.matbio.2013.10.010. Epub 2013 Oct 24.
313 Karyomegalic Interstitial Nephritis: A Case Report and Review of the Literature.Medicine (Baltimore). 2016 May;95(20):e3349. doi: 10.1097/MD.0000000000003349.
314 FAR2 is associated with kidney disease in mice and humans.Physiol Genomics. 2018 Aug 1;50(8):543-552. doi: 10.1152/physiolgenomics.00118.2017. Epub 2018 Apr 13.
315 Fetuin-B Links Nonalcoholic Fatty Liver Disease to Chronic Kidney Disease in Obese Chinese Adults: A Cross-Sectional Study.Ann Nutr Metab. 2019;74(4):287-295. doi: 10.1159/000499843. Epub 2019 Apr 9.
316 Nuclear factor erythroid 2-related factor 2 as a treatment target of kidney diseases.Curr Opin Nephrol Hypertens. 2020 Jan;29(1):128-135. doi: 10.1097/MNH.0000000000000556.
317 Familial tumoral calcinosis and the role of O-glycosylation in the maintenance of phosphate homeostasis.Biochim Biophys Acta. 2009 Sep;1792(9):847-52. doi: 10.1016/j.bbadis.2008.10.008. Epub 2008 Oct 25.
318 Association of common gene variants in glucokinase regulatory protein with cardiorenal disease: A systematic review and meta-analysis.PLoS One. 2018 Oct 23;13(10):e0206174. doi: 10.1371/journal.pone.0206174. eCollection 2018.
319 Review of glucagon-like peptide-1 receptor agonists for the treatment of type 2 diabetes mellitus in patients with chronic kidney disease and their renal effects.J Diabetes. 2019 Dec;11(12):938-948. doi: 10.1111/1753-0407.12969. Epub 2019 Aug 14.
320 Activation of GSDMD contributes to acute kidney injury induced by cisplatin.Am J Physiol Renal Physiol. 2020 Jan 1;318(1):F96-F106. doi: 10.1152/ajprenal.00351.2019. Epub 2019 Nov 4.
321 Structural impact analysis of missense SNPs present in the uroguanylin gene by long-term molecular dynamics simulations.J Theor Biol. 2016 Dec 7;410:9-17. doi: 10.1016/j.jtbi.2016.09.008. Epub 2016 Sep 9.
322 Guanylin and uroguanylin regulate electrolyte transport in isolated human cortical collecting ducts.Kidney Int. 2005 Apr;67(4):1420-7. doi: 10.1111/j.1523-1755.2005.00219.x.
323 Screening potential prognostic biomarkers of long non-coding RNAs for predicting the risk of chronic kidney disease.Braz J Med Biol Res. 2019 Nov 7;52(11):e8333. doi: 10.1590/1414-431X20198333. eCollection 2019.
324 Effect of atorvastatin on iron metabolism regulation in patients with chronic kidney disease - a randomized double blind crossover study.Ren Fail. 2018 Nov;40(1):700-709. doi: 10.1080/0886022X.2018.1535983.
325 Interferon (IFN)-Induced Protein 35 (IFI35), a Type I Interferon-Dependent Transcript, Upregulates Inflammatory Signaling Pathways by Activating Toll-Like Receptor 3 in Human Mesangial Cells.Kidney Blood Press Res. 2016;41(5):635-642. doi: 10.1159/000447932. Epub 2016 Sep 17.
326 Elements of Palliative Care in the Last 6Months of Life: Frequency, Predictors, and Timing.J Gen Intern Med. 2020 Mar;35(3):753-761. doi: 10.1007/s11606-019-05349-0. Epub 2019 Oct 24.
327 Electronegative LDL-mediated cardiac electrical remodeling in a rat model of chronic kidney disease.Sci Rep. 2017 Jan 17;7:40676. doi: 10.1038/srep40676.
328 Common charge-shift mutation Glu65Lys in K+ channel ?Subunit KCNMB1: pleiotropic consequences for glomerular filtration rate and progressive renal disease.Am J Nephrol. 2010;32(5):414-24. doi: 10.1159/000320131. Epub 2010 Sep 23.
329 Intelligent Diagnostic Prediction and Classification System for Chronic Kidney Disease.Sci Rep. 2019 Jul 3;9(1):9583. doi: 10.1038/s41598-019-46074-2.
330 Keratin 18 and heat-shock protein in chronic kidney disease.Adv Clin Chem. 2013;62:123-49. doi: 10.1016/b978-0-12-800096-0.00003-2.
331 A novel biomarker of laminin turnover is associated with disease progression and mortality in chronic kidney disease.PLoS One. 2018 Oct 1;13(10):e0204239. doi: 10.1371/journal.pone.0204239. eCollection 2018.
332 Anti-inflammatory effects of Lefty-1 in renal tubulointerstitial inflammation via regulation of the NF-B pathway.Int J Mol Med. 2018 Mar;41(3):1293-1304. doi: 10.3892/ijmm.2017.3327. Epub 2017 Dec 18.
333 Creasensor: SIMPLE technology for creatinine detection in plasma.Anal Chim Acta. 2018 Feb 13;1000:191-198. doi: 10.1016/j.aca.2017.11.026. Epub 2017 Nov 22.
334 Plasma Leucine-Rich -2-Glycoprotein 1 Predicts Rapid eGFR Decline and Albuminuria Progression in Type 2 Diabetes Mellitus.J Clin Endocrinol Metab. 2017 Oct 1;102(10):3683-3691. doi: 10.1210/jc.2017-00930.
335 Colistin Use in Patients with Chronic Kidney Disease: Are We Underdosing Patients?.Molecules. 2019 Feb 1;24(3):530. doi: 10.3390/molecules24030530.
336 Clinical Indices Can Standardize and Monitor Pediatric Care: A Novel Mechanism to Improve Quality and Safety.J Pediatr. 2018 Feb;193:190-195.e1. doi: 10.1016/j.jpeds.2017.09.073. Epub 2017 Dec 6.
337 Personalized Treatment for Small Renal Tumors: Decision Analysis of Competing Causes of Mortality.Radiology. 2019 Mar;290(3):732-743. doi: 10.1148/radiol.2018181114. Epub 2019 Jan 15.
338 Weighted Gene Correlation Network Analysis (WGCNA) Detected Loss of MAGI2 Promotes Chronic Kidney Disease (CKD) by Podocyte Damage.Cell Physiol Biochem. 2018;51(1):244-261. doi: 10.1159/000495205. Epub 2018 Nov 16.
339 Cardiovascular risk of sitagliptin in ischemic stroke patients with type 2 diabetes and chronic kidney disease: A nationwide cohort study.Medicine (Baltimore). 2018 Dec;97(52):e13844. doi: 10.1097/MD.0000000000013844.
340 Effect of diet protein restriction on progression of chronic kidney disease: A systematic review and meta-analysis.PLoS One. 2018 Nov 7;13(11):e0206134. doi: 10.1371/journal.pone.0206134. eCollection 2018.
341 Treatment of Uremic Pruritus: A Systematic Review.Am J Kidney Dis. 2017 Nov;70(5):638-655. doi: 10.1053/j.ajkd.2017.05.018. Epub 2017 Jul 15.
342 Different Abnormalities of Cortical Neural Synchronization Mechanisms in Patients with Mild Cognitive Impairment due to Alzheimer's and Chronic Kidney Diseases: An EEG Study.J Alzheimers Dis. 2018;65(3):897-915. doi: 10.3233/JAD-180245.
343 Identification of an argpyrimidine-modified protein in human red blood cells from schizophrenic patients: A possible biomarker for diseases involving carbonyl stress.Biochem Biophys Res Commun. 2017 Nov 4;493(1):573-577. doi: 10.1016/j.bbrc.2017.08.150. Epub 2017 Sep 1.
344 IgA nephropathy: an update.Curr Opin Nephrol Hypertens. 2017 May;26(3):165-171. doi: 10.1097/MNH.0000000000000312.
345 Evaluation of inactive Matrix-Gla-Protein (MGP) as a biomarker for incident and recurrent kidney stones.J Nephrol. 2020 Feb;33(1):101-107. doi: 10.1007/s40620-019-00623-0. Epub 2019 Jun 20.
346 RIPK3 promotes kidney fibrosis via AKT-dependent ATP citrate lyase.JCI Insight. 2018 Feb 8;3(3):e94979. doi: 10.1172/jci.insight.94979. eCollection 2018 Feb 8.
347 Detrimental effect of renin-angiotensin blockade on progression of chronic kidney disease at later stages: A matter of dosage adjustment?.Nefrologia (Engl Ed). 2020 Jan-Feb;40(1):38-45. doi: 10.1016/j.nefro.2019.02.013. Epub 2019 Jun 10.
348 Spontaneous Extracellular Matrix Accumulation in a Human in vitro Model of Renal Fibrosis Is Mediated by V Integrins.Nephron. 2019;142(4):328-350. doi: 10.1159/000499506. Epub 2019 May 2.
349 Incremental prognostic value of SPECT-MPI in chronic kidney disease: A reclassification analysis.J Nucl Cardiol. 2018 Oct;25(5):1658-1673. doi: 10.1007/s12350-016-0756-0. Epub 2017 Jan 3.
350 Identification of salivary peptidomic biomarkers in chronic kidney disease patients undergoing haemodialysis.Clin Chim Acta. 2019 Feb;489:154-161. doi: 10.1016/j.cca.2018.12.003. Epub 2018 Dec 7.
351 MXRA5 is a TGF-1-regulated human protein with anti-inflammatory and anti-fibrotic properties.J Cell Mol Med. 2017 Jan;21(1):154-164. doi: 10.1111/jcmm.12953. Epub 2016 Sep 6.
352 The incidence, prevalence and trends of Chronic Kidney Disease and Chronic Kidney Disease of uncertain aetiology (CKDu) in the North Central Province of Sri Lanka: an analysis of 30,566 patients.BMC Nephrol. 2019 Aug 28;20(1):338. doi: 10.1186/s12882-019-1501-0.
353 Molecular Markers of Tubulointerstitial Fibrosis and Tubular Cell Damage in Patients with Chronic Kidney Disease.PLoS One. 2015 Aug 28;10(8):e0136994. doi: 10.1371/journal.pone.0136994. eCollection 2015.
354 Stabilization of hypoxia-inducible factor 1 by cobalt chloride impairs podocyte morphology and slit-diaphragm function.J Cell Biochem. 2019 May;120(5):7667-7678. doi: 10.1002/jcb.28041. Epub 2018 Nov 1.
355 Higher Serum Levels of Osteoglycin Are Associated with All-Cause Mortality and Cardiovascular and Cerebrovascular Events in Patients with Advanced Chronic Kidney Disease.Tohoku J Exp Med. 2017 Aug;242(4):281-290. doi: 10.1620/tjem.242.281.
356 Effects of carnitine on oxidative stress response to intravenous iron administration to patients with CKD: impact of haptoglobin phenotype.BMC Nephrol. 2015 Aug 13;16:135. doi: 10.1186/s12882-015-0119-0.
357 Effects of vadadustat on hemoglobin concentrations in patients receiving hemodialysis previously treated with erythropoiesis-stimulating agents.Nephrol Dial Transplant. 2019 Jan 1;34(1):90-99. doi: 10.1093/ndt/gfy055.
358 Elevated serum levels of procollagen C-proteinase enhancer-1 in patients with chronic kidney disease is associated with a declining glomerular filtration rate.Nephrology (Carlton). 2019 Sep;24(9):938-942. doi: 10.1111/nep.13521. Epub 2019 Apr 29.
359 Hypoxia-inducible factor stabilizers for treating anemia of chronic kidney disease.Curr Opin Nephrol Hypertens. 2018 Sep;27(5):331-338. doi: 10.1097/MNH.0000000000000431.
360 Reduction of mitochondria and up regulation of pyruvate dehydrogenase kinase 4 of skeletal muscle in patients with chronic kidney disease.Nephrology (Carlton). 2020 Mar;25(3):230-238. doi: 10.1111/nep.13606. Epub 2019 Jun 7.
361 The association of profilin-1 levels with survival in chronic kidney disease.Eur J Clin Invest. 2017 Dec;47(12). doi: 10.1111/eci.12839. Epub 2017 Oct 27.
362 Association of the salivary triggering receptor expressed on myeloid cells/its ligand peptidoglycan recognition protein 1 axis with oral inflammation in kidney disease.J Periodontol. 2018 Jan;89(1):117-129. doi: 10.1902/jop.2017.170218.
363 CKD autophagy activation and skeletal muscle atrophy-a preliminary study of mitophagy and inflammation.Eur J Clin Nutr. 2019 Jun;73(6):950-960. doi: 10.1038/s41430-018-0381-x. Epub 2019 Jan 3.
364 Papillary renal cell carcinoma with a somatic mutation in MET in a patient with autosomal dominant polycystic kidney disease.Cancer Genet. 2016 Jan-Feb;209(1-2):11-20. doi: 10.1016/j.cancergen.2015.11.002. Epub 2015 Dec 1.
365 Abnormalities in focal adhesion complex formation, regulation, and function in human autosomal recessive polycystic kidney disease epithelial cells.Am J Physiol Cell Physiol. 2010 Apr;298(4):C831-46. doi: 10.1152/ajpcell.00032.2009. Epub 2009 Nov 18.
366 Tubular Peroxiredoxin 3 as a Predictor of Renal Recovery from Acute Tubular Necrosis in Patients with Chronic Kidney Disease.Sci Rep. 2017 Feb 27;7:43589. doi: 10.1038/srep43589.
367 Chronic kidney disease and vitamin D metabolism in human bone marrow-derived MSCs.Ann N Y Acad Sci. 2017 Aug;1402(1):43-55. doi: 10.1111/nyas.13464.
368 The Long Pentraxin PTX3 Is an Endogenous Inhibitor of Hyperoxaluria-Related Nephrocalcinosis and Chronic Kidney Disease.Front Immunol. 2018 Sep 25;9:2173. doi: 10.3389/fimmu.2018.02173. eCollection 2018.
369 Efficacy and safety of once-monthly risedronate in osteoporosis subjects with mild-to-moderate chronic kidney disease: a post hoc subgroup analysis of a phase III trial in Japan.J Bone Miner Metab. 2019 Jul;37(4):730-740. doi: 10.1007/s00774-018-0977-1. Epub 2018 Dec 6.
370 Trans-ethnic Fine Mapping Highlights Kidney-Function Genes Linked to Salt Sensitivity.Am J Hum Genet. 2016 Sep 1;99(3):636-646. doi: 10.1016/j.ajhg.2016.07.012.
371 Hyperphosphatemia induces protective autophagy in endothelial cells through the inhibition of Akt/mTOR signaling.J Vasc Surg. 2015 Jul;62(1):210-221.e2. doi: 10.1016/j.jvs.2014.02.040. Epub 2014 May 3.
372 Renalase gene polymorphism and epinephrine level in chronic kidney disease.Appl Biochem Biotechnol. 2015 Feb;175(4):2309-17. doi: 10.1007/s12010-014-1433-x. Epub 2014 Dec 9.
373 Expression of the NRF2 Target Gene NQO1 Is Enhanced in Mononuclear Cells in Human Chronic Kidney Disease.Oxid Med Cell Longev. 2017;2017:9091879. doi: 10.1155/2017/9091879. Epub 2017 Jul 13.
374 News in pathophysiology, definition and classification of hepatorenal syndrome: A step beyond the International Club of Ascites (ICA) consensus document.J Hepatol. 2019 Oct;71(4):811-822. doi: 10.1016/j.jhep.2019.07.002. Epub 2019 Jul 11.
375 RTN1 mediates progression of kidney disease by inducing ER stress.Nat Commun. 2015 Jul 31;6:7841. doi: 10.1038/ncomms8841.
376 Catch-up growth in children with chronic kidney disease started on enteral feeding after 2 years of age.Pediatr Nephrol. 2020 Jan;35(1):113-118. doi: 10.1007/s00467-019-04382-9. Epub 2019 Oct 24.
377 Heterozygous Loss-of-Function SEC61A1 Mutations Cause Autosomal-Dominant Tubulo-Interstitial and Glomerulocystic Kidney Disease with Anemia.Am J Hum Genet. 2016 Jul 7;99(1):174-87. doi: 10.1016/j.ajhg.2016.05.028.
378 Circulating secreted frizzled-related protein 5 and chronic kidney disease in patients with acute ST-segment elevation myocardial infarction.Cytokine. 2018 Oct;110:367-373. doi: 10.1016/j.cyto.2018.04.009. Epub 2018 May 25.
379 Evaluation of the new Sebia free light chain assay using the AP22 ELITE instrument.Clin Chim Acta. 2018 Dec;487:161-167. doi: 10.1016/j.cca.2018.09.030. Epub 2018 Sep 20.
380 Role of Cytosolic Serine Hydroxymethyl Transferase 1 (SHMT1) in Phosphate-Induced Vascular Smooth Muscle Cell Calcification.Kidney Blood Press Res. 2018;43(4):1212-1221. doi: 10.1159/000492248. Epub 2018 Aug 2.
381 Barley--glucans reduce systemic inflammation, renal injury and aortic calcification through ADAM17 and neutral-sphingomyelinase2 inhibition.Sci Rep. 2019 Nov 28;9(1):17810. doi: 10.1038/s41598-019-54306-8.
382 Targeting STUB1-tissue factor axis normalizes hyperthrombotic uremic phenotype without increasing bleeding risk.Sci Transl Med. 2017 Nov 22;9(417):eaam8475. doi: 10.1126/scitranslmed.aam8475.
383 Sodium bicarbonate loading limits tubular cast formation independent of glomerular injury and proteinuria in Dahl salt-sensitive rats.Clin Sci (Lond). 2018 Jun 20;132(11):1179-1197. doi: 10.1042/CS20171630. Print 2018 Jun 15.
384 Increased trefoil factor 2 levels in patients with chronic kidney disease.PLoS One. 2017 Mar 29;12(3):e0174551. doi: 10.1371/journal.pone.0174551. eCollection 2017.
385 The Application of T.SPOT-TB Assay for Early Diagnosis of Active Tuberculosis in Chronic Kidney Disease Patients Receiving Immunosuppressive Treatment.J Invest Surg. 2020 Oct;33(9):853-858. doi: 10.1080/08941939.2019.1566417. Epub 2019 Mar 27.
386 Uremia Impacts VE-Cadherin and ZO-1 Expression in Human Endothelial Cell-to-Cell Junctions.Toxins (Basel). 2018 Oct 7;10(10):404. doi: 10.3390/toxins10100404.
387 Transmembrane protein 126B protects against high fat diet (HFD)-induced renal injury by suppressing dyslipidemia via inhibitionof ROS.Biochem Biophys Res Commun. 2019 Jan 29;509(1):40-47. doi: 10.1016/j.bbrc.2018.12.003. Epub 2018 Dec 20.
388 High-dose HOOK effect in urinary DcR2 assay in patients with chronic kidney disease.Clin Biochem. 2018 Aug;58:32-36. doi: 10.1016/j.clinbiochem.2018.06.001. Epub 2018 Jun 5.
389 A Drosophila model of insulin resistance associated with the human TRIB3 Q/R polymorphism.Dis Model Mech. 2017 Dec 19;10(12):1453-1464. doi: 10.1242/dmm.030619.
390 Effects of the Administration of 25(OH) Vitamin D3 in an Experimental Model of Chronic Kidney Disease in Animals Null for 1-Alpha-Hydroxylase.PLoS One. 2017 Jan 20;12(1):e0170654. doi: 10.1371/journal.pone.0170654. eCollection 2017.
391 Genetic polymorphisms and the risk of accelerated renal function decline in women.PLoS One. 2009;4(3):e4787. doi: 10.1371/journal.pone.0004787. Epub 2009 Mar 10.
392 Association of sickle cell trait with chronic kidney disease and albuminuria in African Americans.JAMA. 2014 Nov 26;312(20):2115-25. doi: 10.1001/jama.2014.15063.
393 Association of gene polymorphisms with chronic kidney disease in Japanese individuals.Int J Mol Med. 2009 Oct;24(4):539-47. doi: 10.3892/ijmm_00000263.
394 C4A deficiency and poor prognosis in patients with IgA nephropathy.Clin Nephrol. 1991 Jul;36(1):1-5.
395 Urinary mRNA expression of CCN2/CCN3 as a noninvasive marker for monitoring glomerular structure changes in nondiabetic chronic kidney disease.Biomarkers. 2012 Dec;17(8):714-20. doi: 10.3109/1354750X.2012.722229. Epub 2012 Oct 15.
396 Expression of parafibromin in distant metastatic parathyroid tumors in patients with advanced secondary hyperparathyroidism due to chronic kidney disease.World J Surg. 2008 May;32(5):815-21. doi: 10.1007/s00268-007-9458-8.
397 Indoxyl sulfate signals for rapid mRNA stabilization of Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 2 (CITED2) and suppresses the expression of hypoxia-inducible genes in experimental CKD and uremia.FASEB J. 2013 Oct;27(10):4059-75. doi: 10.1096/fj.13-231837. Epub 2013 Jun 21.
398 Claudin-19 mutations and clinical phenotype in Spanish patients with familial hypomagnesemia with hypercalciuria and nephrocalcinosis.PLoS One. 2013;8(1):e53151. doi: 10.1371/journal.pone.0053151. Epub 2013 Jan 3.
399 Genetic risk for myocardial infarction in Japanese individuals with or without chronic kidney disease.Int J Mol Med. 2010 May;25(5):743-9. doi: 10.3892/ijmm_00000400.
400 Association of CYBA rs7195830 polymorphism with estimated glomerular filtration rate in an adult Han sample from Jiangsu province, China.Chin Med J (Engl). 2013;126(17):3311-5.
401 Protection against loss of innate defenses in adulthood by low advanced glycation end products (AGE) intake: role of the antiinflammatory AGE receptor-1.J Clin Endocrinol Metab. 2009 Nov;94(11):4483-91. doi: 10.1210/jc.2009-0089. Epub 2009 Oct 9.
402 DNA hypermethylation and DNA hypomethylation is present at different loci in chronic kidney disease.Epigenetics. 2014 Mar;9(3):366-76. doi: 10.4161/epi.27161. Epub 2013 Nov 19.
403 Bone biopsy practice patterns across Europe: the European renal osteodystrophy initiative-a position paper.Nephrol Dial Transplant. 2017 Oct 1;32(10):1608-1613. doi: 10.1093/ndt/gfw468.
404 Serum Erythroferrone Levels Associate with Mortality and Cardiovascular Events in Hemodialysis and in CKD Patients: A Two Cohorts Study.J Clin Med. 2019 Apr 16;8(4):523. doi: 10.3390/jcm8040523.
405 Genome-wide association study for renal traits in the Framingham Heart and Atherosclerosis Risk in Communities Studies.BMC Med Genet. 2008 Jun 3;9:49. doi: 10.1186/1471-2350-9-49.
406 Identification of chromosome 3q28 and ALPK1 as susceptibility loci for chronic kidney disease in Japanese individuals by a genome-wide association study.J Med Genet. 2013 Jun;50(6):410-8. doi: 10.1136/jmedgenet-2013-101518. Epub 2013 Mar 28.
407 Association of a polymorphism of the apolipoprotein E gene with chronic kidney disease in Japanese individuals with metabolic syndrome.Genomics. 2009 Mar;93(3):221-6. doi: 10.1016/j.ygeno.2008.11.001. Epub 2008 Dec 6.
408 Intestinal fatty acid-binding protein levels in patients with chronic renal failure.J Surg Res. 2018 Oct;230:94-100. doi: 10.1016/j.jss.2018.04.057. Epub 2018 May 25.
409 Increased Serum Interleukin-34 Levels Are Related to the Presence and Severity of Cardiac Dysfunction in Patients With Ischemic Cardiomyopathy.Front Physiol. 2018 Jul 11;9:904. doi: 10.3389/fphys.2018.00904. eCollection 2018.
410 Multiple loci associated with indices of renal function and chronic kidney disease.Nat Genet. 2009 Jun;41(6):712-7. doi: 10.1038/ng.377. Epub 2009 May 10.
411 Decreased microRNA is involved in the vascular remodeling abnormalities in chronic kidney disease (CKD).PLoS One. 2013 May 22;8(5):e64558. doi: 10.1371/journal.pone.0064558. Print 2013.
412 Functional proteins involved in regulation of intracellular Ca(2+) for drug development: the extracellular calcium receptor and an innovative medical approach to control secondary hyperparathyroidism by calcimimetics.J Pharmacol Sci. 2005 Mar;97(3):355-60. doi: 10.1254/jphs.fmj04007x6. Epub 2005 Mar 17.
413 Poricoic acid A enhances melatonin inhibition of AKI-to-CKD transition by regulating Gas6/AxlNFB/Nrf2 axis.Free Radic Biol Med. 2019 Apr;134:484-497. doi: 10.1016/j.freeradbiomed.2019.01.046. Epub 2019 Feb 2.
414 Genetic variance in ABCB1 and CYP3A5 does not contribute toward the development of chronic kidney disease after liver transplantation.Pharmacogenet Genomics. 2014 Sep;24(9):427-35. doi: 10.1097/FPC.0000000000000063.
415 New PAX2 heterozygous mutation in a child with chronic kidney disease: a case report and review of the literature.BMC Nephrol. 2018 Sep 21;19(1):245. doi: 10.1186/s12882-018-1044-9.
416 Serum and urinary SOD3 in patients with type 2 diabetes: comparison with early chronic kidney disease patients and association with development of diabetic nephropathy.Am J Physiol Renal Physiol. 2019 Jan 1;316(1):F32-F41. doi: 10.1152/ajprenal.00401.2017. Epub 2018 Oct 10.