Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTRMIZ7)

• DTT Name: Peroxisome proliferator-activated receptor (PPAR)
• Gene Name: PPAR
• DTT Type: Clinical trial target; [1]
• UniProt ID: PPARA_HUMAN ; PPARD_HUMAN ; PPARG_HUMAN
• TTD ID: T85042
• KEGG Pathway:
  PPAR signaling pathway (hsa03320)
  cAMP signaling pathway (hsa04024)
  Adipocytokine signaling pathway (hsa04920)
  Glucagon signaling pathway (hsa04922)
  Insulin resistance (hsa04931)
  Non-alcoholic fatty liver disease (hsa04932)
  Alcoholic liver disease (hsa04936)
  Hepatitis C (hsa05160)
  Chemical carcinogenesis - receptor activation (hsa05207)
  Diabetic cardiomyopathy (hsa05415)
• Reactome Pathway:
  BMAL1 (R-HSA-1368108)
  PPARA activates gene expression (R-HSA-1989781)
  Transcriptional activation of mitochondrial biogenesis (R-HSA-2151201)
  Activation of gene expression by SREBF (SREBP) (R-HSA-2426168)
  Transcriptional regulation of white adipocyte differentiation (R-HSA-381340)
  Nuclear Receptor transcription pathway (R-HSA-383280)
  Regulation of lipid metabolism by PPARalpha (R-HSA-400206)
  Circadian Clock (R-HSA-400253)
  SUMOylation of intracellular receptors (R-HSA-4090294)
  Cytoprotection by HMOX1 (R-HSA-9707564)
  Heme signaling (R-HSA-9707616)
  RORA activates gene expression (R-HSA-1368082)

Molecular Interaction Atlas (MIA) of This DTT

3 Clinical Trial Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
A278	DMKXO9V	Non-alcoholic steatohepatitis	DB92.1	IND submitted	[2]
IVA337	DMJV3AX	Non-alcoholic steatohepatitis	DB92.1	Phase 2	[1]
ABTL0812	DMM1W9R	Pancreatic cancer	2C10	Phase 1/2	[3]

References

• [1] Pan-PPAR agonist IVA337 is effective in experimental lung fibrosis and pulmonary hypertension. Ann Rheum Dis. 2017 Nov;76(11):1931-1940.
• [2] Clinical pipeline report, company report or official report of Klus Pharma
• [3] The anti-cancer drug ABTL0812 induces ER stress-mediated cytotoxic autophagy by increasing dihydroceramide levels in cancer cells. Autophagy. 2021 Jun;17(6):1349-1366.