Details of the Drug

General Information of Drug (ID: DMOSTXF)

Drug Name
Rigosertib
Synonyms
Rigosertib; 592542-59-1; UNII-67DOW7F9GL; 67DOW7F9GL; N-[2-Methoxy-5-({[(E)-2-(2,4,6-Trimethoxyphenyl)ethenyl]sulfonyl}methyl)phenyl]glycine; ON-01910.Na; Rigosertib [USAN:INN]; 6FS; Rigosertib (USAN); AC1OCFT5; SCHEMBL498624; Estybon (proposed trade name); SCHEMBL498623; GTPL7833; CHEMBL1241855; ON01910.Na; DTXSID30207984; CHEBI:124939; OWBFCJROIKNMGD-BQYQJAHWSA-N; 1910 Na; ZINC3942646; BCP08296; BDBM50060917; 4006AH; AKOS015966442; DB12146; SB16468; (E)-2-((2-methoxy-5-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)phenyl)amino)acetic a
Indication
Disease Entry ICD 11 Status REF
Myelodysplastic syndrome 2A37 Phase 3 [1]
Solid tumour/cancer 2A00-2F9Z Phase 3 [2]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 1 Molecular Weight (mw) 451.5
Logarithm of the Partition Coefficient (xlogp) 2.5
Rotatable Bond Count (rotbonds) 11
Hydrogen Bond Donor Count (hbonddonor) 2
Hydrogen Bond Acceptor Count (hbondacc) 9
Chemical Identifiers
Formula
C21H25NO8S
IUPAC Name
2-[2-methoxy-5-[[(E)-2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonylmethyl]anilino]acetic acid
Canonical SMILES
COC1=C(C=C(C=C1)CS(=O)(=O)/C=C/C2=C(C=C(C=C2OC)OC)OC)NCC(=O)O
InChI
InChI=1S/C21H25NO8S/c1-27-15-10-19(29-3)16(20(11-15)30-4)7-8-31(25,26)13-14-5-6-18(28-2)17(9-14)22-12-21(23)24/h5-11,22H,12-13H2,1-4H3,(H,23,24)/b8-7+
InChIKey
OWBFCJROIKNMGD-BQYQJAHWSA-N
Cross-matching ID
PubChem CID
6918736
ChEBI ID
CHEBI:124939
CAS Number
592542-59-1
UNII
67DOW7F9GL
DrugBank ID
DB12146
TTD ID
D0KF9Q
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
PI3-kinase gamma (PIK3CG) TTHBTOP PK3CG_HUMAN Modulator [3]
Polo-like kinase 1 (PLK1) TTIYVQP PLK1_HUMAN Modulator [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
2'-5'-oligoadenylate synthase 1 (OAS1) OT8ZLOCY OAS1_HUMAN Gene/Protein Processing [4]
3',5'-cyclic-AMP phosphodiesterase 4B (PDE4B) OTOA8WU2 PDE4B_HUMAN Gene/Protein Processing [4]
3-phosphoinositide-dependent protein kinase 1 (PDPK1) OTT09ZVP PDPK1_HUMAN Post-Translational Modifications [5]
Actin, cytoplasmic 1 (ACTB) OT1MCP2F ACTB_HUMAN Gene/Protein Processing [4]
Actin, cytoplasmic 2 (ACTG1) OTH4V7VQ ACTG_HUMAN Gene/Protein Processing [4]
ADP-ribosylation factor-binding protein GGA2 (GGA2) OT43HO27 GGA2_HUMAN Gene/Protein Processing [4]
Albumin (ALB) OTVMM513 ALBU_HUMAN Protein Interaction/Cellular Processes [6]
Angiopoietin-1 receptor (TEK) OT78YN57 TIE2_HUMAN Post-Translational Modifications [7]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Gene/Protein Processing [7]
Astrocytic phosphoprotein PEA-15 (PEA15) OTKCKTSX PEA15_HUMAN Gene/Protein Processing [4]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Myelodysplastic syndrome
ICD Disease Classification 2A37
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
PI3-kinase gamma (PIK3CG) DTT PIK3CG 1.98E-01 -0.05 -0.55
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 134 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JK1 CTRP2 -3.5194 -0.3969 -3.5228 63.5239
MEC1 CTRP2 -3.295 -0.5495 -3.2982 59.4403
JM1 CTRP2 -3.2477 -1.1609 -3.2478 61.8905
MOLM-16 CTRP2 -6.4361 -4.7313 -6.4361 82.9522
KM-H2 CTRP2 -6.3788 -5.4804 -6.3788 82.76
Jurkat CTRP2 -6.3238 -5.2273 -6.3238 82.3819
NB4 CTRP2 -6.1846 -5.7156 -6.1846 81.471
KE-97 CTRP2 -6.0523 -4.1706 -6.0523 80.4032
AMO1 CTRP2 -5.971 -4.3999 -5.971 79.9763
SKM-1 CTRP2 -5.9424 -5.1692 -5.9424 79.8571
Karpas-299 CTRP2 -5.9043 -4.3576 -5.9043 79.5438
KMS-34 CTRP2 -5.8442 -4.8219 -5.8442 79.2
NU-DUL-1 CTRP2 -5.8019 -4.7205 -5.8019 78.9165
JVM-2 CTRP2 -5.5059 -0.0132 -5.5546 73.3892
RS4;11 CTRP2 -5.4189 -2.4188 -5.4195 75.719
OCI-AML-2 CTRP2 -5.3327 -4.1736 -5.3327 75.7925
KCL-22 CTRP2 -5.2199 -3.3478 -5.2199 74.9751
HuNS1 CTRP2 -5.1589 0.2146 -5.2332 69.7554
NCO2 CTRP2 -5.1324 -2.0902 -5.1332 73.9028
SUP-T1 CTRP2 -5.1132 -2.2586 -5.1137 73.9004
Ku812 CTRP2 -5.0052 -1.7289 -5.007 72.9459
K-562 CTRP2 -4.9832 -0.1672 -5.0279 69.378
RPMI-8226 CTRP2 -4.9276 -2.9705 -4.9277 73.034
MOTN-1 CTRP2 -4.7592 2.7545 -5.0379 67.0814
Reh CTRP2 -4.7445 -3.1469 -4.7445 71.8627
MOLM-6 CTRP2 -4.7315 -1.6371 -4.7328 71.3421
Ki-JK CTRP2 -4.7141 -0.4557 -4.7291 70.3599
F-36P CTRP2 -4.6157 -2.9644 -4.6157 71.0036
SUP-T11 CTRP2 -4.5859 1.1114 -4.6704 68.177
RL CTRP2 -4.4895 4.6906 -5.1122 64.131
Raji CTRP2 -4.4405 -1.6883 -4.4411 69.632
MOLP-8 CTRP2 -4.314 -0.1566 -4.3298 68.0272
NU-DHL-1 CTRP2 -4.3014 -2.8224 -4.3014 68.9205
THP-1 CTRP2 -4.1675 -1.9193 -4.1676 67.9713
Ri-1 CTRP2 -4.1093 1.0251 -4.1691 66.0101
SUP-HD1 CTRP2 -4.0913 3.792 -4.4934 63.435
MV4-11 CTRP2 -4.0868 -1.0633 -4.0886 67.2408
Granta-519 CTRP2 -4.0475 2.3915 -4.229 64.5059
SU-DHL-8 CTRP2 -4.0397 -1.6186 -4.04 67.0992
SU-DHL-4 CTRP2 -4.0278 -1.647 -4.028 67.0275
LAMA-84 CTRP2 -3.9705 -1.2953 -3.9711 66.5899
MOLT-13 CTRP2 -3.9099 -2.1345 -3.9099 66.3065
SU-DHL-6 CTRP2 -3.9052 -0.2582 -3.9134 65.8009
KMS-11 CTRP2 -3.9004 -1.55 -3.9006 66.1918
NOMO-1 CTRP2 -3.8357 -1.3987 -3.836 65.7518
PL21 CTRP2 -3.7938 -2.6987 -3.7938 65.5434
HDLM-2 CTRP2 -3.7617 3.1888 -4.0346 62.5397
KMS-28BM CTRP2 -3.7554 -0.577 -3.7587 65.0392
SEM CTRP2 -3.6471 -2.2036 -3.6471 64.565
ALL-SIL CTRP2 -3.6071 -1.0577 -3.6076 64.2254
HEL 92.1.7 CTRP2 -3.5931 -1.9785 -3.5931 61.6478
M-07e CTRP2 -3.5775 -1.8932 -3.5776 64.0983
CMK CTRP2 -3.5597 -0.7913 -3.5609 63.8738
HEL CTRP2 -3.5473 -2.064 -3.5473 63.8999
RCH-ACV CTRP2 -3.5186 -1.5267 -3.5186 63.6952
WSU-DLCL2 CTRP2 -3.5096 -3.021 -3.5096 63.6499
JeKo-1 CTRP2 -3.4411 -0.3055 -3.4448 63.0101
SU-DHL-10 CTRP2 -3.4225 -2.8666 -3.4225 63.0695
DoHH2 CTRP2 -3.3773 -2.436 -3.3773 62.7684
Peer CTRP2 -3.3744 -1.6177 -3.3744 62.7444
PF-382 CTRP2 -3.3645 -0.9273 -3.365 62.6377
MM1.S CTRP2 -3.3623 -1.1328 -3.3624 62.6421
JVM-3 CTRP2 -3.3404 -2.1288 -3.3404 62.5227
NALM-6 CTRP2 -3.339 -2.2123 -3.339 62.5135
Kasumi-2 CTRP2 -3.2767 -2.2348 -3.2767 62.0985
KMS-27 CTRP2 -3.268 -2.7621 -3.268 62.0407
Mono-Mac-1 CTRP2 -3.2304 0.5177 -3.2451 61.452
Ci-1 CTRP2 -3.2176 -0.5183 -3.2189 61.6335
GDM-1 CTRP2 -3.2095 2.2107 -3.3227 60.5113
NCI-H929 CTRP2 -3.2005 1.2797 -3.2439 60.9554
HT CTRP2 -3.1869 -2.6134 -3.1869 61.5005
SR CTRP2 -3.1462 0.5644 -3.1608 60.9247
U266B1 CTRP2 -3.1077 4.1091 -3.4895 58.8826
KMS-21-BM CTRP2 -3.0668 -1.4635 -3.0668 60.6984
EoL-1 CTRP2 -3.0605 2.5589 -3.202 59.5219
KMS-18 CTRP2 -3.015 -1.1331 -3.015 60.3496
DEL CTRP2 -2.9529 -2.2811 -2.9529 59.9411
SK-MM-2 CTRP2 -2.9304 0.7215 -2.9453 59.5518
TF-1 CTRP2 -2.9132 3.2766 -3.2291 55.7389
EHEB CTRP2 -2.8928 1.8883 -2.9632 58.914
SIG-M5 CTRP2 -2.8915 -0.9346 -2.8918 56.6378
L-540 CTRP2 -2.8754 -0.9405 -2.8755 59.4197
U-937 CTRP2 -2.8191 -1.9269 -2.8191 59.0497
ME1 CTRP2 -2.7663 4.1505 -3.128 57.1979
MC116 CTRP2 -2.7501 -1.555 -2.7501 58.5904
L-428 CTRP2 -2.7009 0.7548 -2.7129 58.1092
HPB-ALL CTRP2 -2.6713 -1.297 -2.6713 58.0649
P31/FUJ CTRP2 -2.6305 -1.9711 -2.6305 57.7934
KMS-12-BM CTRP2 -2.5632 -1.6199 -2.5632 57.3448
BV-173 CTRP2 -2.555 -1.1063 -2.555 57.29
EM-2 CTRP2 -2.5298 -0.7924 -2.5299 57.1213
RPMI-8402 CTRP2 -2.522 -1.5452 -2.522 57.0708
MOLT-16 CTRP2 -2.5136 -1.8857 -2.5136 57.0147
JURL-MK1 CTRP2 -2.4938 -1.6862 -2.4938 56.8828
L-363 CTRP2 -2.3875 -1.2662 -2.3875 56.1744
KHM-1B CTRP2 -2.3694 -0.6998 -2.3694 56.0532
KYO-1 CTRP2 -2.3494 -0.3264 -2.3496 55.9164
MOLM-13 CTRP2 -2.3293 -1.0705 -2.3293 55.7868
Kasumi-1 CTRP2 -2.3289 -0.1975 -2.3292 55.778
P12-Ichikawa CTRP2 -2.322 -1.7686 -2.322 55.7381
KE-37 CTRP2 -2.2965 -1.7737 -2.2965 55.568
KMS-20 CTRP2 -2.2849 -0.3984 -2.285 55.489
MHH-CALL-4 CTRP2 -2.2569 2.3208 -2.333 55.0163
OPM-2 CTRP2 -2.2352 1.6057 -2.2656 55.0164
Hs 611.T CTRP2 -2.2187 1.5373 -2.2456 54.9221
CML-T1 CTRP2 -2.2096 -0.9515 -2.2096 54.9894
OCI-Ly3 CTRP2 -2.18 0.1991 -2.1811 54.782
JJN-3 CTRP2 -2.1572 -0.3994 -2.1573 54.6395
EJM CTRP2 -2.1543 2.5337 -2.2439 54.3505
TALL-1 [Human adult T-ALL] CTRP2 -2.1065 1.609 -2.1336 54.1998
SU-DHL-1 CTRP2 -2.0769 0.5951 -2.08 54.0876
LP-1 CTRP2 -2.0701 1.1828 -2.0824 54.0078
RPMI-6666 CTRP2 -1.8867 -0.4587 -1.8867 52.8382
HL-60 CTRP2 -1.7406 -0.1119 -1.7408 48.4294
SUP-B15 CTRP2 -1.6724 0.111 -1.6725 51.4102
OCI-AML-5 CTRP2 -1.6086 -1.0705 -1.6086 50.9851
MOLP-2 CTRP2 -1.5002 3.5771 -1.6703 50.2432
GA-10 CTRP2 -1.3969 -0.8807 -1.3969 49.5752
SET-2 CTRP2 -1.3947 -0.024 -1.3947 49.5601
OCI-Ly19 CTRP2 -1.3788 1.0756 -1.3817 49.4559
Pfeiffer CTRP2 -1.3755 2.4872 -1.4264 49.4482
HuT 78 CTRP2 -0.7359 1.6478 -0.74 45.1813
Mono-Mac-6 CTRP2 -0.7177 19.1709 -6.7512 48.059
Karpas-422 CTRP2 -0.6698 1.0634 -0.6701 44.7321
AML-193 CTRP2 -0.605 6.2347 -1.2651 45.247
EB1 CTRP2 0.0696 3.7494 -0.0223 40.0648
HD-MY-Z CTRP2 0.78 8.6444 -0.5732 38.4864
MHH-CALL-3 CTRP2 1.0936 9.8772 -0.7341 37.6928
P3HR-1 CTRP2 2.4991 13.8313 -1.0906 34.0839
L-1236 CTRP2 3.2971 14.177 -0.4894 30.6089
KMM-1 CTRP2 7.5833 13.5333 3.492 8.0574
DND-41 CTRP2 7.6666 19.1633 0.7829 17.7539
Karpas-620 CTRP2 8.1348 9.5294 5.5928 0.1541
REC-1 CTRP2 8.705 19.2655 1.4986 13.7428
⏷ Show the Full List of 134 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 21 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE8 CTRP2 -4.1312 6.8075 -5.2779 61.1801
KYSE-70 CTRP2 -6.1643 15.6246 -10.7249 61.1413
TE-4 CTRP2 -5.2781 5.0291 -6.0505 66.378
TE-11 CTRP2 -4.6006 1.4921 -4.7667 65.718
KYSE-180 CTRP2 -3.1331 1.6888 -3.1991 60.3727
TE-9 CTRP2 -2.5015 7.9066 -3.8497 54.5638
TE-10 CTRP2 -2.4263 11.6883 -5.1791 53.3771
TE-14 CTRP2 -2.0734 3.6143 -2.2892 53.6526
TE-6 CTRP2 -0.4287 9.5199 -2.2001 45.3368
KYSE-410 CTRP2 0.5221 6.0411 0.0187 38.1725
EC-GI-10 CTRP2 0.7687 11.4445 -1.7383 40.4687
TE-5 CTRP2 0.883 6.4217 0.3042 36.0905
KYSE-510 CTRP2 3.6758 13.2032 0.3401 27.4535
KYSE-150 CTRP2 4.0734 12.8689 0.8767 24.8439
TE-1 CTRP2 5.83 20.587 -1.4063 27.0456
KYSE-520 CTRP2 7.2867 23.4603 -1.6512 24.9132
OE19 CTRP2 7.4016 16.9181 1.6931 15.1805
KYSE-30 CTRP2 7.7964 18.0174 1.4479 15.3589
KYSE-140 CTRP2 7.913 22.5465 -0.7058 21.5791
COLO 680N CTRP2 8.4272 19.5184 1.1753 15.2454
KYSE-450 CTRP2 10.7821 21.8943 1.634 10.4688
⏷ Show the Full List of 21 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 34 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
N2a-PK1 CTRP2 8.8823 20.56 0.9942 15.1254
BxPC-3 CTRP2 -1.7262 1.8262 -1.7525 51.7351
HuP-T4 CTRP2 -0.4009 12.5529 -3.4252 46.0357
SU.86.86 CTRP2 -0.2899 27.0863 -10.1302 47.7209
L3.3 CTRP2 -0.1183 7.9026 -1.2667 43.1175
QGP-1 CTRP2 0.2258 11.3678 -2.267 42.9702
KP-4 CTRP2 0.2697 6.5722 -0.4094 40.1186
PaTu 8988t CTRP2 0.7549 8.7116 -0.6258 38.6813
PSN1 CTRP2 2.4638 16.1681 -2.2418 36.2505
KP-3 CTRP2 2.9323 16.783 -2.0971 34.8205
Panc 03.27 CTRP2 3.2169 52.5016 -19.5806 44.8528
YAPC CTRP2 3.7927 17.4842 -1.6456 31.9104
PK-59 CTRP2 4.0286 21.729 -3.5352 34.5814
HuP-T3 CTRP2 5.1479 20.8136 -2.7541 28.3216
Panc 08.13 CTRP2 5.6954 19.3924 -0.9227 26.1893
KP-2 CTRP2 5.7322 13.0005 2.3028 16.0827
SNU-213 CTRP2 6.2445 17.4537 0.5056 21.2166
PaTu 8988s CTRP2 6.2719 15.145 1.6823 17.2899
Panc 10.05 CTRP2 6.5902 21.1524 -1.0597 24.7914
Panc 04.03 CTRP2 6.7358 19.7854 -0.9683 20.8641
Hs 766T CTRP2 6.7488 16.9559 1.164 18.1611
SW1990 CTRP2 6.8235 21.2373 -0.9129 24.0047
Panc 02.03 CTRP2 7.4723 10.5231 4.8536 2.8277
SNU-410 CTRP2 7.6163 18.6196 1.0139 17.1034
Panc 05.04 CTRP2 7.7318 10.6994 4.9273 2.2681
SUIT-2 CTRP2 7.7935 9.5064 5.4638 0.5236
DAN-G CTRP2 8.1245 26.0903 -2.3022 24.9171
HPAC CTRP2 8.1765 9.5566 5.5986 0.1381
AsPC-1 CTRP2 8.22 19.0717 1.243 15.3526
PaTu 8902 CTRP2 8.5614 17.3709 2.3169 11.0897
Capan-2 CTRP2 9.2626 23.9907 -0.4086 18.6577
HPAF-II CTRP2 9.9171 21.5529 1.2318 12.8783
TCC-Pan2 CTRP2 12.153 25.0309 1.03 10.7458
CFPAC-1 CTRP2 12.8093 26.7108 0.6568 11.1107
⏷ Show the Full List of 34 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 49 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SH4 CTRP2 8.4794 27.5374 -2.7464 26.202
HMCB CTRP2 -6.5058 9.4283 -8.7055 65.5067
A2058 CTRP2 -4.3645 2.1351 -4.5348 66.1466
G-361 CTRP2 -3.866 2.4306 -4.041 63.6398
CJM [Human melanoma] CTRP2 -3.4796 1.2249 -3.5291 62.5561
RPMI-7951 CTRP2 -2.3088 -0.2617 -2.309 55.646
Mel Ho CTRP2 -2.0436 6.2575 -2.8414 52.944
IGR-37 CTRP2 -1.8841 -0.4358 -1.8841 52.8207
LOX-IMVI CTRP2 -1.5966 4.8228 -1.9955 50.7767
Hs 852.T CTRP2 -0.6667 39.298 -16.4603 48.9241
Hs 294T CTRP2 -0.519 19.0697 -6.5087 47.507
Hs 936.T CTRP2 -0.158 36.6893 -14.711 48.0906
Mel JuSo CTRP2 -0.0136 5.5781 -0.4456 41.3637
Hs 944.T CTRP2 0.4744 7.4704 -0.4759 39.4425
IGR-1 CTRP2 0.5796 17.3733 -4.6352 43.8443
WM1799 CTRP2 0.6571 10.4778 -1.4414 40.4225
A-375 CTRP2 0.7226 9.5111 -0.975 39.4397
IGR-39 CTRP2 0.8089 287.0303 -138.8349 49.5646
WM88 CTRP2 0.8752 11.9267 -1.8398 40.2577
SK-MEL-5 CTRP2 1.0085 7.1834 0.2001 35.9049
COLO 741 CTRP2 1.1709 9.6577 -0.5623 37.083
WM983B CTRP2 1.7393 9.1737 0.2339 33.3159
RVH-421 CTRP2 2.3087 12.9436 -0.8597 34.1431
MDA-MB-435S CTRP2 2.8221 29.653 -8.5422 41.5764
WM793 CTRP2 3.6374 20.7309 -3.39 35.2021
K029AX CTRP2 4.1065 22.4096 -3.8044 34.8011
COLO 800 CTRP2 4.1609 16.367 -0.7599 29.1267
MeWo CTRP2 4.6503 11.1426 1.661 15.8626
IPC-298 CTRP2 6.0209 16.773 0.6605 21.1856
Hs 934.T CTRP2 6.0576 17.6556 0.2498 22.3463
HT-144 CTRP2 6.169 24.215 -2.9373 29.4688
Hs 940.T CTRP2 7.0123 10.2844 4.6667 4.1676
SK-MEL-1 CTRP2 7.13 20.4263 -0.263 21.7639
SK-MEL-28 CTRP2 7.2262 8.0155 5.7888 0.0875
SK-MEL-2 CTRP2 7.4046 8.3094 5.7515 0.099
COLO 829 CTRP2 7.5872 25.6905 -2.5243 26.24
SK-MEL-3 CTRP2 7.9636 18.8912 1.1418 16.1029
UACC-62 CTRP2 8.0173 9.1701 5.6747 0.0804
COLO 792 CTRP2 8.2712 33.9599 -6.1038 30.8676
SK-MEL-30 CTRP2 8.2956 21.2626 0.2203 18.4087
UACC-257 CTRP2 8.3633 9.7308 5.6055 0.0987
Hs 688(A).T CTRP2 9.127 23.5681 -0.3001 18.5693
WM115 CTRP2 9.6547 24.6062 -1.2121 16.898
Hs 895.T CTRP2 10.7908 37.3348 -6.5982 26.3244
WM266-4 CTRP2 10.9028 24.3481 -0.2716 12.5242
A101D CTRP2 11.5154 21.8289 2.1109 8.0901
SK-MEL-31 CTRP2 11.7222 27.5502 -0.4244 15.3444
WT2-iPS CTRP2 13.1033 30.7176 -1.0224 15.2226
Hs 839.T CTRP2 13.4842 38.0308 -4.2535 21.4958
⏷ Show the Full List of 49 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 CTRP2 -1.2117 10.2509 -3.319 48.9775
Cancer Drug Sensitivity Data Curated from 11 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SK-N-SH CTRP2 -13.0699 14.5104 -17.614 71.093
SK-N-FI CTRP2 -9.5842 -2.2201 -9.6684 85.8261
NH-6 CTRP2 -7.2233 15.7379 -12.2537 61.9137
Kelly CTRP2 -5.5198 -4.1382 -5.5198 77.0249
KP-N-SI9s CTRP2 -5.2759 7.6265 -6.7755 64.0054
NB1 CTRP2 -4.2871 -2.1474 -4.2871 68.7769
CHP-126 CTRP2 -3.6823 1.282 -3.7425 63.616
MHH-NB-11 CTRP2 -3.4241 -1.9743 -3.4241 63.0796
SiMa CTRP2 -3.1981 2.6579 -3.3593 60.1894
SK-N-BE(2) CTRP2 -1.8016 7.0162 -2.8021 51.6643
KP-N-YN CTRP2 8.2099 17.343 2.0824 12.4695
⏷ Show the Full List of 11 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-478 CTRP2 -2.7076 2.7455 -2.8495 57.509
SNU-308 CTRP2 1.7191 16.4994 -3.1143 39.4191
SNU-1079 CTRP2 1.9324 18.4727 -3.8587 39.7176
HuH-28 CTRP2 3.5421 12.873 0.3722 27.7061
SNU-869 CTRP2 4.4138 40.069 -12.3452 41.1987
SNU-1196 CTRP2 5.2586 15.3909 0.7011 22.6496
HuCC-T1 CTRP2 5.9599 15.971 1.0105 20.1969
SNU-245 CTRP2 7.2279 14.2781 2.8674 11.0996
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 15 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MHH-ES-1 CTRP2 -6.2628 -5.4032 -6.2628 81.9896
SJSA-1 CTRP2 -3.4021 5.157 -4.0368 59.5572
TC71 CTRP2 -3.3699 -0.4012 -3.3724 62.5859
U2OS CTRP2 -2.5638 5.7612 -3.2742 55.5503
SaOS-2 CTRP2 -2.5297 -0.2394 -2.5302 57.109
SK-ES-1 CTRP2 -2.3773 -1.2379 -2.3773 56.1065
SK-N-MC CTRP2 -2.333 -0.8229 -2.333 55.8111
A-673 CTRP2 -1.3629 -0.9208 -1.3629 45.7333
HOS CTRP2 -1.3571 7.3801 -2.4337 49.4915
SW1353 CTRP2 0.5078 7.9968 -0.6245 39.6019
G-292 clone A141B1 CTRP2 0.9147 8.2006 -0.2615 37.3434
CAL-78 CTRP2 6.5083 20.4373 -0.7692 24.2307
Hs 822.T CTRP2 8.4877 22.4732 -0.2333 19.3826
Hs 888.T CTRP2 9.0112 25.2046 -1.1896 21.0323
MG-63 CTRP2 10.9985 43.9935 -8.9762 30.7101
⏷ Show the Full List of 15 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 67 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HMC-1-8 CTRP2 -4.1116 -1.4538 -4.1122 67.5183
CAL-148 CTRP2 -2.6577 -1.886 -2.6577 57.9744
Hs 578T CTRP2 -2.5936 6.3504 -3.4679 55.4689
CAL-51 CTRP2 -2.4864 2.9133 -2.6346 56.202
HCC1395 CTRP2 -2.0349 6.9919 -3.0486 52.7626
DU4475 CTRP2 -1.5678 2.4331 -1.6226 50.6907
MDA-MB-157 CTRP2 -1.066 5.8054 -1.6514 47.8088
AU565 CTRP2 -1.0329 10.7286 -3.3202 48.2762
JIMT-1 CTRP2 -0.7727 4.1225 -0.9724 45.7259
MCF-7 CTRP2 -0.7366 10.7707 -3.0248 47.0374
HCC1806 CTRP2 -0.57 17.2553 -5.7128 47.4375
HCC1954 CTRP2 0.1217 10.6956 -2.0922 43.1557
HCC1500 CTRP2 0.2938 6.6839 -0.417 40.037
MDA-MB-468 CTRP2 1.8174 9.5996 0.1387 33.3114
ZR-75-1 CTRP2 2.5035 22.8821 -5.4811 39.9915
HCC2218 CTRP2 2.6512 9.3615 1.1063 27.9478
MDA-MB-361 CTRP2 3.3312 16.0736 -1.3785 32.4877
EFM-192A CTRP2 3.9092 29.9183 -7.7155 39.1917
MDA-MB-453 CTRP2 4.8692 18.7896 -1.3323 28.848
CAMA-1 CTRP2 5.3413 17.9276 -0.4928 25.8485
HCC1419 CTRP2 5.3878 12.4351 2.2866 16.868
KPL-1 CTRP2 6.0709 7.3348 5.4211 2.5692
Hs 578Bst CTRP2 6.2371 17.0236 0.7146 20.5883
CAL-120 CTRP2 6.879 10.8718 4.286 5.9259
MDA-MB-231 CTRP2 6.8869 19.1636 0.173 20.9815
ZR-75-30 CTRP2 7.3454 16.7419 1.7374 15.1213
HDQ-P1 CTRP2 7.4805 16.0449 2.1847 13.2749
HCC1428 CTRP2 7.8436 18.2043 1.391 15.4731
BT-474 CTRP2 8.0447 15.3666 2.9268 9.5759
T-47D CTRP2 8.2415 11.3022 4.9419 1.7424
BT-549 CTRP2 8.3552 21.3585 0.2175 18.3205
BT-20 CTRP2 8.7246 20.3558 0.1961 13.9805
HCC1143 CTRP2 8.7952 26.5189 -2.0005 23.2263
HCC1937 CTRP2 9.3095 17.4153 2.7953 8.3184
BT 245 CTRP2 -4.2212 1.8426 -4.3519 65.8006
BT 239 CTRP2 -3.8113 -0.3387 -3.8175 65.2845
BT 145 CTRP2 -2.5595 4.1986 -2.9134 56.1273
BT 330 CTRP2 -1.925 6.2126 -2.6994 52.3716
BT 504 CTRP2 -1.8702 4.6774 -2.2619 52.3204
BT 286 CTRP2 -0.9776 6.502 -1.7486 47.4223
BT 112 CTRP2 -0.3353 27.5553 -10.4007 47.8472
BT 231 CTRP2 0.1927 38.9464 -15.506 47.6928
BT 172 CTRP2 2.0085 17.8033 -3.4632 39.0865
BT 428 CTRP2 2.0702 30.9561 -9.8609 43.4981
BT 416 CTRP2 2.3968 15.6223 -2.0433 36.1053
BT147 CTRP2 2.5017 13.6667 -1.0102 33.9122
BT 333 CTRP2 2.7568 24.9955 -6.2933 40.1593
BT164 CTRP2 2.8073 21.5191 -4.5324 38.4237
BT 248 CTRP2 3.2693 15.9204 -1.3617 32.6079
BT 422 CTRP2 3.5682 21.7691 -3.9662 36.1308
BT 359 CTRP2 3.965 28.4493 -6.9348 38.4709
BT 232 CTRP2 3.9929 20.219 -2.8176 33.5605
BT 340 CTRP2 4.4215 21.7266 -3.1871 33.248
BT 444 CTRP2 5.1513 20.6624 -2.0216 29.6973
BT 228 CTRP2 5.4919 27.5389 -5.1667 33.9984
BT 179 CTRP2 6.1189 806.1121 -393.9274 49.4796
BT 320 CTRP2 6.2141 11.3851 3.5141 10.288
BT 498 CTRP2 6.6341 15.6315 1.733 16.4182
BT 224 CTRP2 7.9823 33.6229 -6.165 31.3524
BT 139 CTRP2 8.2417 19.8719 0.8655 16.5374
BT 482 CTRP2 9.0196 23.2049 -0.2003 18.4601
BT 216 CTRP2 9.0422 21.5684 0.6167 16.0582
BT 131 CTRP2 9.1362 24.109 -0.5587 19.2473
BT 440 CTRP2 9.4882 27.0004 -1.7204 21.5635
BT 159 CTRP2 11.5161 31.4249 -2.4256 20.337
BT 328 CTRP2 12.0989 27.8434 -0.3167 14.601
BT 187 CTRP2 12.127 24.9417 1.0553 10.6997
⏷ Show the Full List of 67 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Tongue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
YD-38 CTRP2 -2.775 2.613 -2.906 57.9396
Cancer Drug Sensitivity Data Curated from 41 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KNS-60 CTRP2 -5.7637 8.8457 -7.703 64.2867
Becker CTRP2 -3.8391 31.6229 -15.6911 53.613
LN-18 CTRP2 -3.3512 1.9045 -3.4436 61.4503
Daoy CTRP2 -2.6412 -0.4835 -2.6414 57.855
YH-13 CTRP2 -2.415 14.3321 -6.2743 52.8966
SF539 CTRP2 -1.8106 0.0542 -1.8107 52.3302
AM-38 CTRP2 -1.1344 6.9093 -2.0423 48.3227
SNU-466 CTRP2 -0.6611 6.8652 -1.5132 45.7516
DK-MG CTRP2 -0.3893 10.4342 -2.5219 45.4273
TM-31 CTRP2 0.0933 18.6452 -5.71 45.6896
ONS-76 CTRP2 0.1766 6.0477 -0.3602 40.3976
GaMG CTRP2 0.4644 6.4856 -0.1712 38.8391
A-172 CTRP2 0.9869 6.4688 0.4035 35.4455
LN-229 CTRP2 1.3552 16.996 -3.7024 41.0248
M059K CTRP2 1.3829 35.7203 -12.8373 45.5481
KALS-1 CTRP2 1.8525 11.018 -0.4391 34.5925
SF126 CTRP2 2.5587 13.1865 -0.728 33.1502
SF268 CTRP2 2.6675 8.4503 1.5066 26.5776
U-118MG CTRP2 2.9468 22.2431 -4.762 38.369
SNU-738 CTRP2 4.1824 11.8786 1.4602 22.6515
SW1088 CTRP2 4.5172 20.5152 -2.5 31.9041
KNS-81 CTRP2 4.5592 33.0575 -8.7189 38.8929
SNU-489 CTRP2 4.9241 16.5572 -0.1725 25.9075
42-MG-BA CTRP2 5.0865 17.9591 -0.7289 26.9813
GB-1 CTRP2 5.5223 16.969 0.1411 23.7531
CAS-1 CTRP2 5.8176 17.9866 -0.1167 23.866
U-87MG ATCC CTRP2 7.1954 18.8255 0.5859 19.19
SNU-626 CTRP2 7.3487 8.9237 5.4917 0.7175
NMC-G1 CTRP2 7.4211 15.1706 2.5717 11.9211
U-251MG CTRP2 7.8261 16.653 2.1418 12.8627
SNU-201 CTRP2 7.9116 9.6519 5.4588 0.4772
GMS-10 CTRP2 8.1337 13.445 3.9067 5.6486
SNU-1105 CTRP2 8.2242 42.4175 -10.3591 35.1854
8-MG-BA CTRP2 8.5873 16.6565 2.6788 9.7215
SF295 CTRP2 8.8903 29.4422 -3.3757 25.8187
SNB-75 CTRP2 9.4126 24.0964 -0.3517 18.2808
CCF-STTG1 CTRP2 9.5104 23.5877 -0.0334 17.2607
DBTRG-05MG CTRP2 9.6369 30.8761 -3.5194 25.0029
KG-1-C CTRP2 10.3635 24.2659 0.2334 15.2991
T98G CTRP2 11.7325 25.0095 0.7792 11.9708
GOS-3 CTRP2 15.1979 44.4028 -6.1466 22.7144
⏷ Show the Full List of 41 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 21 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JHUEM-2 CTRP2 -9.0308 11.8941 -12.3078 68.0893
HEC-50B CTRP2 -5.5112 32.8388 -17.8826 55.6896
HEC-251 CTRP2 -3.9209 17.405 -9.164 56.0111
HEC-265 CTRP2 -3.5489 0.2467 -3.5622 63.4668
RL95-2 CTRP2 -3.0736 -1.9166 -3.0736 60.7456
ESS-1 CTRP2 -1.497 4.8155 -1.8857 50.2089
AN3-CA CTRP2 -1.422 15.0628 -5.5746 49.8808
JHUEM-1 CTRP2 -0.1279 4.7524 -0.5233 38.0984
HEC-151 CTRP2 0.1913 3.7622 0.1049 39.247
JHUEM-7 CTRP2 0.7088 15.9166 -3.8249 42.8948
HEC-108 CTRP2 0.858 11.6486 -1.7353 40.1669
MFE-296 CTRP2 0.8597 6.4716 0.264 36.2817
MFE-319 CTRP2 1.1194 12.0647 -1.6516 39.1926
HEC-59 CTRP2 2.3157 15.6686 -2.1433 36.4823
HEC-1-A CTRP2 2.9837 13.3837 -0.4085 31.2436
EFE-184 CTRP2 4.6578 15.3725 0.1798 25.5353
HEC-6 CTRP2 4.7409 40.5311 -12.2968 40.7524
KLE CTRP2 5.6982 24.5184 -3.4826 31.2492
HEC-1-B CTRP2 11.2256 28.0013 -0.9737 17.3809
EN CTRP2 15.3005 42.2733 -5.058 20.925
Ishikawa (Heraklio) 02 ER- CTRP2 -3.3911 0.6355 -3.4122 62.3618
⏷ Show the Full List of 21 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 20 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
786-O CTRP2 -1.1966 7.7841 -2.6711 46.2169
TUHR4TKB CTRP2 0.2247 8.1132 -0.9715 41.3052
BFTC-909 CTRP2 0.4528 9.8696 -1.4047 41.0975
KMRC-3 CTRP2 1.9166 17.2792 -3.2983 39.1245
UO-31 CTRP2 2.0987 14.2446 -1.6762 36.2999
769-P CTRP2 2.3832 12.2554 -0.4661 33.0593
KMRC-1 CTRP2 4.1814 15.9072 -0.5143 28.4835
TUHR10TKB CTRP2 4.6079 15.8305 -0.092 26.4007
ACHN CTRP2 5.0576 15.8357 0.3039 24.2821
VMRC-RCW CTRP2 6.1148 16.1845 1.0329 19.8135
KMRC-2 CTRP2 7.2407 8.5923 4.6094 0.1219
A-498 CTRP2 7.2726 16.8884 1.6089 15.6994
SNU-1272 CTRP2 7.3452 26.1009 -2.9215 27.4032
TUHR14TKB CTRP2 8.4841 10.4503 5.3953 0.378
Caki-2 CTRP2 8.7239 35.8741 -6.7004 30.9811
VMRC-RCZ CTRP2 9.6575 24.6001 -0.4218 18.1098
RCC10RGB CTRP2 9.7476 21.4935 1.1456 13.3865
KMRC-20 CTRP2 10.7087 24.1548 0.5193 14.0085
Caki-1 CTRP2 11.1744 20.5901 2.4713 7.2771
OS-RC-2 CTRP2 11.4156 27.2189 -0.4704 15.8497
⏷ Show the Full List of 20 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 48 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CL-34 CTRP2 -5.393 2.5892 -5.6922 69.5248
LoVo CTRP2 -5.3135 10.5765 -7.8283 62.02
CCK-81 CTRP2 -4.1228 -1.5238 -4.1233 67.6068
HT115 CTRP2 -3.2467 -0.4574 -3.2484 61.8114
SW48 CTRP2 -3.208 -1.2767 -3.208 61.6324
T84 CTRP2 -3.1622 -0.0908 -3.1661 61.2032
SNU-175 CTRP2 -2.7932 2.2083 -2.8851 58.2112
HCT 15 CTRP2 -2.5611 4.487 -3.1104 53.4146
MDST8 CTRP2 -2.1295 25.2954 -11.0222 51.3004
LS513 CTRP2 -2.105 -1.0275 -2.105 54.2926
NCI-H716 CTRP2 -2.0602 6.2291 -2.8516 53.0304
SK-CO-1 CTRP2 -1.7459 6.8981 -2.705 51.4087
GP2d CTRP2 -1.7242 6.5931 -2.5897 51.3303
RKO CTRP2 -1.6904 3.2705 -1.8327 51.4239
COLO205 CTRP2 -1.285 4.9793 -1.6907 48.9865
SNU-407 CTRP2 -1.1279 2.1499 -1.1521 47.8118
SNU-C2A CTRP2 -0.9026 5.3027 -1.3482 46.7717
NCI-H508 CTRP2 -0.7356 2.7873 -0.7817 45.2612
LS180 CTRP2 -0.5092 4.2451 -0.709 44.0554
COLO 320 CTRP2 -0.4483 7.4882 -1.4823 44.77
KM12 CTRP2 -0.3813 6.7557 -1.1746 44.1248
CW-2 CTRP2 0.0185 10.2567 -2.0199 43.4573
SNU-61 CTRP2 0.4646 7.9718 -0.6621 39.8377
HT-55 CTRP2 0.7842 8.6985 -0.5895 38.5035
SNU-C5 CTRP2 1.1005 9.4292 -0.5429 37.2853
SNU-C4 CTRP2 1.2863 5.1485 1.066 32.4215
HCC-56 CTRP2 1.7419 7.0648 1.0353 30.9954
CL-11 CTRP2 1.7783 9.8159 0.0066 33.7717
SNU-C1 CTRP2 1.8522 8.0559 0.7971 31.3665
DLD-1 CTRP2 3.4972 16.5545 -1.4597 32.2437
SW948 CTRP2 3.7635 9.1709 2.3284 20.5705
LS1034 CTRP2 4.164 9.3392 2.6521 18.2992
HCT 116 CTRP2 4.3644 15.0966 0.0519 26.5727
COLO201 CTRP2 4.5621 16.7708 -0.5992 27.8154
SNU-1033 CTRP2 5.1754 18.6406 -0.9918 27.4238
COLO 678 CTRP2 6.5541 20.6741 -0.8502 24.3471
LS411N CTRP2 6.6854 12.1789 3.4936 9.515
SW1417 CTRP2 6.8728 15.0175 2.2282 14.1698
C2BBe1 CTRP2 6.8787 14.2469 2.616 12.6814
LS123 CTRP2 7.3571 19.0959 0.5778 18.9278
NCI-H747 CTRP2 7.4569 16.72 1.8332 14.59
OUMS-23 CTRP2 7.6163 17.6507 1.4936 15.5055
SNU-503 CTRP2 8.1718 32.5164 -5.4631 30.1678
HCT 8 CTRP2 8.4047 20.2845 0.7829 16.535
RCM-1 [Human ESC] CTRP2 8.7281 10.1486 5.5912 0.0673
SW1116 CTRP2 8.7387 39.4643 -8.4767 32.8929
SW620 CTRP2 9.6963 22.9214 0.4216 15.6815
HT-29 CTRP2 11.8384 27.6212 -0.3816 15.0884
⏷ Show the Full List of 48 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 22 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HLF CTRP2 -7.5083 33.7032 -20.2352 57.8894
JHH-1 CTRP2 -5.4294 47.8661 -25.0584 54.0494
SNU-423 CTRP2 -1.7513 6.8898 -2.7084 51.4358
SNU-878 CTRP2 -1.6003 3.0309 -1.7096 50.8788
SNU-886 CTRP2 -1.5882 22.042 -8.954 57.1433
SNU-182 CTRP2 -1.2842 8.289 -2.6621 49.1806
JHH-2 CTRP2 -0.3003 13.1333 -3.575 45.7818
SNU-398 CTRP2 -0.2365 12.0006 -3.0171 45.2214
Li-7 CTRP2 -0.2131 5.4464 -0.6311 42.5729
JHH-4 CTRP2 0.3154 5.3698 -0.0374 39.1189
SNU-761 CTRP2 1.4747 22.4732 -6.232 42.7421
JHH-5 CTRP2 1.7522 8.9008 -0.0255 29.8532
HuH-6 CTRP2 2.2067 10.2347 0.2688 31.7512
PLC/PRF/5 CTRP2 3.8936 19.0367 -2.321 32.9401
HuH-1 CTRP2 4.7827 21.2874 -2.6525 31.6234
SK-HEP-1 CTRP2 4.928 16.7959 -0.2879 26.2052
SNU-449 CTRP2 6.4254 16.0204 1.3703 18.079
JHH-6 CTRP2 7.0448 7.7513 5.8144 0.0934
Hep 3B2.1-7 CTRP2 7.3782 17.937 1.1698 17.0055
SNU-387 CTRP2 9.2832 19.6237 1.7275 12.1221
Hep-G2 CTRP2 10.1735 29.2123 -2.3045 21.8666
SNU-475 CTRP2 12.0531 25.7981 0.6131 12.0812
⏷ Show the Full List of 22 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 136 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H1703 CTRP2 -9.1436 -2.7686 -9.1869 86.4257
DMS 273 CTRP2 -8.2955 6.9184 -9.8523 71.2153
NCI-H1341 CTRP2 -6.7387 -0.2337 -6.8473 76.3352
NCI-H1792 CTRP2 -5.5126 51.2815 -26.804 53.8838
NCI-H526 CTRP2 -5.2934 -3.0379 -5.2934 75.3454
NCI-H661 CTRP2 -4.9618 6.1705 -6.0016 64.3379
Calu-6 CTRP2 -4.7243 26.4332 -14.0913 55.6
NCI-H446 CTRP2 -4.6304 -1.0722 -4.6348 70.4141
NCI-H520 CTRP2 -4.5854 10.2666 -6.9319 60.3621
PC-14 CTRP2 -4.2057 11.2501 -6.8955 58.8394
NCI-H1184 CTRP2 -4.1726 3.694 -4.5632 63.8502
NCI-H889 CTRP2 -3.886 3.4978 -4.219 62.8323
HCC44 CTRP2 -3.7441 0.0539 -3.7561 64.7044
NCI-H211 CTRP2 -3.5977 -1.4665 -3.5978 64.2117
NCI-H1694 CTRP2 -3.5757 0.4181 -3.5939 63.5428
NCI-H23 CTRP2 -3.5755 0.8972 -3.6113 63.2815
NCI-H524 CTRP2 -3.5363 -0.4892 -3.5391 63.6548
VMRC-LCD CTRP2 -3.5044 8.3146 -5.0742 58.1456
NCI-H1975 CTRP2 -3.3241 0.2285 -3.3339 62.1229
HCC1588 CTRP2 -3.0567 3.1521 -3.2738 59.1767
HCC827 CTRP2 -2.7308 10.5116 -5.0377 54.6669
SHP-77 CTRP2 -2.657 -1.957 -2.657 57.97
SBC-5 CTRP2 -2.6263 -2.0171 -2.6263 57.7657
NCI-H1155 CTRP2 -2.3972 -1.5502 -2.3972 56.239
RERF-LC-A1 CTRP2 -2.3806 -1.1852 -2.3806 56.1283
Lu-99 CTRP2 -2.2875 0.515 -2.2912 55.4753
NCI-H841 CTRP2 -2.2532 4.8524 -2.7156 54.3283
NCI-H1339 CTRP2 -2.2156 4.081 -2.5199 54.3398
NCI-H2081 CTRP2 -2.1554 11.2433 -4.7137 52.5338
NCI-H838 CTRP2 -2.1403 1.1226 -2.1636 51.2592
RERF-LC-MS CTRP2 -1.9716 4.8228 -2.403 52.8497
NCI-H1734 CTRP2 -1.922 6.5093 -2.7809 52.3105
LK2 CTRP2 -1.7405 -1.1439 -1.7405 51.8642
COLO 699 CTRP2 -1.7342 10.5241 -3.9815 51.0689
DMS 114 CTRP2 -1.715 1.9314 -1.7457 51.6577
NCI-H2286 CTRP2 -1.6214 20.5206 -8.2717 50.3811
HARA [Human squamous cell lung carcinoma] CTRP2 -1.6024 0.2063 -1.6025 50.9437
NCI-H69 CTRP2 -1.5798 9.2915 -3.3438 50.5078
LCLC-97TM1 CTRP2 -1.4476 7.809 -2.6737 49.9378
HCC2279 CTRP2 -1.3545 5.9533 -2.0055 49.4264
MOR/CPR CTRP2 -1.2105 7.301 -2.2487 48.7532
LCLC-103H CTRP2 -0.8195 5.9294 -1.4152 46.4146
LXF 289 CTRP2 -0.7275 20.2797 -7.2824 48.1764
COLO 668 CTRP2 -0.6329 5.1694 -1.0239 45.1015
NCI-H2087 CTRP2 -0.572 9.2159 -2.236 45.9393
NCI-H1355 CTRP2 -0.5555 12.9126 -3.7407 46.7136
NCI-H358 CTRP2 -0.3495 7.2115 -1.2838 44.1183
HCC1438 CTRP2 -0.3193 4.5346 -0.5542 42.9085
NCI-H2110 CTRP2 -0.2857 3.063 -0.3328 42.2961
NCI-H1581 CTRP2 -0.2309 4.2021 -0.4033 42.2176
EBC-1 CTRP2 -0.1628 117.0131 -54.6939 49.3926
NCI-H810 CTRP2 -0.1462 10.6129 -2.3391 44.3731
NCI-H650 CTRP2 -0.0214 15.5247 -4.3687 45.3553
DMS 454 CTRP2 0.0265 5.7664 -0.4493 41.2011
Lu-65 CTRP2 0.1079 5.8954 -0.3942 40.7504
NCI-H2122 CTRP2 0.1445 6.5532 -0.5401 40.883
NCI-H1373 CTRP2 0.3195 14.6944 -3.6473 43.8844
NCI-H226 CTRP2 0.5958 24.3174 -7.9528 45.4332
HCC78 CTRP2 0.6536 15.7245 -3.7899 43.0222
NCI-H1651 CTRP2 0.7191 7.0792 -0.0795 37.6532
NCI-H2141 CTRP2 0.7382 14.8138 -3.2839 42.3364
LUDLU-1 CTRP2 0.7478 15.9418 -3.7983 42.7634
Calu-3 CTRP2 0.956 12.7829 -2.139 40.4016
HCC366 CTRP2 1.0047 8.8331 -0.4068 37.3362
NCI-H1568 CTRP2 1.0324 22.5406 -7.237 42.7161
COR-L95 CTRP2 1.1437 7.6339 -0.1201 32.1541
HCC95 CTRP2 1.1705 6.7089 0.5301 34.4407
A-549 CTRP2 1.3028 12.5386 -1.6781 38.6544
NCI-H2009 CTRP2 1.3696 11.0737 -0.9583 37.2031
SK-MES-1 CTRP2 1.4144 15.0909 -3.2517 37.9331
HCC4006 CTRP2 1.4561 12.0377 -1.7586 35.2275
DMS 53 CTRP2 1.4791 4.7779 1.3421 30.8718
LOU-NH91 CTRP2 1.5112 13.4721 -1.8953 38.3551
NCI-H322 CTRP2 1.6441 18.3936 -4.0944 40.6696
CAL-12T CTRP2 1.9212 21.6251 -5.4019 41.1743
NCI-H1666 CTRP2 2.0156 10.3771 0.0102 33.0137
COR-L88 CTRP2 2.2123 10.7252 0.0578 32.2892
NCI-H1944 CTRP2 2.4948 15.7806 -2.0257 35.8179
NCI-H1092 CTRP2 2.5729 14.7326 -1.9872 32.5486
NCI-H2170 CTRP2 2.9939 11.1875 0.6347 28.4188
NCI-H1105 CTRP2 3.2449 23.9518 -5.3374 38.3448
NCI-H1435 CTRP2 3.3858 21.5913 -4.0424 36.6133
NCI-H292 CTRP2 3.4069 14.866 -0.7197 30.8704
NCI-H460 CTRP2 3.5733 13.7538 -0.0233 28.7167
NCI-H1299 CTRP2 3.6086 17.5675 -1.8547 32.7462
NCI-H1838 CTRP2 3.7311 14.2223 -0.1026 28.5269
HCC1833 CTRP2 3.7553 14.8272 -0.3752 29.1668
NCI-H2106 CTRP2 3.7696 15.5275 -0.7047 29.9321
NCI-H2405 CTRP2 3.807 15.1695 -0.4948 29.3357
Sq-1 CTRP2 3.8726 11.2631 1.4603 23.4276
NCI-H1623 CTRP2 3.9069 65.1147 -25.2904 45.2263
NCI-H1650 CTRP2 4.0063 21.1641 -3.2746 34.2451
HCC2108 CTRP2 4.0217 33.9972 -9.6514 40.32
NCI-H2023 CTRP2 4.3523 22.9679 -3.8658 34.3922
NCI-H2228 CTRP2 4.434 62.308 -23.4404 44.4653
NCI-H727 CTRP2 4.4832 13.1709 1.109 23.1058
NCI-H1573 CTRP2 4.5803 14.9029 0.3428 25.2463
EPLC-272H CTRP2 4.8172 20.8837 -2.4212 31.1393
HCC1195 CTRP2 4.846 38.2927 -11.089 39.9818
KNS-62 CTRP2 4.9272 14.1834 1.0101 22.4022
NCI-H2444 CTRP2 5.4891 45.6592 -14.2276 40.7345
NCI-H2085 CTRP2 5.5518 22.341 -2.5179 29.8566
SW1271 CTRP2 5.7934 33.405 -7.8456 36.3293
NCI-H1385 CTRP2 5.849 20.8362 -1.5149 27.2497
NCI-H1869 CTRP2 5.8905 16.502 0.6869 21.3672
HCC1171 CTRP2 5.898 16.5443 0.672 21.3981
LC-1/sq-SF CTRP2 5.9434 15.8122 1.0761 20.0159
ChaGo-K-1 CTRP2 6.3175 41.8104 -11.6116 38.3862
HCC2935 CTRP2 6.6592 12.1284 3.4983 9.5417
DMS 79 CTRP2 6.7997 16.9085 1.2282 17.8525
BEN CTRP2 6.8233 10.0958 4.6254 4.6183
NCI-H2030 CTRP2 6.8813 23.3916 -1.942 26.2548
HOP-92 CTRP2 6.9693 17.3899 1.1229 17.8906
NCI-H196 CTRP2 7.0032 19.3953 0.1502 20.8344
RERF-LC-Ad1 CTRP2 7.1294 8.156 5.6982 0.2911
NCI-H647 CTRP2 7.1734 23.5876 -1.805 25.4484
NCI-H1915 CTRP2 7.4388 23.4331 -1.517 24.3491
HOP-62 CTRP2 7.6622 11.5197 4.5089 3.9171
SK-LU-1 CTRP2 7.7158 21.6761 -0.426 21.1788
NCI-H2196 CTRP2 7.7816 23.3429 -1.9359 21.6679
NCI-H1563 CTRP2 7.9273 9.4778 5.5312 0.3153
HCC15 CTRP2 8.0517 16.8131 2.2275 12.1902
NCI-H2172 CTRP2 8.1398 23.2973 -0.904 21.7066
NCI-H1755 CTRP2 8.2199 10.4065 5.3002 0.7059
T3M-10 CTRP2 8.4708 10.4255 5.3992 0.3753
SW1573 CTRP2 8.8394 23.3332 -0.3957 19.2692
NCI-H2291 CTRP2 9.1435 28.5932 -2.763 24.2829
NCI-H1793 CTRP2 9.43 22.2694 0.551 15.6811
EKVX CTRP2 9.6923 21.6842 1.0162 13.8735
NCI-H2126 CTRP2 9.7518 33.257 -4.6092 26.6928
COR-L105 CTRP2 10.4077 25.3592 -0.2628 16.6231
RERF-LC-Ad2 CTRP2 10.5893 27.7366 -1.2871 18.9933
NCI-H2342 CTRP2 10.6219 24.4894 0.3014 14.7569
NCI-H441 CTRP2 10.9005 26.371 -0.412 16.3618
Calu-1 CTRP2 11.2433 23.2725 1.2814 11.0308
Hs 888.Lu CTRP2 10.8145 46.7441 -10.4797 32.3373
⏷ Show the Full List of 136 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Thigh Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
H-STS CTRP2 -5.2034 -2.864 -5.2035 74.7305
SYO-1 CTRP2 -2.6501 13.4208 -6.1298 53.7362
P-STS CTRP2 -1.2548 13.8214 -4.8564 49.3167
Cancer Drug Sensitivity Data Curated from 39 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
2004 CTRP2 -1.0523 13.1156 -4.3411 48.5744
OC 314 CTRP2 -4.1047 -0.1767 -4.1169 66.8951
Caov-3 CTRP2 -4.0086 34.9144 -17.4353 53.537
A2780 CTRP2 -2.5631 0.2839 -2.5664 57.2939
ONCO-DG-1 CTRP2 -2.1004 5.3335 -2.6607 53.422
TOV-112D CTRP2 -1.8498 3.2666 -2.0017 52.3929
MCAS CTRP2 -1.6859 2.4684 -1.7482 51.4445
COV434 CTRP2 -1.6738 7.827 -2.9252 50.9943
OVK18 CTRP2 -1.6355 4.4222 -1.9562 51.0208
IGROV-1 CTRP2 -0.3371 6.3527 -1.0065 43.708
SNU-8 CTRP2 -0.219 6.7564 -0.998 43.1773
OVCAR-8 CTRP2 -0.0135 5.2638 -0.3711 41.2136
OAW42 CTRP2 0.0888 12.4859 -2.8918 44.0195
OV7 CTRP2 0.5616 23.6979 -7.6841 45.4046
OVCAR-4 CTRP2 0.5781 10.0295 -1.338 40.5467
ES2 CTRP2 0.8078 8.1416 -0.3545 37.9351
TOV-21G CTRP2 1.4269 15.8221 -3.0762 40.1631
RMG-I CTRP2 2.085 22.2777 -5.5693 40.9525
JHOC-5 CTRP2 2.3141 38.6112 -13.4434 44.4068
OV-90 CTRP2 3.1447 9.0636 1.7446 24.3824
TYK-nu CTRP2 3.2664 12.0779 0.4858 28.1082
EFO-21 CTRP2 3.5274 12.4379 0.5668 27.1785
COV644 CTRP2 3.5969 23.9178 -5.0058 37.3016
SNU-119 CTRP2 3.6017 13.1919 0.2753 27.8271
DOV13 CTRP2 4.5471 15.3006 0.1161 25.9689
COV362 CTRP2 4.8684 12.8103 1.6375 20.4076
OV56 CTRP2 5.6529 19.5517 -1.0382 26.5507
OAW28 CTRP2 6.3267 30.2205 -5.8092 33.4034
HEY A8 CTRP2 6.5687 27.6607 -4.3301 31.04
JHOS-2 CTRP2 6.7287 27.7237 -4.924 29.4636
SK-OV-3 CTRP2 6.8119 29.697 -5.1485 31.7981
EFO-27 CTRP2 7.806 13.3995 3.7112 6.86
FU-OV-1 CTRP2 8.0055 9.507 5.5516 0.2511
OVCAR-5 CTRP2 8.3243 17.8412 1.9212 12.8668
Kuramochi CTRP2 8.539 13.6434 4.0677 4.5409
OVTOKO CTRP2 8.9165 24.0315 -0.6822 19.906
SNU-840 CTRP2 9.1037 16.2135 3.2271 6.9947
OVSAHO CTRP2 10.9161 24.1147 0.6754 13.2795
OVISE CTRP2 11.605 27.2275 -0.3484 15.2891
⏷ Show the Full List of 39 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 21 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Aska-SS CTRP2 -0.7464 15.7908 -5.2174 47.8074
Yamato-SS CTRP2 8.7174 28.6088 -3.0949 25.5579
Rh41 CTRP2 -3.319 -1.6929 -3.319 62.3777
RD CTRP2 -2.7905 12.1098 -5.7341 54.4459
G-402 CTRP2 -2.571 19.1979 -8.6028 52.6725
TTC-709 CTRP2 -2.5179 6.4275 -3.4073 55.1049
RKN CTRP2 -2.4597 3.9401 -2.7582 55.7006
SW982 CTRP2 -2.4496 4.4171 -2.8371 55.4796
G-401 CTRP2 -2.3821 3.9912 -2.6834 55.2679
BT-16 CTRP2 -0.8371 6.6159 -1.6291 46.6683
KYM-1 CTRP2 -0.6309 4.2964 -0.8485 44.8552
A-204 CTRP2 -0.02 9.6006 -1.7972 43.3628
Tm87-16 CTRP2 0.1993 13.8454 -3.3831 44.0526
BT-12 CTRP2 1.018 6.1048 0.5423 34.9469
TE 617.T CTRP2 1.2949 16.001 -3.804 39.0068
GCT CTRP2 1.3034 6.8945 0.6155 33.7339
HT-1080 CTRP2 1.3719 6.4434 0.5831 29.0815
SK-UT-1 CTRP2 1.7161 8.932 0.3079 33.1954
Hs 729.T CTRP2 2.5284 9.4097 0.5254 25.6685
MES-SA CTRP2 2.7782 15.1634 -1.4585 34.0579
SK-LMS-1 CTRP2 6.0942 22.0151 -1.8995 27.6037
⏷ Show the Full List of 21 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Clivus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
U-CH1 CTRP2 7.7652 9.5738 5.4245 0.6391
Cancer Drug Sensitivity Data Curated from 7 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MSTO-211H CTRP2 -3.5281 8.8303 -5.2768 57.9722
NCI-H28 CTRP2 -2.9105 -1.7394 -2.9105 59.6585
NCI-H2452 CTRP2 0.3729 17.009 -4.6665 44.4185
NCI-H2052 CTRP2 4.838 16.8578 -0.3979 26.6903
IST-Mes1 CTRP2 5.2574 24.0783 -3.6365 32.3079
ACC-MESO-1 CTRP2 8.72 17.0582 2.5762 9.9131
JL-1 CTRP2 13.9321 33.0155 -1.5711 15.6014
⏷ Show the Full List of 7 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
22Rv1 CTRP2 -2.6516 2.7415 -2.7897 57.1974
LNCaP clone FGC CTRP2 -0.8732 6.3678 -1.5957 46.8168
VCaP CTRP2 0.4607 24.9428 -8.3836 45.8541
DU145 CTRP2 6.2778 17.4812 0.5193 21.11
PaCa-3 CTRP2 8.3272 18.5756 1.5644 14.1028
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
YD-15 CTRP2 -5.0374 -3.6108 -5.0374 73.8181
A-253 CTRP2 7.9106 23.3466 -1.1049 22.5813
Cancer Drug Sensitivity Data Curated from 31 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Fu97 CTRP2 -4.5894 21.1933 -11.5393 56.4131
NCI-N87 CTRP2 -3.7814 15.1285 -8.0313 56.3125
SNU-5 CTRP2 -3.2749 -0.7355 -3.2756 62.033
ECC12 CTRP2 -3.0149 -2.0924 -3.0149 60.3541
23132/87 CTRP2 -3.0023 -1.8464 -3.0023 60.2701
GSS CTRP2 -2.2143 -0.6498 -2.2143 55.02
SNU-620 CTRP2 -2.2125 -1.3837 -2.2125 55.0088
ECC10 CTRP2 -1.1406 2.8515 -1.2089 47.9351
SH-10-TC CTRP2 -0.9511 2.5089 -0.9877 46.6632
NUGC-4 CTRP2 -0.7609 5.9434 -1.3551 46.0771
IM95 CTRP2 -0.5106 1.3964 -0.5115 43.6729
NUGC-3 CTRP2 0.3559 46.9437 -19.3199 47.8814
HGC-27 CTRP2 0.4626 7.3499 -0.4479 39.4321
MKN74 CTRP2 2.0565 15.3204 -2.2268 37.3091
SNU-601 CTRP2 2.2199 10.8391 0.0148 32.3764
HuG1-N CTRP2 3.0006 10.8093 0.8156 27.8554
LMSU CTRP2 3.1838 16.575 -1.7606 33.5954
GSU CTRP2 3.3054 9.3736 1.7728 23.837
SNU-216 CTRP2 3.401 12.7878 0.278 28.3417
MKN1 CTRP2 4.5883 11.6938 1.9302 20.002
SNU-719 CTRP2 4.6307 14.7515 0.463 24.7772
MKN45 CTRP2 6.9202 11.1759 4.1668 6.3505
MKN7 CTRP2 6.9852 18.7577 0.4538 19.972
SNU-1 CTRP2 7.7745 22.2797 -0.6803 21.7465
SNU-668 CTRP2 9.1696 21.6042 0.6902 15.6426
Hs 746.T CTRP2 9.3499 30.9523 -3.7735 25.8606
KE-39 CTRP2 12.1737 24.1614 1.4409 9.4859
AGS CTRP2 13.8572 33.0156 -1.6188 15.7921
SNG-M CTRP2 -0.6329 4.308 -0.8527 44.8714
SNU-685 CTRP2 4.3355 19.251 -2.032 31.4342
SNU-1077 CTRP2 8.5756 20.2332 0.933 15.7926
⏷ Show the Full List of 31 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 12 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
FTC-238 CTRP2 -3.7713 12.1768 -6.7974 57.2704
ML-1 [Human leukemia] CTRP2 -3.2596 19.2084 -9.2993 54.2013
8305C CTRP2 -3.1833 8.9675 -4.9524 56.7421
BHT-101 CTRP2 -2.4783 4.1403 -2.8146 55.7274
B-CPAP CTRP2 -1.3113 4.0445 -1.5388 49.0922
SW579 CTRP2 -0.0648 7.0823 -1.1957 39.3951
CAL-62 CTRP2 0.0789 6.7901 -0.6839 41.4153
TT CTRP2 0.9102 9.7476 -0.8733 38.5926
8505C CTRP2 4.1274 19.0125 -2.0991 32.0178
CGTH-W-1 CTRP2 4.6294 16.0942 -0.2035 26.6501
FTC-133 CTRP2 8.1606 21.8578 -0.1754 19.7529
TT2609-C02 CTRP2 10.7683 26.9076 -0.761 17.447
⏷ Show the Full List of 12 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 27 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
YD-10B CTRP2 -5.3952 -3.3017 -5.3952 76.0645
CAL-27 CTRP2 -5.1534 2.6707 -5.4477 68.6094
BICR 22 CTRP2 -3.9817 17.109 -9.0961 56.2199
SCC-4 CTRP2 -3.7612 3.7258 -4.1245 62.1088
PE/CA-PJ15 CTRP2 -2.3547 20.7073 -9.083 52.042
BICR 6 CTRP2 -2.0113 19.0181 -7.9609 51.3685
SNU-1214 CTRP2 -0.7713 6.3822 -1.4887 46.2449
BICR 18 CTRP2 -0.5869 10.8262 -2.8899 46.4053
CAL-33 CTRP2 -0.5006 4.4245 -0.7303 44.0503
SNU-1076 CTRP2 0.4303 6.8189 -0.3102 39.2749
Detroit 562 CTRP2 0.4624 11.058 -1.8892 41.7141
HSC-3 CTRP2 0.5342 9.6042 -1.2115 40.5111
SCC-25 CTRP2 1.3366 18.4408 -4.4108 41.7245
BICR 16 CTRP2 1.715 11.3778 -0.7392 35.6689
HSC-2 CTRP2 3.1935 14.8013 -0.8894 31.8006
SCC-9 CTRP2 3.5838 32.8255 -9.4482 40.8683
SNU-1066 CTRP2 5.0339 20.4165 -2.0002 29.8947
BHY CTRP2 6.0994 23.0914 -2.4333 28.6629
YD-8 CTRP2 6.9115 21.4297 -0.9381 23.9068
FaDu CTRP2 7.6248 15.2982 1.8758 9.5183
BICR 56 CTRP2 8.3112 20.3016 0.7054 16.9261
HSC-4 CTRP2 8.4964 17.8612 2.0338 12.2045
SNU-899 CTRP2 9.9198 23.7663 0.1685 16.0994
SNU-46 CTRP2 10.114 24.8944 -0.2423 16.9736
PE/CA-PJ41 (clone D2) CTRP2 11.5111 28.2861 -0.9165 16.8719
BICR 31 CTRP2 12.3201 39.3147 -5.6949 25.143
SNU-1041 CTRP2 14.0243 32.7674 -1.3966 15.0984
⏷ Show the Full List of 27 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
5637 CTRP2 -5.6297 26.0536 -14.8095 57.0234
647V CTRP2 -4.9296 8.4568 -6.6679 62.4361
SCaBER CTRP2 -3.482 22.0371 -10.8178 54.1959
RT-112 CTRP2 -3.3705 -1.811 -3.3705 62.7218
JMSU-1 CTRP2 -0.463 5.0547 -0.8136 44.0049
VM-CUB-1 CTRP2 -0.2185 4.7911 -0.4936 42.3444
RT-4 CTRP2 0.3135 5.4885 -0.0673 39.1972
UM-UC-3 CTRP2 0.8338 7.2037 0.0039 37.029
SW1710 CTRP2 0.8365 6.5968 0.2009 36.5304
253J CTRP2 0.8981 9.0406 -0.6015 38.116
T24 CTRP2 1.7552 21.2067 -5.3527 41.5044
639V CTRP2 2.7435 12.5763 -0.2601 31.5421
253J-BV CTRP2 2.9874 11.7003 0.39 29.1447
CAL-29 CTRP2 3.0326 9.3247 1.5153 25.494
BC-3C CTRP2 3.5125 8.7062 2.2789 21.4272
BFTC-905 CTRP2 3.5617 13.9208 -0.1152 28.9887
U-BLC1 CTRP2 5.1427 13.6496 1.4665 20.3911
HT-1376 CTRP2 7.1835 20.3969 -0.2061 21.5124
TCCSUP CTRP2 7.6661 23.166 -1.2053 23.2339
J82 CTRP2 8.1349 17.227 2.0851 12.5765
UM-UC-1 CTRP2 8.3387 42.079 -10.0984 34.8388
KMBC-2 CTRP2 9.589 23.7825 -0.0723 17.2547
HT-1197 CTRP2 9.632 20.5735 1.5085 12.3693
KU-19-19 CTRP2 11.5318 36.0177 -4.6516 24.4601
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HeLa CTRP2 -3.7883 1.5978 -3.8755 63.9349

References

1 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7833).
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5 Styryl sulfonyl compounds inhibit translation of cyclin D1 in mantle cell lymphoma cells. Oncogene. 2009 Mar 26;28(12):1518-28. doi: 10.1038/onc.2008.502. Epub 2009 Feb 9.
6 Discontinuous drug binding to proteins: binding of an antineoplastic benzyl styryl sulfone to albumin and enzymes in vitro and in phase I clinical trials. Drug Metab Dispos. 2010 Sep;38(9):1480-5. doi: 10.1124/dmd.110.033001. Epub 2010 May 25.
7 Rigosertib as a selective anti-tumor agent can ameliorate multiple dysregulated signaling transduction pathways in high-grade myelodysplastic syndrome. Sci Rep. 2014 Dec 4;4:7310. doi: 10.1038/srep07310.