Details of Disease

General Information of Disease (ID: DIS5XOOY)

• Disease Name: Ischemia
• Synonyms: ischemia
• Disease Class: 8B10-8B11: Ischemia
• Definition: Lack of blood supply to an area of the body, resulting in impairment of tissue oxygenation.|Editor note: represented as a finding in other ontologies
• Disease Hierarchy:
  DISVS67S: Vascular disease
  DIS5XOOY: Ischemia
• ICD Code:
  ICD-11: ICD-11: 8B10-8B11
  ICD-9: ICD-9: 459.89
  Expand ICD-9: 459.89
• Disease Identifiers:
  MONDO ID: MONDO_0005053
  MESH ID: D007511
  UMLS CUI: C0022116
  MedGen ID: 5899
  SNOMED CT ID: 52674009

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 2 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
SKI-758	DMQ8E9R	Approved	Small molecular drug	[1]
Sodium sulfide sulfur	DMGJUYS	Approved	Small molecular drug	[2]

This Disease is Treated as An Indication in 4 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Autologous stem cell therapy	DMGQPP8	Phase 3	NA	[3]
Disufenton sodium	DMJS8V3	Phase 3	Small molecular drug	[4]
ALD-301	DMORO8G	Phase 2	NA	[5]
RAXOFELAST	DMK2E0N	Phase 2	Small molecular drug	[6]

This Disease is Treated as An Indication in 6 Discontinued Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
KN-38-7271	DMN4BIA	Discontinued in Phase 2	NA	[7]
MS-424	DMX3R9V	Discontinued in Phase 2	Small molecular drug	[8]
ETC-276	DMGM5VI	Discontinued in Phase 1	NA	[9]
LF-943	DMT0UH6	Terminated	NA	[10]
LXR-015-2	DMXYDJR	Terminated	NA	[11]
R-59494	DM36JFP	Terminated	Small molecular drug	[12]

This Disease is Treated as An Indication in 10 Investigative Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Anti-CD47 mab	DMS9Y39	Investigative	Monoclonal antibody	[13]
AP-101	DMHR3ZG	Investigative	NA	[14]
EDP-09	DMTYWTM	Investigative	NA	[13]
Human AM/AMBP-1	DM2EC4M	Investigative	NA	[13]
Ipoxyn	DMK3XF9	Investigative	NA	[13]
LC-280126	DM19IRU	Investigative	NA	[13]
LUF-5833	DMDHUL8	Investigative	NA	[15]
MFH-244	DMW646O	Investigative	NA	[13]
Poloxafuse-R	DMLGORR	Investigative	NA	[13]
SB therapeutics induced gene therapy	DMURE7J	Investigative	NA	[13]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 43 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
ABAT	TTT2LD9	Limited	Biomarker	[16]
ADORA1	TTK25J1	Limited	Biomarker	[17]
ADORA3	TTJFY5U	Limited	Biomarker	[18]
AKT2	TTH24WI	Limited	Biomarker	[19]
ANGPT2	TTKLQTJ	Limited	Biomarker	[20]
ANXA1	TTUCK4B	Limited	Biomarker	[21]
AVP	TTJ8EWH	Limited	Biomarker	[22]
BAX	TTQ57WJ	Limited	Biomarker	[23]
BECN1	TT5M7LN	Limited	Biomarker	[24]
CRHR2	TTIY658	Limited	Biomarker	[25]
CX3CL1	TT1OFBQ	Limited	Biomarker	[26]
CXCL12	TT4UGTF	Limited	Biomarker	[27]
CXCR3	TT1UCIJ	Limited	Biomarker	[28]
EGR1	TTE8LGD	Limited	Biomarker	[29]
GJA1	TT4F7SL	Limited	Biomarker	[30]
GJB2	TTRGZX3	Limited	Biomarker	[30]
HMOX1	TTI6V2A	Limited	Therapeutic	[31]
HTR1B	TTK8CXU	Limited	Biomarker	[32]
IL18	TTRICUF	Limited	Biomarker	[33]
ITGAV	TTT1R2L	Limited	Biomarker	[34]
LONP1	TTM1VPZ	Limited	Biomarker	[35]
MAPK9	TT3IVG2	Limited	Biomarker	[31]
MMP14	TTJ4QE7	Limited	Biomarker	[36]
PCNA	TTLG1PD	Limited	Biomarker	[37]
PLAU	TTGY7WI	Limited	Therapeutic	[38]
PRKCA	TTFJ8Q1	Limited	Biomarker	[39]
PTGES	TTYLQ8V	Limited	Biomarker	[40]
PTK2	TTON5IT	Limited	Biomarker	[41]
REN	TTB2MXP	Limited	Biomarker	[42]
S100A4	TTPR5SX	Limited	Biomarker	[37]
SERPINH1	TTPSWQG	Limited	Biomarker	[37]
SST	TTWF7UG	Limited	Therapeutic	[43]
TNFRSF1A	TTG043C	Limited	Biomarker	[44]
XDH	TT7RJY8	Limited	Biomarker	[45]
ASIC1	TTRJYB6	Strong	Biomarker	[46]
CALCA	TTVSFJW	Strong	Biomarker	[47]
LGMN	TTPTWV5	Strong	Altered Expression	[48]
NOS3	TTCM4B3	Strong	Biomarker	[49]
PPARG	TTT2SVW	Strong	Therapeutic	[50]
SLC29A4	TTTR957	Strong	Biomarker	[51]
SOD1	TTP9K3Q	Strong	Biomarker	[52]
THBD	TTAPV67	Strong	Biomarker	[53]
TP53	TT12KOD	Strong	Biomarker	[54]

This Disease Is Related to 1 DTP Molecule(s)

Gene Name	DTP ID	Evidence Level	Mode of Inheritance	REF
KCNK2	DTENHUP	Strong	Biomarker	[55]

This Disease Is Related to 15 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
ACTA2	OTEDLG8E	Limited	Biomarker	[37]
ADNP	OTEGICWR	Limited	Biomarker	[56]
ARID1B	OTILK3Q7	Limited	Biomarker	[57]
ATG5	OT4T5SMS	Limited	Biomarker	[24]
CD68	OTOYEY3J	Limited	Biomarker	[37]
CKM	OTME0KO7	Limited	Biomarker	[58]
CP	OTM8JE4Y	Limited	Biomarker	[59]
CYCS	OTBFALJD	Limited	Biomarker	[23]
LIPC	OTZY5SC9	Limited	Biomarker	[60]
MAP1LC3A	OTPMGIU4	Limited	Biomarker	[24]
MUC13	OTWKS9MF	Limited	Biomarker	[61]
MUC2	OT3X4QVX	Limited	Biomarker	[61]
OXT	OT48M72Z	Limited	Biomarker	[22]
SF1	OTLEDM2S	Limited	Biomarker	[62]
NDUFB2	OT4717TF	Strong	Biomarker	[63]

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