Details of the Drug

General Information of Drug (ID: DMEWQHP)

Drug Name
AZ-628
Synonyms Mutant B-Raf Kinase inhibitors, AstraZeneca; Mutant B-Raf (V600E) kinase inhibitors (cancer), AstraZeneca
Indication
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Investigative [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 451.5
Logarithm of the Partition Coefficient (xlogp) 4.2
Rotatable Bond Count (rotbonds) 5
Hydrogen Bond Donor Count (hbonddonor) 2
Hydrogen Bond Acceptor Count (hbondacc) 5
Chemical Identifiers
Formula
C27H25N5O2
IUPAC Name
3-(2-cyanopropan-2-yl)-N-[4-methyl-3-[(3-methyl-4-oxoquinazolin-6-yl)amino]phenyl]benzamide
Canonical SMILES
CC1=C(C=C(C=C1)NC(=O)C2=CC(=CC=C2)C(C)(C)C#N)NC3=CC4=C(C=C3)N=CN(C4=O)C
InChI
InChI=1S/C27H25N5O2/c1-17-8-9-21(31-25(33)18-6-5-7-19(12-18)27(2,3)15-28)14-24(17)30-20-10-11-23-22(13-20)26(34)32(4)16-29-23/h5-14,16,30H,1-4H3,(H,31,33)
InChIKey
ZGBGPEDJXCYQPH-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
11676786
ChEBI ID
CHEBI:91354
CAS Number
878739-06-1
TTD ID
D0C0ZC

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Serine/threonine-protein kinase B-raf (BRAF) TTWCGQT BRAF_HUMAN Inhibitor [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
GTPase KRas (KRAS) OT78QCN8 RASK_HUMAN Drug Response [3]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Post-Translational Modifications [3]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Post-Translational Modifications [3]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Solid tumour/cancer
ICD Disease Classification 2A00-2F9Z
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Serine/threonine-protein kinase B-raf (BRAF) DTT BRAF 3.00E-01 0.1 0.2
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 147 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JM1 GDSC1 3.6213 9.3488 -0.4267 13.2
SIG-M5 GDSC1 -5.9627 -2.1549 -5.9973 84.9681
OCI-AML-2 GDSC1 -5.3787 -2.7123 -5.3842 85.1453
NB4 GDSC1 -4.3059 1.8769 -4.8486 67.0163
KMOE-2 GDSC1 -3.3455 -0.0655 -3.4264 64.4186
ALL-SIL GDSC1 -2.9076 0.2491 -2.999 59.9513
LAMA-84 GDSC1 -2.4901 0.3358 -2.5662 55.5923
EM-2 GDSC1 -2.1559 1.3316 -2.372 51.6582
MEG-01 GDSC1 -1.5915 2.2799 -1.9994 45.8563
OCI-AML-5 GDSC1 -1.4607 4.7133 -2.7525 45.8839
MY-M12 GDSC1 -1.3804 5.7721 -3.123 45.771
ML-2 GDSC1 -1.2484 4.2725 -2.348 43.8087
PL-21 GDSC1 -1.1976 9.7752 -4.7928 46.192
HL-60 GDSC1 -1.1312 6.7742 -3.3206 44.5367
A4/Fukuda GDSC1 -1.077 5.7543 -2.8051 43.489
697 GDSC1 -1.0658 6.6253 -3.1869 43.9964
OCI-AML-3 GDSC1 -1.0492 5.1739 -2.5211 42.8131
GDM-1 GDSC1 -0.9755 5.0233 -2.3798 42.058
JURL-MK1 GDSC1 -0.8125 5.6177 -2.4752 41.2648
KCL-22 GDSC1 -0.7941 2.3625 -1.1555 36.8539
JSC-1 GDSC1 -0.6071 5.9646 -2.4252 39.9496
BV-173 GDSC1 -0.5773 3.996 -1.5291 36.9852
OCI-Ly19 GDSC1 -0.5735 8.3677 -3.5196 41.9451
GA-10 GDSC1 -0.4671 7.5378 -3.0216 40.5291
MOLP-8 GDSC1 -0.179 9.0456 -3.4705 40.0339
BE-13 GDSC1 -0.1297 6.7779 -2.3336 37.1146
QIMR-WIL GDSC1 0.0362 3.9201 -0.8581 30.1212
SU-DHL-8 GDSC1 0.0557 5.5515 -1.5749 33.4669
K-562 GDSC1 0.1654 4.7231 -1.0835 30.6013
MOLM-13 GDSC1 0.1717 5.628 -1.4966 32.5163
SUP-B15 GDSC1 0.18 4.1579 -0.8143 29.0745
CTV-1 GDSC1 0.2994 2.0675 0.1252 22.4009
H9 GDSC1 0.3155 7.0871 -2.0548 33.9832
ALL-PO GDSC1 0.3466 4.4946 -0.7974 28.08
NKM-1 GDSC1 0.4885 6.4904 -1.6025 31.3689
NOMO-1 GDSC1 0.5079 6.6492 -1.661 31.5242
MV4-11 GDSC1 0.6092 3.3308 -0.0116 21.6714
Ramos.2G6.4C10 GDSC1 0.7315 6.451 -1.3545 29.0757
SUP-T1 GDSC1 0.7753 4.906 -0.5673 24.5366
DoHH2 GDSC1 0.793 14.3168 -5.1911 39.2054
ME1 GDSC1 0.8304 36.4703 -16.2193 45.6704
Karpas-231 GDSC1 0.9294 4.761 -0.3498 22.4062
RPMI-8226 GDSC1 1.0672 5.6391 -0.6453 23.6493
DND-41 GDSC1 1.1429 7.6039 -1.5448 28.1199
SU-DHL-6 GDSC1 1.2842 2.7599 0.9323 11.4316
OPM-2 GDSC1 1.4088 5.0602 -0.047 18.1814
VAL GDSC1 1.483 8.3188 -1.5999 26.9605
NU-DUL-1 GDSC1 1.4994 6.6346 -0.7466 22.3883
PF-382 GDSC1 1.5631 3.5053 0.8582 10.7211
SU-DHL-1 GDSC1 1.7007 5.6514 -0.0808 17.2191
KG-1 GDSC1 1.7917 6.4736 -0.4127 19.117
MOLT-13 GDSC1 1.8268 7.6713 -0.9812 22.4378
NK-92MI GDSC1 1.9392 5.6793 0.1095 14.9319
TK [Human B-cell lymphoma] GDSC1 2.0072 9.9243 -1.9562 26.5408
EB2 GDSC1 2.0938 8.719 -1.2816 23.0539
BC-3 GDSC1 2.0997 6.4396 -0.1373 16.0928
YT GDSC1 2.1565 3.8539 1.2 5.7648
MOLT-4 GDSC1 2.1762 6.0238 0.133 13.8941
SUP-HD1 GDSC1 2.2005 8.9648 -1.3168 22.8491
KE-37 GDSC1 2.2279 8.9615 -1.2927 22.6263
L-540 GDSC1 2.2438 7.1377 -0.3686 17.137
JJN-3 GDSC1 2.2684 8.0312 -0.7949 19.7175
HAL-01 GDSC1 2.2876 10.7996 -2.1625 26.4117
Ku812 GDSC1 2.3529 7.0846 -0.2545 15.9923
SR GDSC1 2.3657 7.2777 -0.3406 16.5224
BC-1 GDSC1 2.4158 5.8291 0.42 10.9479
IM-9 GDSC1 2.4353 7.9698 -0.6304 18.1344
OCI-M1 GDSC1 2.444 4.1494 1.2691 4.341
EHEB GDSC1 2.446 9.3163 -1.2934 21.8639
ST486 GDSC1 2.4777 10.4445 -1.831 24.3525
CESS GDSC1 2.499 10.6386 -1.9108 24.6345
SU-DHL-16 GDSC1 2.5325 5.7338 0.5562 9.5455
KOPN-8 GDSC1 2.5348 12.2964 -2.7096 27.6613
VL51 GDSC1 2.6149 6.3791 0.2994 11.2038
P32/ISH GDSC1 2.6156 3.8632 1.5177 2.0679
CA46 GDSC1 2.616 7.5017 -0.2559 15.1108
RPMI-8402 GDSC1 2.6374 4.49 1.2378 4.0568
MLMA GDSC1 2.6962 6.932 0.0875 12.4788
WIL2 NS GDSC1 2.6963 7.4078 -0.1478 14.1186
RC-K8 GDSC1 2.7127 4.7482 1.1649 4.4076
LP-1 GDSC1 2.7229 5.1864 0.9616 5.9065
Mono-Mac-6 GDSC1 2.8356 8.006 -0.3383 14.9469
EoL-1 GDSC1 2.8512 10.4592 -1.5429 21.7725
Raji GDSC1 2.8515 5.8808 0.7152 7.4049
CRO-AP2 GDSC1 2.8582 5.3837 0.9589 5.5669
Namalwa GDSC1 2.8693 6.6893 0.3344 10.1708
JVM-2 GDSC1 2.8722 10.0074 -1.302 20.4905
RPMI-6666 GDSC1 2.8803 9.6851 -1.1358 19.5807
MHH-PREB-1 GDSC1 2.907 6.4826 0.4623 9.1252
MC116 GDSC1 2.9365 4.2792 1.5137 1.4941
HC-1 GDSC1 2.971 5.8189 0.8266 6.2563
WSU-DLCL2 GDSC1 2.9737 6.0306 0.7271 6.9849
LC4-1 GDSC1 2.9939 6.4487 0.5396 8.3129
Jiyoye GDSC1 2.9982 8.0079 -0.2181 13.6479
AMO1 GDSC1 3.0253 7.9665 -0.1779 13.2971
HH [Human lymphoma] GDSC1 3.0556 6.0957 0.751 6.5944
KY821 GDSC1 3.0993 5.4847 1.0663 4.2023
Farage GDSC1 3.1027 8.847 -0.5537 15.4916
P31/FUJ GDSC1 3.1034 4.8155 1.3707 2.1161
Loucy GDSC1 3.2116 5.5654 1.0973 3.7423
Karpas-45 GDSC1 3.3004 8.9712 -0.4703 14.3809
JVM-3 GDSC1 3.332 5.9994 0.9712 4.3635
Hs 445 GDSC1 3.3802 8.5334 -0.2002 12.4132
U-698-M GDSC1 3.3817 10.629 -1.2241 18.509
EJM GDSC1 3.397 6.1363 0.9475 4.3902
Granta-519 GDSC1 3.4086 5.4697 1.2507 2.3577
DEL GDSC1 3.4498 4.9216 1.4983 0.9102
DG-75 GDSC1 3.4655 5.6621 1.1979 2.5945
TUR GDSC1 3.5349 7.127 0.5749 6.6854
ROS-50 GDSC1 3.5387 13.2875 -2.4183 23.5436
Sc-1 GDSC1 3.5647 9.7489 -0.6605 14.7919
CCRF-CEM GDSC1 3.588 11.2885 -1.3965 18.8031
ARH-77 GDSC1 3.6238 11.6653 -1.5552 19.4926
Karpas-422 GDSC1 3.6678 8.8409 -0.1502 11.3037
SU-DHL-4 GDSC1 3.7082 5.5809 1.3537 1.3467
HDLM-2 GDSC1 3.7495 6.7877 0.8591 4.281
RPMI-8866 GDSC1 3.8363 7.8438 0.4297 6.9972
L-428 GDSC1 3.8421 5.5961 1.4079 0.9465
WSU-NHL GDSC1 3.8544 9.311 -0.2495 11.4607
CTB-1 GDSC1 3.8663 12.3793 -1.7284 19.6428
U266B1 GDSC1 3.8741 10.7379 -0.9228 15.4631
MOLT-16 GDSC1 3.8801 9.5048 -0.3248 11.8724
SUP-M2 GDSC1 3.8812 4.9757 1.649 0.1411
RS4;11 GDSC1 3.9916 11.0804 -1.0066 15.615
Daudi GDSC1 4.0049 12.7037 -1.7869 19.5379
Karpas-299 GDSC1 4.0246 5.6665 1.4576 0.6021
NALM-6 GDSC1 4.1239 11.1789 -0.9627 15.0226
Kasumi-1 GDSC1 4.1525 10.713 -0.7195 13.5658
SK-MM-2 GDSC1 4.1751 5.8816 1.4384 0.5729
RL GDSC1 4.1804 13.2524 -1.9288 19.7166
GR-ST GDSC1 4.192 14.9434 -2.7482 23.0372
ATN-1 GDSC1 4.2042 5.6293 1.5397 0.2666
THP-1 GDSC1 4.2366 14.7399 -2.6157 22.4218
P30/OHK GDSC1 4.2382 8.6605 0.2985 6.9988
A3/Kawakami GDSC1 4.2996 12.7188 -1.585 17.8
BALL-1 GDSC1 4.3613 11.2626 -0.842 13.7431
SKM-1 GDSC1 4.4636 13.1191 -1.6644 17.7616
KM-H2 GDSC1 4.5044 10.8127 -0.5349 11.6202
MN-60 GDSC1 4.5141 7.1517 1.0962 1.7404
DB GDSC1 4.5271 11.3381 -0.7683 12.9205
L-363 GDSC1 4.61 12.1004 -1.0757 14.4185
Reh GDSC1 4.7355 13.1585 -1.4971 16.2777
L-1236 GDSC1 4.7524 7.2837 1.1498 1.2623
SCC-3 GDSC1 4.9056 12.7632 -1.1954 14.3472
BL-41 GDSC1 4.9555 17.2826 -3.3401 23.2381
HEL GDSC1 5.0335 13.799 -1.6032 16.0831
HT GDSC1 6.0174 13.4261 -0.8139 10.0031
⏷ Show the Full List of 147 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE-12 GDSC1 0.4719 5.8469 -1.3089 30.1174
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC1 3.604 6.9492 0.7 5.6583
Cancer Drug Sensitivity Data Curated from 26 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NB69 GDSC1 -2.3973 0.5214 -2.4909 54.4937
NB(TU)1 GDSC1 -1.4144 2.2972 -1.8114 43.9525
SJNB-14 GDSC1 -1.0051 0.7648 -1.0428 37.7817
LA-N-6 GDSC1 -0.5028 6.4643 -2.5518 39.6782
GI-ME-N GDSC1 0.1201 25.5907 -11.3964 45.4848
SK-N-BE(2)-M17 GDSC1 0.3284 3.7716 -0.4923 26.3456
SiMa GDSC1 1.7167 7.9411 -1.2098 24.109
SJNB-5 GDSC1 1.9808 6.6361 -0.334 17.8719
SJNB-10 GDSC1 2.2839 10.298 -1.9149 25.3852
KP-N-YN GDSC1 2.5359 20.5576 -6.8361 36.7591
GOTO GDSC1 2.5518 8.522 -0.8133 18.8394
TGW GDSC1 3.2274 5.5641 1.1072 3.6411
SJNB-17 GDSC1 3.2836 6.0321 0.9268 4.7798
NB1 GDSC1 3.2845 9.1794 -0.5836 15.1321
Kelly GDSC1 3.322 7.1553 0.4234 8.2788
NH-12 GDSC1 3.3808 6.4312 0.8022 5.4411
SK-N-FI GDSC1 3.4757 11.1125 -1.3926 19.1082
MHH-NB-11 GDSC1 3.4854 9.1209 -0.4114 13.4804
IMR-5 GDSC1 3.6851 6.1728 1.0941 2.8783
SK-N-DZ GDSC1 3.8091 5.4683 1.443 0.8229
SJNB-7 GDSC1 3.9826 10.208 -0.5924 13.2525
CHP-126 GDSC1 3.9977 5.4059 1.5417 0.3471
KP-N-YS GDSC1 4.1702 10.2318 -0.4781 12.0869
SJNB-6 GDSC1 4.4207 6.1852 1.4239 0.4809
SJNB-13 GDSC1 4.4746 6.1277 1.4646 0.3443
SJNB-12 GDSC1 4.5254 7.4814 0.9683 2.3878
⏷ Show the Full List of 26 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 21 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NOS-1 [Human HNSCC] GDSC1 -1.8515 9.382 -5.2437 49.3088
SJSA-1 GDSC1 -0.0755 9.7605 -3.7215 40.0409
H-EMC-SS GDSC1 1.3182 6.224 -0.7041 22.8976
EW-12 GDSC1 1.8445 5.5522 0.0927 15.414
EW-3 GDSC1 1.9614 5.8404 0.0475 15.2972
EW-24 GDSC1 2.0115 4.3998 0.8097 9.3373
EW-22 GDSC1 2.0897 9.9694 -1.9102 26.0476
EW-11 GDSC1 2.1851 10.3678 -2.0307 26.223
ES6 GDSC1 2.6588 10.627 -1.7775 23.507
EW-13 GDSC1 2.6657 7.4917 -0.2127 14.6579
EW-18 GDSC1 2.8967 8.1987 -0.3875 15.0747
SK-PN-DW GDSC1 3.0585 9.7103 -1.0125 18.3373
ES5 GDSC1 3.1443 6.5244 0.6057 7.4271
SK-ES-1 GDSC1 3.2949 7.0171 0.4712 8.0075
TC-71 GDSC1 3.3224 7.393 0.3101 9.0805
ES1 GDSC1 3.6885 9.5317 -0.4685 13.2777
ES7 GDSC1 3.905 9.694 -0.3986 12.2702
ES8 GDSC1 4.0083 14.0712 -2.4546 22.3941
EW-16 GDSC1 4.3484 6.5405 1.2622 1.1313
EW-1 GDSC1 4.5954 6.6997 1.3048 0.7711
ES4 GDSC1 4.7762 6.7285 1.3648 0.4778
⏷ Show the Full List of 21 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 14 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
DU4475 GDSC1 -4.9351 -2.3138 -4.9422 81.6141
HCC1599 GDSC1 2.1924 7.9436 -0.813 20.098
HCC2157 GDSC1 2.6686 6.4901 0.2849 11.1413
HCC1187 GDSC1 2.6946 11.3753 -2.1221 24.8944
COLO 824 GDSC1 2.789 8.047 -0.3937 15.4567
BT-474 GDSC1 3.3396 5.2873 1.2928 2.2091
Evsa-T GDSC1 3.6089 5.1547 1.4775 0.8508
UACC-812 GDSC1 3.6547 6.072 1.1215 2.7574
HCC1500 GDSC1 3.6768 9.7065 -0.5611 13.8788
CAL-148 GDSC1 3.741 5.1246 1.544 0.4808
MRK-nu-1 GDSC1 3.8689 14.2998 -2.6703 23.6002
OCUB-M GDSC1 4.2198 11.5729 -1.0866 15.4531
HCC2218 GDSC1 4.3342 5.8482 1.5108 0.2862
MFM-223 GDSC1 4.716 6.326 1.4831 0.2223
⏷ Show the Full List of 14 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 27 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ONS-76 GDSC1 -2.7153 2.8602 -3.4041 55.8556
D-392MG GDSC1 -1.3229 14.746 -7.3172 47.7429
KS-1 [Human Krukenberg tumour] GDSC1 -0.3237 5.0297 -1.7157 36.1437
D-502MG GDSC1 1.051 8.3137 -1.9788 30.3686
KINGS-1 GDSC1 1.6549 7.8398 -1.2123 24.3661
8-MG-BA GDSC1 2.0439 5.432 0.3204 12.9837
D-247MG GDSC1 2.3212 11.1831 -2.3267 26.9475
SF268 GDSC1 2.4656 7.8413 -0.5423 17.4804
AM-38 GDSC1 2.6274 5.1567 0.9091 6.5723
Onda 10 GDSC1 2.9234 9.2735 -0.8988 18.117
D-336MG GDSC1 3.0113 5.9678 0.7824 6.4779
KALS-1 GDSC1 3.0478 5.9468 0.8167 6.1328
D283 Med GDSC1 3.2614 6.808 0.5485 7.5393
SF539 GDSC1 3.3863 8.5524 -0.2052 12.4291
NMC-G1 GDSC1 3.3882 5.3062 1.3102 2.0244
D-263MG GDSC1 3.3957 23.8219 -7.7707 36.0809
D-542MG GDSC1 3.5329 11.3638 -1.4739 19.352
GB-1 GDSC1 3.5695 9.4139 -0.4944 13.7651
GI-1 GDSC1 3.7401 15.7831 -3.5005 26.7673
Becker GDSC1 4.0258 9.7887 -0.363 11.7407
SF126 GDSC1 4.5433 12.9367 -1.5214 16.8701
KNS-81-FD GDSC1 4.5706 14.9359 -2.471 21.0082
U-87MG ATCC GDSC1 4.8141 13.7452 -1.7252 17.1818
CAS-1 GDSC1 5.0259 17.8987 -3.5904 23.8843
Onda 11 GDSC1 5.1216 7.0595 1.3759 0.3155
SNB-75 GDSC1 5.4086 12.4156 -0.7158 10.6691
KNS-42 GDSC1 5.9547 17.4949 -2.7512 18.9197
⏷ Show the Full List of 27 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ETK-1 GDSC1 3.9782 6.6755 1.0323 2.7881
TGBC1TKB GDSC1 4.1585 5.6359 1.5205 0.3325
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RL95-2 GDSC1 5.976 14.9616 -1.543 13.7362
Cancer Drug Sensitivity Data Curated from 9 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LB996-RCC GDSC1 2.1309 5.8672 0.1744 13.7536
TK-10 GDSC1 2.2668 6.3162 0.06 14.1024
BB65-RCC GDSC1 2.4971 4.4864 1.1428 5.1579
LB1047-RCC GDSC1 2.6058 5.6193 0.667 8.48
LB2241-RCC GDSC1 2.6203 7.4528 -0.2282 14.9107
OS-RC-2 GDSC1 3.1221 7.3182 0.208 10.3491
RCC10RGB GDSC1 4.0928 6.2311 1.2704 1.3395
RXF 393L GDSC1 4.1595 12.7557 -1.7017 18.7257
HA7-RCC GDSC1 5.2157 6.9715 1.439 0.177
⏷ Show the Full List of 9 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 15 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RKO GDSC1 -4.3983 0.0163 -4.5581 71.6557
LS411N GDSC1 -3.3917 3.6218 -4.3951 59.5621
HCC2998 GDSC1 -1.841 3.3952 -2.6413 48.6379
NCI-H747 GDSC1 -1.0152 9.2242 -4.354 45.0343
LS513 GDSC1 -0.3425 5.8203 -2.0946 37.5355
CL-11 GDSC1 0.6552 5.8606 -1.1403 28.3762
KM12 GDSC1 0.8523 9.0933 -2.5433 33.2218
MDST8 GDSC1 1.7002 8.6557 -1.5809 26.0153
LS1034 GDSC1 2.7039 6.7653 0.1756 11.8245
LS123 GDSC1 2.8901 8.2813 -0.4332 15.3899
C2BBe1 GDSC1 2.9519 7.7374 -0.1192 13.1233
NCI-H716 GDSC1 3.0364 7.1788 0.2153 10.5418
SNU-C1 GDSC1 3.7111 9.0464 -0.2194 11.6396
CW-2 GDSC1 4.4458 9.7562 -0.0789 8.969
COLO 320HSR GDSC1 5.046 6.692 1.4744 0.1592
⏷ Show the Full List of 15 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC1 4.319 6.0189 1.4447 0.4711
Cancer Drug Sensitivity Data Curated from 64 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Calu-6 GDSC1 -4.1307 0.5002 -4.3489 68.9449
NCI-H1648 GDSC1 -0.563 5.6465 -2.2359 39.2031
NCI-H2135 GDSC1 -0.3675 3.2533 -1.0084 33.3222
IST-SL2 GDSC1 1.2225 8.0164 -1.6785 28.3863
LC-2/ad GDSC1 1.7719 8.043 -1.2136 23.9135
NCI-H720 GDSC1 2.001 3.9593 1.0211 7.715
NCI-H1975 GDSC1 2.0682 6.3469 -0.1169 16.0664
NCI-H2171 GDSC1 2.4696 8.5488 -0.8918 19.5792
HOP-62 GDSC1 2.6896 12.6769 -2.7753 27.4033
NCI-H847 GDSC1 2.7273 4.5971 1.246 3.7704
COLO 668 GDSC1 2.7296 4.6963 1.2007 4.0989
NCI-H1581 GDSC1 2.8787 6.7863 0.2937 10.4385
NCI-H1869 GDSC1 2.9525 4.9209 1.2363 3.3214
NCI-H23 GDSC1 2.9696 10.9253 -1.6826 22.0665
EKVX GDSC1 3.0018 6.2678 0.6323 7.6098
NCI-H1876 GDSC1 3.0048 5.8888 0.8157 6.2494
NCI-H2196 GDSC1 3.0094 6.7286 0.415 9.1808
NCI-H1355 GDSC1 3.0676 12.2986 -2.2889 24.4102
NCI-H1092 GDSC1 3.1066 5.4008 1.1094 3.881
DMS 114 GDSC1 3.1068 7.0845 0.3106 9.6616
NCI-H69 GDSC1 3.2035 6.2453 0.777 6.0359
SBC-1 GDSC1 3.2524 6.9217 0.4884 7.9942
NCI-H1304 GDSC1 3.2615 5.033 1.361 1.914
Ms-1 GDSC1 3.2633 5.9753 0.9405 4.7278
NCI-H2141 GDSC1 3.2937 4.9461 1.4143 1.548
NCI-H1155 GDSC1 3.2981 5.1713 1.3208 2.1027
NCI-H748 GDSC1 3.328 9.1668 -0.5459 14.7719
NCI-H345 GDSC1 3.3403 4.141 1.7428 0.1137
Lu-65 GDSC1 3.3446 9.2406 -0.57 14.8725
NCI-H1836 GDSC1 3.3601 6.1338 0.9266 4.6141
NCI-H128 GDSC1 3.3851 12.9422 -2.364 23.7684
IST-SL1 GDSC1 3.4469 6.5516 0.7872 5.3978
HCC33 GDSC1 3.4767 5.5259 1.2624 2.1762
NCI-H1770 GDSC1 3.5211 12.958 -2.2687 22.991
NCI-H322M GDSC1 3.5917 10.1366 -0.8302 15.7153
NCI-H2081 GDSC1 3.6091 5.5651 1.3128 1.6901
NCI-H209 GDSC1 3.6588 6.8752 0.7668 5.083
SHP-77 GDSC1 3.6898 9.0837 -0.2517 11.9044
Lu-165 GDSC1 3.7682 5.7739 1.3037 1.5362
NCI-H524 GDSC1 3.8763 9.3852 -0.2703 11.5369
NCI-H1436 GDSC1 3.9364 5.7288 1.3974 0.9081
DMS 79 GDSC1 3.9439 6.8044 0.959 3.2904
NCI-H2227 GDSC1 4.0207 5.8591 1.3835 0.895
NCI-H64 GDSC1 4.0513 9.6843 -0.2966 11.262
NCI-H1694 GDSC1 4.086 5.7115 1.4655 0.5356
NCI-H526 GDSC1 4.1608 5.2416 1.656 0.0756
Lu-139 GDSC1 4.1908 11.2596 -0.9557 14.8107
NCI-H82 GDSC1 4.2176 9.6768 -0.1851 10.1581
NCI-H510A GDSC1 4.3648 11.0204 -0.7243 13.0625
LB647-SCLC GDSC1 4.4141 6.6795 1.2369 1.1831
NCI-H446 GDSC1 4.4429 6.1095 1.4593 0.3712
Lu-134-A GDSC1 4.4446 11.2111 -0.7622 13.0848
NCI-H1963 GDSC1 4.4584 6.6708 1.2592 1.0499
COR-L95 GDSC1 4.4652 12.8591 -1.5377 17.1462
NCI-H211 GDSC1 4.5377 11.3056 -0.7459 12.7674
NCI-H1666 GDSC1 4.6334 12.5122 -1.2565 15.3133
COR-L88 GDSC1 4.6909 14.7654 -2.303 20.0285
NCI-H1838 GDSC1 4.853 12.6849 -1.1928 14.457
CPC-N GDSC1 4.9899 13.0847 -1.2925 14.6503
NCI-H1650 GDSC1 5.6897 16.4996 -2.4533 18.3281
NCI-H1299 GDSC1 5.9129 13.97 -1.1237 11.8059
NCI-H226 GDSC1 5.9937 15.8911 -1.9661 15.6307
LXF 289 GDSC1 6.0909 19.5926 -3.6646 21.8025
NCI-H187 GDSC1 8.2967 24.1779 -4.3832 19.8764
⏷ Show the Full List of 64 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CBTCi002-A GDSC1 2.9822 9.4016 -0.9175 18.0386
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE-5 GDSC1 1.968 9.946 -1.9997 26.8655
TE-9 GDSC1 2.3641 5.7601 0.4141 11.1632
TE-10 GDSC1 2.955 4.7468 1.3172 2.7525
EC-GI-10 GDSC1 3.0913 6.2897 0.6823 7.0063
TE-1 GDSC1 3.1084 8.7965 -0.5246 15.2933
TE-15 GDSC1 3.9461 6.6736 1.0164 2.9339
TE-6 GDSC1 4.6488 6.9823 1.2209 1.0527
TE-8 GDSC1 4.9903 15.7161 -2.5541 20.3177
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ES-2 GDSC1 -0.2564 7.1615 -2.6386 38.5951
OVCAR-4 GDSC1 2.4285 7.3532 -0.3284 16.2245
Kuramochi GDSC1 4.1732 14.0971 -2.3469 21.5243
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
PSN1 GDSC1 -3.9014 -0.1179 -4.0097 68.8809
MZ-PC-1 GDSC1 -1.7541 13.3638 -7.0495 49.1308
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MSTO-211H GDSC1 1.2971 2.7881 0.9331 11.363
MPP 89 GDSC1 1.6246 13.7099 -4.1706 34.6994
IST-Mes1 GDSC1 3.0788 8.6663 -0.4823 15.1177
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LNCaP clone FGC GDSC1 3.666 6.6274 0.883 4.2838
VCaP GDSC1 4.0444 8.0793 0.4479 6.4236
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 GDSC1 3.296 7.9667 0.0155 11.201
Cancer Drug Sensitivity Data Curated from 18 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A101D GDSC1 -7.8815 17.9318 -15.1877 62.1506
SH-4 GDSC1 -7.5487 2.7129 -8.6238 75.5214
MZ-MEL-7 GDSC1 -7.2749 14.9647 -13.2241 62.5888
LB2518-MEL GDSC1 -7.1914 -1.0105 -7.398 83.6055
HT-144 GDSC1 -7.1365 2.3688 -8.074 75.3321
UACC-257 GDSC1 -5.7638 5.7995 -7.7462 66.4593
COLO 829 GDSC1 -5.1256 5.997 -7.1424 64.2913
MMAc-SF GDSC1 -4.3592 8.0856 -7.1981 59.875
CP66-MEL GDSC1 -2.7898 5.8304 -4.609 54.6257
SK-MEL-1 GDSC1 -1.1595 2.8048 -1.6971 41.6117
MZ-MEL-2 GDSC1 -0.9794 5.227 -2.4725 42.2777
IST-MEL1 GDSC1 -0.6259 20.1354 -9.3394 46.4237
LB373-MEL-D GDSC1 -0.122 12.1723 -4.9473 42.0153
SK-MEL-2 GDSC1 1.538 5.4922 -0.1447 18.3266
DJM-1 GDSC1 1.9575 3.7971 1.0658 7.5218
A-388 GDSC1 2.2766 5.4262 0.5116 10.7188
LOX-IMVI GDSC1 2.928 11.7319 -2.1158 24.1275
COLO 800 GDSC1 3.3145 12.5182 -2.2078 23.3395
⏷ Show the Full List of 18 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuTu 80 GDSC1 0.5532 7.3512 -1.9598 32.5047
Cancer Drug Sensitivity Data Curated from 9 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SW872 GDSC1 -2.9916 18.9513 -10.9257 52.4477
MFH-ino GDSC1 0.9288 12.9973 -4.415 37.4887
TE 441.T GDSC1 1.4911 7.6226 -1.2459 25.2002
KYM-1 GDSC1 2.5993 14.7925 -3.904 31.0809
SK-LMS-1 GDSC1 3.1653 5.0491 1.3021 2.4498
SW684 GDSC1 3.387 4.7432 1.5404 0.7753
EW-8 GDSC1 3.9095 5.6237 1.4262 0.8092
SK-UT-1 GDSC1 4.1263 14.5077 -2.5824 22.581
VA-ES-BJ GDSC1 6.3414 18.2476 -2.853 18.4999
⏷ Show the Full List of 9 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-1 GDSC1 -1.0502 5.6745 -2.7423 43.2217
ECC12 GDSC1 0.8161 4.3888 -0.2828 22.5009
SNU-5 GDSC1 2.1042 5.0376 0.5671 10.8905
SNU-16 GDSC1 2.2305 5.6007 0.3879 11.814
HSC-39 GDSC1 2.2448 3.7127 1.3381 4.3982
RF-48 GDSC1 2.4949 5.1131 0.8341 7.5387
GCIY GDSC1 3.0426 6.3143 0.6377 7.4602
SCH GDSC1 3.4425 4.8427 1.526 0.7881
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CGTH-W-1 GDSC1 -3.541 24.3411 -14.0683 53.0074
K5 GDSC1 -2.9404 17.0957 -9.9773 52.5354
Cancer Drug Sensitivity Data Curated from 4 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
BB49-HNC GDSC1 -0.9006 37.8778 -18.4099 48.4497
BB30-HNC GDSC1 0.908 4.0177 -0.0186 20.2391
SCC-15 GDSC1 1.8644 4.6272 0.5718 11.7348
LB771-HNC GDSC1 3.3735 6.0069 0.9925 4.1293
Cancer Drug Sensitivity Data Curated from 10 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NEC8 GDSC1 0.5845 9.0882 -2.7833 35.0772
KGN GDSC1 1.6905 13.4949 -4.0073 34.1212
NT2-D1 GDSC1 2.3434 4.5371 1.005 6.6851
SW954 GDSC1 2.594 5.3676 0.7819 7.6401
NCC-IT GDSC1 3.0946 7.343 0.1767 10.6488
DSH1 GDSC1 3.6667 13.7198 -2.5355 23.6416
LB831-BLC GDSC1 3.7415 6.1122 1.1498 2.4469
JAR GDSC1 3.8065 5.6073 1.3879 1.0721
OMC-1 [Human cervical carcinoma] GDSC1 4.2038 5.9545 1.423 0.6077
SW962 GDSC1 4.572 16.5572 -3.2623 23.8929
⏷ Show the Full List of 10 Cancer Drug Sensitivity Data of This Drug

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8475).
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8475).
3 BAY61-3606 affects the viability of colon cancer cells in a genotype-directed manner. PLoS One. 2012;7(7):e41343. doi: 10.1371/journal.pone.0041343. Epub 2012 Jul 18.