Details of the Drug

General Information of Drug (ID: DMMUS8X)

Drug Name
AMG 108
Indication
Disease Entry ICD 11 Status REF
Rheumatoid arthritis FA20 Discontinued in Phase 2 [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
Cross-matching ID
PubChem CID
444499
DrugBank ID
DB05545
TTD ID
D0W7VG
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Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Interleukin 1 receptor type 2 (IL1R2) TT51DEV IL1R2_HUMAN Antagonist [2]
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Molecular Expression Atlas of This Drug

ICD Disease Classification 15 Disease of the musculoskeletal system/connective tissue
Disease Class ICD-11: FA20 Rheumatoid arthritis
The Studied Tissue Synovial tissue
The Studied Disease Rheumatoid arthritis [ICD-11:FA20]
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Interleukin 1 receptor type 2 (IL1R2) DTT IL1R2 3.43E-01 0.21 0.4
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

References

1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800020487)
2 Clinical pipeline report, company report or official report of Amgen (2009).