Details of the Drug

General Information of Drug (ID: DMG1VXR)

Drug Name
SBC-014
Synonyms AVI-014; Glycosylated recombinant G-CSF (neutropenia), AviGenics; Glycosylated recombinant G-CSF (neutropenia), Synageva
Indication
Disease Entry ICD 11 Status REF
Neutropenia 4B00.0 Phase 2 [1]
Cross-matching ID
DrugBank ID
DB17086
TTD ID
D01LRM

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Granulocyte colony-stimulating factor receptor (G-CSF-R) TTC70AJ CSF3R_HUMAN Modulator [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Neutropenia
ICD Disease Classification 4B00.0
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Granulocyte colony-stimulating factor receptor (G-CSF-R) DTT CSF3R 2.08E-08 0.36 0.96
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

References

1 ClinicalTrials.gov (NCT00497809) Safety and Efficacy Study of GCSF Therapy to Treat Patients at High Risk for Chemotherapy Induced Severe Neutropenia. U.S. National Institutes of Health.
2 A glycosylated recombinant human granulocyte colony stimulating factor produced in a novel protein production system (AVI-014) in healthy subjects: a first-in human, single dose, controlled study. BMC Clin Pharmacol. 2009; 9: 2.