Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMEWQHP)

• Drug Name: AZ-628 Drug Info
• Synonyms: Mutant B-Raf Kinase inhibitors, AstraZeneca; Mutant B-Raf (V600E) kinase inhibitors (cancer), AstraZeneca

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 11676786
  ChEBI ID: CHEBI:91354
  CAS Number: CAS 878739-06-1
  TTD Drug ID: DMEWQHP

Molecule-Related Drug Atlas

Drug(s) Targeting Serine/threonine-protein kinase B-raf (BRAF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dabrafenib	DMX6OE3	Melanoma	2C30	Approved	[4]
Vemurafenib	DM62UG5	Melanoma	2C30	Approved	[5]
LGX818	DMNQXV8	Melanoma	2C30	Approved	[6]
PLX8394	DMRTD7I	Solid tumour/cancer	2A00-2F9Z	Phase 2	[7]
CEP-32496	DMAO04B	Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[8]
BGB-283	DMVYTG7	Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[9]
ARQ 736	DMP9ZT1	Solid tumour/cancer	2A00-2F9Z	Phase 1	[10]
RO-5212054	DML4C3Q	Solid tumour/cancer	2A00-2F9Z	Phase 1	[11]
ASN003	DMJCX6D	Solid tumour/cancer	2A00-2F9Z	Phase 1	[12]
BMS-908662	DM3K8VM	Solid tumour/cancer	2A00-2F9Z	Phase 1	[13]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[14]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[15]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[16]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[17]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[18]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[19]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[20]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[21]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[22]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[23]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[24]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[15]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[25]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[26]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[27]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[14]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[28]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[29]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[17]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[18]

Drug(s) Affected By GTPase KRas (KRAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[30]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[31]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[32]
Tiazofurin	DM5JWV9	Solid tumour/cancer	2A00-2F9Z	Approved	[33]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[34]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[35]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[36]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[37]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Serine/threonine-protein kinase B-raf (BRAF)	TTWCGQT	BRAF_HUMAN	Inhibitor	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
GTPase KRas (KRAS)	OT78QCN8	RASK_HUMAN	Drug Response	[3]
Mitogen-activated protein kinase 1 (MAPK1)	OTH85PI5	MK01_HUMAN	Post-Translational Modifications	[3]
Mitogen-activated protein kinase 3 (MAPK3)	OTCYKGKO	MK03_HUMAN	Post-Translational Modifications	[3]

References

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