Details of the Drug

General Information of Drug (ID: DMN4BIA)

Drug Name

KN-38-7271

Synonyms

Cannabinoid 1/2 receptor agonists (cerebrovascular ischemia/pain), Bayer; Cannabinoid 1/2 receptor agonists (traumatic brain injury/stroke), KeyNeurotek

Indication

Disease Entry	ICD 11	Status	REF
Ischemia	8B10-8B11	Discontinued in Phase 2	[1]
------------------------------------------------------------------------------------

Structure

3D Structure is Not Available

3D MOL

2D MOL

Cross-matching ID

TTD ID: D0LF5B

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Cannabinoid receptor 1 (CB1)	TT6OEDT	CNR1_HUMAN	Modulator	[2]
Cannabinoid receptor 2 (CB2)	TTMSFAW	CNR2_HUMAN	Modulator	[2]

------------------------------------------------------------------------------------

Molecular Interaction Atlas (MIA)

MIA Detail

Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease

Ischemia

ICD Disease Classification

8B10-8B11

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Cannabinoid receptor 1 (CB1)	DTT	CNR1	5.59E-02	-0.22	-0.45
Cannabinoid receptor 1 (CB1)	DTT	CNR1	7.68E-01	-0.06	-0.46

Molecular Expression Atlas (MEA)

MEA Detail

Jump to Detail Molecular Expression Atlas of This Drug

References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800014615)
2	BAY 38-7271: a novel highly selective and highly potent cannabinoid receptor agonist for the treatment of traumatic brain injury.CNS Drug Rev.2003 Winter;9(4):343-58.