Details of Disease

General Information of Disease (ID: DISGCAMX)

• Disease Name: Neutropenia
• Synonyms: neutropenic disorder; neutropenia
• Disease Class: 4B00: Neutropenia
• Definition: A decrease in the number of neutrophils found in the blood.
• Disease Hierarchy:
  DISJS4LS: Agranulocytosis
  DISGCAMX: Neutropenia
• ICD Code:
  ICD-11: ICD-11: 4B00.0
  ICD-9: ICD-9: 288
  Expand ICD-11: '4B00.0
  Expand ICD-9: 288
• Disease Identifiers:
  MONDO ID: MONDO_0001475
  UMLS CUI: C0853697
  MedGen ID: 163121
  HPO ID: HP:0001875
  SNOMED CT ID: 165517008

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 3 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Efbemalenograstim	DMDNJ18	Approved	NA	[1]
Eflapegrastim	DMACVEI	Approved	NA	[2]
Tbo-Filgrastim	DML6OE7	Approved	NA	[3]

This Disease is Treated as An Indication in 8 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Neugranin	DMLRKJX	Preregistration	NA	[4]
DA-3031	DM6S4R2	Phase 3	Small molecular drug	[5]
LA-EP2006	DMI3YLK	Phase 3	NA	[6]
MK-4214	DMA25NO	Phase 3	NA	[7]
MAXY-G34	DMWLIPJ	Phase 2	NA	[8]
Romyelocel-L	DMTFO7B	Phase 2	Cell therapy	[9]
SBC-014	DMG1VXR	Phase 2	NA	[10]
MK-6302	DMZUA5C	Phase 1	NA	[7]

This Disease is Treated as An Indication in 9 Investigative Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
BBT-007	DMT0X6Q	Investigative	NA	[11]
BBT-015	DMYWDIX	Investigative	NA	[12]
BBT-018	DM7XT4I	Investigative	NA	[12]
GC-003	DMFRP7G	Investigative	NA	[12]
IRX-03	DM96390	Investigative	NA	[12]
MGMTP140K gene-modified hematopoietic progenitor cells	DM40V5L	Investigative	NA	[12]
SRG	DMU4AT6	Investigative	Small molecular drug	[12]
ST-7	DMWN2M3	Investigative	NA	[12]
ZP-G-CSF	DM9XFYZ	Investigative	NA	[13]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 1 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
ELANE	TTPLTSQ	Definitive	Autosomal dominant	[14]

This Disease Is Related to 1 DTP Molecule(s)

Gene Name	DTP ID	Evidence Level	Mode of Inheritance	REF
SLC35A2	DT0567K	Strong	Genetic Variation	[15]

References

• [1] FDA Approved Drug Products from FDA Official Website. 2023. Application Number: 761134
• [2] FDA Approved Drug Products from FDA Official Website. 2022. Application Number: 761148.
• [3] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6968).
• [4] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800017176)
• [5] ClinicalTrials.gov (NCT01674855) Phase III Study of DA-3031(PEG-G-CSF) in Chemotherapy-induced Neutropenia. U.S. National Institutes of Health.
• [6] ClinicalTrials.gov (NCT01516736) Phase III Study Comparing the Efficacy and Safety of LA-EP2006 and Peg-Filgrastim. U.S. National Institutes of Health.
• [7] Clinical pipeline report, company report or official report of Merck.
• [8] ClinicalTrials.gov (NCT00501332) Evaluation of Maxy-G34 in Breast Cancer Patients Treated With TAC (Docetaxel, Adriamycin, Cyclophosphamide) Chemotherapy. U.S. National Institutes of Health.
• [9] ClinicalTrials.gov (NCT02282215) Safety and Efficacy of Human Myeloid Progenitor Cells (CLT-008) During Chemotherapy for Acute Myeloid Leukemia. U.S. National Institutes of Health.
• [10] ClinicalTrials.gov (NCT00497809) Safety and Efficacy Study of GCSF Therapy to Treat Patients at High Risk for Chemotherapy Induced Severe Neutropenia. U.S. National Institutes of Health.
• [11] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1707).
• [12] The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
• [13] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1719).
• [14] Technical standards for the interpretation and reporting of constitutional copy-number variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics (ACMG) and the Clinical Genome Resource (ClinGen). Genet Med. 2020 Feb;22(2):245-257. doi: 10.1038/s41436-019-0686-8. Epub 2019 Nov 6.
• [15] SLC35A2-CDG: Functional characterization, expanded molecular, clinical, and biochemical phenotypes of 30 unreported Individuals.Hum Mutat. 2019 Jul;40(7):908-925. doi: 10.1002/humu.23731. Epub 2019 Apr 24.