Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMOSTXF)

• Drug Name: Rigosertib Drug Info
• Synonyms: Rigosertib; 592542-59-1; UNII-67DOW7F9GL; 67DOW7F9GL; N-[2-Methoxy-5-({[(E)-2-(2,4,6-Trimethoxyphenyl)ethenyl]sulfonyl}methyl)phenyl]glycine; ON-01910.Na; Rigosertib [USAN:INN]; 6FS; Rigosertib (USAN); AC1OCFT5; SCHEMBL498624; Estybon (proposed trade name); SCHEMBL498623; GTPL7833; CHEMBL1241855; ON01910.Na; DTXSID30207984; CHEBI:124939; OWBFCJROIKNMGD-BQYQJAHWSA-N; 1910 Na; ZINC3942646; BCP08296; BDBM50060917; 4006AH; AKOS015966442; DB12146; SB16468; (E)-2-((2-methoxy-5-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)phenyl)amino)acetic a

Indication

Disease Entry	ICD 11	Status	REF
Myelodysplastic syndrome	2A37	Phase 3	[1]
Solid tumour/cancer	2A00-2F9Z	Phase 3	[2]

• Cross-matching ID:
  PubChem CID: 6918736
  ChEBI ID: CHEMBL1241855
  CAS Number: CAS 592542-59-1
  TTD Drug ID: DMOSTXF

Molecule-Related Drug Atlas

Drug(s) Targeting Polo-like kinase 1 (PLK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Volasertib	DMOFH1M	Acute myeloid leukaemia	2A60	Phase 3	[7]
PCM-075	DMYFRTB	Acute myeloid leukaemia	2A60	Phase 2	[1]
BI 2536	DMJSADP	Acute myeloid leukaemia	2A60	Phase 2	[8]
MK-1496	DME1ZAH	Solid tumour/cancer	2A00-2F9Z	Phase 1	[9]
GSK461364	DM0P729	Non-hodgkin lymphoma	2B33.5	Phase 1	[8]
TAK-960	DMN4OGH	Solid tumour/cancer	2A00-2F9Z	Phase 1	[10]
CYC140	DMC6PKJ	Acute myeloid leukaemia	2A60	Phase 1	[11]
Dihydropyrido pyrazinone compound 3	DM3PEUN	N. A.	N. A.	Patented	[12]
Dihydropyrido pyrazinone compound 2	DMOTG2Y	N. A.	N. A.	Patented	[12]
HMN-214	DMH4ANG	Pancreatic cancer	2C10	Discontinued in Phase 1	[8]

Drug(s) Targeting PI3-kinase gamma (PIK3CG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BAY 80-6946	DMLOS5R	Follicular lymphoma	2A80	Approved	[13]
IPI-145	DMWA24P	Follicular lymphoma	2A80	Approved	[14]
Buparlisib	DM1WEHC	Breast cancer	2C60-2C65	Phase 3	[15]
Enzastaurin	DM5H0R9	Diffuse large B-cell lymphoma	2A81	Phase 3	[1]
GDC-0032	DMT4QHD	Breast cancer	2C60-2C65	Phase 3	[1]
PQR309	DMMCYZ8	Squamous head and neck cell carcinom	2D60.0	Phase 2	[16]
SAR245409	DMQM7IL	Solid tumour/cancer	2A00-2F9Z	Phase 2	[17]
XL147	DMML7BE	Solid tumour/cancer	2A00-2F9Z	Phase 2	[17]
SF1126	DML10K3	Head and neck cancer	2D42	Phase 2	[18]
PF-05212384	DMBL3VD	Solid tumour/cancer	2A00-2F9Z	Phase 2	[19]

Drug(s) Affected By NF-kappa-B inhibitor epsilon (NFKBIE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[20]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[21]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[22]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[23]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[24]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[26]
Bortezomib	DMNO38U	Leukemia		Approved	[27]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[28]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[20]

Drug(s) Affected By Nuclear factor 1 B-type (NFIB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[30]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[31]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[24]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[33]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[34]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[35]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[36]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[37]

Drug(s) Affected By Protein Mdm4 (MDM4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[38]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[39]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[31]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[24]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[40]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[41]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[33]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[42]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[43]

Drug(s) Affected By Protein MTSS 1 (MTSS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[44]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[45]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[24]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[47]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[48]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[33]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[49]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[36]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[50]

Drug(s) Affected By Bcl-2-like protein 11 (BCL2L11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[51]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[52]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[53]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[22]
Remdesivir	DMBFZ6L	Coronavirus Disease 2019 (COVID-19)	1D6Y	Approved	[54]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[55]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[30]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[56]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[57]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[58]

Drug(s) Affected By Cytohesin-interacting protein (CYTIP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[22]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[59]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[60]
Bortezomib	DMNO38U	Leukemia		Approved	[41]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[43]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[61]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[62]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[63]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[64]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[65]

Drug(s) Affected By Serine/threonine-protein kinase Chk2 (CHEK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[66]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[67]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[68]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[69]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[70]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[71]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[73]

Drug(s) Affected By 2'-5'-oligoadenylate synthase 1 (OAS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[74]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[44]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[74]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[76]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[77]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[78]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[58]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[31]

Drug(s) Affected By Myc proto-oncogene protein (MYC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[79]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[80]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[81]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[82]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[83]
Selenium	DM25CGV	N. A.	N. A.	Approved	[84]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[85]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[52]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[86]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[87]

Drug(s) Affected By HLA class II histocompatibility antigen, DQ beta 1 chain (HLA-DQB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[88]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[89]
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[89]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[90]
Allopurinol	DMLPAOB	Gout	FA25	Approved	[91]
Ticlopidine	DMO946V	Acute coronary syndrome	BA41	Approved	[92]
Selenium	DM25CGV	N. A.	N. A.	Approved	[93]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[89]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[94]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[76]

Drug(s) Affected By Albumin (ALB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[36]
Sulfamethoxazole	DMB08GE	Acute otitis media	AB00	Approved	[95]
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[96]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[97]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[98]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[99]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[100]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[101]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[102]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[103]

Drug(s) Affected By Receptor tyrosine-protein kinase erbB-2 (ERBB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Trastuzumab	DMZQOUX	Breast cancer	2C60-2C65	Approved	[95]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[104]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[105]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[81]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[106]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[107]
Selenium	DM25CGV	N. A.	N. A.	Approved	[93]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[108]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[109]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]

Drug(s) Affected By Transcription factor Jun (JUN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[110]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[111]
Fructose	DM43AN2	Vomiting	MD90	Approved	[95]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[112]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[113]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[80]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[114]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[115]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[116]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[117]

Drug(s) Affected By Tyrosine-protein kinase Lck (LCK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[118]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[120]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[76]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[121]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[122]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[123]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[124]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[125]

Drug(s) Affected By Tyrosine-protein kinase Fyn (FYN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[126]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[127]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[24]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[128]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[47]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[33]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[49]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[34]

Drug(s) Affected By Eukaryotic translation initiation factor 4E (EIF4E)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[129]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[130]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[76]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[131]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[132]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[133]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[26]
Momelotinib	DMF98Q0	Myelofibrosis	2A20.2	Approved	[134]
Flurbiprofen	DMGN4BY	Osteoarthritis	FA00-FA05	Approved	[133]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[33]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[135]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[136]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[137]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[138]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[139]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[140]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[139]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[141]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[142]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[143]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[144]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[145]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[146]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[147]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[113]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[148]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[149]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[150]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[151]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[149]

Drug(s) Affected By Transcriptional activator Myb (MYB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[152]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[20]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[153]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[109]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[154]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[155]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[152]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[156]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[157]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]

Drug(s) Affected By cAMP-dependent protein kinase type I-alpha regulatory subunit (PRKAR1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[158]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[70]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[159]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[33]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[160]
Mitotane	DMU1GX0	Adrenocortical carcinoma	2D11.Z	Approved	[161]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[162]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[163]

Drug(s) Affected By Fatty acid-binding protein, adipocyte (FABP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[164]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[165]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[166]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[164]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[24]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[167]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[168]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[169]

Drug(s) Affected By Ezrin (EZR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[170]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[20]
Selenium	DM25CGV	N. A.	N. A.	Approved	[93]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[108]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[171]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[30]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[70]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[77]
Haloperidol	DM96SE0	Delirium		Approved	[170]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[31]

Drug(s) Affected By CD44 antigen (CD44)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[172]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[152]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[20]
Selenium	DM25CGV	N. A.	N. A.	Approved	[173]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[174]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[175]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[176]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[30]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[177]

Drug(s) Affected By Histone H2AX (H2AX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[178]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[179]
Selenium	DM25CGV	N. A.	N. A.	Approved	[93]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[180]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[181]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[182]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[183]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[184]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[185]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[186]

Drug(s) Affected By Transcription factor JunD (JUND)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[113]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[80]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[107]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[187]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[44]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[188]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[189]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[190]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[83]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[77]

Drug(s) Affected By Transcription factor E3 (TFE3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[22]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[121]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[191]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[191]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[24]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[191]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[48]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[192]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[33]

Drug(s) Affected By Lamin-B1 (LMNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[193]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[194]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[195]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[196]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[44]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[197]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[31]

Drug(s) Affected By B-cell differentiation antigen CD72 (CD72)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[198]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[199]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[200]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[201]

Drug(s) Affected By Tyrosine-protein phosphatase non-receptor type 6 (PTPN6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[20]
Selenium	DM25CGV	N. A.	N. A.	Approved	[93]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[22]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[202]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[203]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[24]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Sodium chloride	DMM3950	Skin burns	ME65.0	Approved	[204]
Bortezomib	DMNO38U	Leukemia		Approved	[205]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[33]

Drug(s) Affected By G1/S-specific cyclin-D2 (CCND2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[158]
Selenium	DM25CGV	N. A.	N. A.	Approved	[84]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[108]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[109]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[154]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[207]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[208]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[209]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]

Drug(s) Affected By M-phase inducer phosphatase 3 (CDC25C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[67]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[107]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[108]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[44]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[210]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[22]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[189]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[211]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[212]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]

Drug(s) Affected By Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA (MAN1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[44]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[76]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[30]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[83]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[159]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[43]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[213]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[214]

Drug(s) Affected By Tyrosine-protein kinase RYK (RYK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[44]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[83]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[215]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[33]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[216]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[217]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[218]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[219]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[220]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[221]

Drug(s) Affected By Catenin beta-1 (CTNNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[112]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[107]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[222]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[223]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[224]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[225]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[226]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[227]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[228]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[229]

Drug(s) Affected By DNA damage-inducible transcript 3 protein (DDIT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[230]
Triacetin	DM0AEPG	Onychomycosis	EE12.1	Approved	[231]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[80]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[232]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[233]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[234]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[235]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[236]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[194]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[44]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[207]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[237]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[114]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[238]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[239]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[234]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[240]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[241]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[140]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[242]

Drug(s) Affected By Interleukin-6 receptor subunit beta (IL6ST)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[172]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[243]
Selenium	DM25CGV	N. A.	N. A.	Approved	[93]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[44]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[244]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[245]
Lenalidomide	DM6Q7U4	Adult T-cell leukemia/lymphoma		Approved	[246]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[246]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]

Drug(s) Affected By ETS translocation variant 5 (ETV5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[247]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[164]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[24]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[248]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[33]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[43]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[36]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[249]

Drug(s) Affected By Regulator of G-protein signaling 2 (RGS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[20]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[87]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[250]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[44]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[171]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[251]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[39]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[58]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[252]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[209]

Drug(s) Affected By Tyrosine-protein kinase FRK (FRK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[44]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[94]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[83]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[31]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[24]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[253]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[60]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[126]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[33]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[213]

Drug(s) Affected By Nuclear receptor subfamily 4 group A member 2 (NR4A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[254]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[255]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[256]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[78]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[257]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[258]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[217]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[65]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[48]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[259]

Drug(s) Affected By Mitogen-activated protein kinase 9 (MAPK9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[112]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[107]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[116]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[260]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[261]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[22]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[116]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[262]
Sorbitol	DMAN0DE	Constipation	DD91.1	Approved	[263]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[24]

Drug(s) Affected By Ran GTPase-activating protein 1 (RANGAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[93]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[22]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[264]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[24]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[26]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[265]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[266]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[221]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[267]

Drug(s) Affected By Crk-like protein (CRKL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nilotinib	DM7HXWT	Chronic myelogenous leukaemia	2A20.0	Approved	[268]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[269]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[26]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[270]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[271]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[221]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[267]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[272]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[219]
PMID25656651-Compound-5	DMAI95U	Chronic myeloid leukaemia	2A20	Patented	[273]

Drug(s) Affected By Max-interacting protein 1 (MXI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[44]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[191]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[191]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[24]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[191]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[65]
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[274]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[275]

Drug(s) Affected By Tyrosine-protein kinase Blk (BLK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[58]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[40]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[48]
Bortezomib	DMNO38U	Leukemia		Approved	[41]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[266]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[276]
Afimoxifene	DMFORDT	Breast cancer	2C60-2C65	Phase 2	[277]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[63]
PMID25656651-Compound-5	DMAI95U	Chronic myeloid leukaemia	2A20	Patented	[278]
SB-431542	DM0YOXQ	Pulmonary fibrosis	CB03.4	Preclinical	[279]

Drug(s) Affected By Protein FosB (FOSB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[230]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[20]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[76]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[121]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[257]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[39]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[164]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[280]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[281]

Drug(s) Affected By Epithelial membrane protein 1 (EMP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[20]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[282]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[44]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[197]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[282]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[197]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[30]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[39]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[58]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]

Drug(s) Affected By BH3-interacting domain death agonist (BID)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[172]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[138]
Selenium	DM25CGV	N. A.	N. A.	Approved	[283]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[284]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[244]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[171]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[285]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[286]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[287]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[24]

Drug(s) Affected By Claudin-15 (CLDN15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Tetracycline	DMZA017	Acne vulgaris	ED80	Approved	[288]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[289]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[290]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[219]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[118]

Drug(s) Affected By Actin, cytoplasmic 1 (ACTB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[107]
Selenium	DM25CGV	N. A.	N. A.	Approved	[93]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[291]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[44]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[22]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[292]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[38]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[31]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[44]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]

Drug(s) Affected By Rho-related GTP-binding protein RhoB (RHOB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[210]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[197]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[197]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[30]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[293]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[264]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[31]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[294]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[24]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[295]

Drug(s) Affected By Small ribosomal subunit protein eS6 (RPS6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[296]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[153]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[297]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[298]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[299]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[300]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[301]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[302]
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[303]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[24]

Drug(s) Affected By Actin, cytoplasmic 2 (ACTG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[93]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[210]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[171]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[38]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[31]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[159]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[304]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[26]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[33]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[216]

Drug(s) Affected By Tropomyosin alpha-4 chain (TPM4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[118]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[44]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[130]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[38]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[31]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[24]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[26]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[44]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[305]

Drug(s) Affected By Histone H3.3 (H3-3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[158]
Selenium	DM25CGV	N. A.	N. A.	Approved	[93]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[153]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[171]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[203]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[33]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[198]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[90]

Drug(s) Affected By cAMP-responsive element modulator (CREM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[153]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[38]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[24]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[306]
Bortezomib	DMNO38U	Leukemia		Approved	[41]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[307]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[36]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[308]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[267]

Drug(s) Affected By Histone-lysine N-methyltransferase 2A (KMT2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[309]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[310]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[39]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[311]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[312]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[313]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[33]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[43]

Drug(s) Affected By Dual specificity protein phosphatase 2 (DUSP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[20]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[87]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[171]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[38]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[314]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[315]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[65]
Epanova	DMHEAGL	Hypertriglyceridemia	5C80.1	Approved	[316]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[317]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[318]

Drug(s) Affected By 3',5'-cyclic-AMP phosphodiesterase 4B (PDE4B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[171]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[83]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[78]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[319]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[65]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[60]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[275]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[320]

Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[321]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[322]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[138]
Selenium	DM25CGV	N. A.	N. A.	Approved	[93]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[323]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[108]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[324]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[325]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[284]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[326]

Drug(s) Affected By Son of sevenless homolog 2 (SOS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[252]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[45]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[31]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[33]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[327]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[328]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[267]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[217]

Drug(s) Affected By Inositol 1,4,5-triphosphate receptor associated 2 (IRAG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[329]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[43]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[276]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[330]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[63]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[331]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[65]

Drug(s) Affected By Dual specificity protein phosphatase 4 (DUSP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[135]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[44]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[22]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[76]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[30]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[332]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[209]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[65]

Drug(s) Affected By Phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[230]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[333]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[138]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[182]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[334]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[44]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[335]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[336]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[155]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[189]

Drug(s) Affected By Krueppel-like factor 5 (KLF5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[20]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[187]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[44]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[30]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[83]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[58]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[31]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[209]

Drug(s) Affected By Protein-tyrosine kinase 2-beta (PTK2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[337]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[338]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[128]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[275]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[339]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[198]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[266]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[267]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[340]

Drug(s) Affected By Genetic suppressor element 1 (GSE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[44]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[33]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[43]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[198]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[36]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[308]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[267]

Drug(s) Affected By Nuclear mitotic apparatus protein 1 (NUMA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[299]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[341]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[26]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[40]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[342]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[36]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[343]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[344]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[217]

Drug(s) Affected By Astrocytic phosphoprotein PEA-15 (PEA15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[93]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[44]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[22]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[39]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[24]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[26]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[60]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[33]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[43]

Drug(s) Affected By Interferon regulatory factor 4 (IRF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[345]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[346]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[347]
Bortezomib	DMNO38U	Leukemia		Approved	[348]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[349]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[266]
phorbol 12-myristate 13-acetate	DMJWD62	Acute myeloid leukaemia	2A60	Phase 2	[350]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[351]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[63]
T-5224	DMD3CUJ	Rheumatoid arthritis	FA20	Discontinued in Phase 2	[348]

Drug(s) Affected By Microtubule-associated protein RP/EB family member 1 (MAPRE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[215]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[26]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[170]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[170]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[352]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[353]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[33]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[36]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[267]

Drug(s) Affected By Exostosin-1 (EXT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[22]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[30]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[39]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[31]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[209]
Cotinine	DMCEZ1B	Insecticide	N.A.	Approved	[354]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[48]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[33]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[34]

Drug(s) Affected By Serine/arginine-rich splicing factor 7 (SRSF7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[355]
Selenium	DM25CGV	N. A.	N. A.	Approved	[93]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[44]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[299]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[264]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[159]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[26]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[170]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[306]

Drug(s) Affected By Pleckstrin homology-like domain family A member 2 (PHLDA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[20]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[44]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[210]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[94]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[127]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[76]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[30]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[83]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[24]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]

Drug(s) Affected By Histone H2A.V (H2AZ2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[24]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[26]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[356]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[192]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[33]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[50]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[215]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[357]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[358]

Drug(s) Affected By Syntaxin-12 (STX12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[22]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[159]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[359]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[65]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[26]
Bortezomib	DMNO38U	Leukemia		Approved	[41]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[198]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[266]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[340]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[63]

Drug(s) Affected By Polycomb group protein ASXL1 (ASXL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[65]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[317]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[33]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[36]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[267]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[93]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[358]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[63]

Drug(s) Affected By DDB1- and CUL4-associated factor 11 (DCAF11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[20]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[24]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[26]
Bortezomib	DMNO38U	Leukemia		Approved	[41]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[33]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[213]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[221]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[360]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[201]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[247]

Drug(s) Affected By Protein NDRG1 (NDRG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[361]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[362]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[363]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[364]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[210]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[365]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[24]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[366]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[275]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[48]

Drug(s) Affected By TRAF family member-associated NF-kappa-B activator (TANK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[107]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[22]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[58]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[367]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[65]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[40]
Bortezomib	DMNO38U	Leukemia		Approved	[41]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[327]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[368]

Drug(s) Affected By Proline-rich AKT1 substrate 1 (AKT1S1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[31]
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[303]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[159]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[26]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[41]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[33]
Cabazitaxel	DMPAZHC	Breast cancer	2C60-2C65	Approved	[369]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[162]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[340]

Drug(s) Affected By MAP/microtubule affinity-regulating kinase 4 (MARK4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[118]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[22]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[266]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[267]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[340]
Afimoxifene	DMFORDT	Breast cancer	2C60-2C65	Phase 2	[277]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[63]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[247]

Drug(s) Affected By Tribbles homolog 1 (TRIB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[135]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[20]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[153]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[171]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[78]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[45]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[31]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[24]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[48]

Drug(s) Affected By Krueppel-like factor 6 (KLF6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[135]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[370]
Selenium	DM25CGV	N. A.	N. A.	Approved	[93]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[242]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[250]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[44]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[210]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[30]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[31]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[24]

Drug(s) Affected By Mitogen-activated protein kinase kinase kinase 3 (MAP3K3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[371]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[372]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[22]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[40]
Romidepsin	DMT5GNL	Cutaneous T-cell lymphoma	2B01	Approved	[373]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[374]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[266]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[375]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[217]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[340]

Drug(s) Affected By Calsyntenin-3 (CLSTN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[171]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[76]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[215]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[275]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[376]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[213]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[63]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[220]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[377]

Drug(s) Affected By DNA damage-inducible transcript 4 protein (DDIT4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[230]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[355]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[242]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[378]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[44]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[379]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[189]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[70]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[380]

Drug(s) Affected By Bcl-2-associated transcription factor 1 (BCLAF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[20]
Selenium	DM25CGV	N. A.	N. A.	Approved	[93]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[247]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[65]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[26]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[381]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[73]

Drug(s) Affected By Eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[382]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[80]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[233]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[20]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[233]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[383]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[233]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[384]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[385]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[386]

Drug(s) Affected By ADP-ribosylation factor-binding protein GGA2 (GGA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[387]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[215]
Afimoxifene	DMFORDT	Breast cancer	2C60-2C65	Phase 2	[388]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[389]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[247]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[390]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[221]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[359]

Drug(s) Affected By F-box only protein 2 (FBXO2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[93]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[44]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[30]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[391]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[209]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[26]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[275]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[33]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[216]

Drug(s) Affected By Transcription factor MafF (MAFF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[392]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[393]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[20]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[394]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[44]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[244]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[210]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[76]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[190]

Drug(s) Affected By Disheveled-associated activator of morphogenesis 1 (DAAM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[93]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[159]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[366]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[65]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[33]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[36]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[221]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[340]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[119]

Drug(s) Affected By Krueppel-like factor 12 (KLF12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[395]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[164]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[171]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[39]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[24]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[359]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[48]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[318]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[216]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[396]

Drug(s) Affected By Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[172]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[20]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[44]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[22]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[38]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[397]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[45]
Cantharidin	DMBP5N3	Molluscum contagiosum infection	1E76	Approved	[398]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[399]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
PI3-kinase gamma (PIK3CG)	TTHBTOP	PK3CG_HUMAN	Modulator	[3]
Polo-like kinase 1 (PLK1)	TTIYVQP	PLK1_HUMAN	Modulator	[3]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
2'-5'-oligoadenylate synthase 1 (OAS1)	OT8ZLOCY	OAS1_HUMAN	Gene/Protein Processing	[4]
3',5'-cyclic-AMP phosphodiesterase 4B (PDE4B)	OTOA8WU2	PDE4B_HUMAN	Gene/Protein Processing	[4]
Actin, cytoplasmic 1 (ACTB)	OT1MCP2F	ACTB_HUMAN	Gene/Protein Processing	[4]
Actin, cytoplasmic 2 (ACTG1)	OTH4V7VQ	ACTG_HUMAN	Gene/Protein Processing	[4]
ADP-ribosylation factor-binding protein GGA2 (GGA2)	OT43HO27	GGA2_HUMAN	Gene/Protein Processing	[4]
Albumin (ALB)	OTVMM513	ALBU_HUMAN	Protein Interaction/Cellular Processes	[5]
Astrocytic phosphoprotein PEA-15 (PEA15)	OTKCKTSX	PEA15_HUMAN	Gene/Protein Processing	[4]
B-cell differentiation antigen CD72 (CD72)	OTPOJID2	CD72_HUMAN	Gene/Protein Processing	[4]
Bcl-2-associated transcription factor 1 (BCLAF1)	OT7T8H6A	BCLF1_HUMAN	Gene/Protein Processing	[4]
Bcl-2-like protein 1 (BCL2L1)	OTRC5K9O	B2CL1_HUMAN	Gene/Protein Processing	[6]

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