Details of the Drug-Related molecule(s) Interaction Atlas

EMBELIN Drug Info

EMBELIN; 550-24-3; Embelic acid; Emberine; 2,5-dihydroxy-3-undecylcyclohexa-2,5-diene-1,4-dione; 2,5-Dihydroxy-3-undecyl-1,4-benzoquinone; 2,5-Dihydroxy-3-undecyl-p-benzoquinone; 2,5-Dihydroxy-3-undecyl-2,5-cyclohexadiene-1,4-dione; UNII-SHC6U8F5ER; CHEBI:4778; Embelin, Embelia ribes; C17H26O4; NSC91874; XIAP inhibitor, Embelin; EINECS 208-979-8; NSC 91874; SHC6U8F5ER; BRN 1885786; Apoptosis Activator III, Embelin; AK115155; p-Benzoquinone, 2,5-dihydroxy-3-undecyl-; SR-01000597536; Spectrum_001513; Tocris-2156; SpecPlus_000501

Cross-matching ID

PubChem CID

3218

ChEBI ID

CHEMBL221137

CAS Number

CAS 550-24-3

TTD Drug ID

DMFZO4Y

General Information of Drug (ID: DMFZO4Y)

Molecule-Related Drug Atlas

Molecule Type:

DTT

DOT

Drug Status:

Clinical Trial Drug(s)

Investigative Drug(s)

Approved Drug(s)

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Drug(s) Targeting XIAP messenger RNA (XIAP mRNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ASTX660	DMMKW8L	Lymphoma	2A80-2A86	Phase 2	[4]
AEG35156	DM2HRYD	Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[5]
AZD5582	DMPIHN6	Discovery agent	N.A.	Investigative	[6]
SM-337	DMOSTP9	Discovery agent	N.A.	Investigative	[7]
SM-131	DMP8VO6	Discovery agent	N.A.	Investigative	[8]
BV-6	DMDTV7A	Discovery agent	N.A.	Investigative	[9]
SM-122	DMC7YQE	Discovery agent	N.A.	Investigative	[7]
ARPFAQK-FAM	DMU70YP	Discovery agent	N.A.	Investigative	[1]
AVPIAQKSEK-FAM	DMNQ9R4	Discovery agent	N.A.	Investigative	[1]
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Drug(s) Affected By Tumor necrosis factor receptor superfamily member 10A (TNFRSF10A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[10]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[11]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[12]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[13]
Vismodegib	DM5IXKQ	Basal cell carcinoma	2C32	Approved	[14]
Bupropion	DM5PCS7	Depression	6A70-6A7Z	Approved	[15]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[16]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[17]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[18]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[19]
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Drug(s) Affected By Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[20]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[21]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[22]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[23]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[24]
Selenium	DM25CGV	N. A.	N. A.	Approved	[25]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[20]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[26]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[27]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[26]
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Drug(s) Affected By Zinc finger protein SNAI2 (SNAI2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[28]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[29]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[30]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[31]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[32]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[33]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[33]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[34]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[36]
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Drug(s) Affected By Zinc finger protein SNAI1 (SNAI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[37]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[28]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[29]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[38]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[39]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[40]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[41]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[34]
Aldosterone	DM9S2JW	Hypertension	BA00-BA04	Approved	[42]
Sanguinarine	DMDINFS	Dental plaque	DA08.4	Approved	[43]
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Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[44]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[45]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[46]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[47]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[48]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[49]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[48]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[50]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[51]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[52]
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Drug(s) Affected By Zinc finger protein GLI2 (GLI2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[53]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[38]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[30]
Vismodegib	DM5IXKQ	Basal cell carcinoma	2C32	Approved	[14]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[54]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[36]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[56]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[57]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[58]
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Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[59]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[60]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[61]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[62]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[63]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[64]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[65]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[66]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[67]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[65]
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Drug(s) Affected By Cadherin-1 (CDH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[68]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[28]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[69]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[70]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[71]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[11]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[73]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[74]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[31]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
XIAP messenger RNA (XIAP mRNA)	TTK3WBU	XIAP_HUMAN	Inhibitor	[1]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Cadherin-1 (CDH1)	OTFJMXPM	CADH1_HUMAN	Gene/Protein Processing	[2]
E3 ubiquitin-protein ligase XIAP	OT24GP9B	XIAP_HUMAN	Protein Interaction/Cellular Processes	[3]
Interleukin-8 (CXCL8)	OTS7T5VH	IL8_HUMAN	Gene/Protein Processing	[2]
Poly polymerase 1 (PARP1)	OT310QSG	PARP1_HUMAN	Protein Interaction/Cellular Processes	[2]
Tumor necrosis factor receptor superfamily member 10A (TNFRSF10A)	OTBPCU2O	TR10A_HUMAN	Gene/Protein Processing	[2]
Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B)	OTA1CPBV	TR10B_HUMAN	Gene/Protein Processing	[2]
Vascular endothelial growth factor A, long form	OTIM9MZ3	VEGFA_HUMAN	Gene/Protein Processing	[2]
Zinc finger E-box-binding homeobox 1	OTEDXTGD	ZEB1_HUMAN	Gene/Protein Processing	[2]
Zinc finger protein GLI2 (GLI2)	OTIRV97L	GLI2_HUMAN	Gene/Protein Processing	[2]
Zinc finger protein SNAI1 (SNAI1)	OTDPYAMC	SNAI1_HUMAN	Gene/Protein Processing	[2]

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