Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMP2BWX)

Drug Name

Ispinesib Drug Info

Synonyms

SB-715992; Ispinesib (SB-715992 /CK0238273); SB-715992, CK0238273,Ispinesib; N-(3-aminopropyl)-N-[(1R)-1-(3-benzyl-7-chloro-4-oxoquinazolin-2-yl)-2-methylpropyl]-4-methylbenzamide

Indication

Disease Entry	ICD 11	Status	REF
Head and neck cancer	2D42	Phase 2	[1]
Ovarian cancer	2C73	Phase 2	[1]
Renal cell carcinoma	2C90	Phase 2	[1]
Solid tumour/cancer	2A00-2F9Z	Phase 2	[1]

Therapeutic Class

Anticancer Agents

Cross-matching ID

PubChem CID: 6851740
ChEBI ID: CHEBI:94692
CAS Number: CAS 336113-53-2
TTD Drug ID: DMP2BWX

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Kinesin-like protein KIF11 (KIF11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AZD-4877	DMFVL5J	Acute myeloid leukaemia	2A60	Phase 2	[3]
ARRY-520	DMTOI7S	Multiple myeloma	2A83	Phase 2	[4]
SB-743921	DM6XJ9S	Solid tumour/cancer	2A00-2F9Z	Phase 2	[5]
LY2523355	DMCV602	Acute myeloid leukaemia	2A60	Phase 2	[3]
ARQ 621	DMCRLQZ	Haematological malignancy	2B33.Y	Phase 1	[3]
4SC-205	DMG75P3	Lymphoma	2A80-2A86	Phase 1	[6]
MK-0731	DM2TAUR	Solid tumour/cancer	2A00-2F9Z	Phase 1	[3]
Monastrol	DMLSEJN	Discovery agent	N.A.	Investigative	[7]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Kinesin-like protein KIF11 (KIF11)	TTTRP0H	KIF11_HUMAN	Inhibitor	[2]

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References

1	ClinicalTrials.gov (NCT00095628) SB-715992 in Treating Patients With Recurrent or Metastatic Head and Neck Cancer. U.S. National Institutes of Health.
2	Initial testing (stage 1) of the kinesin spindle protein inhibitor ispinesib by the pediatric preclinical testing program. Pediatr Blood Cancer. 2009 Dec 15;53(7):1255-63.
3	Kinesins and cancer. Nat Rev Cancer. 2012 Jul 24;12(8):527-39.
4	Inhibition of KSP by ARRY-520 induces cell cycle block and cell death via the mitochondrial pathway in AML cells. Leukemia. 2009 Oct;23(10):1755-62.
5	Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2009 Jan-Feb;31(1):47-57.
6	2011 Pipeline of 4SC AG.
7	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.