Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMD1E4J)

• Drug Name: UNC0379 Drug Info
• Synonyms: 1620401-82-2; 6,7-Dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine; UNC-0379; CHEMBL3318285; UNC 0379; 6,7-Dimethoxy-2-pyrrolidin-1-yl-N-(5-pyrrolidin-1-ylpentyl)quinazolin-4-amine; C23H35N5O2; 4-Quinazolinamine, 6,7-dimethoxy-2-(1-pyrrolidinyl)-N-[5-(1-pyrrolidinyl)pentyl]-; CS-3345; HY-12335; SCHEMBL22568439; AOB6365; EX-A461; SYN5081; BCP10429; 3362AH; BDBM50051117; MFCD28167817; s7570; ZINC98214604; AKOS025404942; UNC 0379;UNC-0379; CCG-268809; SB19349; NCGC00384189-06; NCGC00384189-10; AK174945; AS-16447; DA-43617; B8009; FT-0699830; A14320; UNC0379 trifluoroacetate salt, >=98% (HPLC)

Indication

Disease Entry	ICD 11	Status	REF
Hepatocellular carcinoma	2C12.02	Preclinical	[1]

• Cross-matching ID:
  PubChem CID: 78357767
  ChEBI ID: CHEMBL3318285
  TTD Drug ID: DMD1E4J

Molecule-Related Drug Atlas

Drug(s) Targeting SET domain containing 8 (KMT5A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
MS2177	DMDEJBQ	Solid tumour/cancer	2A00-2F9Z	Preclinical	[1]
nahuoic acid A	DM1LWMU	Discovery agent	N.A.	Investigative	[3]
MS453	DMBTPDL	Discovery agent	N.A.	Investigative	[4]

Drug(s) Affected By SH3 and PX domain-containing protein 2B (SH3PXD2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[5]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[6]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[7]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[8]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[9]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[10]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[11]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[12]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[13]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[14]

Drug(s) Affected By Retrotransposon-like protein 1 (RTL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[15]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[16]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[12]
chlordane	DMMHU8G	Discovery agent	N.A.	Investigative	[16]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[17]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[18]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[19]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[20]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[21]
Selenium	DM25CGV	N. A.	N. A.	Approved	[22]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[17]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[23]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[24]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[23]

Drug(s) Affected By Insulin-induced gene 1 protein (INSIG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[25]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[26]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[27]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[29]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[30]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[28]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[31]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[32]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[33]

Drug(s) Affected By Proline dehydrogenase 1, mitochondrial (PRODH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[27]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[35]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[32]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[32]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[6]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[36]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[27]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[37]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[38]

Drug(s) Affected By Microtubule cross-linking factor 2 (MTCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[15]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[39]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[40]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[41]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[8]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[9]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[42]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[12]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[43]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[13]

Drug(s) Affected By CTD nuclear envelope phosphatase 1 (CTDNEP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[42]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[6]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[45]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[9]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[42]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[43]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[46]

Drug(s) Affected By Adenomatous polyposis coli protein 2 (APC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[15]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[47]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[48]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[49]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[12]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[43]
AHPN	DM8G6O4	Discovery agent	N.A.	Investigative	[50]
Lithium chloride	DMHYLQ2	Discovery agent	N.A.	Investigative	[36]

Drug(s) Affected By Histone H1.0 (H1-0)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[51]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[53]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[6]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[39]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[55]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[56]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[57]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[9]

Drug(s) Affected By Nuclear factor 1 C-type (NFIC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[42]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[13]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[58]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[6]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[15]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[60]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[61]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[40]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[62]

Drug(s) Affected By Guanine nucleotide-binding protein G(o) subunit alpha (GNAO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[64]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[40]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[8]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[65]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[12]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[66]

Drug(s) Affected By Histone H1.4 (H1-4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[67]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[68]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[69]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[55]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[70]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[51]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[9]
Lucanthone	DMZLBUO	Solid tumour/cancer	2A00-2F9Z	Approved	[71]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[72]

Drug(s) Affected By Microtubule-associated protein 2 (MAP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[73]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[74]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[24]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[35]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[28]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[75]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[6]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[76]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]

Drug(s) Affected By Ski oncogene (SKI)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[77]
Selenium	DM25CGV	N. A.	N. A.	Approved	[42]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[68]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[15]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[78]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[79]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[40]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[57]

Drug(s) Affected By Protein SON (SON)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[80]
Selenium	DM25CGV	N. A.	N. A.	Approved	[42]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[13]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[81]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[33]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[33]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[33]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[33]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]

Drug(s) Affected By DNA-directed RNA polymerase II subunit RPB1 (POLR2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[42]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[24]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[82]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[13]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[83]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[84]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[85]
Deferasirox	DM6ETS0	Beta thalassemia	3A50.2	Approved	[86]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[75]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]

Drug(s) Affected By ATP synthase subunit delta, mitochondrial (ATP5F1D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[87]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[6]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[15]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[88]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[79]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[89]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[41]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[90]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[9]

Drug(s) Affected By Mu-type opioid receptor (OPRM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Alvimopan	DMHR8KW	Gastrointestinal disease	DE2Z	Approved	[91]
Fentanyl	DM8WAHT	Analgesia	MB40.8	Approved	[92]
Morphine	DMRMS0L	Advanced cancer	2A00-2F9Z	Approved	[93]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[24]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[94]
Butorphanol	DM5KYPJ	Pain	MG30-MG3Z	Approved	[95]
Oliceridine	DM6MDCF	Acute pain	MG31	Approved	[92]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[15]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[97]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[98]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[99]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[100]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[101]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[102]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[103]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[104]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[105]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[106]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[17]

Drug(s) Affected By Neurogenic locus notch homolog protein 1 (NOTCH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[107]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[108]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[109]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[15]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[110]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[111]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[112]
Mebendazole	DMO14SG	Ascariasis	1F62	Approved	[113]

Drug(s) Affected By Atrophin-1 (ATN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[114]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[36]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[9]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[115]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[116]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[117]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[12]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[13]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[13]

Drug(s) Affected By 3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7 (HSD17B7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[118]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[26]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[119]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[120]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[30]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[15]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[112]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[55]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[70]

Drug(s) Affected By Actin, aortic smooth muscle (ACTA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[121]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[122]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[123]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[124]
Pirfenidone	DM6VZFQ	Idiopathic pulmonary fibrosis	CB03.4	Approved	[125]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[59]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[32]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[126]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[32]

Drug(s) Affected By Coxsackievirus and adenovirus receptor (CXADR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[32]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[5]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[6]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[127]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[55]
Valsartan	DMREUQ6	Chronic heart failure	BD1Z	Approved	[127]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[40]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[57]

Drug(s) Affected By Protein BTG2 (BTG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[103]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[17]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[128]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[81]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[129]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[130]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[131]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[84]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[67]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[132]

Drug(s) Affected By Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMGCS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[133]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[134]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[51]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[135]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[135]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[136]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[135]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[119]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[27]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[81]

Drug(s) Affected By Large neutral amino acids transporter small subunit 1 (SLC7A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[137]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[138]
Selenium	DM25CGV	N. A.	N. A.	Approved	[42]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[128]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[139]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[140]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[30]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[35]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[141]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[137]

Drug(s) Affected By Cytochrome P450 4F3 (CYP4F3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[142]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[119]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[143]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[30]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[145]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[55]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[70]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[41]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[146]

Drug(s) Affected By Isopentenyl-diphosphate Delta-isomerase 1 (IDI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[136]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[26]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[119]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[147]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[30]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[75]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[6]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]

Drug(s) Affected By Dihydropyrimidinase-related protein 3 (DPYSL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[134]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[148]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[24]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[149]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[33]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[33]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[6]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]

Drug(s) Affected By Nuclear factor 1 X-type (NFIX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[138]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[24]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[68]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[15]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[150]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[151]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[152]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[70]

Drug(s) Affected By Poly(rC)-binding protein 2 (PCBP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[84]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[153]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[68]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[145]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[133]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[40]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[62]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[154]

Drug(s) Affected By Coiled-coil domain-containing protein 85B (CCDC85B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[155]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[156]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[55]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[70]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[157]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[57]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[8]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[158]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[159]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[43]

Drug(s) Affected By Serine/threonine-protein kinase SBK1 (SBK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[160]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[161]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[162]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[70]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[154]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[117]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[159]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[43]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[134]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[145]

Drug(s) Affected By BCL-6 corepressor-like protein 1 (BCORL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[99]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[51]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[120]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[163]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[75]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[155]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[15]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[151]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[57]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[164]

Drug(s) Affected By Glutamate-rich protein 3 (ERICH3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[120]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[15]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[145]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[165]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[166]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[12]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[165]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[145]

Drug(s) Affected By FERM and PDZ domain-containing protein 2 (FRMPD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[32]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[32]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[40]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[41]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[167]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[164]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[168]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[169]
Mivebresib	DMCPF90	Acute myeloid leukaemia	2A60	Phase 1	[168]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[12]

Drug(s) Affected By Apical endosomal glycoprotein (MAMDC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[15]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[9]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[65]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[164]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[43]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[170]

Drug(s) Affected By Helicase SRCAP (SRCAP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[79]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[171]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[9]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[164]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[12]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[13]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[13]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[134]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[172]

Drug(s) Affected By Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[173]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[128]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[84]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[32]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[32]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[75]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[6]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[166]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[174]

Drug(s) Affected By Ribonucleoside-diphosphate reductase subunit M2 B (RRM2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[175]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[128]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[176]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[176]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[59]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[63]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[33]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[33]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[6]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]

Drug(s) Affected By Cation channel sperm-associated auxiliary subunit delta (CATSPERD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[145]

Drug(s) Affected By Ribonucleoprotein PTB-binding 1 (RAVER1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[133]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[68]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[15]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]

Drug(s) Affected By DNA damage-regulated autophagy modulator protein 1 (DRAM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[175]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[128]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[63]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[6]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[15]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[145]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[178]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[179]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[62]

Drug(s) Affected By Mitochondria-eating protein (SPATA18)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[180]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[128]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[68]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[35]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[112]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[180]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[55]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[178]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[178]

Drug(s) Affected By DNA damage-binding protein 2 (DDB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[51]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[128]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[181]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[59]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[32]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[32]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[75]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[33]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[33]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[128]

Drug(s) Affected By Acidic leucine-rich nuclear phosphoprotein 32 family member B (ANP32B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[99]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[84]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[6]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[15]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[156]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[51]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[9]
Aminoglutethimide	DMWFHMZ	Cushing disease	5A70	Approved	[182]

Drug(s) Affected By Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (INPP5D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[15]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[55]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[178]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[70]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[41]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[158]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[166]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[164]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[35]

Drug(s) Affected By StAR-related lipid transfer protein 4 (STARD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[26]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[28]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[32]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[32]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[15]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[55]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[40]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[184]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[9]

Drug(s) Affected By CAP-Gly domain-containing linker protein 3 (CLIP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[185]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[85]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[15]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[151]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[112]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[178]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[178]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[41]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[166]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[164]

Drug(s) Affected By Dynein heavy chain domain-containing protein 1 (DNHD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[51]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[128]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[15]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[154]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[12]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[43]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[186]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[134]

Drug(s) Affected By Nectin-4 (NECTIN4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[128]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[187]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[161]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[68]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[145]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[188]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[70]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[40]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[41]

Drug(s) Affected By Cyclin-L2 (CCNL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[189]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[15]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[55]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[190]

Drug(s) Affected By Msx2-interacting protein (SPEN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[42]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[191]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[163]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[155]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[110]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[55]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[79]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[40]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[8]

Drug(s) Affected By SH3 and cysteine-rich domain-containing protein (STAC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[161]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[6]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[15]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[112]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[193]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[70]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[57]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[154]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[194]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[166]

Drug(s) Affected By Krueppel-like factor 16 (KLF16)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[68]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[15]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[60]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[79]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[195]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[57]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[171]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[196]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[43]

Drug(s) Affected By BolA-like protein 2 (BOLA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[73]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[120]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[15]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[197]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[60]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[9]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[12]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[134]

Drug(s) Affected By Tyrosine-protein phosphatase non-receptor type 23 (PTPN23)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[68]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[15]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[79]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[9]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[198]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[43]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[13]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[199]

Drug(s) Affected By Proline-rich protein 36 (PRR36)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[151]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[154]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[166]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[65]
GSK2110183	DMZHB37	leukaemia	2A60-2B33	Phase 2	[200]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[13]

Drug(s) Affected By Thiol S-methyltransferase TMT1A (TMT1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[148]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[128]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[160]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[32]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[32]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[75]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[6]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[201]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 27 (EDA2R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[128]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[180]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[75]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[6]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[15]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[33]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[202]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[203]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[164]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[12]

Drug(s) Affected By p53-induced death domain-containing protein 1 (PIDD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[17]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[175]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[128]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[32]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[32]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[33]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[189]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[15]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[33]

Drug(s) Affected By Arginine-glutamic acid dipeptide repeats protein (RERE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[134]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[24]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[13]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[204]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[15]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[55]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[40]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[62]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[164]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[12]

Drug(s) Affected By ProSAAS (PCSK1N)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[68]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[15]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[205]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[65]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[12]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[190]

Drug(s) Affected By Proline-rich protein 12 (PRR12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[6]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[15]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[79]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[12]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[13]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[13]

Drug(s) Affected By Neurogenic locus notch homolog protein 3 (NOTCH3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[42]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[59]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[206]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[110]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[197]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[112]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[70]
Tetracycline	DMZA017	Acne vulgaris	ED80	Approved	[207]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[49]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[12]

Drug(s) Affected By Protocadherin gamma-C3 (PCDHGC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[208]
Selenium	DM25CGV	N. A.	N. A.	Approved	[42]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[24]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[15]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[60]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[209]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[70]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[9]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[48]

Drug(s) Affected By RNA-binding protein Nova-2 (NOVA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[151]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[8]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[9]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[210]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[211]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[35]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[212]

Drug(s) Affected By Leucine zipper putative tumor suppressor 1 (LZTS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[35]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[5]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[15]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[197]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[112]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[178]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[178]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[154]

Drug(s) Affected By NADH dehydrogenase 1 beta subcomplex subunit 9 (NDUFB9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[213]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[214]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[90]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[9]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[210]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[186]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[215]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
SET domain containing 8 (KMT5A)	TTGC95K	KMT5A_HUMAN	Inhibitor	[1]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7 (HSD17B7)	OTV7VOV3	DHB7_HUMAN	Gene/Protein Processing	[2]
Acidic leucine-rich nuclear phosphoprotein 32 family member B (ANP32B)	OT3SQMLU	AN32B_HUMAN	Gene/Protein Processing	[2]
Actin, aortic smooth muscle (ACTA2)	OTEDLG8E	ACTA_HUMAN	Gene/Protein Processing	[2]
Adenomatous polyposis coli protein 2 (APC2)	OTRH91CX	APCL_HUMAN	Gene/Protein Processing	[2]
Apical endosomal glycoprotein (MAMDC4)	OTTL3DWT	AEGP_HUMAN	Gene/Protein Processing	[2]
Arginine-glutamic acid dipeptide repeats protein (RERE)	OT3G4GBZ	RERE_HUMAN	Gene/Protein Processing	[2]
ATP synthase subunit delta, mitochondrial (ATP5F1D)	OTXTAG2V	ATPD_HUMAN	Gene/Protein Processing	[2]
Atrophin-1 (ATN1)	OTNZFLKY	ATN1_HUMAN	Gene/Protein Processing	[2]
BCL-6 corepressor-like protein 1 (BCORL1)	OTPTFQN5	BCORL_HUMAN	Gene/Protein Processing	[2]
BolA-like protein 2 (BOLA2)	OTVZP6YB	BOLA2_HUMAN	Gene/Protein Processing	[2]

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