Details of the Drug

General Information of Drug (ID: DMFZO4Y)

Drug Name
EMBELIN
Synonyms
EMBELIN; 550-24-3; Embelic acid; Emberine; 2,5-dihydroxy-3-undecylcyclohexa-2,5-diene-1,4-dione; 2,5-Dihydroxy-3-undecyl-1,4-benzoquinone; 2,5-Dihydroxy-3-undecyl-p-benzoquinone; 2,5-Dihydroxy-3-undecyl-2,5-cyclohexadiene-1,4-dione; UNII-SHC6U8F5ER; CHEBI:4778; Embelin, Embelia ribes; C17H26O4; NSC91874; XIAP inhibitor, Embelin; EINECS 208-979-8; NSC 91874; SHC6U8F5ER; BRN 1885786; Apoptosis Activator III, Embelin; AK115155; p-Benzoquinone, 2,5-dihydroxy-3-undecyl-; SR-01000597536; Spectrum_001513; Tocris-2156; SpecPlus_000501
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 1 Molecular Weight (mw) 294.4
Logarithm of the Partition Coefficient (xlogp) 5.4
Rotatable Bond Count (rotbonds) 10
Hydrogen Bond Donor Count (hbonddonor) 2
Hydrogen Bond Acceptor Count (hbondacc) 4
Chemical Identifiers
Formula
C17H26O4
IUPAC Name
2,5-dihydroxy-3-undecylcyclohexa-2,5-diene-1,4-dione
Canonical SMILES
CCCCCCCCCCCC1=C(C(=O)C=C(C1=O)O)O
InChI
InChI=1S/C17H26O4/c1-2-3-4-5-6-7-8-9-10-11-13-16(20)14(18)12-15(19)17(13)21/h12,18,21H,2-11H2,1H3
InChIKey
IRSFLDGTOHBADP-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
3218
ChEBI ID
CHEBI:4778
CAS Number
550-24-3
TTD ID
D05HSW
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
XIAP messenger RNA (XIAP mRNA) TTK3WBU XIAP_HUMAN Inhibitor [1]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
72 kDa type IV collagenase (MMP2) OT5NIWA2 MMP2_HUMAN Gene/Protein Processing [2]
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Gene/Protein Processing [2]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Gene/Protein Processing [2]
Beclin-1 (BECN1) OT4X293M BECN1_HUMAN Gene/Protein Processing [3]
Cadherin-1 (CDH1) OTFJMXPM CADH1_HUMAN Gene/Protein Processing [2]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Protein Interaction/Cellular Processes [2]
Caspase-9 (CASP9) OTD4RFFG CASP9_HUMAN Protein Interaction/Cellular Processes [3]
Cyclin-dependent kinase 2 (CDK2) OTB5DYYZ CDK2_HUMAN Gene/Protein Processing [2]
Cyclin-dependent kinase 6 (CDK6) OTR95N0X CDK6_HUMAN Gene/Protein Processing [2]
DNA fragmentation factor subunit alpha (DFFA) OTFPFMT8 DFFA_HUMAN Protein Interaction/Cellular Processes [3]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 36 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RPMI-3460/CS1 GDSC1 4.2777 7.6417 3.0377 18.1426
SaOS-2 GDSC1 1.3536 6.2376 0.6252 46.8375
ES4 GDSC1 2.0856 4.1405 2.0061 36.8867
EW-16 GDSC1 2.134 5.2041 1.8143 37.4997
SJSA-1 GDSC1 2.14 5.1248 1.8439 37.3195
NOS-1 [Human HNSCC] GDSC1 2.3563 3.7927 2.3338 33.1862
NY GDSC1 2.3902 4.3298 2.3029 33.1571
ES7 GDSC1 2.5811 6.3521 1.8983 34.1107
HOS GDSC1 2.7638 3.9913 2.7438 28.0785
ES1 GDSC1 2.9532 6.5597 2.2079 30.2288
EW-18 GDSC1 3.2379 6.3143 2.608 26.2003
CHSA8926 GDSC1 3.2511 8.846 1.4781 32.212
CAL-72 GDSC1 3.2875 5.8029 2.8636 24.2405
ES6 GDSC1 3.2911 5.0196 3.1296 22.4188
EW-13 GDSC1 3.3152 5.3354 3.0599 22.7543
ES8 GDSC1 3.4325 9.2154 1.4767 31.2996
A-673 GDSC1 3.6399 6.3324 3.0195 21.2969
SK-ES-1 GDSC1 3.7557 6.3751 3.1202 19.9976
CHSA0108 GDSC1 4.0299 6.2436 3.4583 16.187
MHH-ES-1 GDSC1 4.0365 5.9084 3.6122 15.0199
EW-7 GDSC1 4.1967 6.2776 3.6109 14.2541
G-292 clone A141B1 GDSC1 4.5502 5.3125 4.3989 6.6706
EW-1 GDSC1 4.6056 6.3909 3.9536 9.8007
HuO9 GDSC1 4.7822 6.4126 4.1049 7.8892
SK-PN-DW GDSC1 4.8297 6.9288 3.8902 9.3863
HuO-3N1 GDSC1 4.8348 5.9441 4.3841 5.4906
MG-63 GDSC1 4.8699 7.2689 3.7554 10.287
ES5 GDSC1 4.9744 8.4725 3.2424 13.8221
U2OS GDSC1 4.988 7.5389 3.7206 10.1191
H-EMC-SS GDSC1 5.0902 7.8323 3.6583 10.236
EW-3 GDSC1 5.3323 9.9558 2.7933 15.7403
EW-11 GDSC1 5.4048 10.0219 2.8179 15.3215
EW-24 GDSC1 5.7223 10.0046 3.0712 12.5121
TC-71 GDSC1 5.83 7.7686 4.2311 3.6341
CHSA0011 GDSC1 6.5161 8.927 4.1097 3.0706
CAL-78 GDSC1 6.8327 10.8923 3.405 7.1727
⏷ Show the Full List of 36 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 146 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JM1 GDSC1 2.7974 4.4009 2.7293 27.9647
SIG-M5 GDSC1 0.4175 1.3573 0.4175 57.2797
KE-37 GDSC1 0.8855 2.029 0.8852 51.4293
SU-DHL-5 GDSC1 1.1321 1.9731 1.1321 48.3483
ALL-PO GDSC1 1.3566 3.6281 1.2974 45.7285
CCRF-CEM GDSC1 1.3812 2.8379 1.3755 45.2595
MC116 GDSC1 1.4703 4.2631 1.3213 44.615
SUP-M2 GDSC1 1.7643 3.5235 1.7366 40.5952
NALM-6 GDSC1 1.7771 3.0805 1.772 40.3159
Loucy GDSC1 1.8162 3.2336 1.807 39.85
P32/ISH GDSC1 1.8788 2.999 1.8766 39.0282
NU-DUL-1 GDSC1 1.8847 3.6244 1.8544 39.1119
BC-1 GDSC1 1.9272 3.461 1.9103 38.5093
SU-DHL-8 GDSC1 1.9295 3.314 1.9199 38.4382
SUP-B15 GDSC1 1.9687 3.381 1.9573 37.9597
ALL-SIL GDSC1 1.9832 3.9072 1.9291 38.0162
RPMI-8402 GDSC1 1.9956 3.9895 1.9316 37.9159
QIMR-WIL GDSC1 2.1035 3.5716 2.0862 36.3106
L-428 GDSC1 2.1704 4.4961 2.0335 36.1534
BL-41 GDSC1 2.2047 4.0164 2.1509 35.2642
DND-41 GDSC1 2.3006 3.6794 2.2839 33.846
P30/OHK GDSC1 2.3503 3.4132 2.3463 33.1458
EoL-1 GDSC1 2.3755 3.6029 2.3654 32.8691
EB2 GDSC1 2.3954 3.8669 2.3685 32.7243
OCI-AML-2 GDSC1 2.4268 3.1775 2.4264 32.1678
Karpas-231 GDSC1 2.4466 3.7493 2.4308 32.0165
Daudi GDSC1 2.4607 5.9582 1.9187 34.7819
L-540 GDSC1 2.4853 5.3985 2.1373 33.4884
NB4 GDSC1 2.4945 4.736 2.333 32.3096
HT GDSC1 2.4962 5.6128 2.0786 33.735
WIL2 NS GDSC1 2.501 3.9062 2.4759 31.3945
HC-1 GDSC1 2.5811 5.2268 2.295 31.9848
GR-ST GDSC1 2.5869 5.2849 2.2836 32.015
CESS GDSC1 2.6052 5.1245 2.3514 31.5014
SU-DHL-4 GDSC1 2.6397 3.9786 2.6149 29.6599
TK [Human B-cell lymphoma] GDSC1 2.6474 4.3283 2.5798 29.8334
SUP-T1 GDSC1 2.6484 4.6958 2.5098 30.2667
PF-382 GDSC1 2.6515 5.5929 2.2536 31.7835
HL-60 GDSC1 2.6641 3.9743 2.6409 29.3446
NK-92MI GDSC1 2.6741 5.3056 2.3721 30.949
A3/Kawakami GDSC1 2.7759 4.7092 2.6455 28.6311
OCI-Ly19 GDSC1 2.8159 5.4344 2.4851 29.3995
KOPN-8 GDSC1 2.8209 5.4573 2.483 29.3819
DoHH2 GDSC1 2.9311 5.7084 2.5155 28.5272
Jiyoye GDSC1 2.9341 5.7232 2.5135 28.5221
CTV-1 GDSC1 2.9673 4.9617 2.792 26.5408
ST486 GDSC1 3.0456 5.1275 2.8309 25.8278
P12-Ichikawa GDSC1 3.0473 5.2001 2.8111 25.9483
Sc-1 GDSC1 3.1069 5.9665 2.6082 26.9292
Reh GDSC1 3.1452 5.1133 2.9438 24.503
RPMI-6666 GDSC1 3.1485 5.7034 2.7515 25.7622
VL51 GDSC1 3.1632 5.2557 2.9202 24.5575
KCL-22 GDSC1 3.1646 5.8401 2.718 25.8919
MN-60 GDSC1 3.1767 5.537 2.8414 25.007
MOLT-4 GDSC1 3.1843 4.5079 3.1279 23.0563
Raji GDSC1 3.2316 7.4751 2.0959 29.2925
RPMI-8866 GDSC1 3.2419 6.3419 2.6008 26.2239
Namalwa GDSC1 3.2878 6.468 2.5961 26.0039
DEL GDSC1 3.3109 6.2524 2.7101 25.1372
NOMO-1 GDSC1 3.3252 4.81 3.2204 21.6151
MHH-PREB-1 GDSC1 3.34 7.6205 2.1384 28.4778
Farage GDSC1 3.3467 6.8623 2.4867 26.3796
RS4;11 GDSC1 3.4257 5.3411 3.178 21.3301
ML-2 GDSC1 3.4568 5.9978 2.9675 22.6151
697 GDSC1 3.4845 4.4754 3.4543 19.1356
MY-M12 GDSC1 3.5119 5.8341 3.091 21.4645
MOLT-16 GDSC1 3.5205 5.9118 3.0694 21.5689
MOLP-8 GDSC1 3.5402 5.2798 3.3225 19.6988
HEL GDSC1 3.5602 5.5871 3.2368 20.1855
RPMI-8226 GDSC1 3.5767 6.5999 2.8378 22.8778
JSC-1 GDSC1 3.6534 5.614 3.3266 19.0544
Ramos.2G6.4C10 GDSC1 3.6931 6.6898 2.9165 21.7462
YT GDSC1 3.6968 5.6985 3.3407 18.7242
SU-DHL-1 GDSC1 3.7182 6.0692 3.2129 19.5255
Hs 445 GDSC1 3.7213 5.5894 3.4086 18.1126
BALL-1 GDSC1 3.7533 6.5635 3.0342 20.6207
WSU-NHL GDSC1 3.8574 5.9963 3.3888 17.5501
ARH-77 GDSC1 3.8859 5.9368 3.4436 17.0076
Karpas-45 GDSC1 3.9074 6.4194 3.2552 18.2737
SR GDSC1 3.9242 6.6563 3.1647 18.849
BV-173 GDSC1 3.9706 5.7865 3.5949 15.4782
CA46 GDSC1 3.9915 7.6582 2.7591 21.3861
JURL-MK1 GDSC1 4.0199 6.5555 3.3065 17.3554
HDLM-2 GDSC1 4.0367 7.271 2.9876 19.5886
SU-DHL-16 GDSC1 4.046 5.3014 3.8634 13.1574
SCC-3 GDSC1 4.0552 5.4982 3.8002 13.5572
CTB-1 GDSC1 4.1652 6.3518 3.5453 14.8941
LAMA-84 GDSC1 4.1768 6.7809 3.3562 16.2547
Karpas-422 GDSC1 4.2333 8.0475 2.7981 20.0239
L-363 GDSC1 4.2997 7.4169 3.1678 17.1005
U-698-M GDSC1 4.3233 7.835 2.9854 18.3181
Mono-Mac-6 GDSC1 4.3753 8.9521 2.4819 21.4996
MV4-11 GDSC1 4.4368 5.1708 4.3315 7.7501
ME1 GDSC1 4.449 7.8377 3.0994 16.9589
MOLM-13 GDSC1 4.4534 7.048 3.4912 14.0124
Karpas-620 GDSC1 4.4674 6.9128 3.5701 13.3493
BE-13 GDSC1 4.5662 6.1452 4.0351 9.3412
VAL GDSC1 4.574 8.0476 3.1081 16.3754
HAL-01 GDSC1 4.5753 6.0492 4.0899 8.8797
MEG-01 GDSC1 4.6241 6.858 3.7417 11.3676
ATN-1 GDSC1 4.6385 7.2434 3.5644 12.6789
KM-H2 GDSC1 4.6679 7.3458 3.54 12.7486
GDM-1 GDSC1 4.673 7.1651 3.6341 12.0017
EM-2 GDSC1 4.7324 7.6132 3.4642 13.073
KG-1 GDSC1 4.7545 6.0517 4.2578 6.8076
H9 GDSC1 4.8029 6.2843 4.187 7.1633
A4/Fukuda GDSC1 4.8237 10.6785 2.0125 22.4847
AMO1 GDSC1 4.8607 8.2589 3.253 14.1711
K-562 GDSC1 4.8872 7.4176 3.696 10.6846
SU-DHL-6 GDSC1 4.9022 6.4266 4.2036 6.6443
KMS-12-BM GDSC1 4.9158 7.5694 3.6445 10.9778
TUR GDSC1 4.9536 9.76 2.5812 18.533
U266B1 GDSC1 4.955 7.078 3.9233 8.6529
EHEB GDSC1 4.9633 7.4195 3.7596 9.9052
PL-21 GDSC1 4.9689 7.7351 3.6064 11.0762
HH [Human lymphoma] GDSC1 4.9998 7.7946 3.6025 10.9925
THP-1 GDSC1 5.1135 10.3374 2.4253 18.9345
JJN-3 GDSC1 5.1165 9.498 2.8473 16.1381
L-1236 GDSC1 5.1232 7.2423 3.9798 7.6087
SK-MM-2 GDSC1 5.268 7.9545 3.7397 8.9925
RC-K8 GDSC1 5.2822 10.563 2.45 18.1694
OCI-AML-3 GDSC1 5.2981 7.964 3.7585 8.7478
MLMA GDSC1 5.3173 7.6786 3.9151 7.468
OPM-2 GDSC1 5.3626 8.3535 3.615 9.642
KMOE-2 GDSC1 5.399 8.6277 3.507 10.3463
LP-1 GDSC1 5.4769 9.0683 3.3483 11.2845
LC4-1 GDSC1 5.4928 8.4482 3.6674 8.8243
Granta-519 GDSC1 5.5683 9.8017 3.0547 13.1224
BC-3 GDSC1 5.593 7.9041 4.0076 5.9186
IM-9 GDSC1 5.7054 8.364 3.8634 6.6974
Ku812 GDSC1 5.7237 8.482 3.8191 6.9814
OCI-AML-5 GDSC1 5.747 8.7427 3.7087 7.7485
DB GDSC1 5.8187 10.166 3.0635 12.2667
JVM-3 GDSC1 5.8599 7.8379 4.2176 3.6622
RL GDSC1 5.861 8.7376 3.7909 6.8129
OCI-M1 GDSC1 6.1942 8.2361 4.2355 2.8365
WSU-DLCL2 GDSC1 6.2001 7.3592 4.6079 0.6454
SUP-HD1 GDSC1 6.2272 9.8135 3.5232 7.8094
Karpas-299 GDSC1 6.2997 10.5436 3.2223 9.7583
NKM-1 GDSC1 6.3096 13.6486 1.7127 19.0568
EJM GDSC1 6.3149 11.1756 2.9276 11.7452
KY821 GDSC1 6.3447 10.6395 3.2069 9.7451
P31/FUJ GDSC1 6.4248 10.0975 3.5184 7.3463
DG-75 GDSC1 6.5812 11.3796 3.0123 10.4525
JVM-2 GDSC1 6.9906 9.8162 3.9786 3.0933
ROS-50 GDSC1 7.185 12.9032 2.6873 11.0351
⏷ Show the Full List of 146 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 4 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KYSE-50 GDSC1 2.8297 4.1714 2.7958 27.3432
HCE-4 GDSC1 3.1371 4.4031 3.0934 23.5645
TE-12 GDSC1 3.7688 6.2579 3.1848 19.4696
KYSE-220 GDSC1 4.77 6.4012 4.0995 7.9808
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC1 4.2812 6.6108 3.5382 14.4119
Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NH-12 GDSC1 1.4753 7.5608 0.2434 46.3323
CHP-212 GDSC1 1.7968 4.5708 1.6114 40.8923
SK-N-SH GDSC1 2.2164 3.5994 2.2015 34.8869
SK-N-MC-IXC GDSC1 2.4002 3.4724 2.3955 32.5265
SJNB-14 GDSC1 2.4938 4.7708 2.3239 32.368
TGW GDSC1 2.5052 3.128 2.5052 31.185
SiMa GDSC1 2.6887 4.9929 2.4795 30.2063
SJNB-6 GDSC1 2.7067 4.2302 2.6577 28.9757
Kelly GDSC1 2.9661 5.2331 2.7125 27.0663
SJNB-12 GDSC1 3.051 5.9116 2.5695 27.4935
MHH-NB-11 GDSC1 3.2626 6.5294 2.5439 26.474
SJNB-7 GDSC1 3.5264 4.6449 3.473 18.7625
NB(TU)1 GDSC1 3.5674 5.795 3.1653 20.6483
SJNB-13 GDSC1 3.7297 5.9488 3.275 19.0219
SK-N-AS GDSC1 3.7998 6.1079 3.2814 18.618
SJNB-5 GDSC1 4.4402 6.5411 3.7246 12.2833
GOTO GDSC1 4.5894 7.4157 3.435 13.8712
NB69 GDSC1 4.6053 6.8373 3.7348 11.4987
KP-N-YS GDSC1 4.6597 6.2277 4.0837 8.561
CHP-126 GDSC1 4.9246 7.4781 3.6976 10.5318
IMR-5 GDSC1 5.0681 8.0014 3.5557 11.1071
GI-ME-N GDSC1 5.0955 6.9408 4.108 6.6956
NB1 GDSC1 5.1479 10.5326 2.356 19.24
SK-N-DZ GDSC1 5.1615 7.6626 3.8008 8.8776
SJNB-10 GDSC1 5.1626 7.5856 3.8401 8.5674
KP-N-YN GDSC1 5.2903 8.8971 3.2878 12.3575
LA-N-6 GDSC1 5.6083 8.3668 3.7927 7.5154
SK-N-BE(2)-M17 GDSC1 5.895 8.5633 3.8977 5.9261
SK-N-FI GDSC1 6.0482 8.2268 4.1539 3.6944
⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuCC-T1 GDSC1 3.3213 5.5067 3.0083 23.0716
Cancer Drug Sensitivity Data Curated from 50 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CAL-51 GDSC1 2.2055 3.0494 2.205 34.9343
EFM-19 GDSC1 2.3134 4.4727 2.1934 34.3005
CAMA-1 GDSC1 2.3368 8.1061 0.9047 39.406
OCUB-M GDSC1 2.4331 3.6965 2.42 32.168
EFM-192A GDSC1 2.5382 4.38 2.4537 31.2993
MCF-7 GDSC1 2.6866 3.8451 2.6737 28.9982
MDA-MB-330 GDSC1 2.7476 4.1441 2.7119 28.3807
MDA-MB-436 GDSC1 2.8021 5.3911 2.4842 29.4871
MDA-MB-157 GDSC1 2.827 4.2419 2.7843 27.433
CAL-85-1 GDSC1 2.957 4.6084 2.8638 26.1344
HCC1599 GDSC1 3.0427 4.8602 2.9004 25.3872
DU4475 GDSC1 3.2478 5.2049 3.0281 23.3501
HCC1937 GDSC1 3.3378 5.2219 3.1209 22.2118
HCC1569 GDSC1 3.3736 6.7121 2.5801 25.6457
AU565 GDSC1 3.4114 5.6807 3.0423 22.3435
JIMT-1 GDSC1 3.4742 5.3347 3.2327 20.684
HCC202 GDSC1 3.5036 4.9755 3.3736 19.5566
Hs 578T GDSC1 3.5899 6.1887 3.0288 21.4891
HCC1954 GDSC1 3.6159 4.8358 3.531 17.8522
BT-20 GDSC1 3.6355 6.0391 3.139 20.4769
MRK-nu-1 GDSC1 3.6539 5.737 3.2799 19.3821
HCC2218 GDSC1 3.7223 5.9682 3.2592 19.1728
ZR-75-30 GDSC1 3.7625 14.4754 -0.8048 36.8771
HCC1419 GDSC1 3.9115 4.9955 3.8133 14.251
MDA-MB-361 GDSC1 3.9546 5.3677 3.7411 14.5119
HCC38 GDSC1 4.049 5.7119 3.708 14.2557
MDA-MB-468 GDSC1 4.1152 5.2563 3.954 12.1456
MDA-MB-231 GDSC1 4.1544 5.8582 3.7558 13.3768
HCC1806 GDSC1 4.2771 5.8166 3.9 11.7062
MDA-MB-175-VII GDSC1 4.2809 5.5338 4.0249 10.7667
HDQ-P1 GDSC1 4.2953 8.3457 2.7088 20.3583
CAL-120 GDSC1 4.347 7.1198 3.3565 15.4912
UACC-893 GDSC1 4.4452 6.701 3.6521 12.8169
HCC1500 GDSC1 4.4634 6.6347 3.7014 12.3596
HCC1395 GDSC1 4.5497 7.2975 3.4574 13.864
HCC1428 GDSC1 4.6109 7.6393 3.3435 14.4762
MDA-MB-415 GDSC1 4.8455 9.9906 2.3748 20.2617
BT-474 GDSC1 4.8644 8.1515 3.3099 13.7317
HCC2157 GDSC1 4.8763 7.8873 3.452 12.6098
UACC-812 GDSC1 4.8979 7.2887 3.7695 10.0713
HCC70 GDSC1 5.1089 6.3175 4.4296 4.1191
COLO 824 GDSC1 5.1395 10.0873 2.5717 17.9041
CAL-148 GDSC1 5.1617 9.4399 2.9134 15.5149
MFM-223 GDSC1 5.1979 7.1893 4.0656 6.6815
BT-549 GDSC1 5.2367 8.5708 3.4078 11.6429
T-47D GDSC1 5.2648 6.8467 4.287 4.7343
HCC1187 GDSC1 5.4733 9.7658 2.9991 13.8305
Evsa-T GDSC1 5.9895 10.3714 3.0876 11.581
MDA-MB-453 GDSC1 6.8411 9.2415 4.1459 2.3211
BT-483 GDSC1 6.9787 13.5741 2.2289 14.3164
⏷ Show the Full List of 50 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 52 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
D-542MG GDSC1 1.206 2.6549 1.2019 47.4369
SF295 GDSC1 1.7246 3.2518 1.7123 41.0101
8-MG-BA GDSC1 1.885 3.0633 1.8818 38.9564
GI-1 GDSC1 1.9674 3.6907 1.9353 38.0928
D-566MG GDSC1 2.0613 3.5808 2.0418 36.8511
GB-1 GDSC1 2.0936 4.5726 1.9339 37.2098
Onda 11 GDSC1 2.2704 4.7044 2.0963 35.1325
H4 GDSC1 2.4636 3.9257 2.4348 31.8853
D-423MG GDSC1 2.5912 4.5491 2.4791 30.8117
Daoy GDSC1 2.6395 3.5849 2.6359 29.5286
NMC-G1 GDSC1 2.7858 6.7343 1.9599 32.5466
YKG-1 GDSC1 2.8369 4.2767 2.7903 27.3339
SF268 GDSC1 2.8692 5.2514 2.6014 28.3516
Hs 683 GDSC1 2.8887 4.3677 2.8327 26.7472
LN-18 GDSC1 3.0424 5.3882 2.7462 26.4027
U-251MG GDSC1 3.1179 7.0515 2.1691 29.5106
SK-MG-1 GDSC1 3.2343 4.399 3.1977 22.3039
LNZTA3WT4 GDSC1 3.2723 8.9089 1.4688 32.143
ONS-76 GDSC1 3.3026 6.6078 2.552 26.2052
MOG-G-UVW GDSC1 3.3466 5.6311 2.9911 23.0495
SF126 GDSC1 3.4067 6.0508 2.8933 23.3914
A-172 GDSC1 3.4261 5.1551 3.2376 20.9196
SW1783 GDSC1 3.4377 4.8906 3.3236 20.2717
MOG-G-CCM GDSC1 3.4407 4.9432 3.3134 20.3233
LN-229 GDSC1 3.4961 6.8739 2.6341 24.6528
GaMG GDSC1 3.5353 5.5238 3.2331 20.3465
AM-38 GDSC1 3.5755 6.0068 3.0891 21.1411
T98G GDSC1 3.7123 8.5365 2.0702 26.9743
SF539 GDSC1 3.7189 5.4776 3.4476 17.8502
CAS-1 GDSC1 3.7418 7.9053 2.4005 24.8986
DBTRG-05MG GDSC1 3.7461 5.1209 3.5967 16.6631
D283 Med GDSC1 3.7749 6.3812 3.1372 19.7797
SW1088 GDSC1 3.8163 7.7986 2.5234 23.7674
KS-1 [Human Krukenberg tumour] GDSC1 3.8278 5.4988 3.5568 16.495
M059J GDSC1 3.8514 5.6644 3.5185 16.6442
Onda 10 GDSC1 3.8591 6.9768 2.9521 20.6802
PFSK-1 GDSC1 3.8662 5.4645 3.6107 15.9081
Becker GDSC1 3.962 7.1609 2.9672 20.0824
KALS-1 GDSC1 4.0225 6.1732 3.4822 16.0464
KNS-81-FD GDSC1 4.125 7.0097 3.1974 17.6666
SNB-75 GDSC1 4.1264 5.7383 3.778 13.3526
D-392MG GDSC1 4.1379 5.8306 3.7507 13.4964
YH-13 GDSC1 4.2313 6.9631 3.3221 16.2614
LN-405 GDSC1 4.2785 6.2307 3.7139 13.0963
D-502MG GDSC1 4.462 5.544 4.2093 8.5048
U-118MG GDSC1 4.6179 7.0395 3.6466 12.129
42-MG-BA GDSC1 4.9236 8.4674 3.2023 14.3092
KNS-42 GDSC1 5.0163 7.8919 3.5676 11.2018
U-87MG ATCC GDSC1 5.2106 8.7885 3.2783 12.7037
KINGS-1 GDSC1 5.3037 7.175 4.1541 5.6483
D-263MG GDSC1 5.8966 15.1135 0.6697 25.101
DK-MG GDSC1 6.0753 8.0174 4.2652 2.8668
⏷ Show the Full List of 52 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TGBC1TKB GDSC1 3.4021 6.6029 2.657 24.9964
ETK-1 GDSC1 3.4607 6.296 2.8488 23.407
TGBC24TKB GDSC1 4.4765 6.7157 3.6746 12.5093
Cancer Drug Sensitivity Data Curated from 7 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MFE-319 GDSC1 2.3958 3.7589 2.3774 32.6669
AN3-CA GDSC1 2.7313 4.2056 2.6871 28.6382
ESS-1 GDSC1 2.9603 5.0286 2.7661 26.7515
MFE-296 GDSC1 3.8919 5.2759 3.7055 15.1021
MFE-280 GDSC1 4.0208 8.7514 2.2567 24.4511
EN GDSC1 4.0612 6.0824 3.562 15.2681
KLE GDSC1 4.4594 6.7169 3.6579 12.711
⏷ Show the Full List of 7 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 25 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
VMRC-RCW GDSC1 2.5781 3.8112 2.5633 30.3661
LB1047-RCC GDSC1 2.7893 4.6552 2.672 28.3805
769-P GDSC1 2.9742 4.5581 2.8922 25.8473
OS-RC-2 GDSC1 3.1517 6.7463 2.3362 28.3587
786-O GDSC1 3.189 4.8311 3.067 23.4283
A-704 GDSC1 3.2829 5.4634 2.9818 23.4657
BB65-RCC GDSC1 3.3968 7.0678 2.4465 26.3632
ACHN GDSC1 3.453 5.2583 3.2347 20.7886
SW156 GDSC1 3.5588 5.4059 3.3002 19.7504
BFTC-909 GDSC1 3.609 4.7711 3.5377 17.8481
SW13 GDSC1 3.7042 5.8505 3.2882 19.0594
CAL-54 GDSC1 3.7798 4.9514 3.6814 15.8958
LB2241-RCC GDSC1 3.8207 5.0837 3.6892 15.6098
LB996-RCC GDSC1 3.8968 5.5496 3.6113 15.7416
VMRC-RCZ GDSC1 4.1267 6.0877 3.6264 14.4722
HA7-RCC GDSC1 4.1969 6.8962 3.3209 16.4262
UO-31 GDSC1 4.2047 6.5589 3.4881 15.1392
A-498 GDSC1 4.3681 5.182 4.2534 8.6711
KMRC-1 GDSC1 4.4821 9.8091 2.1512 23.0623
SN12C GDSC1 4.4982 6.3355 3.8788 10.8437
RXF 393L GDSC1 4.8339 7.6061 3.5561 11.9724
KMRC-20 GDSC1 5.0014 7.2702 3.866 8.9327
TK-10 GDSC1 5.0043 8.2004 3.4034 12.5021
RCC10RGB GDSC1 5.1454 6.9693 4.1337 6.323
Caki-1 GDSC1 5.1549 12.2411 1.5077 23.8928
⏷ Show the Full List of 25 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 37 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LoVo GDSC1 1.9554 3.5296 1.9353 38.175
RKO GDSC1 2.2866 4.4821 2.1624 34.655
LS411N GDSC1 2.7021 4.9593 2.5032 29.9769
HCC2998 GDSC1 2.92 4.6717 2.8105 26.7024
HT-29 GDSC1 2.9497 4.9759 2.769 26.7951
LS180 GDSC1 2.9833 4.3495 2.9366 25.5056
GP5d GDSC1 3.1243 5.8607 2.6671 26.4508
SNU-C1 GDSC1 3.18 8.8168 1.4226 32.8183
COLO205 GDSC1 3.1834 6.2088 2.5937 26.5931
HCT 15 GDSC1 3.2545 4.8946 3.1228 22.6762
SW626 GDSC1 3.304 5.5234 2.9838 23.3345
T84 GDSC1 3.3728 4.5839 3.318 20.691
KM12 GDSC1 3.4959 7.4191 2.3865 26.2158
NCI-H747 GDSC1 3.7197 6.2761 3.1263 20.1354
LS123 GDSC1 3.8332 6.0038 3.3604 17.878
SW48 GDSC1 3.9023 8.8583 2.094 25.9384
HCT 116 GDSC1 4.0785 5.5516 3.804 13.4085
COLO 320HSR GDSC1 4.1442 6.3321 3.5333 15.0827
SW620 GDSC1 4.2216 6.249 3.6488 13.852
RCM-1 [Human ESC] GDSC1 4.4048 9.004 2.4826 21.3696
SW837 GDSC1 4.5104 8.5962 2.7791 18.967
C2BBe1 GDSC1 4.5464 8.3198 2.9484 17.6381
HT-55 GDSC1 4.7991 7.166 3.7453 10.6377
CaR-1 GDSC1 4.9008 7.2714 3.7806 9.9739
LS1034 GDSC1 4.9032 6.9363 3.95 8.6359
LS513 GDSC1 5.0124 6.8549 4.0829 7.1872
SW1463 GDSC1 5.017 14.707 0.1607 29.81
MDST8 GDSC1 5.1306 6.856 4.1785 6.0209
SNU-C2B GDSC1 5.2288 7.2635 4.0528 6.6798
SW1417 GDSC1 5.3535 8.8299 3.3711 11.5214
SW948 GDSC1 5.6545 9.5757 3.2321 11.5706
HT115 GDSC1 6.0208 10.1712 3.2079 10.6398
NCI-H716 GDSC1 6.0852 9.2205 3.7112 6.8098
CCK-81 GDSC1 6.2234 11.4302 2.7387 13.2638
COLO 678 GDSC1 6.3756 8.7199 4.1228 3.2427
CL-11 GDSC1 6.6313 9.9665 3.7086 5.5397
CW-2 GDSC1 7.5461 9.6096 4.3184 0.7552
⏷ Show the Full List of 37 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC1 5.8814 8.1318 4.0936 4.5134
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JHH-7 GDSC1 1.9326 3.1587 1.9281 38.3695
JHH-1 GDSC1 2.4876 3.2685 2.487 31.4088
HLE GDSC1 2.6629 3.9342 2.6428 29.3402
JHH-4 GDSC1 2.6788 3.7834 2.6689 29.0772
SNU-398 GDSC1 2.941 3.8971 2.9334 25.7847
Hep 3B2.1-7 GDSC1 3.0894 3.822 3.0872 23.896
SK-HEP-1 GDSC1 3.2459 4.5233 3.1916 22.2737
Huh-7 GDSC1 3.4449 4.0724 3.4425 19.4539
SNU-423 GDSC1 3.6016 4.4775 3.5784 17.6276
JHH-6 GDSC1 3.6712 6.1353 3.136 20.3135
Hep-G2/C3A GDSC1 3.9332 5.2873 3.7464 14.5908
SNU-449 GDSC1 3.9992 5.5328 3.7271 14.3745
HuH-1 GDSC1 4.1194 5.6532 3.8061 13.1831
SNU-387 GDSC1 4.474 6.839 3.6123 12.9983
JHH-2 GDSC1 5.2768 6.7126 4.362 4.1136
SNU-475 GDSC1 7.2821 12.8133 2.792 10.1505
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 168 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
IA-LM GDSC1 0.8356 2.121 0.8347 52.0499
HCC44 GDSC1 1.585 3.789 1.5205 42.9683
NCI-H2122 GDSC1 1.6233 4.0724 1.5204 42.648
Lu-135 GDSC1 1.7159 3.0515 1.7104 41.0825
NCI-H847 GDSC1 2.1989 3.2874 2.1954 35.0357
DMS 273 GDSC1 2.2687 3.1683 2.2677 34.1475
SK-MES-1 GDSC1 2.2707 5.1004 1.9934 35.676
NCI-H460 GDSC1 2.2939 3.1355 2.2932 33.8305
NCI-H2087 GDSC1 2.3555 3.9878 2.3144 33.3096
NCI-H1568 GDSC1 2.3581 4.3935 2.2569 33.6382
NCI-H2795 GDSC1 2.363 5.0247 2.1154 34.4094
Calu-6 GDSC1 2.3715 4.5047 2.25 33.5914
HOP-62 GDSC1 2.4035 4.3315 2.3169 32.988
NCI-H1437 GDSC1 2.5563 5.5406 2.1681 32.8636
NCI-H1651 GDSC1 2.562 6.826 1.6874 35.2094
NCI-H2009 GDSC1 2.6349 3.5472 2.6321 29.5808
NCI-H441 GDSC1 2.6682 4.6606 2.5392 29.9601
NCI-H727 GDSC1 2.6809 7.0069 1.7362 34.2579
ChaGo-K-1 GDSC1 2.6881 4.3438 2.6211 29.3215
LCLC-97TM1 GDSC1 2.7127 6.2529 2.0771 32.38
NCI-H2342 GDSC1 2.7197 3.5892 2.7172 28.5193
NCI-H290 GDSC1 2.7792 5.1494 2.534 29.3165
SBC-3 GDSC1 2.8425 3.8156 2.8358 27.0109
HOP-92 GDSC1 2.8431 5.3762 2.5336 28.9346
NCI-H2405 GDSC1 2.8884 4.3364 2.837 26.7216
RERF-LC-KJ GDSC1 2.8913 5.0103 2.6959 27.615
NCI-H810 GDSC1 2.9082 8.8408 1.1446 35.3521
EBC-1 GDSC1 2.9249 4.831 2.7792 26.8753
SK-LU-1 GDSC1 2.9404 4.9238 2.7727 26.826
NCI-H2347 GDSC1 2.9558 4.8715 2.8029 26.5384
NCI-H2172 GDSC1 2.9883 4.1724 2.9631 25.3058
LC-2/ad GDSC1 2.9918 4.6166 2.9 25.6913
Calu-3 GDSC1 3.0063 6.5173 2.2812 29.5027
NCI-H1770 GDSC1 3.0453 4.0506 3.0327 24.5129
NCI-H1915 GDSC1 3.0587 5.0669 2.8628 25.5408
NCI-H2085 GDSC1 3.0904 6.5196 2.3683 28.5103
LK-2 GDSC1 3.1032 4.0107 3.0949 23.7618
A-427 GDSC1 3.1053 4.7851 2.9868 24.4498
SW1271 GDSC1 3.124 4.8373 2.9947 24.2882
NCI-H1944 GDSC1 3.1617 4.2605 3.137 23.1346
LCLC-103H GDSC1 3.1655 4.6279 3.0859 23.4433
LXF 289 GDSC1 3.1718 5.5561 2.8294 25.1145
NCI-H1648 GDSC1 3.2087 5.1258 3.0094 23.6989
NCI-H841 GDSC1 3.2406 4.4062 3.2035 22.2285
CAL-12T GDSC1 3.2408 5.489 2.9274 24.07
NCI-H1299 GDSC1 3.3504 4.1649 3.3418 20.6737
NCI-H1876 GDSC1 3.3588 4.9151 3.2314 21.3455
NCI-H522 GDSC1 3.377 5.3005 3.1385 21.872
NCI-H1048 GDSC1 3.4116 4.8719 3.2998 20.5822
HCC827 GDSC1 3.4727 5.2798 3.2492 20.5789
NCI-H358 GDSC1 3.4814 5.015 3.3385 19.9204
COR-L23 GDSC1 3.5073 5.0096 3.3683 19.571
NCI-H1355 GDSC1 3.514 5.6486 3.1644 20.9406
UMC-11 GDSC1 3.5238 4.4799 3.4954 18.6329
NCI-H2722 GDSC1 3.5416 5.5273 3.2386 20.2733
NCI-H3122 GDSC1 3.5437 5.4474 3.2695 20.0469
NCI-H2110 GDSC1 3.5753 5.121 3.4106 18.8975
NCI-H2030 GDSC1 3.5916 5.3903 3.3411 19.2863
HCC78 GDSC1 3.6268 5.6573 3.2818 19.5125
NCI-H2804 GDSC1 3.6329 6.0201 3.1441 20.4542
NCI-H2170 GDSC1 3.6496 6.1454 3.1093 20.6144
NCI-H1435 GDSC1 3.7602 5.1486 3.6037 16.5361
NCI-H596 GDSC1 3.7678 5.4766 3.5005 17.2139
PC-14 GDSC1 3.7999 7.0718 2.8494 21.6819
NCI-H2461 GDSC1 3.815 6.0006 3.3427 18.0985
NCI-H520 GDSC1 3.8299 5.0174 3.7182 15.3604
NCI-H1563 GDSC1 3.8445 4.6374 3.8163 14.6235
COLO 668 GDSC1 3.8623 4.9935 3.7601 14.8915
NCI-H1734 GDSC1 3.9272 5.8981 3.5029 16.3675
NCI-H3255 GDSC1 3.9543 5.3393 3.751 14.4436
SBC-5 GDSC1 3.9733 5.0041 3.8785 13.4562
NCI-H196 GDSC1 3.9766 5.8023 3.5946 15.4502
DMS 53 GDSC1 3.9898 5.6257 3.6806 14.7586
HARA [Human squamous cell lung carcinoma] GDSC1 4.0176 6.5977 3.2848 17.5259
PaCa-3 GDSC1 4.0191 5.719 3.6737 14.6577
NCI-H2369 GDSC1 4.0227 5.5736 3.7361 14.1877
LOU-NH91 GDSC1 4.0728 6.7367 3.275 17.3379
RERF-LC-MS GDSC1 4.0788 5.9241 3.6492 14.5369
Lu-99A GDSC1 4.0855 5.8431 3.691 14.1963
A-549 GDSC1 4.1056 6.5544 3.3923 16.3157
NCI-H661 GDSC1 4.1077 5.7971 3.7337 13.772
NCI-H2591 GDSC1 4.1411 6.1789 3.5999 14.6
NCI-H650 GDSC1 4.1475 6.3659 3.5211 15.1582
NCI-H226 GDSC1 4.1545 6.8188 3.3165 16.652
NCI-H2373 GDSC1 4.187 5.1659 4.0625 10.9949
HCC15 GDSC1 4.1997 6.3727 3.5699 14.5477
NCI-H1650 GDSC1 4.2222 6.9305 3.329 16.2514
NCI-H2731 GDSC1 4.2502 7.0297 3.3082 16.2805
NCI-H2803 GDSC1 4.2672 7.1972 3.2436 16.6844
NCI-H1703 GDSC1 4.2729 5.9888 3.819 12.3313
NCI-H1781 GDSC1 4.2962 5.5588 4.0305 10.6482
Lu-139 GDSC1 4.32 5.801 3.9508 11.1196
NCI-H2228 GDSC1 4.3434 5.8178 3.9672 10.8838
NCI-H1975 GDSC1 4.3602 6.0634 3.8725 11.5164
NCI-H647 GDSC1 4.3657 7.1762 3.3467 15.4836
NCI-H292 GDSC1 4.3943 5.8939 3.9844 10.5123
NCI-H2595 GDSC1 4.422 5.9246 3.998 10.279
RERF-LC-Sq1 GDSC1 4.4243 6.4052 3.7745 11.9713
NCI-H1792 GDSC1 4.4884 7.083 3.5065 13.7462
NCI-H1623 GDSC1 4.5131 7.1717 3.4858 13.8004
LC-1/sq GDSC1 4.5317 7.7632 3.2111 15.7921
NCI-H1688 GDSC1 4.5475 5.5176 4.3087 7.3485
ABC-1 GDSC1 4.5723 5.7347 4.2352 7.7833
COR-L88 GDSC1 4.5813 14.5806 -0.1435 32.2585
NCI-H2141 GDSC1 4.6266 7.4839 3.4346 13.7215
NCI-H1304 GDSC1 4.7333 12.2626 1.1441 27.1249
NCI-H2869 GDSC1 4.7638 6.4029 4.0931 8.0561
SBC-1 GDSC1 4.7698 6.3739 4.1129 7.8772
NCI-H209 GDSC1 4.7837 7.5145 3.5583 12.149
COR-L105 GDSC1 4.8193 5.9862 4.3493 5.8264
NCI-H2023 GDSC1 4.8361 8.1439 3.2895 13.993
NCI-H1993 GDSC1 4.9324 6.9711 3.9576 8.4672
DMS 114 GDSC1 4.9715 7.7938 3.5792 11.2764
NCI-H526 GDSC1 4.9854 8.6246 3.1755 14.2758
NCI-H1869 GDSC1 4.9938 8.1352 3.4272 12.3597
NCI-H211 GDSC1 4.9955 6.7142 4.1392 6.8048
BEN GDSC1 5.0136 7.4825 3.7701 9.6398
EKVX GDSC1 5.0234 11.1051 1.9669 21.9808
Ms-1 GDSC1 5.0329 7.8696 3.5926 10.9492
EPLC-272H GDSC1 5.0927 8.7483 3.2025 13.6839
NCI-H1581 GDSC1 5.1067 7.4306 3.8725 8.5072
NCI-H1963 GDSC1 5.1165 7.692 3.7498 9.4315
LB647-SCLC GDSC1 5.1312 11.2836 1.9669 21.5825
NCI-H1092 GDSC1 5.1401 8.0195 3.6054 10.4692
NCI-H1573 GDSC1 5.1434 9.041 3.0977 14.2675
IST-SL1 GDSC1 5.1489 8.2525 3.4961 11.2777
NCI-H513 GDSC1 5.1552 9.7721 2.742 16.7177
HCC33 GDSC1 5.1611 6.933 4.1643 6.0298
NCI-H1793 GDSC1 5.1876 6.9294 4.1869 5.7644
NCI-H2135 GDSC1 5.1981 7.6384 3.842 8.4312
NCI-H69 GDSC1 5.2511 7.9858 3.7109 9.2723
NCI-H838 GDSC1 5.2832 7.8536 3.8018 8.4601
NCI-H1666 GDSC1 5.2882 7.1249 4.1671 5.5952
NCI-H187 GDSC1 5.3071 6.6977 4.3915 3.7947
NCI-H2444 GDSC1 5.3079 7.8892 3.8033 8.3678
NCI-H82 GDSC1 5.3255 8.1555 3.6847 9.2281
NCI-H64 GDSC1 5.3426 7.4153 4.0646 6.2237
IST-SL2 GDSC1 5.3518 7.6062 3.9772 6.8749
NCI-H1694 GDSC1 5.4198 8.5518 3.5607 9.871
SHP-77 GDSC1 5.4934 7.9008 3.9374 6.748
NCI-H2081 GDSC1 5.5207 8.2542 3.7838 7.8461
SW1573 GDSC1 5.5358 10.2296 2.8172 14.883
Lu-65 GDSC1 5.5471 8.8442 3.5127 9.8287
NCI-H2818 GDSC1 5.5959 7.5783 4.1673 4.6963
NCI-H2029 GDSC1 5.6159 8.3506 3.8061 7.3904
NCI-H2196 GDSC1 5.646 7.8931 4.05 5.4479
NCI-H1836 GDSC1 5.673 8.9148 3.5712 9.0009
NCI-H1755 GDSC1 5.7256 10.7498 2.7052 15.0125
Lu-165 GDSC1 5.7671 9.053 3.5718 8.7182
NCI-H345 GDSC1 5.8166 8.3082 3.967 5.6151
NCI-H1693 GDSC1 5.8183 9.9977 3.146 11.6829
NCI-H2171 GDSC1 5.8518 8.0477 4.1141 4.4353
NCI-H1155 GDSC1 5.8622 9.1041 3.6145 8.1262
NCI-H524 GDSC1 5.9249 8.0048 4.1806 3.7796
NCI-H2291 GDSC1 6.0138 8.4708 4.0192 4.7375
DMS 79 GDSC1 6.0534 7.6885 4.399 2.0215
NCI-H1436 GDSC1 6.0572 8.9842 3.8051 6.1937
NCI-H510A GDSC1 6.0919 7.9702 4.2959 2.6278
NCI-H23 GDSC1 6.1228 10.0973 3.3156 9.5819
COR-L95 GDSC1 6.1712 8.4124 4.1428 3.5114
CPC-N GDSC1 6.5101 9.4093 3.8905 4.5466
NCI-H720 GDSC1 6.7597 8.0281 4.5863 0.3344
NCI-H748 GDSC1 7.3198 18.0527 0.2915 22.5603
NCI-H2227 GDSC1 7.3225 8.9478 4.4714 0.3918
NCI-H1838 GDSC1 7.5468 14.2986 2.2633 12.6934
NCI-H322M GDSC1 7.6461 10.0958 4.1765 1.2403
Lu-134-A GDSC1 7.7619 19.7944 -0.2408 23.3629
NCI-H446 GDSC1 7.9901 16.3009 1.6051 15.1662
⏷ Show the Full List of 168 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CBTCi002-A GDSC1 4.2238 8.2692 2.6807 20.8608
Cancer Drug Sensitivity Data Curated from 23 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
OE21 GDSC1 2.1951 4.1768 2.118 35.5177
KYSE-270 GDSC1 2.4451 3.4465 2.4417 31.9577
KYSE-510 GDSC1 2.5388 4.1692 2.4869 31.0898
KYSE-410 GDSC1 2.7166 5.7109 2.2832 31.2106
T.T GDSC1 2.7789 5.6245 2.3808 30.2566
KYSE-450 GDSC1 2.8801 4.2796 2.836 26.7784
TE-15 GDSC1 2.9735 4.382 2.9213 25.6637
TE-9 GDSC1 2.9932 6.6589 2.2084 29.9953
KYSE-180 GDSC1 3.0419 5.2328 2.7953 26.0835
TE-5 GDSC1 3.1531 5.4202 2.8558 25.0447
TE-10 GDSC1 3.2544 4.8319 3.1381 22.5748
KYSE-140 GDSC1 3.3516 5.3283 3.1018 22.2646
KYSE-150 GDSC1 3.6346 5.7032 3.2725 19.5364
TE-8 GDSC1 3.6885 5.0792 3.5463 17.3319
OE33 GDSC1 3.8872 5.7951 3.5037 16.5653
KYSE-70 GDSC1 3.8919 6.444 3.2284 18.5438
KYSE-520 GDSC1 4.1153 8.1748 2.6261 21.7074
COLO 680N GDSC1 4.1826 6.8227 3.342 16.3335
TE-1 GDSC1 4.3533 6.4479 3.6855 12.9685
TE-11 GDSC1 4.3584 6.0733 3.8661 11.5736
TE-6 GDSC1 4.401 8.3945 2.7809 19.4146
OE19 GDSC1 4.7974 6.3775 4.1359 7.586
EC-GI-10 GDSC1 5.9756 8.9251 3.7789 6.5964
⏷ Show the Full List of 23 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 25 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TOV-112D GDSC1 2.4672 3.2236 2.4668 31.6623
OV-90 GDSC1 2.6064 4.9152 2.4105 31.1381
Kuramochi GDSC1 2.6712 7.1477 1.6662 34.6302
SK-OV-3 GDSC1 3.0996 5.2457 2.854 25.3625
IGROV-1 GDSC1 3.1106 3.944 3.1054 23.6504
RMG-I GDSC1 3.3524 4.7273 3.2683 21.1381
OVCAR-8 GDSC1 3.4733 5.0965 3.3065 20.1837
OVCAR-4 GDSC1 3.6489 6.0866 3.1331 20.4491
OC 314 GDSC1 3.6824 4.1761 3.6812 16.4775
A2780 GDSC1 3.6854 5.583 3.3726 18.5584
OVCAR-3 GDSC1 3.7059 6.3554 3.0775 20.5517
OAW42 GDSC1 3.7262 4.233 3.7244 15.934
EFO-27 GDSC1 3.7603 5.2039 3.5864 16.6548
FU-OV-1 GDSC1 3.8651 6.3382 3.2484 18.5304
TYK-nu GDSC1 3.8804 5.0306 3.7697 14.7232
OAW28 GDSC1 4.0541 6.5714 3.3334 16.9948
EFO-21 GDSC1 4.0621 6.1953 3.5127 15.6287
OVTOKO GDSC1 4.3428 7.7402 3.0499 17.7709
Caov-4 GDSC1 4.8459 8.0244 3.3575 13.443
OVKATE GDSC1 4.8539 8.3284 3.2126 14.4975
ES-2 GDSC1 4.9738 6.6902 4.133 6.9333
Caov-3 GDSC1 5.1009 7.3007 3.9326 8.0561
TOV-21G GDSC1 5.1139 6.799 4.1935 5.9595
OVISE GDSC1 5.1187 6.3442 4.424 4.1304
OVCAR-5 GDSC1 5.7099 8.1336 3.9781 5.8175
⏷ Show the Full List of 25 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 30 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
PaTu 8988t GDSC1 1.9896 3.9988 1.924 37.9991
Hs 766T GDSC1 2.067 7.2153 1.0071 40.8403
MIA PaCa-2 GDSC1 2.4066 3.4583 2.4023 32.4443
HuP-T4 GDSC1 2.6078 4.5351 2.5 30.5784
MZ-PC-1 GDSC1 2.6522 4.4978 2.5554 29.9573
HPAC GDSC1 2.7581 5.2365 2.4849 29.7494
SW1990 GDSC1 2.7678 5.3369 2.4643 29.8169
CFPAC-1 GDSC1 2.772 4.5898 2.667 28.5171
PSN1 GDSC1 2.7835 3.9054 2.7704 27.7889
BxPC-3 GDSC1 2.7856 4.218 2.7433 27.9476
KP-2 GDSC1 2.9061 4.1127 2.8824 26.3236
SUIT-2 GDSC1 3.0952 4.6491 3.0055 24.3865
Capan-1 GDSC1 3.1825 4.6568 3.0986 23.2589
KP-1N GDSC1 3.3019 5.5514 2.9716 23.4294
Panc 03.27 GDSC1 3.396 4.4225 3.3668 20.2352
KP-4 GDSC1 3.574 4.3239 3.5637 17.8902
PaTu 8902 GDSC1 3.6685 5.6223 3.3397 18.882
Panc 10.05 GDSC1 3.7045 4.8147 3.6321 16.6628
Panc 04.03 GDSC1 3.7388 6.4487 3.0704 20.4362
SU.86.86 GDSC1 4.1378 6.4444 3.4753 15.5462
Capan-2 GDSC1 4.1756 5.9195 3.7508 13.3096
DAN-G GDSC1 4.2087 4.885 4.1649 10.1749
PL4 GDSC1 4.2206 6.1384 3.6985 13.4841
HPAF-II GDSC1 4.2569 8.5141 2.5908 21.3092
KP-3 GDSC1 4.5686 6.4434 3.8934 10.4247
Panc 02.03 GDSC1 4.6513 6.8554 3.7678 11.0532
HuP-T3 GDSC1 5.4156 7.0969 4.2745 4.3804
Panc 08.13 GDSC1 5.4409 7.1911 4.2467 4.5218
AsPC-1 GDSC1 5.6605 10.751 2.6547 15.5576
YAPC GDSC1 7.3382 15.6941 1.4539 17.5111
⏷ Show the Full List of 30 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H2052 GDSC1 3.5823 5.1032 3.4235 18.77
NCI-H28 GDSC1 4.1574 5.3609 3.9617 11.8639
MPP 89 GDSC1 4.3888 6.9698 3.4687 14.462
IST-Mes1 GDSC1 5.2635 8.372 3.5282 10.6364
NCI-H2452 GDSC1 5.4344 7.2334 4.2214 4.7342
MSTO-211H GDSC1 5.4833 9.4527 3.1625 12.6283
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
DU145 GDSC1 3.3306 4.9588 3.1892 21.7916
PC-3 GDSC1 3.7819 5.8636 3.3649 18.1078
VCaP GDSC1 4.0689 6.3574 3.4463 16.0885
LNCaP clone FGC GDSC1 4.242 7.1982 3.2193 16.9761
22Rv1 GDSC1 4.5094 8.5111 2.8205 18.6862
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 GDSC1 3.315 5.7145 2.9263 23.6647
Cancer Drug Sensitivity Data Curated from 56 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
WT2-iPS GDSC1 1.0281 2.2929 1.0269 49.6494
SK-MEL-5 GDSC1 1.6396 2.7787 1.6381 42.0135
UACC-62 GDSC1 1.6799 2.6467 1.6795 41.5037
WM35 GDSC1 1.8947 3.7985 1.8479 39.0742
A2058 GDSC1 1.9656 4.0135 1.8964 38.3144
COLO 679 GDSC1 2.069 3.6574 2.0443 36.7849
CP66-MEL GDSC1 2.0925 2.8635 2.0923 36.3447
COLO 829 GDSC1 2.1886 3.9681 2.1397 35.4358
A-375 GDSC1 2.345 3.6019 2.3341 33.2557
Hs 938.T GDSC1 2.4013 3.4845 2.3963 32.5148
HMV-II GDSC1 2.4244 4.9175 2.2112 33.4716
CHL-1 GDSC1 2.5271 3.6538 2.5189 30.9625
SK-MEL-24 GDSC1 2.5555 7.1119 1.5611 35.7886
SK-MEL-28 GDSC1 2.5745 3.5009 2.5718 30.3357
Mel Ho GDSC1 2.6103 4.7408 2.458 30.8233
G-361 GDSC1 2.6983 4.1215 2.6622 28.9985
MZ-MEL-2 GDSC1 2.71 5.62 2.3077 31.1089
A-388 GDSC1 2.7363 5.048 2.5163 29.6864
A-431 GDSC1 2.744 3.646 2.7406 28.2212
WM793 GDSC1 2.8042 5.3914 2.4863 29.4619
IGR-37 GDSC1 2.8537 4.666 2.7397 27.5568
IST-MEL1 GDSC1 2.9838 6.4707 2.2768 29.6578
Hs 940.T GDSC1 3.0118 4.7117 2.9016 25.5616
A101D GDSC1 3.019 4.4973 2.9516 25.1929
WM115 GDSC1 3.047 7.2244 2.0204 30.7169
LB2518-MEL GDSC1 3.1634 4.2358 3.1412 23.0979
DJM-1 GDSC1 3.1805 6.035 2.6599 26.1824
SH-4 GDSC1 3.2957 7.5036 2.1474 28.663
IGR-1 GDSC1 3.3435 4.9013 3.2182 21.5229
HT-144 GDSC1 3.3506 5.2415 3.1286 22.0873
RVH-421 GDSC1 3.4169 5.079 3.2501 20.8867
SK-MEL-30 GDSC1 3.5007 5.8721 3.0642 21.7109
GAK GDSC1 3.5118 7.5582 2.3381 26.4265
WM278 GDSC1 3.5334 5.4989 3.24 20.308
Mel JuSo GDSC1 3.5802 4.7445 3.5121 18.1866
451Lu GDSC1 3.5926 5.7747 3.2 20.2707
SK-MEL-2 GDSC1 3.6188 5.0589 3.4762 18.2043
M14 GDSC1 3.7063 5.0588 3.5716 17.0588
WM1552C GDSC1 3.8356 5.6887 3.4921 16.916
IPC-298 GDSC1 3.8394 5.6906 3.4953 16.8734
SK-MEL-3 GDSC1 3.9811 6.4854 3.2998 17.5906
CP50-MEL-B GDSC1 3.9813 4.7846 3.9388 13.0073
MZ-MEL-7 GDSC1 4.0062 7.0758 3.0506 19.2818
MMAc-SF GDSC1 4.0126 6.063 3.5206 15.8117
MeWo GDSC1 4.1158 7.1505 3.1214 18.2632
LOX-IMVI GDSC1 4.1535 6.0535 3.6688 14.0268
LB373-MEL-D GDSC1 4.1914 6.0886 3.6916 13.675
COLO 792 GDSC1 4.3726 4.9399 4.3307 8.1146
RPMI-7951 GDSC1 4.6033 6.7887 3.7568 11.3366
UACC-257 GDSC1 4.6297 6.2029 4.0676 8.8138
COLO 800 GDSC1 4.6576 6.5906 3.904 9.9679
G-mel GDSC1 4.8411 8.5309 3.1004 15.371
VMRC-MELG GDSC1 5.3997 10.3855 2.6327 16.5807
COLO 783 GDSC1 5.8498 8.1237 4.0769 4.7139
SK-MEL-1 GDSC1 6.0199 10.0145 3.2835 10.1018
EquiPSC Line K2 GDSC1 3.3583 5.0973 3.1809 21.6887
⏷ Show the Full List of 56 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuTu 80 GDSC1 1.331 2.2755 1.3308 45.8632
Cancer Drug Sensitivity Data Curated from 22 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HT-1080 GDSC1 1.9266 3.2902 1.9179 38.4696
Hs 633.T GDSC1 2.0488 3.0002 2.0479 36.8958
SK-UT-1 GDSC1 2.1218 3.6481 2.1001 36.1081
MFH-ino GDSC1 2.4725 4.2978 2.3968 32.0632
SK-LMS-1 GDSC1 2.5424 4.3614 2.4615 31.2253
SW982 GDSC1 2.8192 4.6899 2.697 28.0393
Rh30 GDSC1 3.0971 4.6574 3.0058 24.3736
G-401 GDSC1 3.1506 4.9069 3.0063 24.0555
SW872 GDSC1 3.4365 4.8184 3.3397 20.1717
Rh41 GDSC1 3.5084 5.0574 3.3562 19.6466
VA-ES-BJ GDSC1 3.5572 7.5058 2.4074 25.7741
EW-8 GDSC1 3.6151 6.1976 3.0512 21.2016
GCT GDSC1 3.6723 4.4722 3.6538 16.7129
G-402 GDSC1 3.7164 5.849 3.3018 18.8989
A-204 GDSC1 3.8641 5.9481 3.4161 17.3177
MES-SA GDSC1 4.0056 5.2925 3.8228 13.6613
RD GDSC1 4.0847 5.9293 3.6531 14.4795
RKN GDSC1 4.2354 5.2893 4.0719 10.6664
KYM-1 GDSC1 4.6851 6.1545 4.1431 7.992
TE 441.T GDSC1 4.8499 6.3024 4.2198 6.7193
SW684 GDSC1 5.0288 13.1759 0.936 26.9138
STS-0421 GDSC1 5.117 6.7935 4.1988 5.9079
⏷ Show the Full List of 22 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 25 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MKN28 GDSC1 2.6282 4.22 2.5753 29.9804
Fu97 GDSC1 2.7125 4.0422 2.6855 28.7643
MKN45 GDSC1 2.9603 10.2037 0.5503 36.9948
HGC-27 GDSC1 3.0326 4.7915 2.906 25.4094
IM95 GDSC1 3.0666 4.6877 2.9663 24.813
OCUM-1 GDSC1 3.0839 5.7638 2.66 26.7262
AGS GDSC1 3.1209 5.5877 2.7633 25.841
GCIY GDSC1 3.1716 5.7307 2.7663 25.535
NUGC-3 GDSC1 3.3618 5.4571 3.0694 22.4293
RF-48 GDSC1 3.6851 5.9393 3.232 19.5593
MKN1 GDSC1 3.7688 5.6374 3.441 17.6309
RERF-GC-1B GDSC1 3.946 6.2408 3.3741 17.2158
TMK-1 GDSC1 3.978 5.4231 3.7461 14.3514
NUGC-4 GDSC1 4.1238 5.485 3.8783 12.6379
23132/87 GDSC1 4.2645 6.6501 3.5034 14.7507
SCH GDSC1 4.5266 7.8092 3.1837 16.0158
ECC10 GDSC1 4.7945 7.3509 3.6492 11.4041
NCI-N87 GDSC1 4.8345 7.7557 3.4819 12.5402
MKN7 GDSC1 4.8862 7.0476 3.8799 9.2506
TGBC11TKB GDSC1 5.087 8.2075 3.4682 11.7096
SNU-1 GDSC1 5.0877 7.8508 3.647 10.3316
SNU-5 GDSC1 5.5383 8.7749 3.5402 9.6485
HSC-39 GDSC1 5.5942 9.4634 3.2421 11.6893
SNU-16 GDSC1 6.9078 8.2066 4.5787 0.2874
SNG-M GDSC1 2.081 2.8056 2.0809 36.4878
⏷ Show the Full List of 25 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ML-1 [Human leukemia] GDSC1 2.0914 3.1892 2.0884 36.3758
ASH-3 GDSC1 2.3633 5.305 2.0338 34.8427
TT2609-C02 GDSC1 2.9753 4.0208 2.962 25.3927
8505C GDSC1 3.0353 4.5129 2.9665 24.9989
KMH-2 GDSC1 3.0439 5.0032 2.8644 25.617
IHH-4 GDSC1 3.1287 3.892 3.1256 23.4105
CAL-62 GDSC1 3.2143 5.1416 3.0108 23.6572
B-CPAP GDSC1 3.2366 5.2907 2.989 23.6775
HTC-C3 GDSC1 3.5557 7.813 2.2626 26.6513
BHT-101 GDSC1 3.771 5.5202 3.4879 17.2864
CGTH-W-1 GDSC1 4.0335 7.1089 3.0614 19.0763
K5 GDSC1 4.3756 5.2304 4.2443 8.6945
FTC-133 GDSC1 4.3998 5.6711 4.0898 9.6964
8305C GDSC1 4.4864 6.4849 3.7957 11.5349
TT GDSC1 4.5693 6.1757 4.0235 9.4171
WRO GDSC1 5.0682 7.5241 3.7943 9.2548
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 41 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
BB30-HNC GDSC1 2.0584 3.5512 2.0407 36.8764
KON GDSC1 2.2645 4.1793 2.192 34.6303
NCI-H3118 GDSC1 2.2773 3.7232 2.2566 34.1618
BHY GDSC1 2.3658 4.1369 2.3066 33.2914
JHU-029 GDSC1 2.6582 7.4211 1.5349 35.2702
OSC-20 GDSC1 2.7284 3.9057 2.7131 28.4912
SCC-15 GDSC1 2.7725 5.1196 2.5354 29.3477
Ca9-22 GDSC1 2.8228 4.3354 2.7668 27.5704
HSC-2 GDSC1 2.982 4.7034 2.871 25.9385
PCI-15A GDSC1 3.1142 5.4683 2.7974 25.6542
HO-1-u-1 GDSC1 3.2316 5.6003 2.8783 24.4517
BICR 10 GDSC1 3.2447 5.2978 2.9955 23.5871
BICR 22 GDSC1 3.3749 5.2252 3.1602 21.7358
HSC-4 GDSC1 3.502 4.8279 3.4087 19.3307
SCC-9 GDSC1 3.5409 6.0304 3.043 21.6456
PCI-04B GDSC1 3.5568 4.6617 3.5028 18.3865
JHU-011 GDSC1 3.5607 4.4739 3.5354 18.1515
HO-1-N-1 GDSC1 3.6351 6.0963 3.1147 20.6507
BICR 31 GDSC1 3.6353 5.4237 3.3767 18.7994
PCI-06A GDSC1 3.6765 6.4306 3.0145 21.1449
FaDu GDSC1 3.6954 4.9194 3.5975 16.9464
HSC-3 GDSC1 3.7497 4.8829 3.6657 16.1751
CAL-27 GDSC1 3.767 5.6575 3.4313 17.71
Detroit 562 GDSC1 3.8245 6.4327 3.165 19.3337
CAL-33 GDSC1 3.9875 6.2173 3.4269 16.6247
PE/CA-PJ15 GDSC1 4.0385 5.2916 3.8588 13.2301
SCC-4 GDSC1 4.0781 7.2206 3.0516 18.9409
SAS GDSC1 4.1012 6.3328 3.49 15.6098
DOK GDSC1 4.1475 6.1231 3.6317 14.3323
BICR 78 GDSC1 4.2317 5.7238 3.8936 11.9768
UPCI-SCC-090 GDSC1 4.2712 10.2382 1.7512 26.1329
KOSC-2 GDSC1 4.2838 6.0384 3.8075 12.366
SKN-3 GDSC1 4.3273 5.1027 4.2354 9.0207
LB771-HNC GDSC1 4.365 6.1169 3.8524 11.6467
BB49-HNC GDSC1 4.4336 11.8549 1.0898 28.5196
OSC-19 GDSC1 4.5119 5.9004 4.0984 9.1008
SAT [Human HNSCC] GDSC1 4.6058 8.617 2.8534 18.0623
PCI-30 GDSC1 4.8101 5.6508 4.5054 4.6476
PCI-38 GDSC1 5.1542 8.1966 3.5283 11.0124
SCC-25 GDSC1 5.514 12.1496 1.844 20.903
JHU-022 GDSC1 5.7941 11.7302 2.2716 17.5301
⏷ Show the Full List of 41 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HT-1376 GDSC1 2.1724 3.8936 2.1311 35.5927
BFTC-905 GDSC1 2.1969 2.9756 2.1966 35.0405
J82 GDSC1 2.4192 3.8316 2.3964 32.4022
UM-UC-3 GDSC1 3.1202 6.6219 2.3564 28.4143
SW780 GDSC1 3.4173 4.1104 3.4131 19.8102
639V GDSC1 3.5303 4.2928 3.5204 18.4336
TCCSUP GDSC1 3.5631 6.4625 2.8839 22.6327
RT-112 GDSC1 3.634 7.6548 2.4138 25.3483
SW1710 GDSC1 3.6669 5.8118 3.2643 19.425
CAL-29 GDSC1 3.7002 6.4804 3.017 21.008
5637 GDSC1 3.7055 6.2405 3.1269 20.2036
647V GDSC1 3.7578 5.0725 3.6239 16.4112
HT-1197 GDSC1 4.3562 7.74 3.0624 17.6232
KU-19-19 GDSC1 4.5909 5.1578 4.5023 5.715
RT-4 GDSC1 5.0582 6.8542 4.121 6.7242
T24 GDSC1 5.4399 7.4245 4.1319 5.4072
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NT2-D1 GDSC1 0.0907 1.5119 0.09 61.3032
PA-1 GDSC1 1.6394 3.2096 1.6265 42.0749
KGN GDSC1 1.6592 3.964 1.5757 42.1387
NEC8 GDSC1 2.372 3.4687 2.3669 32.8818
CAL-39 GDSC1 2.417 3.7824 2.3978 32.407
SW962 GDSC1 2.8951 5.9605 2.3841 29.5428
LB831-BLC GDSC1 3.0751 5.5337 2.7326 26.3041
HeLa GDSC1 3.2935 7.3779 2.2023 28.3647
OMC-1 [Human cervical carcinoma] GDSC1 3.3705 6.831 2.5249 26.0128
SiSo GDSC1 3.4104 5.3829 3.1473 21.6254
JEG-3 GDSC1 3.4566 5.7566 3.062 21.962
C-33 A GDSC1 3.6147 4.5908 3.577 17.5567
SW954 GDSC1 3.6637 5.3383 3.437 18.2241
SKN GDSC1 3.6668 5.3048 3.4517 18.1051
HEC-1 GDSC1 3.6838 6.4524 3.0124 21.1233
SW756 GDSC1 3.7465 4.878 3.6633 16.2102
C-4-I GDSC1 3.7925 6.417 3.1393 19.677
OVMIU GDSC1 3.7982 7.0805 2.8436 21.7297
DoTc2 4510 GDSC1 3.8686 5.7665 3.4958 16.7181
NCC-IT GDSC1 4.1081 8.5455 2.4384 22.946
BPH-1 GDSC1 4.1498 5.1525 4.0264 11.4505
Ca Ski GDSC1 4.2319 5.9751 3.7837 12.7921
ME-180 GDSC1 4.2462 5.7815 3.8837 11.9782
HT-3 GDSC1 4.4095 7.3512 3.3021 15.6285
MS751 GDSC1 4.6094 6.394 3.9556 9.7687
DSH1 GDSC1 4.7238 5.8835 4.3113 6.5223
SKG-IIIa GDSC1 5.1074 8.2867 3.4452 11.812
SiHa GDSC1 5.1188 6.8185 4.1878 5.9878
JAR GDSC1 6.5877 11.8936 2.7699 12.0377
⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug

References

1 Discovery of embelin as a cell-permeable, small-molecular weight inhibitor of XIAP through structure-based computational screening of a traditional... J Med Chem. 2004 May 6;47(10):2430-40.
2 Embelin suppresses growth of human pancreatic cancer xenografts, and pancreatic cancer cells isolated from KrasG12D mice by inhibiting Akt and Sonic hedgehog pathways. PLoS One. 2014 Apr 2;9(4):e92161.
3 XIAP inhibitor embelin induces autophagic and apoptotic cell death in human oral squamous cell carcinoma cells. Environ Toxicol. 2017 Nov;32(11):2371-2378. doi: 10.1002/tox.22450. Epub 2017 Jul 19.