Details of the Drug

General Information of Drug (ID: DMJSMDL)

Drug Name

Cefiderocol

Synonyms

Cephalosporin, GSK2696266; S-649266

Indication

Disease Entry	ICD 11	Status	REF
Hospital-acquired pneumonia	CA40.Z	Approved	[1]
Urinary tract infection	GC08	Approved	[1]
Ventilator-associated pneumonia	PK81.0	Approved	[1]
Healthcare-associated pneumonia	CA00-CA40	Phase 3	[2]
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Affected Organisms

Pseudomonas aeruginosaEscherichia coliAcinetobacter baumanniiKlebsiella pneumoniaeSerratia marcescensStenotrophomonas maltophiliaAcinetobacter calcoaceticusAcinetobacter haemolyticusAcinetobacter johnsoniiAcinetobacter lwoffiiAeromonas hydrophilaCampylobacter jejuniElizabethkingia meningosepticaEnterobacter cloacaeHaemophilus influenzaeKlebsiella oxytocaMoraxella catarrhalisMorganella morganiiNeisseria gonorrhoeaeNeisseria meningitidisProteus mirabilisProteus vulgarisProvidencia rettgeriCitrobacter freundiiProvidencia stuartiiPseudomonas putidaPseudomonas stutzeriSalmonella enteritidisSalmonella paratyphiSalmonella typhiSalmonella typhimuriumSalmonella choleraesuisShigella flexneriYersinia enterocoliticaVibrio vulnificusVibrio fluvialisMicrococcus luteusStreptococcus pneumoniaeStreptococcus pyogenesYersinia pseudotuberculosis

ATC Code

J01DI04: Cefiderocol

J01DI: Other cephalosporins and penems

J01D: OTHER BETA-LACTAM ANTIBACTERIALS

J01: ANTIBACTERIALS FOR SYSTEMIC USE

J: ANTIINFECTIVES FOR SYSTEMIC USE

Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

Chemical Identifiers

Formula: C30H34ClN7O10S2
Canonical SMILES: CC(C)(C(=O)O)ON=C(C1=CSC(=N1)N)C(=O)NC2C3N(C2=O)C(=C(CS3)C[N+]4(CCCC4)CCNC(=O)C5=C(C(=C(C=C5)O)O)Cl)C(=O)[O-]
InChI: 1S/C30H34ClN7O10S2/c1-30(2,28(46)47)48-36-19(16-13-50-29(32)34-16)24(42)35-20-25(43)37-21(27(44)45)14(12-49-26(20)37)11-38(8-3-4-9-38)10-7-33-23(41)15-5-6-17(39)22(40)18(15)31/h5-6,13,20,26H,3-4,7-12H2,1-2H3,(H7-,32,33,34,35,36,39,40,41,42,44,45,46,47)/t20-,26-/m1/s1
InChIKey: DBPPRLRVDVJOCL-FQRUVTKNSA-N

Cross-matching ID

PubChem CID: 77843966
CAS Number: 1225208-94-5
UNII: SZ34OMG6E8
DrugBank ID: DB14879
TTD ID: D0Q7MA

Combinatorial Drugs (CBD)

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Repurposed Drugs (RPD)

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References

1	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2020
2	ClinicalTrials.gov (NCT02714595) Study of Cefiderocol (S-649266) or Best Available Therapy for the Treatment of Severe Infections Caused by Carbapenem-resistant Gram-negative Pathogens (CREDIBLE - CR). U.S. National Institutes of Health.