Details of the Drug

General Information of Drug (ID: DMER9YA)

Drug Name

Galsulfase

Synonyms

Aryplase; Aryplase (TN); Galsulfase (genetical recombination); Galsulfase (USAN/INN); Galsulfase (genetical recombination) (JAN)

Indication

Disease Entry	ICD 11	Status	REF
Mucopolysaccharidosis	5C56.3	Approved	[1]

Therapeutic Class

Enzyme Replacement Agents

Affected Organisms

Humans and other mammals

ATC Code

A16AB08: Galsulfase

A16AB: Enzymes

A16A: OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS

A16: OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS

A: ALIMENTARY TRACT AND METABOLISM

Sequence

SGAGASRPPHLVFLLADDLGWNDVGFHGSRIRTPHLDALAAGGVLLDNYYTQPLCTPSRS
QLLTGRYQIRTGLQHQIIWPCQPSCVPLDEKLLPQLLKEAGYTTHMVGKWHLGMYRKECL
PTRRGFDTYFGYLLGSEDYYSHERCTLIDALNVTRCALDFRDGEEVATGYKNMYSTNIFT
KRAIALITNHPPEKPLFLYLALQSVHEPLQVPEEYLKPYDFIQDKNRHHYAGMVSLMDEA
VGNVTAALKSSGLWNNTVFIFSTDNGGQTLAGGNNWPLRGRKWSLWEGGVRGVGFVASPL
LKQKGVKNRELIHISDWLPTLVKLARGHTNGTKPLDGFDVWKTISEGSPSPRIELLHNID
PNFVDSSPCPRNSMAPAKDDSSLPEYSAFNTSVHAAIRHGNWKLLTGYPGCGYWFPPPSQ
YNVSEIPSSDPPTKTLWLFDIDRDPEERHDLSREYPHIVTKLLSRLQFYHKHSVPVYFPA
QDPRCDPKATGVWGPWM

ADMET Property

Half-life: The concentration or amount of drug in body reduced by one-half in 6 - 21 minutes [2]
Vd: The volume of distribution (Vd) of drug is 0.056-0.323 L/kg []

Cross-matching ID

UNII: 59UA429E5G
DrugBank ID: DB01279
TTD ID: D05UHF

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
N-acetylgalactosamine-4-sulfatase (G4S)	TTESQTG	ARSB_HUMAN	Modulator	[3]

Molecular Interaction Atlas (MIA)

MIA Detail

Jump to Detail Molecular Interaction Atlas of This Drug

References

1	Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77.
2	Trend Analysis of a Database of Intravenous Pharmacokinetic Parameters in Humans for 1352 Drug Compounds
3	Enzyme replacement therapy for mucopolysaccharidosis VI: long-term cardiac effects of galsulfase (Naglazyme ) therapy. J Inherit Metab Dis. 2013 Mar;36(2):385-94.