Details of the Drug Combinations

General Information of This Drug (ID: DMCE08M)

Drug Name
AT7519   DMCE08M
Synonyms LZE; AT 7519, AT7519; AT-7519; 4-[(2,6-dichlorobenzoyl)amino]-N-(4-piperidyl)-2H-pyrazole-3-carboxamide
Indication
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Phase 1 [1]
Therapeutic Class
Anticancer Agents
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

23 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
(-)-englerin A + AT7519 DC6PA4H (-)-englerin A Ewing sarcoma (Cell Line: TC-71) [2]
ABT-263 + AT7519 DCKKO2B ABT-263 Ewing sarcoma (Cell Line: TC-71) [3]
AT13387 + AT7519 DCZWL21 AT13387 Ewing sarcoma (Cell Line: TC-71) [2]
AT7519 + PF-3758309 DCXCTN2 PF-3758309 Ewing sarcoma (Cell Line: TC-71) [2]
AT7519 + JQ1 DC4MCSR JQ1 Ewing sarcoma (Cell Line: TC-71) [2]
AT7519 + Panobinostat DCKHYGR Panobinostat Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
AT7519 + Eltanexor oral DC16VO6 Eltanexor oral Ewing sarcoma (Cell Line: TC-71) [2]
AT7519 + Exherin DC6MVUM Exherin Ewing sarcoma (Cell Line: TC-71) [2]
AT7519 + SCH 727965 DCZW43S SCH 727965 Ewing sarcoma (Cell Line: TC-71) [2]
AT7519 + THAPSIGARGIN DC4JUJ5 THAPSIGARGIN Ewing sarcoma (Cell Line: TC-71) [2]
AT7519 + Mitomycin DCBE0UD Mitomycin Diffuse large B cell lymphoma (Cell Line: TMD8) [2]
AT7519 + Mitotane DC1F2RS Mitotane Ewing sarcoma (Cell Line: TC-71) [2]
AT7519 + Cytarabine DCPM6ER Cytarabine Ewing sarcoma (Cell Line: TC-71) [2]
AXL-1717 + AT7519 DCFZRDC AXL-1717 Ewing sarcoma (Cell Line: TC-71) [2]
BN-2629 + AT7519 DC1PRON BN-2629 Ewing sarcoma (Cell Line: TC-71) [2]
Efaproxyn + AT7519 DC4L9QL Efaproxyn Ewing sarcoma (Cell Line: TC-71) [2]
Epothilone D + AT7519 DC2BJ9C Epothilone D Ewing sarcoma (Cell Line: TC-71) [2]
Etoposide + AT7519 DC53VV8 Etoposide Ewing sarcoma (Cell Line: TC-71) [2]
Everolimus + AT7519 DCNV1VG Everolimus Ewing sarcoma (Cell Line: TC-71) [2]
MK-2206 + AT7519 DCJGM3N MK-2206 Ewing sarcoma (Cell Line: TC-71) [2]
Ombrabulin + AT7519 DCA1KXN Ombrabulin Ewing sarcoma (Cell Line: TC-71) [2]
Pelitinib + AT7519 DCCU40S Pelitinib Ewing sarcoma (Cell Line: TC-71) [2]
SNX-5422 + AT7519 DCJ498O SNX-5422 Ewing sarcoma (Cell Line: TC-71) [2]
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⏷ Show the Full List of 23 DrugCom(s)

References

1 ClinicalTrials.gov (NCT02503709) Onalespib and CDKI AT7519 in Treating Patients With Solid Tumors That Are Metastatic or Cannot Be Removed by Surgery in National Cancer Institute (NCI).
2 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
3 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.