Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMM7ZXR)

Drug Name

GSK2126458 Drug Info

Synonyms

1086062-66-9; Omipalisib; GSK-2126458; GSK 2126458; UNII-1X8F5A3NA0; 2,4-difluoro-N-(2-methoxy-5-(4-(pyridazin-4-yl)quinolin-6-yl)pyridin-3-yl)benzenesulfonamide; 2,4-difluoro-N-[2-methoxy-5-(4-pyridazin-4-ylquinolin-6-yl)pyridin-3-yl]benzenesulfonamide; 2,4-Difluoro-N-[2-methoxy-5-[4-(4-pyridazinyl)-6-quinolinyl]-3-pyridinyl]benzenesulfonamide; 1X8F5A3NA0; Omipalisib (GSK2126458, GSK458); C25H17F2N5O3S; Omipalisib [USAN:INN]

Indication

Disease Entry	ICD 11	Status	REF
Lymphoma	2A80-2A86	Phase 1	[1]

Cross-matching ID

PubChem CID: 25167777
ChEBI ID: CHEBI:95093
CAS Number: CAS 1086062-66-9
TTD Drug ID: DMM7ZXR

Molecule-Related Drug Atlas

Molecule Type:

DTT

DOT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting PI3-kinase gamma (PIK3CG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BAY 80-6946	DMLOS5R	Follicular lymphoma	2A80	Approved	[5]
IPI-145	DMWA24P	Follicular lymphoma	2A80	Approved	[6]
Buparlisib	DM1WEHC	Breast cancer	2C60-2C65	Phase 3	[7]
Enzastaurin	DM5H0R9	Diffuse large B-cell lymphoma	2A81	Phase 3	[8]
Rigosertib	DMOSTXF	Myelodysplastic syndrome	2A37	Phase 3	[9]
GDC-0032	DMT4QHD	Breast cancer	2C60-2C65	Phase 3	[8]
PQR309	DMMCYZ8	Squamous head and neck cell carcinom	2D60.0	Phase 2	[10]
SAR245409	DMQM7IL	Solid tumour/cancer	2A00-2F9Z	Phase 2	[11]
XL147	DMML7BE	Solid tumour/cancer	2A00-2F9Z	Phase 2	[11]
SF1126	DML10K3	Head and neck cancer	2D42	Phase 2	[12]
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Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[13]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[14]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[15]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[16]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[17]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[18]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[17]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[19]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[20]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[21]
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Drug(s) Affected By Ribosomal protein S6 kinase beta-1 (RPS6KB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[22]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[23]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[24]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[25]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[3]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[26]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[27]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[29]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[30]
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Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[31]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[32]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[33]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[34]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[35]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[36]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[37]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[38]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[39]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[40]
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Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[41]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[32]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[42]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[43]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[44]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[31]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[45]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[46]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[34]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[35]
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Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[47]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[48]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[49]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[50]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[51]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[25]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[52]
Selenium	DM25CGV	N. A.	N. A.	Approved	[53]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[54]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[55]
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Drug(s) Affected By Small ribosomal subunit protein eS6 (RPS6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[56]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[57]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[58]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[29]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[59]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[60]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[62]
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[47]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
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Drug(s) Affected By Eukaryotic translation initiation factor 4E-binding protein 1 (EIF4EBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[55]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[65]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[67]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[68]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[61]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[69]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[70]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
PI3-kinase gamma (PIK3CG)	TTHBTOP	PK3CG_HUMAN	Modulator	[2]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Eukaryotic translation initiation factor 4E-binding protein 1 (EIF4EBP1)	OTHBQVD5	4EBP1_HUMAN	Post-Translational Modifications	[3]
Mitogen-activated protein kinase 1 (MAPK1)	OTH85PI5	MK01_HUMAN	Post-Translational Modifications	[3]
Mitogen-activated protein kinase 3 (MAPK3)	OTCYKGKO	MK03_HUMAN	Post-Translational Modifications	[3]
Poly polymerase 1 (PARP1)	OT310QSG	PARP1_HUMAN	Post-Translational Modifications	[4]
RAC-alpha serine/threonine-protein kinase (AKT1)	OT8H2YY7	AKT1_HUMAN	Post-Translational Modifications	[3]
Ribosomal protein S6 kinase beta-1 (RPS6KB1)	OTAELNGX	KS6B1_HUMAN	Post-Translational Modifications	[4]
Small ribosomal subunit protein eS6 (RPS6)	OTT4D1LN	RS6_HUMAN	Post-Translational Modifications	[4]

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References

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2	Company report (GSK)
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