Details of the Drug

General Information of Drug (ID: DMM1W9R)

Drug Name

ABTL0812

Synonyms

ABTL-0812; 57818-44-7; alpha-Hydroxylinoleic acid; ABTL0812; (alpha)-Hydroxylinoleic acid; 2-hydroxy-9Z,12Z-Octadecadienoic acid; (9Z,12Z)-2-hydroxyoctadeca-9,12-dienoic acid; 0DE74TJ7EZ; 9,12-Octadecadienoic acid, 2-hydroxy-, (9Z,12Z)-; (9Z,12Z)-2-Hydroxy-9,12-octadecadienoic acid; 9,12-Octadecadienoic acid, 2-hydroxy-, (Z,Z)-; hydroxylinoleic acid; a-Hydroxylinoleic acid; 2-hydroxylinoleic acid; UNII-0DE74TJ7EZ; SCHEMBL320069; CHEBI:136927; DTXSID301258077; .ALPHA.-HYDROXYLINOLEIC ACID; HY-U00141; LMFA02000290; s9611; AKOS040740632; CS-7178; (9Z,12Z)-2-hydroxyoctadecadienoic acid; MS-24253

Indication

Disease Entry	ICD 11	Status	REF
Pancreatic cancer	2C10	Phase 1/2	[1]
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Drug Type

Small molecule

Structure

3D MOL

2D MOL

Chemical Identifiers

Formula: C18H32O3
Canonical SMILES: CCCCCC=CCC=CCCCCCCC(C(=O)O)O
InChI: InChI=1S/C18H32O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17(19)18(20)21/h6-7,9-10,17,19H,2-5,8,11-16H2,1H3,(H,20,21)/b7-6-,10-9-
InChIKey: AFDSETGKYZMEEA-HZJYTTRNSA-N

Cross-matching ID

PubChem CID: 21158511
UNII: 0DE74TJ7EZ
DrugBank ID: DB16027
TTD ID: DMBQ10

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Peroxisome proliferator-activated receptor (PPAR)	TTRMIZ7	PPARA_HUMAN ; PPARD_HUMAN ; PPARG_HUMAN	Agonist	[2]

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Molecular Interaction Atlas (MIA)

MIA Detail

Jump to Detail Molecular Interaction Atlas of This Drug

References

1	ClinicalTrials.gov (NCT04431258) A Phase I Open Label Followed by a Phase II Randomized, Controlled Study to Assess the Efficacy and Safety of ABTL0812 in Combination With FOLFIRINOX for First-line Treatment of Metastatic Pancreatic. U.S.National Institutes of Health.
2	The anti-cancer drug ABTL0812 induces ER stress-mediated cytotoxic autophagy by increasing dihydroceramide levels in cancer cells. Autophagy. 2021 Jun;17(6):1349-1366.