Details of the Drug

General Information of Drug (ID: DMCLR6G)

Drug Name

Pegloticase

Synonyms

Krystexxa (TN)

Indication

Disease Entry	ICD 11	Status	REF
Gout	FA25	Approved	[1]
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Affected Organisms

Humans and other mammals

ATC Code

M04AX02: Pegloticase

M04AX: Other antigout preparations

M04A: ANTIGOUT PREPARATIONS

M04: ANTIGOUT PREPARATIONS

M: MUSCULO-SKELETAL SYSTEM

Sequence

TYKKNDEVEFVRTGYGKDMIKVLHIQRDGKYHSIKEVATTVQLTLSSKKDYLHGDNSDVI
PTDTIKNTVNVLAKFKGIKSIETFAVTICEHFLSSFKHVIRAQVYVEEVPWKRFEKNGVK
HVHAFIYTPTGTHFCEVEQIRNGPPVIHSGIKDLKVLKTTQSGFEGFIKDQFTTLPEVKD
RCFATQVYCKWRYHQGRDVDFEATWDTVRSIVLQKFAGPYDKGEYSPSVQKTLYDIQVLT
LGQVPEIEDMEISLPNIHYLNIDMSKMGLINKEEVLLPLDNPYGKITGTVKRKLSSRL

Cross-matching ID

UNII: R581OT55EA
DrugBank ID: DB09208
TTD ID: D06ZIT

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Uric acid (URA)	TTZ1SWF	NOUNIPROTAC	Modulator	[2]

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Molecular Interaction Atlas (MIA)

MIA Detail

Jump to Detail Molecular Interaction Atlas of This Drug

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7463).
2	Mullard A: 2010 FDA drug approvals. Nat Rev Drug Discov. 2011 Feb;10(2):82-5.