Details of Disease

General Information of Disease (ID: DISYI6GA)

• Disease Name: Hospital-acquired pneumonia
• Disease Class: CA40: Pneumonia
• Disease Hierarchy:
  DIS01GPL: Grass pollen hypersensitivity
  DISYI6GA: Hospital-acquired pneumonia
• ICD Code:
  ICD-11: ICD-11: CA40.Z
  Expand ICD-11: 'CA40.Z

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 1 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Cefiderocol	DMJSMDL	Approved	Small molecular drug	[1]

This Disease is Treated as An Indication in 5 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
AR-301	DM2YQK8	Phase 3	Antibody	[2]
MEDI4893	DMXB4NL	Phase 2b	Antibody	[3]
ASN100	DMWPGLS	Phase 2	Monoclonal antibody	[4]
Panobacumab	DMV27SP	Phase 2	Monoclonal antibody	[5]
KBP-7072	DMXJDXH	Phase 1	Small molecular drug	[6]

Molecular Interaction Atlas (MIA) of This Disease

References

• [1] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2020
• [2] ClinicalTrials.gov (NCT01589185) Safety, Pharmacokinetics and Efficacy of KBSA301 in Severe Pneumonia (S. Aureus). U.S. National Institutes of Health.
• [3] Mechanisms of neutralization of a human anti-alpha-toxin antibody. J Biol Chem. 2014 Oct 24;289(43):29874-80.
• [4] ClinicalTrials.gov (NCT02940626) Prevention of S. Aureus Pneumonia Study in Heavily Colonized, Mechanically Ventilated Subjects
• [5] ClinicalTrials.gov (NCT00851435) Safety and Pharmacokinetics of KBPA-101 in Hospital Acquired Pneumonia Caused by O11 Pseudomonas Aeruginosa. U.S. National Institutes of Health.
• [6] ClinicalTrials.gov (NCT04532957) A Multiple Ascending Dose Study to Investigate Safety of KBP-7072 in Healthy Subjects. U.S. National Institutes of Health.