Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMEM2SW)

Drug Name
CYCLOPAMINE Drug Info
Synonyms
CYCLOPAMINE; 11-Deoxojervine; 4449-51-8; UNII-ZH658AJ192; CHEMBL254129; CHEBI:4021; 11-Deoxyjervine; ZH658AJ192; HSDB 3505; Jervine, 11-deoxo-; Spiro[9H-benzo[a]fluorene-9,2'(3'H)-furo[3,2-b]pyridin]-3-ol, 1,2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11,11a,11b-octadecahydro-3',6',10,11b-tetramethyl-, (2'R,3S,3'R,3'aS,6'S,6aS,6bS,7'aR,11aS,11bR)- (9CI); (3beta,22S,23R)-17,23-epoxyveratraman-3-ol; Veratraman-3-ol, 17,23-epoxy-, (3beta,23beta)-; CY8; [3H]-Cyclopamine; AC1L9DRQ; DSSTox_CID_23709; DSSTox_RID_80067; SCHEMBL29153
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
442972
ChEBI ID
CHEMBL254129
CAS Number
CAS 4449-51-8
TTD Drug ID
DMEM2SW

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Patented Agent(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Smoothened homolog (SMO)
Drug Name Drug ID Indication ICD 11 Highest Status REF
PF-04449913 DMSB068 Chronic myelomonocytic leukaemia 2A40 Approved [5]
Vismodegib DM5IXKQ Basal cell carcinoma 2C32 Approved [6]
LDE225 DMM9F25 Basal cell carcinoma 2C32 Phase 2 [7]
LY2940680 DMTJWIQ Solid tumour/cancer 2A00-2F9Z Phase 1/2 [5]
BMS-833923 DM459Q7 Solid tumour/cancer 2A00-2F9Z Phase 1b [8]
LEQ-506 DM5INZP Solid tumour/cancer 2A00-2F9Z Phase 1 [9]
TAK-441 DM7DFBL Solid tumour/cancer 2A00-2F9Z Phase 1 [10]
PMID25726713-Compound-49 DM2CT4G N. A. N. A. Patented [11]
PMID25726713-Compound-51 DMF0OW4 N. A. N. A. Patented [11]
PMID25726713-Compound-48 DMSIOUA N. A. N. A. Patented [11]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Macrophage mannose receptor 1 (MRC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [12]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [13]
Valsartan DMREUQ6 Chronic heart failure BD1Z Approved [14]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [15]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [16]
Drug(s) Affected By Neurogenic locus notch homolog protein 1 (NOTCH1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [17]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [18]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [19]
Propranolol DM79NTF Angina pectoris BA40 Approved [20]
Testosterone DM7HUNW Hot flushes GA30 Approved [21]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [12]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [22]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [23]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [24]
Mebendazole DMO14SG Ascariasis 1F62 Approved [25]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein patched homolog 1 (PTCH1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [26]
Quercetin DM3NC4M Obesity 5B81 Approved [27]
Vismodegib DM5IXKQ Basal cell carcinoma 2C32 Approved [28]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [29]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [30]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [31]
Ethanol DMDRQZU Chronic pain MG30 Approved [32]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [33]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [34]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [35]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein smoothened (SMO)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [36]
Quercetin DM3NC4M Obesity 5B81 Approved [37]
Vismodegib DM5IXKQ Basal cell carcinoma 2C32 Approved [28]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [38]
Leflunomide DMR8ONJ Arthritis FA20 Approved [39]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [12]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [24]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [40]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [41]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [34]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Resistin-like beta (RETNLB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Folic Acid DMEMBJC Colorectal carcinoma Approved [42]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [43]

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Smoothened homolog (SMO) TT8J1S3 SMO_HUMAN Inhibitor [1]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Macrophage mannose receptor 1 (MRC1) OTTVCOPT MRC1_HUMAN Gene/Protein Processing [2]
Neurogenic locus notch homolog protein 1 (NOTCH1) OTI1WADQ NOTC1_HUMAN Protein Interaction/Cellular Processes [3]
Protein patched homolog 1 (PTCH1) OTMG07H5 PTC1_HUMAN Gene/Protein Processing [4]
Protein smoothened (SMO) OTXXE208 SMO_HUMAN Gene/Protein Processing [4]
Resistin-like beta (RETNLB) OT9JJQQQ RETNB_HUMAN Gene/Protein Processing [2]

References

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14 Valsartan improves adipose tissue function in humans with impaired glucose metabolism: a randomized placebo-controlled double-blind trial. PLoS One. 2012;7(6):e39930. doi: 10.1371/journal.pone.0039930. Epub 2012 Jun 29.
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16 Environmental pollutant induced cellular injury is reflected in exosomes from placental explants. Placenta. 2020 Jan 1;89:42-49. doi: 10.1016/j.placenta.2019.10.008. Epub 2019 Oct 17.
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18 Development of a neural teratogenicity test based on human embryonic stem cells: response to retinoic acid exposure. Toxicol Sci. 2011 Dec;124(2):370-7.
19 Arsenic trioxide inhibits cell growth and induces apoptosis through inactivation of notch signaling pathway in breast cancer. Int J Mol Sci. 2012;13(8):9627-9641. doi: 10.3390/ijms13089627. Epub 2012 Aug 2.
20 Propranolol inhibits proliferation and invasion of hemangioma-derived endothelial cells by suppressing the DLL4/Notch1/Akt pathway. Chem Biol Interact. 2018 Oct 1;294:28-33. doi: 10.1016/j.cbi.2018.08.018. Epub 2018 Aug 18.
21 The exosome-like vesicles derived from androgen exposed-prostate stromal cells promote epithelial cells proliferation and epithelial-mesenchymal transition. Toxicol Appl Pharmacol. 2021 Jan 15;411:115384. doi: 10.1016/j.taap.2020.115384. Epub 2020 Dec 25.
22 NOTCH signaling is activated in and contributes to resistance in enzalutamide-resistant prostate cancer cells. J Biol Chem. 2019 May 24;294(21):8543-8554. doi: 10.1074/jbc.RA118.006983. Epub 2019 Apr 2.
23 The autonomous notch signal pathway is activated by baicalin and baicalein but is suppressed by niclosamide in K562 cells. J Cell Biochem. 2009 Mar 1;106(4):682-92. doi: 10.1002/jcb.22065.
24 Temozolomide induces activation of Wnt/-catenin signaling in glioma cells via PI3K/Akt pathway: implications in glioma therapy. Cell Biol Toxicol. 2020 Jun;36(3):273-278. doi: 10.1007/s10565-019-09502-7. Epub 2019 Nov 22.
25 Mebendazole is a potent inhibitor to chemoresistant T cell acute lymphoblastic leukemia cells. Toxicol Appl Pharmacol. 2020 Jun 1;396:115001. doi: 10.1016/j.taap.2020.115001. Epub 2020 Apr 8.
26 Arsenite and cadmium promote the development of mammary tumors. Carcinogenesis. 2020 Jul 14;41(7):1005-1014. doi: 10.1093/carcin/bgz176.
27 Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
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29 Arsenic trioxide prevents osteosarcoma growth by inhibition of GLI transcription via DNA damage accumulation. PLoS One. 2013 Jul 8;8(7):e69466. doi: 10.1371/journal.pone.0069466. Print 2013.
30 THC exposure of human iPSC neurons impacts genes associated with neuropsychiatric disorders. Transl Psychiatry. 2018 Apr 25;8(1):89. doi: 10.1038/s41398-018-0137-3.
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32 Chronic ethanol exposure increases goosecoid (GSC) expression in human embryonic carcinoma cell differentiation. J Appl Toxicol. 2014 Jan;34(1):66-75.
33 PTCH mutations in basal cell carcinomas from azathioprine-treated organ transplant recipients. Br J Cancer. 2008 Oct 21;99(8):1276-84. doi: 10.1038/sj.bjc.6604665.
34 Activation of AIFM2 enhances apoptosis of human lung cancer cells undergoing toxicological stress. Toxicol Lett. 2016 Sep 6;258:227-236.
35 A fine-needle aspirate-based vulnerability assay identifies polo-like kinase 1 as a mediator of gemcitabine resistance in pancreatic cancer. Mol Cancer Ther. 2010 Feb;9(2):311-8. doi: 10.1158/1535-7163.MCT-09-0693. Epub 2010 Jan 26.
36 Cannabidiol enhances cytotoxicity of anti-cancer drugs in human head and neck squamous cell carcinoma. Sci Rep. 2020 Nov 26;10(1):20622. doi: 10.1038/s41598-020-77674-y.
37 Quercetin suppresses pancreatic ductal adenocarcinoma progression via inhibition of SHH and TGF-/Smad signaling pathways. Cell Biol Toxicol. 2021 Jun;37(3):479-496. doi: 10.1007/s10565-020-09562-0. Epub 2020 Oct 17.
38 Identification of recurrent SMO and BRAF mutations in ameloblastomas. Nat Genet. 2014 Jul;46(7):722-5. doi: 10.1038/ng.2986. Epub 2014 May 25.
39 Endoplasmic reticulum stress and MAPK signaling pathway activation underlie leflunomide-induced toxicity in HepG2 Cells. Toxicology. 2017 Dec 1;392:11-21.
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41 Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics. 2009 Aug 7;38(3):386-401.
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