Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMOSTXF)

• Drug Name: Rigosertib Drug Info
• Synonyms: Rigosertib; 592542-59-1; UNII-67DOW7F9GL; 67DOW7F9GL; N-[2-Methoxy-5-({[(E)-2-(2,4,6-Trimethoxyphenyl)ethenyl]sulfonyl}methyl)phenyl]glycine; ON-01910.Na; Rigosertib [USAN:INN]; 6FS; Rigosertib (USAN); AC1OCFT5; SCHEMBL498624; Estybon (proposed trade name); SCHEMBL498623; GTPL7833; CHEMBL1241855; ON01910.Na; DTXSID30207984; CHEBI:124939; OWBFCJROIKNMGD-BQYQJAHWSA-N; 1910 Na; ZINC3942646; BCP08296; BDBM50060917; 4006AH; AKOS015966442; DB12146; SB16468; (E)-2-((2-methoxy-5-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)phenyl)amino)acetic a

Indication

Disease Entry	ICD 11	Status	REF
Myelodysplastic syndrome	2A37	Phase 3	[1]
Solid tumour/cancer	2A00-2F9Z	Phase 3	[2]

• Cross-matching ID:
  PubChem CID: 6918736
  ChEBI ID: CHEBI:124939
  CAS Number: CAS 592542-59-1
  TTD Drug ID: DMOSTXF

Molecule-Related Drug Atlas

Drug(s) Targeting Polo-like kinase 1 (PLK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Volasertib	DMOFH1M	Acute myeloid leukaemia	2A60	Phase 3	[8]
PCM-075	DMYFRTB	Acute myeloid leukaemia	2A60	Phase 2	[1]
BI 2536	DMJSADP	Acute myeloid leukaemia	2A60	Phase 2	[9]
MK-1496	DME1ZAH	Solid tumour/cancer	2A00-2F9Z	Phase 1	[10]
GSK461364	DM0P729	Non-hodgkin lymphoma	2B33.5	Phase 1	[9]
TAK-960	DMN4OGH	Solid tumour/cancer	2A00-2F9Z	Phase 1	[11]
CYC140	DMC6PKJ	Acute myeloid leukaemia	2A60	Phase 1	[12]
Dihydropyrido pyrazinone compound 3	DM3PEUN	N. A.	N. A.	Patented	[13]
Dihydropyrido pyrazinone compound 2	DMOTG2Y	N. A.	N. A.	Patented	[13]
HMN-214	DMH4ANG	Pancreatic cancer	2C10	Discontinued in Phase 1	[9]

Drug(s) Targeting PI3-kinase gamma (PIK3CG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BAY 80-6946	DMLOS5R	Follicular lymphoma	2A80	Approved	[14]
IPI-145	DMWA24P	Follicular lymphoma	2A80	Approved	[15]
Buparlisib	DM1WEHC	Breast cancer	2C60-2C65	Phase 3	[16]
Enzastaurin	DM5H0R9	Diffuse large B-cell lymphoma	2A81	Phase 3	[1]
GDC-0032	DMT4QHD	Breast cancer	2C60-2C65	Phase 3	[1]
PQR309	DMMCYZ8	Squamous head and neck cell carcinom	2D60.0	Phase 2	[17]
SAR245409	DMQM7IL	Solid tumour/cancer	2A00-2F9Z	Phase 2	[18]
XL147	DMML7BE	Solid tumour/cancer	2A00-2F9Z	Phase 2	[18]
SF1126	DML10K3	Head and neck cancer	2D42	Phase 2	[19]
PF-05212384	DMBL3VD	Solid tumour/cancer	2A00-2F9Z	Phase 2	[20]

Drug(s) Affected By NF-kappa-B inhibitor epsilon (NFKBIE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[21]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[22]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[23]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[24]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[27]
Bortezomib	DMNO38U	Leukemia		Approved	[28]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[29]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[21]

Drug(s) Affected By Chloride intracellular channel protein 1 (CLIC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[23]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[30]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[31]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[32]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[27]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[34]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[35]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[36]

Drug(s) Affected By Nuclear factor 1 B-type (NFIB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[37]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[38]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[31]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[40]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[41]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[42]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[43]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[44]

Drug(s) Affected By Transcription regulator protein BACH1 (BACH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[45]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[46]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[47]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[23]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[48]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[49]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[50]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[31]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]

Drug(s) Affected By Protein Mdm4 (MDM4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[52]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[53]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[31]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[54]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[55]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[40]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[56]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[57]

Drug(s) Affected By 3-phosphoinositide-dependent protein kinase 1 (PDPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[27]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[60]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[61]
Amiloride	DMRTSGP	Congestive heart failure	BD10	Approved	[62]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[63]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[60]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[64]

Drug(s) Affected By Protein MTSS 1 (MTSS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[66]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[67]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[68]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[40]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[69]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[43]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[70]

Drug(s) Affected By Bcl-2-like protein 11 (BCL2L11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[71]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[72]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[73]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[23]
Remdesivir	DMBFZ6L	Coronavirus Disease 2019 (COVID-19)	1D6Y	Approved	[74]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[75]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[38]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[76]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[77]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[78]

Drug(s) Affected By Cytohesin-interacting protein (CYTIP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[23]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[79]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[80]
Bortezomib	DMNO38U	Leukemia		Approved	[55]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[57]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[81]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[82]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[83]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[84]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[85]

Drug(s) Affected By F-box-like/WD repeat-containing protein TBL1X (TBL1X)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[86]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[37]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[52]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[87]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[27]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[88]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[68]
Bortezomib	DMNO38U	Leukemia		Approved	[55]

Drug(s) Affected By Short-chain dehydrogenase/reductase 3 (DHRS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[21]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[90]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[38]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[91]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[66]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[88]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[80]

Drug(s) Affected By Serine/threonine-protein kinase Chk2 (CHEK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[92]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[93]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[94]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[95]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[96]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[97]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[91]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[91]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[98]

Drug(s) Affected By 2'-5'-oligoadenylate synthase 1 (OAS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[99]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[100]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[99]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[101]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[102]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[103]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[78]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[91]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[31]

Drug(s) Affected By Myc proto-oncogene protein (MYC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[104]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[105]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[106]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[107]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[108]
Selenium	DM25CGV	N. A.	N. A.	Approved	[109]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[110]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[72]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[111]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[112]

Drug(s) Affected By HLA class II histocompatibility antigen, DQ beta 1 chain (HLA-DQB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[113]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[114]
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[114]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[115]
Allopurinol	DMLPAOB	Gout	FA25	Approved	[116]
Ticlopidine	DMO946V	Acute coronary syndrome	BA41	Approved	[117]
Selenium	DM25CGV	N. A.	N. A.	Approved	[86]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[114]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[118]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[101]

Drug(s) Affected By Albumin (ALB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[43]
Sulfamethoxazole	DMB08GE	Acute otitis media	AB00	Approved	[119]
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[120]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[121]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[122]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[123]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[124]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[125]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[126]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[127]

Drug(s) Affected By Glucocorticoid receptor (NR3C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[128]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[129]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[21]
Selenium	DM25CGV	N. A.	N. A.	Approved	[86]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[130]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[112]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[131]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[37]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[132]

Drug(s) Affected By Receptor tyrosine-protein kinase erbB-2 (ERBB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Trastuzumab	DMZQOUX	Breast cancer	2C60-2C65	Approved	[119]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[133]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[134]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[106]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[135]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[136]
Selenium	DM25CGV	N. A.	N. A.	Approved	[86]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[137]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[138]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[37]

Drug(s) Affected By Transcription factor Jun (JUN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[139]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[140]
Fructose	DM43AN2	Vomiting	MD90	Approved	[119]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[141]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[142]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[105]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[143]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[144]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[145]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[146]

Drug(s) Affected By Tyrosine-protein kinase Lck (LCK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[147]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[148]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[101]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[87]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[149]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[150]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[151]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[152]

Drug(s) Affected By Tyrosine-protein kinase Fyn (FYN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[153]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[154]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[155]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[67]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[40]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[69]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[41]

Drug(s) Affected By Cyclin-dependent kinase 1 (CDK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[93]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[156]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[157]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[21]
Selenium	DM25CGV	N. A.	N. A.	Approved	[109]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[158]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[159]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[137]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[160]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[138]

Drug(s) Affected By Eukaryotic translation initiation factor 4E (EIF4E)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[161]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[162]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[101]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[163]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[164]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[165]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[27]
Momelotinib	DMF98Q0	Myelofibrosis	2A20.2	Approved	[166]
Flurbiprofen	DMGN4BY	Osteoarthritis	FA00-FA05	Approved	[165]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[40]

Drug(s) Affected By Macrophage colony-stimulating factor 1 receptor (CSF1R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[21]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[112]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[23]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[101]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[167]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[168]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[169]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[68]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[170]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[171]

Drug(s) Affected By Proto-oncogene tyrosine-protein kinase receptor Ret (RET)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[172]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[173]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[172]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[23]
Irbesartan	DMTP1DC	Diabetic kidney disease	GB61.Z	Approved	[174]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[173]
Methazolamide	DM7J2TA	Glaucoma/ocular hypertension	9C61	Approved	[172]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[175]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[66]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]

Drug(s) Affected By Platelet-derived growth factor receptor beta (PDGFRB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[21]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[101]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[177]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[178]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[179]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[180]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[181]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[182]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[183]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[184]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[185]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[186]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[187]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[186]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[188]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[189]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[190]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[191]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[192]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[193]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[194]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[142]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[195]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[196]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[197]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[198]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[196]

Drug(s) Affected By Transcriptional activator Myb (MYB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[173]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[21]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[199]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[138]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[200]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[201]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[173]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[202]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[203]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[91]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[204]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[205]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[206]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[207]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[119]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[182]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[208]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[209]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[210]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[211]

Drug(s) Affected By cAMP-dependent protein kinase type I-alpha regulatory subunit (PRKAR1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[212]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[37]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[40]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[61]
Mitotane	DMU1GX0	Adrenocortical carcinoma	2D11.Z	Approved	[213]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[214]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[215]

Drug(s) Affected By Retinoic acid receptor beta (RARB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[216]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[217]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[218]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[38]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[219]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[220]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[221]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[222]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[216]

Drug(s) Affected By Lysosome-associated membrane glycoprotein 2 (LAMP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[162]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[27]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[63]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[223]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[224]
Bicalutamide	DMZMSPF	Prostate cancer	2C82.0	Approved	[225]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[226]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[38]

Drug(s) Affected By G2/mitotic-specific cyclin-B1 (CCNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[93]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[156]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[143]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[21]
Selenium	DM25CGV	N. A.	N. A.	Approved	[109]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[158]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[187]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[227]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[228]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[229]

Drug(s) Affected By Matrix metalloproteinase-9 (MMP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[230]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[129]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[231]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[232]
Selenium	DM25CGV	N. A.	N. A.	Approved	[233]
Pentosan Polysulfate	DM2HRKE	Interstitial cystitis	GC00.3	Approved	[234]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[188]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[22]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[235]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[236]

Drug(s) Affected By Fatty acid-binding protein, adipocyte (FABP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[237]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[238]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[100]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[132]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[237]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[239]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[240]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[241]

Drug(s) Affected By Ezrin (EZR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[242]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[21]
Selenium	DM25CGV	N. A.	N. A.	Approved	[86]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[137]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[38]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[96]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[102]
Haloperidol	DM96SE0	Delirium		Approved	[242]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[31]

Drug(s) Affected By Nucleoside diphosphate kinase A (NME1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[157]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[144]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[243]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[100]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[244]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[245]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[27]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[246]

Drug(s) Affected By CD44 antigen (CD44)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[247]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[173]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[21]
Selenium	DM25CGV	N. A.	N. A.	Approved	[248]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[249]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[250]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[251]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[38]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[252]

Drug(s) Affected By Histone H2AX (H2AX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[253]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[254]
Selenium	DM25CGV	N. A.	N. A.	Approved	[86]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[255]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[256]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[257]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[258]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[259]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[260]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[261]

Drug(s) Affected By Cytotoxic T-lymphocyte protein 4 (CTLA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[262]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[263]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[264]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[265]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[266]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[267]

Drug(s) Affected By Transcription factor JunD (JUND)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[142]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[105]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[136]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[228]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[268]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[48]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[269]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[108]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[102]

Drug(s) Affected By Early growth response protein 1 (EGR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[270]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[271]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[199]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[272]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[273]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[274]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[275]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[276]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[52]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[277]

Drug(s) Affected By Transcription factor E3 (TFE3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[23]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[87]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[278]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[278]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[278]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[68]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[279]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[40]

Drug(s) Affected By Lamin-B1 (LMNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[280]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[229]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[281]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[282]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[283]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[91]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[91]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[31]

Drug(s) Affected By Ephrin type-A receptor 1 (EPHA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[143]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[23]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[91]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Bortezomib	DMNO38U	Leukemia		Approved	[55]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[40]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[284]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[36]

Drug(s) Affected By Fibroblast growth factor receptor 2 (FGFR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[285]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[21]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[286]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[108]
Lenalidomide	DM6Q7U4	Adult T-cell leukemia/lymphoma		Approved	[287]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[287]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[91]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[288]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[289]

Drug(s) Affected By B-cell differentiation antigen CD72 (CD72)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[36]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[290]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[291]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[292]

Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[293]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[294]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[211]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[295]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[296]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[297]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[298]
Selenium	DM25CGV	N. A.	N. A.	Approved	[86]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[110]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[299]

Drug(s) Affected By Tyrosine-protein phosphatase non-receptor type 6 (PTPN6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[21]
Selenium	DM25CGV	N. A.	N. A.	Approved	[86]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[23]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[300]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[301]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Sodium chloride	DMM3950	Skin burns	ME65.0	Approved	[302]
Bortezomib	DMNO38U	Leukemia		Approved	[303]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[40]

Drug(s) Affected By G1/S-specific cyclin-D2 (CCND2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[212]
Selenium	DM25CGV	N. A.	N. A.	Approved	[109]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[137]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[138]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[200]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[304]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[305]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[306]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[288]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]

Drug(s) Affected By M-phase inducer phosphatase 3 (CDC25C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[93]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[136]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[137]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[131]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[23]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[48]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[307]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[308]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[91]

Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[309]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[310]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[311]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[211]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[312]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[313]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[314]
Selenium	DM25CGV	N. A.	N. A.	Approved	[86]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[123]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[110]

Drug(s) Affected By RAC-beta serine/threonine-protein kinase (AKT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[123]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[228]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[73]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[315]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[228]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[316]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[54]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[317]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[318]

Drug(s) Affected By Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA (MAN1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[37]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[101]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[38]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[108]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[57]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[319]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[320]

Drug(s) Affected By Tyrosine-protein kinase RYK (RYK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[40]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[321]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[322]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[323]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[324]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[325]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[326]

Drug(s) Affected By Catenin beta-1 (CTNNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[141]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[136]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[327]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[243]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[328]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[329]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[330]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[331]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[332]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[333]

Drug(s) Affected By DNA damage-inducible transcript 3 protein (DDIT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[270]
Triacetin	DM0AEPG	Onychomycosis	EE12.1	Approved	[334]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[105]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[335]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[336]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[271]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[337]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[338]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[229]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]

Drug(s) Affected By Vascular endothelial growth factor receptor 2 (KDR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[339]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[37]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[340]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[341]
Haloperidol	DM96SE0	Delirium		Approved	[242]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[242]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[54]
Orlistat	DMRJSP8	Obesity	5B81	Approved	[342]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[305]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[343]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[143]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[344]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[297]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[271]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[158]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[345]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[187]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[346]

Drug(s) Affected By Interleukin-6 receptor subunit beta (IL6ST)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[247]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[347]
Selenium	DM25CGV	N. A.	N. A.	Approved	[86]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[315]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[37]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[348]
Lenalidomide	DM6Q7U4	Adult T-cell leukemia/lymphoma		Approved	[349]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[349]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[91]

Drug(s) Affected By Signal transducer and activator of transcription 3 (STAT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[119]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[247]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[350]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[351]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[352]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[353]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[199]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[354]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[355]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[356]

Drug(s) Affected By ETS translocation variant 5 (ETV5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[357]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[237]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[100]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[358]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[40]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[57]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[43]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[359]

Drug(s) Affected By Regulator of G-protein signaling 2 (RGS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[21]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[112]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[160]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[360]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[53]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[78]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[361]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[288]

Drug(s) Affected By Protein kinase C iota type (PRKCI)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[86]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[23]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[27]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[40]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[362]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[60]
Indomethacin	DMSC4A7	Bursitis		Approved	[363]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[60]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[226]

Drug(s) Affected By Serine/threonine-protein kinase mTOR (MTOR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[364]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[365]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[366]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[367]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[368]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[110]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[369]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[370]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[177]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[371]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[372]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[373]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[374]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[375]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[376]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[377]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[378]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[379]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[380]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[381]

Drug(s) Affected By Tyrosine-protein kinase FRK (FRK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[118]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[108]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[31]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[169]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[80]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[153]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[40]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[319]

Drug(s) Affected By Nuclear receptor subfamily 4 group A member 2 (NR4A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[382]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[383]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[384]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[103]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[385]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[168]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[322]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[85]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[68]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[386]

Drug(s) Affected By Tyrosine-protein kinase SYK (SYK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[38]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[52]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[387]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[321]
Diphenylpyraline	DMW4X37	Allergic rhinitis	CA08.0	Approved	[388]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[389]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[38]

Drug(s) Affected By Mitogen-activated protein kinase 9 (MAPK9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[141]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[136]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[145]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[390]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[391]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[23]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[145]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[392]
Sorbitol	DMAN0DE	Constipation	DD91.1	Approved	[393]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]

Drug(s) Affected By Ran GTPase-activating protein 1 (RANGAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[86]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[23]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[245]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[27]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[394]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[63]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[326]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[171]

Drug(s) Affected By Crk-like protein (CRKL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nilotinib	DM7HXWT	Chronic myelogenous leukaemia	2A20.0	Approved	[395]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[396]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[27]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[397]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[398]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[326]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[171]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[399]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[324]
PMID25656651-Compound-5	DMAI95U	Chronic myeloid leukaemia	2A20	Patented	[400]

Drug(s) Affected By Glioma pathogenesis-related protein 1 (GLIPR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[23]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[401]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[31]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[402]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[85]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[55]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[68]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[403]

Drug(s) Affected By Max-interacting protein 1 (MXI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[100]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[278]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[278]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[278]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[85]
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[404]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[180]

Drug(s) Affected By Tyrosine-protein kinase Blk (BLK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[78]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[54]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[68]
Bortezomib	DMNO38U	Leukemia		Approved	[55]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[63]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[405]
Afimoxifene	DMFORDT	Breast cancer	2C60-2C65	Phase 2	[406]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[83]
PMID25656651-Compound-5	DMAI95U	Chronic myeloid leukaemia	2A20	Patented	[407]
SB-431542	DM0YOXQ	Pulmonary fibrosis	CB03.4	Preclinical	[408]

Drug(s) Affected By Protein FosB (FOSB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[270]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[21]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[101]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[87]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[385]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[53]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[237]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[409]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[410]

Drug(s) Affected By Epithelial membrane protein 1 (EMP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[21]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[276]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[283]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[276]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[283]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[38]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[53]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[78]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[91]

Drug(s) Affected By Caspase-7 (CASP7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[230]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[105]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[411]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[412]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[413]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[413]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[137]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[281]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[414]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[260]

Drug(s) Affected By Caspase-9 (CASP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[415]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[416]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[182]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[209]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[417]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[418]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[185]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[419]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[420]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[421]

Drug(s) Affected By BH3-interacting domain death agonist (BID)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[247]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[185]
Selenium	DM25CGV	N. A.	N. A.	Approved	[422]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[423]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[315]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[424]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[425]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[426]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]

Drug(s) Affected By Claudin-15 (CLDN15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Tetracycline	DMZA017	Acne vulgaris	ED80	Approved	[427]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[428]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[429]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[324]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[147]

Drug(s) Affected By Leukocyte immunoglobulin-like receptor subfamily A member 4 (LILRA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[83]

Drug(s) Affected By Actin, cytoplasmic 1 (ACTB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[136]
Selenium	DM25CGV	N. A.	N. A.	Approved	[86]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[430]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[23]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[431]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[52]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[31]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]

Drug(s) Affected By Rho-related GTP-binding protein RhoB (RHOB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[131]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[283]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[283]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[38]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[432]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[245]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[31]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[433]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[434]

Drug(s) Affected By Small ribosomal subunit protein eS6 (RPS6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[435]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[199]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[436]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[437]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[438]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[439]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[440]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[441]
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[309]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]

Drug(s) Affected By Actin, cytoplasmic 2 (ACTG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[86]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[131]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[52]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[31]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[27]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[40]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[321]

Drug(s) Affected By Tropomyosin alpha-4 chain (TPM4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[147]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[162]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[52]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[31]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[27]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[65]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[442]

Drug(s) Affected By Histone H3.3 (H3-3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[212]
Selenium	DM25CGV	N. A.	N. A.	Approved	[86]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[199]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[301]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[40]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[36]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[115]

Drug(s) Affected By DNA-binding protein inhibitor ID-2 (ID2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[443]
Selenium	DM25CGV	N. A.	N. A.	Approved	[86]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[444]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[315]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[445]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[446]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[48]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[108]
Propylthiouracil	DM6D7N8	Hyperthyroidism	5A02	Approved	[444]

Drug(s) Affected By Angiopoietin-1 receptor (TEK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lenalidomide	DM6Q7U4	Adult T-cell leukemia/lymphoma		Approved	[349]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[349]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[447]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[448]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[449]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[115]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[171]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[450]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[428]

Drug(s) Affected By cAMP-responsive element modulator (CREM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[199]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[52]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[403]
Bortezomib	DMNO38U	Leukemia		Approved	[55]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[451]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[43]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[452]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[171]

Drug(s) Affected By Histone-lysine N-methyltransferase 2A (KMT2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[453]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[454]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[53]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[79]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[455]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[456]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[457]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[40]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[57]

Drug(s) Affected By Dual specificity protein phosphatase 2 (DUSP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[21]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[112]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[52]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[458]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[459]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[85]
Epanova	DMHEAGL	Hypertriglyceridemia	5C80.1	Approved	[460]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[461]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[462]

Drug(s) Affected By 3',5'-cyclic-AMP phosphodiesterase 4B (PDE4B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[108]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[103]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[463]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[66]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[85]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[80]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[180]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[464]

Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[311]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[465]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[185]
Selenium	DM25CGV	N. A.	N. A.	Approved	[86]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[466]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[137]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[467]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[468]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[423]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[273]

Drug(s) Affected By Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[210]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[216]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[469]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[22]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[470]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[243]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[274]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[216]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[471]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[472]

Drug(s) Affected By Son of sevenless homolog 2 (SOS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[361]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[66]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[31]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[79]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[40]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[60]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[473]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[171]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[322]

Drug(s) Affected By Forkhead box protein O1 (FOXO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[313]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[474]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[357]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[23]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[38]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[475]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[476]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[31]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]

Drug(s) Affected By Inositol 1,4,5-triphosphate receptor associated 2 (IRAG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[477]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[57]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[405]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[478]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[83]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[479]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[85]

Drug(s) Affected By Dual specificity protein phosphatase 4 (DUSP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[182]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[23]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[101]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[38]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[480]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[78]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[288]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[85]

Drug(s) Affected By Non-receptor tyrosine-protein kinase TNK1 (TNK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[86]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[476]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[481]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[83]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[357]
[3H]methyltrienolone	DMTSGOW	Discovery agent	N.A.	Investigative	[482]

Drug(s) Affected By Sequestosome-1 (SQSTM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[365]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[366]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[483]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[443]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[484]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[228]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[137]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[131]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[485]

Drug(s) Affected By Eukaryotic translation initiation factor 4E-binding protein 1 (EIF4EBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[486]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[110]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[487]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[162]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[488]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[103]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[440]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[164]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[489]

Drug(s) Affected By Phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[270]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[490]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[185]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[257]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[491]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[492]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[274]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[201]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[48]

Drug(s) Affected By Krueppel-like factor 5 (KLF5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[21]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[228]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[37]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[38]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[108]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[78]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[91]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[31]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[288]

Drug(s) Affected By Protein-tyrosine kinase 2-beta (PTK2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[493]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[494]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[155]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[180]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[495]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[36]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[63]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[171]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[496]

Drug(s) Affected By Genetic suppressor element 1 (GSE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[37]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[40]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[57]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[36]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[43]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[452]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[171]

Drug(s) Affected By Nuclear mitotic apparatus protein 1 (NUMA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[438]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[497]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[27]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[54]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[498]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[43]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[499]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[500]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[322]

Drug(s) Affected By Astrocytic phosphoprotein PEA-15 (PEA15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[86]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[23]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[53]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[27]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[80]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[40]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[57]

Drug(s) Affected By Interferon regulatory factor 4 (IRF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[501]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[502]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[289]
Bortezomib	DMNO38U	Leukemia		Approved	[503]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[504]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[63]
phorbol 12-myristate 13-acetate	DMJWD62	Acute myeloid leukaemia	2A60	Phase 2	[505]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[506]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[83]
T-5224	DMD3CUJ	Rheumatoid arthritis	FA20	Discontinued in Phase 2	[503]

Drug(s) Affected By Microtubule-associated protein RP/EB family member 1 (MAPRE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[27]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[242]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[242]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[507]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[508]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[40]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[43]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[171]

Drug(s) Affected By Exostosin-1 (EXT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[23]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[38]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[53]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[31]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[288]
Cotinine	DMCEZ1B	Insecticide	N.A.	Approved	[509]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[68]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[40]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[41]

Drug(s) Affected By Serine/arginine-rich splicing factor 7 (SRSF7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[443]
Selenium	DM25CGV	N. A.	N. A.	Approved	[86]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[438]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[245]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[27]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[242]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[403]

Drug(s) Affected By Pleckstrin homology-like domain family A member 2 (PHLDA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[21]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[131]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[118]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[154]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[101]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[38]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[108]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]

Drug(s) Affected By Muscleblind-like protein 2 (MBNL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[37]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[96]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[31]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[79]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[510]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[289]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[27]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[511]

Drug(s) Affected By Histone H2A.V (H2AZ2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[27]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[179]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[279]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[40]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[70]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[33]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[226]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[512]

Drug(s) Affected By Syntaxin-12 (STX12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[23]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[513]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[85]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[27]
Bortezomib	DMNO38U	Leukemia		Approved	[55]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[36]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[63]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[496]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[83]

Drug(s) Affected By Polycomb group protein ASXL1 (ASXL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[86]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[85]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[461]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[40]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[43]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[171]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[86]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[512]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[83]

Drug(s) Affected By DDB1- and CUL4-associated factor 11 (DCAF11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[21]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[27]
Bortezomib	DMNO38U	Leukemia		Approved	[55]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[40]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[319]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[326]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[266]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[292]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[357]

Drug(s) Affected By Protein NDRG1 (NDRG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[232]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[514]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[159]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[515]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[131]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[485]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[489]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[180]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[68]

Drug(s) Affected By Estrogen receptor beta (ESR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[129]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[516]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[517]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[518]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[519]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[520]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[521]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[522]
Mestranol	DMG3F94	Contraception	QA21	Approved	[523]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[524]

Drug(s) Affected By TRAF family member-associated NF-kappa-B activator (TANK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[136]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[23]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[78]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[525]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[85]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[54]
Bortezomib	DMNO38U	Leukemia		Approved	[55]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[60]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[526]

Drug(s) Affected By Proline-rich AKT1 substrate 1 (AKT1S1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[31]
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[309]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[27]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[55]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[40]
Cabazitaxel	DMPAZHC	Breast cancer	2C60-2C65	Approved	[527]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[214]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[496]

Drug(s) Affected By MAP/microtubule affinity-regulating kinase 4 (MARK4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[147]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[23]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[63]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[171]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[496]
Afimoxifene	DMFORDT	Breast cancer	2C60-2C65	Phase 2	[406]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[83]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[357]

Drug(s) Affected By Tribbles homolog 1 (TRIB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[182]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[21]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[199]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[103]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[66]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[31]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[68]

Drug(s) Affected By Krueppel-like factor 6 (KLF6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[182]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[528]
Selenium	DM25CGV	N. A.	N. A.	Approved	[86]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[346]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[160]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[131]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[38]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[31]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]

Drug(s) Affected By Mitogen-activated protein kinase kinase kinase 3 (MAP3K3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[365]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[529]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[23]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[54]
Romidepsin	DMT5GNL	Cutaneous T-cell lymphoma	2B01	Approved	[530]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[531]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[63]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[532]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[322]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[496]

Drug(s) Affected By Calsyntenin-3 (CLSTN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[101]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[180]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[533]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[319]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[83]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[325]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[534]

Drug(s) Affected By Reticulon-4 (RTN4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[52]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[289]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[27]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[40]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[319]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[171]
Testosterone undecanoate	DMZO10Y	Hypogonadism	5A61.0	Approved	[535]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[33]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[496]

Drug(s) Affected By DNA damage-inducible transcript 4 protein (DDIT4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[270]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[443]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[346]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[536]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[537]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[37]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[48]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[96]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[538]

Drug(s) Affected By Bcl-2-associated transcription factor 1 (BCLAF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[21]
Selenium	DM25CGV	N. A.	N. A.	Approved	[86]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[357]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[79]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[85]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[27]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[220]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[98]

Drug(s) Affected By Eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[539]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[105]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[336]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[21]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[336]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[540]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[336]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[541]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[542]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[543]

Drug(s) Affected By ADP-ribosylation factor-binding protein GGA2 (GGA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[544]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[33]
Afimoxifene	DMFORDT	Breast cancer	2C60-2C65	Phase 2	[545]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[546]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[357]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[547]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[326]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[513]

Drug(s) Affected By F-box only protein 2 (FBXO2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[86]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[38]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[476]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[288]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[27]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[180]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[40]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[321]

Drug(s) Affected By Transcription factor MafF (MAFF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[45]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[129]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[21]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[548]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[315]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[131]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[37]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[101]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[269]

Drug(s) Affected By Disheveled-associated activator of morphogenesis 1 (DAAM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[86]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[489]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[85]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[40]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[43]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[326]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[496]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[89]

Drug(s) Affected By TNF receptor-associated factor 6 (TRAF6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[73]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[23]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[76]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[228]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[549]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[550]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[54]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[551]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[552]

Drug(s) Affected By Krueppel-like factor 12 (KLF12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[553]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[237]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[53]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[513]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[68]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[462]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[321]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[554]

Drug(s) Affected By Dual specificity protein phosphatase 10 (DUSP10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[105]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[555]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[283]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[446]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[283]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[38]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[446]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[385]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[66]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[31]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-3 (ATF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[270]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[271]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[228]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[404]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[160]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[556]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[67]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[23]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[48]

Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[557]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[112]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[558]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[559]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[375]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[560]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[561]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[311]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[562]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[563]

Drug(s) Affected By Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[247]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[21]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[23]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[52]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[564]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[66]
Cantharidin	DMBP5N3	Molluscum contagiosum infection	1E76	Approved	[565]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[566]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
PI3-kinase gamma (PIK3CG)	TTHBTOP	PK3CG_HUMAN	Modulator	[3]
Polo-like kinase 1 (PLK1)	TTIYVQP	PLK1_HUMAN	Modulator	[3]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
2'-5'-oligoadenylate synthase 1 (OAS1)	OT8ZLOCY	OAS1_HUMAN	Gene/Protein Processing	[4]
3',5'-cyclic-AMP phosphodiesterase 4B (PDE4B)	OTOA8WU2	PDE4B_HUMAN	Gene/Protein Processing	[4]
3-phosphoinositide-dependent protein kinase 1 (PDPK1)	OTT09ZVP	PDPK1_HUMAN	Post-Translational Modifications	[5]
Actin, cytoplasmic 1 (ACTB)	OT1MCP2F	ACTB_HUMAN	Gene/Protein Processing	[4]
Actin, cytoplasmic 2 (ACTG1)	OTH4V7VQ	ACTG_HUMAN	Gene/Protein Processing	[4]
ADP-ribosylation factor-binding protein GGA2 (GGA2)	OT43HO27	GGA2_HUMAN	Gene/Protein Processing	[4]
Albumin (ALB)	OTVMM513	ALBU_HUMAN	Protein Interaction/Cellular Processes	[6]
Angiopoietin-1 receptor (TEK)	OT78YN57	TIE2_HUMAN	Post-Translational Modifications	[7]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Gene/Protein Processing	[7]
Astrocytic phosphoprotein PEA-15 (PEA15)	OTKCKTSX	PEA15_HUMAN	Gene/Protein Processing	[4]

References

• [1] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [2] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7833).
• [3] Phase I study of oral rigosertib (ON 01910.Na), a dual inhibitor of the PI3K and Plk1 pathways, in adult patients with advanced solid malignancies. Clin Cancer Res. 2014 Mar 15;20(6):1656-65.
• [4] ON 01910.Na is selectively cytotoxic for chronic lymphocytic leukemia cells through a dual mechanism of action involving PI3K/AKT inhibition and induction of oxidative stress. Clin Cancer Res. 2012 Apr 1;18(7):1979-91. doi: 10.1158/1078-0432.CCR-11-2113. Epub 2012 Feb 20.
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