Details of the Drug

General Information of Drug (ID: DMF3VXA)

Drug Name
ZOTEPINE
Synonyms
zotepine; 26615-21-4; Nipolept; Lodopin; Zoleptil; Zotepina; Zotepinum; Compound-4; Zotepina [Spanish]; Zotepinum [INN-Latin]; Zotepina [INN-Spanish]; UNII-U29O83JAZW; 2-Chloro-11-(2-(dimethylamino)ethoxy)dibenzo(b,f)thiepin; 2-Chlor-11-(2-dimethylaminoaethoxy)-dibenzo(b,f)-thiepin; C18H18ClNOS; BRN 1435710; U29O83JAZW; CHEMBL285802; CHEBI:32316; HDOZVRUNCMBHFH-UHFFFAOYSA-N; 2-[(8-chlorodibenzo[b,f]thiepin-10-yl)oxy]-N,N-dimethylethanamine; 2-Chloro-11-(2-dimethylaminoethoxy)-dibenzo(b,f)thiepine; NCGC00182081-02
Indication
Disease Entry ICD 11 Status REF
Anxiety disorder 6B00-6B0Z Approved [1]
Affected Organisms
Humans and other mammals
ATC Code
N05AX11: ZOTEPINE
N05AX: Other antipsychotics
N05A: ANTIPSYCHOTICS
N05: PSYCHOLEPTICS
N: NERVOUS SYSTEM
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 331.9
Logarithm of the Partition Coefficient (xlogp) 4.8
Rotatable Bond Count (rotbonds) 4
Hydrogen Bond Donor Count (hbonddonor) 0
Hydrogen Bond Acceptor Count (hbondacc) 3
ADMET Property
Absorption Cmax
The maximum plasma concentration (Cmax) of drug is 6.9-19.6 mcg/L [2]
Absorption Tmax
The time to maximum plasma concentration (Tmax) is 2-4 h [2]
BDDCS Class
Biopharmaceutics Drug Disposition Classification System (BDDCS) Class 2: low solubility and high permeability [3]
Half-life
The concentration or amount of drug in body reduced by one-half in 21 hours [4]
Metabolism
The drug is metabolized via the CYP1A2 and CYP3A4 [5]
Vd
The volume of distribution (Vd) of drug is 109 L/kg [4]
Chemical Identifiers
Formula
C18H18ClNOS
IUPAC Name
2-(3-chlorobenzo[b][1]benzothiepin-5-yl)oxy-N,N-dimethylethanamine
Canonical SMILES
CN(C)CCOC1=CC2=CC=CC=C2SC3=C1C=C(C=C3)Cl
InChI
InChI=1S/C18H18ClNOS/c1-20(2)9-10-21-16-11-13-5-3-4-6-17(13)22-18-8-7-14(19)12-15(16)18/h3-8,11-12H,9-10H2,1-2H3
InChIKey
HDOZVRUNCMBHFH-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
5736
ChEBI ID
CHEBI:32316
CAS Number
26615-21-4
UNII
U29O83JAZW
DrugBank ID
DB09225
TTD ID
D0T6QX
INTEDE ID
DR1739

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
5-HT 2A receptor (HTR2A) TTJQOD7 5HT2A_HUMAN Inhibitor [6]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Substrate [7]
Cytochrome P450 2D6 (CYP2D6) DECB0K3 CP2D6_HUMAN Substrate [8]
Cytochrome P450 1A1 (CYP1A1) DE6OQ3W CP1A1_HUMAN Substrate [8]
Mephenytoin 4-hydroxylase (CYP2C19) DEGTFWK CP2CJ_HUMAN Substrate [8]
Cytochrome P450 1A2 (CYP1A2) DEJGDUW CP1A2_HUMAN Substrate [8]
Cytochrome P450 3A5 (CYP3A5) DEIBDNY CP3A5_HUMAN Substrate [8]
Cytochrome P450 2B6 (CYP2B6) DEPKLMQ CP2B6_HUMAN Substrate [8]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Prolactin (PRL) OTWFQGX7 PRL_HUMAN Gene/Protein Processing [9]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Anxiety disorder
ICD Disease Classification 6B00-6B0Z
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
5-HT 2A receptor (HTR2A) DTT HTR2A 1.68E-01 -0.3 -0.14
5-HT 2A receptor (HTR2A) DTT HTR2A 5.59E-01 0.15 0.21
Cytochrome P450 2B6 (CYP2B6) DME CYP2B6 9.90E-01 3.10E-03 1.75E-02
Cytochrome P450 2B6 (CYP2B6) DME CYP2B6 5.35E-01 1.10E-02 1.19E-01
Cytochrome P450 1A2 (CYP1A2) DME CYP1A2 6.73E-02 6.49E-02 3.07E-01
Cytochrome P450 1A2 (CYP1A2) DME CYP1A2 6.45E-01 2.07E-02 1.74E-01
Cytochrome P450 3A5 (CYP3A5) DME CYP3A5 1.17E-01 -3.87E-02 -2.23E-01
Cytochrome P450 3A5 (CYP3A5) DME CYP3A5 9.74E-01 7.48E-03 1.37E-01
Mephenytoin 4-hydroxylase (CYP2C19) DME CYP2C19 7.39E-01 1.54E-02 4.74E-02
Mephenytoin 4-hydroxylase (CYP2C19) DME CYP2C19 4.64E-02 -8.21E-02 -7.11E-01
Cytochrome P450 2D6 (CYP2D6) DME CYP2D6 2.59E-01 6.29E-02 3.14E-01
Cytochrome P450 2D6 (CYP2D6) DME CYP2D6 4.84E-01 -8.38E-02 -8.46E-01
Cytochrome P450 1A1 (CYP1A1) DME CYP1A1 2.32E-01 -3.66E-02 -1.30E-01
Cytochrome P450 1A1 (CYP1A1) DME CYP1A1 6.55E-01 1.27E-02 8.44E-02
Cytochrome P450 3A4 (CYP3A4) DME CYP3A4 4.66E-01 4.25E-02 1.20E-01
Cytochrome P450 3A4 (CYP3A4) DME CYP3A4 4.75E-01 5.15E-02 3.64E-01
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
U2OS CTRP1 6.7824 9.108 4.2262 2.7056
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MCF-7 CTRP1 7.4075 14.5935 2.0783 15.9526
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SF295 CTRP1 6.7892 8.0592 4.6439 0.4038
GaMG CTRP1 6.8731 8.8086 4.3938 1.5097
LN-229 CTRP1 7.2811 9.6248 4.2551 1.7855
Cancer Drug Sensitivity Data Curated from 10 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HEC-265 CTRP1 6.7618 7.9347 4.678 0.3077
HEC-59 CTRP1 6.772 8.3695 4.5213 0.9404
HEC-151 CTRP1 6.843 12.5498 2.6758 13.8814
HEC-251 CTRP1 7.0646 8.6726 4.5284 0.6536
HEC-6 CTRP1 7.1245 8.4051 4.6465 0.2371
KLE CTRP1 7.2763 9.2532 4.3978 1.0486
MFE-319 CTRP1 7.3912 9.0805 4.5076 0.5165
HEC-108 CTRP1 7.8031 12.858 3.1393 8.2349
JHUEM-2 CTRP1 7.9128 15.966 1.7611 16.3361
Ishikawa (Heraklio) 02 ER- CTRP1 6.3045 7.811 4.5301 1.4751
⏷ Show the Full List of 10 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NU-DUL-1 CTRP1 -0.0493 81.2272 -37.3616 51.0859
MOLM-16 CTRP1 5.57 7.779 4.0977 6.7554
BL-70 CTRP1 5.6394 9.0892 3.5047 11.602
PL21 CTRP1 5.9114 7.6666 4.3784 3.3728
MC116 CTRP1 5.9517 6.8522 4.7522 0.6279
THP-1 CTRP1 6.2979 9.1286 3.9406 5.9271
SU-DHL-4 CTRP1 6.3855 15.0221 1.1351 23.8668
KE-97 CTRP1 6.4254 8.3512 4.3637 2.3889
SKM-1 CTRP1 6.45 7.8026 4.6009 0.8731
OCI-Ly10 CTRP1 6.4555 10.7266 3.2875 10.6598
OCI-AML-3 CTRP1 6.505 18.2804 -0.3888 29.0416
SU-DHL-5 CTRP1 6.5982 7.7291 4.6893 0.3605
NOMO-1 CTRP1 6.7628 7.916 4.685 0.2861
WSU-DLCL2 CTRP1 6.7666 8.0843 4.6261 0.4828
HT CTRP1 6.8116 8.1865 4.6064 0.5272
P3HR-1 CTRP1 6.9478 8.7679 4.4434 1.1518
AMO1 CTRP1 6.968 8.1447 4.6801 0.2135
RPMI-8226 CTRP1 6.9934 8.6061 4.5243 0.7256
EJM CTRP1 7.0306 8.6662 4.517 0.7268
LP-1 CTRP1 7.1652 8.6843 4.5634 0.4585
U-937 CTRP1 7.2556 12.764 2.847 11.5642
Ku812 CTRP1 7.6472 9.3095 4.5222 0.3475
KMS-11 CTRP1 7.8118 9.6684 4.4571 0.4554
GDM-1 CTRP1 7.9504 9.8756 4.4355 0.4532
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
VMRC-RCW CTRP1 6.8338 11.0233 3.3942 8.78
RCC10RGB CTRP1 9.1089 19.5267 0.8576 17.7337
Cancer Drug Sensitivity Data Curated from 37 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-81 CTRP1 6.0519 9.192 3.7499 8.1904
CL-40 CTRP1 6.113 8.2573 4.2294 4.0721
MDST8 CTRP1 6.2168 7.9369 4.4318 2.2953
SW948 CTRP1 6.2671 7.9239 4.4639 1.9762
LS180 CTRP1 6.3365 8.2336 4.3673 2.5296
HCT 116 CTRP1 6.3819 8.432 4.3055 2.8891
LS123 CTRP1 6.4094 9.1455 4.0012 5.159
HT-55 CTRP1 6.4734 7.9606 4.5491 1.1276
CL-34 CTRP1 6.525 11.3791 3.0214 12.4339
SNU-C4 CTRP1 6.5417 9.8587 3.7534 6.7817
SNU-1040 CTRP1 6.5538 8.1764 4.4998 1.3087
HT115 CTRP1 6.5795 8.3965 4.4224 1.743
LoVo CTRP1 6.5994 9.1411 4.1136 3.8616
LS411N CTRP1 6.6605 7.9056 4.6496 0.4657
DLD-1 CTRP1 6.6793 7.901 4.6586 0.4195
SW620 CTRP1 6.7226 9.1564 4.1741 3.1754
HCT 8 CTRP1 6.774 7.976 4.6679 0.3328
SNU-175 CTRP1 6.8014 9.2631 4.1699 3.0591
SK-CO-1 CTRP1 6.9674 8.6486 4.4976 0.8669
COLO 320 CTRP1 7.0709 11.2191 3.4502 7.7565
SNU-61 CTRP1 7.1932 9.1136 4.4158 1.0411
SW48 CTRP1 7.1976 9.0566 4.4393 0.928
COLO205 CTRP1 7.2257 15.2353 1.6438 18.8349
SW403 CTRP1 7.2718 10.076 4.0663 2.9514
SW480 CTRP1 7.2774 10.0909 4.0628 2.9647
COLO 678 CTRP1 7.3167 9.8124 4.1963 2.0784
RCM-1 [Human ESC] CTRP1 7.3305 8.6849 4.6239 0.2183
C2BBe1 CTRP1 7.338 9.6348 4.2768 1.5967
GP2d CTRP1 7.4551 9.5328 4.3667 1.0306
KM12 CTRP1 7.4736 9.1246 4.5231 0.4231
CW-2 CTRP1 7.5403 9.481 4.4205 0.7377
SNU-C2A CTRP1 7.6322 9.9762 4.2727 1.3061
LS513 CTRP1 7.6697 9.1879 4.5721 0.2231
NCI-H508 CTRP1 7.7895 15.9615 1.681 17.0793
RKO CTRP1 7.8216 15.2105 2.0596 14.9438
SNU-C5 CTRP1 7.8702 10.1885 4.2914 1.0134
HT-29 CTRP1 9.0897 19.4184 0.8962 17.6109
⏷ Show the Full List of 37 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 4 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Hep-G2 CTRP1 6.6774 14.7022 1.5106 21.1659
JHH-6 CTRP1 6.7037 7.3732 4.847 0.0196
SNU-398 CTRP1 7.5025 9.9094 4.2423 1.5942
SNU-449 CTRP1 7.7407 9.6053 4.4528 0.5035
Cancer Drug Sensitivity Data Curated from 91 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COR-L51 CTRP1 3.9027 5.959 3.4738 19.9027
NCI-H2141 CTRP1 5.6528 7.7448 4.1729 5.8321
NCI-H1105 CTRP1 6.1342 8.0595 4.3317 3.2165
HCC1359 CTRP1 6.1844 9.1925 3.8379 7.0734
NCI-H596 CTRP1 6.2003 8.0985 4.3519 2.9176
DV-90 CTRP1 6.2313 9.153 3.887 6.5404
LCLC-103H CTRP1 6.2535 7.8945 4.4693 1.9626
SCLC-21H CTRP1 6.2945 10.87 3.1076 12.5201
NCI-H2081 CTRP1 6.3425 9.3874 3.848 6.5549
BEN CTRP1 6.3613 7.4412 4.7011 0.4794
NCI-H2122 CTRP1 6.3704 8.8531 4.1113 4.3883
Sq-1 CTRP1 6.3968 9.2469 3.947 5.6204
SK-LU-1 CTRP1 6.4259 10.2968 3.4729 9.3116
NCI-H1781 CTRP1 6.5073 12.2719 2.5766 15.5756
NCI-H1836 CTRP1 6.508 8.1934 4.4713 1.5425
LCLC-97TM1 CTRP1 6.5214 9.4303 3.9383 5.3802
HCC4006 CTRP1 6.5612 10.1981 3.6074 7.8766
NCI-H441 CTRP1 6.5836 9.385 3.9956 4.7898
NCI-H1930 CTRP1 6.5874 8.446 4.4059 1.8358
EPLC-272H CTRP1 6.5888 8.7602 4.274 2.7191
NCI-H460 CTRP1 6.5989 10.4026 3.5355 8.3344
NCI-H2286 CTRP1 6.6081 8.9359 4.2084 3.1493
NCI-H1694 CTRP1 6.6342 8.7241 4.3129 2.3716
HCC2935 CTRP1 6.6746 9.7542 3.8819 5.4519
NCI-H1915 CTRP1 6.7043 8.6773 4.3673 1.9033
EBC-1 CTRP1 6.7188 8.984 4.2461 2.68
Lu-99 CTRP1 6.7444 8.1884 4.5786 0.6957
NCI-H1435 CTRP1 6.7588 8.846 4.3242 2.0948
COR-L279 CTRP1 6.8061 8.1764 4.608 0.5251
NCI-H82 CTRP1 6.885 11.381 3.2593 9.6471
LC-1/sq-SF CTRP1 6.9029 8.8378 4.3959 1.4608
NCI-H2029 CTRP1 6.9133 8.1471 4.6594 0.2898
NCI-H810 CTRP1 6.9204 8.6611 4.4728 1.0311
NCI-H1048 CTRP1 6.937 8.7741 4.4362 1.2007
COR-L23 CTRP1 6.939 8.598 4.5048 0.8592
HCC78 CTRP1 6.9406 9.8403 3.9944 4.0375
NCI-H2172 CTRP1 6.9433 8.5416 4.5279 0.7511
NCI-H1755 CTRP1 6.9487 8.8225 4.4225 1.2604
NCI-H2126 CTRP1 6.9872 8.2007 4.6677 0.2367
NCI-H841 CTRP1 6.9926 9.256 4.2689 2.0929
CAL-12T CTRP1 6.9985 9.6067 4.1256 3.0139
HCC827 CTRP1 7.0264 9.0921 4.351 1.5611
NCI-H650 CTRP1 7.0389 8.5874 4.5495 0.5887
NCI-H522 CTRP1 7.0487 8.9072 4.4333 1.0976
HCC1195 CTRP1 7.0551 9.0664 4.3741 1.3989
Calu-3 CTRP1 7.0625 9.2985 4.2848 1.8977
LXF 289 CTRP1 7.0764 9.2763 4.3003 1.7879
NCI-H1793 CTRP1 7.1125 8.975 4.4346 1.0285
RERF-LC-KJ CTRP1 7.1229 8.6071 4.5749 0.444
NCI-H1876 CTRP1 7.1483 9.7415 4.1444 2.6436
SHP-77 CTRP1 7.1525 8.4147 4.6533 0.2117
NCI-H661 CTRP1 7.153 9.452 4.2652 1.8922
NCI-H1568 CTRP1 7.1569 8.984 4.4498 0.9164
NCI-H1299 CTRP1 7.2211 8.8358 4.5304 0.5395
NCI-H1792 CTRP1 7.2402 10.0993 4.0406 3.1714
NCI-H727 CTRP1 7.2614 8.9888 4.4904 0.6618
NCI-H2023 CTRP1 7.2692 9.2403 4.3997 1.0463
HCC33 CTRP1 7.2813 8.7523 4.5828 0.3398
NCI-H2009 CTRP1 7.2906 9.0407 4.483 0.6702
VMRC-LCD CTRP1 7.2943 8.8021 4.5701 0.3701
NCI-H23 CTRP1 7.3598 9 4.5245 0.478
NCI-H2030 CTRP1 7.3775 13.1944 2.723 12.0657
KNS-62 CTRP1 7.3851 8.7984 4.6045 0.2436
NCI-H2342 CTRP1 7.3862 9.6882 4.2774 1.539
A-549 CTRP1 7.4309 9.6545 4.31 1.3232
DMS 273 CTRP1 7.4342 8.9566 4.5675 0.316
HCC2108 CTRP1 7.459 9.4446 4.4013 0.8759
COR-L88 CTRP1 7.463 9.1678 4.5038 0.4891
HCC15 CTRP1 7.4918 12.5341 3.1017 9.2174
NCI-H2405 CTRP1 7.4985 9.3413 4.4549 0.6362
HCC44 CTRP1 7.5083 9.3432 4.4581 0.6184
Lu-65 CTRP1 7.5288 9.1055 4.5501 0.3229
Calu-6 CTRP1 7.534 9.4933 4.4134 0.7696
NCI-H1573 CTRP1 7.5752 9.197 4.5352 0.343
ChaGo-K-1 CTRP1 7.6122 9.3496 4.4953 0.4385
NCI-H1963 CTRP1 7.6421 9.6673 4.3925 0.775
COLO 668 CTRP1 7.6594 9.5325 4.448 0.563
NCI-H1944 CTRP1 7.7338 13.8369 2.6484 11.6296
COLO 699 CTRP1 7.7442 9.9252 4.3382 0.9169
HARA [Human squamous cell lung carcinoma] CTRP1 7.7611 9.4037 4.5307 0.2837
NCI-H358 CTRP1 7.7679 10.0569 4.2988 1.0645
NCI-H1437 CTRP1 7.7724 9.551 4.4837 0.3978
NCI-H1355 CTRP1 7.7759 11.6331 3.6646 4.738
NCI-H2073 CTRP1 7.7777 13.8329 2.6776 11.3348
T3M-10 CTRP1 7.813 13.5646 2.8232 10.3105
NCI-H1975 CTRP1 7.8558 9.9243 4.3825 0.6717
NCI-H2110 CTRP1 7.9357 10.7534 4.1037 1.839
HCC1833 CTRP1 7.94 9.5495 4.544 0.2029
NCI-H1666 CTRP1 8.0066 18.8664 0.4307 22.1234
NCI-H3255 CTRP1 8.1235 19.1572 0.3715 22.055
NCI-H1373 CTRP1 8.3453 14.0326 2.9245 8.4662
⏷ Show the Full List of 91 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KYSE-450 CTRP1 6.9276 8.2281 4.6362 0.3522
KYSE-140 CTRP1 7.5179 9.8031 4.2902 1.3332
KYSE-410 CTRP1 7.5364 9.5878 4.3794 0.9069
Cancer Drug Sensitivity Data Curated from 26 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JHOM-1 CTRP1 6.3038 10.0373 3.5152 9.3379
COV318 CTRP1 6.6555 7.8875 4.6542 0.4515
JHOC-5 CTRP1 6.6669 10.2433 3.6528 7.2428
Caov-3 CTRP1 6.6899 11.4885 3.0807 11.5083
OV7 CTRP1 6.7623 10.0079 3.8186 5.7304
HEY A8 CTRP1 6.7961 8.551 4.4611 1.2275
OAW42 CTRP1 6.9165 7.9811 4.7178 0.1481
IGROV-1 CTRP1 6.9267 9.2663 4.2325 2.4241
SNU-840 CTRP1 6.9679 12.7814 2.6494 13.69
JHOS-4 CTRP1 7.0125 8.9111 4.416 1.2238
OVMANA CTRP1 7.0715 8.2634 4.6763 0.1874
OVKATE CTRP1 7.2422 9.2682 4.3775 1.179
OVCAR-8 CTRP1 7.2491 8.8339 4.5418 0.483
SK-OV-3 CTRP1 7.2493 8.6666 4.601 0.3038
OV-90 CTRP1 7.2566 9.4998 4.2936 1.6012
COV362 CTRP1 7.3483 12.248 3.1458 9.2625
A2780 CTRP1 7.375 9.1789 4.4657 0.6781
COV434 CTRP1 7.469 9.3217 4.4506 0.6717
EFO-21 CTRP1 7.476 8.8904 4.6052 0.2127
COV644 CTRP1 7.494 11.9734 3.3583 7.4219
EFO-27 CTRP1 7.9384 9.824 4.4492 0.4205
RMUG-S CTRP1 8.0667 15.2016 2.2214 13.3963
RMG-I CTRP1 8.3987 17.7075 1.2545 17.6254
OVCAR-4 CTRP1 8.8334 16.788 1.9618 13.046
OVK18 CTRP1 8.9777 17.1837 1.8676 13.2259
TYK-nu CTRP1 9.43 17.9418 1.7928 12.6499
⏷ Show the Full List of 26 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 10 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CFPAC-1 CTRP1 6.7288 8.8661 4.301 2.2938
SUIT-2 CTRP1 6.7897 8.4297 4.5057 1.0002
PaTu 8902 CTRP1 6.8348 8.1038 4.6454 0.3725
HPAC CTRP1 7.0513 8.4797 4.5933 0.4235
QGP-1 CTRP1 7.0844 9.3268 4.2837 1.8751
Capan-2 CTRP1 7.4315 9.3615 4.421 0.815
HuP-T4 CTRP1 7.4752 10.0979 4.1552 2.109
Panc 03.27 CTRP1 7.4903 8.8454 4.6255 0.1692
Panc 10.05 CTRP1 7.5778 9.4643 4.4412 0.6353
KP-3 CTRP1 7.7865 10.4527 4.1553 1.7349
⏷ Show the Full List of 10 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MSTO-211H CTRP1 7.1633 9.3739 4.3012 1.6717
NCI-H28 CTRP1 7.307 9.0693 4.479 0.6743
NCI-H2052 CTRP1 7.464 9.4129 4.4151 0.8146
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
PaCa-3 CTRP1 6.8617 9.7335 3.998 4.1702
Cancer Drug Sensitivity Data Curated from 9 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SK-MEL-28 CTRP1 6.2919 7.2957 4.7271 0.4249
Hs 936.T CTRP1 6.5789 8.6695 4.3076 2.5036
Hs 852.T CTRP1 6.8049 10.2323 3.7418 6.2142
SK-MEL-5 CTRP1 6.8205 8.2605 4.5827 0.616
SK-MEL-1 CTRP1 6.9891 8.1061 4.7009 0.1611
G-361 CTRP1 7.035 9.3326 4.2579 2.099
A-375 CTRP1 7.0603 13.7979 2.2239 16.094
Hs 944.T CTRP1 7.2596 9.0341 4.4731 0.7322
COLO 741 CTRP1 7.2965 10.2482 4.0063 3.3035
⏷ Show the Full List of 9 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RKN CTRP1 6.8923 8.055 4.6839 0.2328
G-401 CTRP1 8.4483 15.213 2.4512 11.147
HT-1080 CTRP1 8.7893 18.6451 1.0663 17.5522
Cancer Drug Sensitivity Data Curated from 7 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MKN7 CTRP1 6.9479 8.9437 4.3742 1.527
Fu97 CTRP1 7.2074 9.235 4.3753 1.2253
SH-10-TC CTRP1 7.2951 8.4231 4.6997 0.0935
AGS CTRP1 7.3453 8.5378 4.6787 0.1139
NUGC-4 CTRP1 7.3828 9.0885 4.5016 0.5422
MKN74 CTRP1 7.9652 10.1594 4.3398 0.7558
SNG-M CTRP1 7.4382 8.9297 4.5783 0.287
⏷ Show the Full List of 7 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HSC-2 CTRP1 6.8632 8.1134 4.6526 0.3342
SCC-9 CTRP1 7.123 9.564 4.2054 2.2962
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
5637 CTRP1 7.179 10.1794 3.975 3.721
UM-UC-3 CTRP1 7.2873 9.4545 4.325 1.3981
RT-4 CTRP1 7.4351 9.0386 4.5391 0.3943
HT-1376 CTRP1 7.6959 9.617 4.4317 0.5972
KMBC-2 CTRP1 7.795 12.5675 3.2652 7.4011

References

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