Details of the Drug

General Information of Drug (ID: DMH21E0)

• Drug Name: Sodium Acetate Anhydrous
• Synonyms: Sodium Acetate In Plastic Container

Indication

Disease Entry	ICD 11	Status	REF
Hyponatraemia	5C72	Approved	[1]

• Affected Organisms: Humans and other mammals
• Drug Type: Small molecular drug
• #Ro5 Violations (Lipinski): 0:
  Molecular Weight; 82.03
  Logarithm of the Partition Coefficient; Not Available
  Rotatable Bond Count; 0
  Hydrogen Bond Donor Count; 0
  Hydrogen Bond Acceptor Count; 2
• ADMET Property: Metabolism: The drug is metabolized via the liver []
• Chemical Identifiers:
  Formula: C2H3NaO2
  IUPAC Name: sodium;acetate
  Canonical SMILES: CC(=O)[O-].[Na+]
  InChI: InChI=1S/C2H4O2.Na/c1-2(3)4;/h1H3,(H,3,4);/q;+1/p-1
  InChIKey: VMHLLURERBWHNL-UHFFFAOYSA-M
• Cross-matching ID:
  PubChem CID: 517045
  ChEBI ID: CHEMBL1354
  CAS Number: 127-09-3
  UNII: NVG71ZZ7P0
  DrugBank ID: DB09395
  TTD ID: D0Z4UY
  INTEDE ID: DR1492
• Drug-Molecule Activity Atlas (DMA)NEW: Click to Jump to the Detailed DMA Information of This Drug

Molecular Interaction Atlas of This Drug

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Acetyl-CoA synthetase (ACSS2) Main DME	DEE76VW	ACSA_HUMAN	Substrate	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Acetyl-coenzyme A synthetase 2-like, mitochondrial (ACSS1)	OT6C1WQD	ACS2L_HUMAN	Gene/Protein Processing	[3]
Acetyl-coenzyme A synthetase, cytoplasmic (ACSS2)	OTB1FZJU	ACSA_HUMAN	Gene/Protein Processing	[3]
Arylamine N-acetyltransferase 2 (NAT2)	OTBPDQOY	ARY2_HUMAN	Gene/Protein Processing	[3]
Peroxisomal acyl-coenzyme A oxidase 1 (ACOX1)	OTM0A0DY	ACOX1_HUMAN	Gene/Protein Processing	[3]
Phosphoenolpyruvate carboxykinase, cytosolic (PCK1)	OTNWEJ5Y	PCKGC_HUMAN	Gene/Protein Processing	[3]

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Disease Different from Sodium Acetate Anhydrous (Comorbidity)

DDI Drug Name	DDI Drug ID	Severity	Mechanism	Comorbidity	REF
Choline salicylate	DM8P137	Moderate	as urine pH determines the ionization state of weakly acidic or weakly alkaline drugs. Sodium acetate anhydrous caused by Choline salicylate mediated altered urine pH.	Postoperative inflammation [1A00-CA43]	[4]

References

• [1] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
• [2] Sodium acetate induces a metabolic alkalosis but not the increase in fatty acid oxidation observed following bicarbonate ingestion in humans. J Nutr. 2007 Jul;137(7):1750-6.
• [3] Transcriptional Regulation of Human Arylamine N-Acetyltransferase 2 Gene by Glucose and Insulin in Liver Cancer Cell Lines. Toxicol Sci. 2022 Nov 23;190(2):158-172. doi: 10.1093/toxsci/kfac103.
• [4] Balali-Mood M, Prescott LF "Failure of alkaline diuresis to enhance diflunisal elimination." Br J Clin Pharmacol 10 (1980): 163-5. [PMID: 7426277]