Details of the Drug

General Information of Drug (ID: DMPH7EO)

Drug Name

Apomorphine SL

Synonyms

Apomorphine HCl; Apomorphine chloride; (R)-(-)-Apomorphine hydrochloride; Apomorphinium chloride; Apomorphin hydrochlorid; 314-19-2; pomorphini hydrochloridum; Apomorphinum hydrochloricum; N-Methylnorapomorphine hydrochloride; UNII-9K13MD7A0D; (-)-Apomorphinium hydrochloride; Apomorphine hydrochloride anhydrous; EINECS 206-243-0; NSC 11442; 9K13MD7A0D; 6a-beta-Aporphine-10,11-diol, hydrochloride; 6abeta-Noraporphine-10,11-diol, 6-methyl-, hyd

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]
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Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

#Ro5 Violations (Lipinski):
0

Molecular Weight

303.8

Logarithm of the Partition Coefficient

Not Available

Rotatable Bond Count

0

Hydrogen Bond Donor Count

3

Hydrogen Bond Acceptor Count

3

Chemical Identifiers

Formula: C17H18ClNO2
IUPAC Name: (6aR)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol;hydrochloride
Canonical SMILES: CN1CCC2=C3[C@H]1CC4=C(C3=CC=C2)C(=C(C=C4)O)O.Cl
InChI: InChI=1S/C17H17NO2.ClH/c1-18-8-7-10-3-2-4-12-15(10)13(18)9-11-5-6-14(19)17(20)16(11)12;/h2-6,13,19-20H,7-9H2,1H3;1H/t13-;/m1./s1
InChIKey: SKYZYDSNJIOXRL-BTQNPOSSSA-N

Cross-matching ID

PubChem CID: 9410
CAS Number: 314-19-2
TTD ID: D0B6QP

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Neuron-specific vesicular protein calcyon (CALY)	TT0R12H	CALY_HUMAN	Activator	[1]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Bone morphogenetic protein receptor type-1A (BMPR1A)	OTQOA4ZH	BMR1A_HUMAN	Gene/Protein Processing	[2]
Cytochrome P450 1B1 (CYP1B1)	OTYXFLSD	CP1B1_HUMAN	Gene/Protein Processing	[3]
Furin (FURIN)	OTM2665Z	FURIN_HUMAN	Gene/Protein Processing	[2]
Hepcidin (HAMP)	OT607RBL	HEPC_HUMAN	Gene/Protein Processing	[2]
Prolactin (PRL)	OTWFQGX7	PRL_HUMAN	Gene/Protein Processing	[4]
Somatotropin (GH1)	OT92RTRD	SOMA_HUMAN	Gene/Protein Processing	[4]
Vasopressin-neurophysin 2-copeptin (AVP)	OTAVZ76K	NEU2_HUMAN	Gene/Protein Processing	[5]

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Molecular Interaction Atlas (MIA)

MIA Detail

Jump to Detail Molecular Interaction Atlas of This Drug

References

1	Dopamine and sexual function. Int J Impot Res. 2001 Aug;13 Suppl 3:S18-28.
2	A HAMP promoter bioassay system for identifying chemical compounds that modulate hepcidin expression. Exp Hematol. 2015 May;43(5):404-413.e5. doi: 10.1016/j.exphem.2015.01.005. Epub 2015 Jan 26.
3	Association of CYP1A1 and CYP1B1 inhibition in in vitro assays with drug-induced liver injury. J Toxicol Sci. 2021;46(4):167-176. doi: 10.2131/jts.46.167.
4	A study of dopaminergic sensitivity in Parkinson's disease: comparison in "de novo" and levodopa-treated patients. Clin Neuropharmacol. 1996 Oct;19(5):420-7. doi: 10.1097/00002826-199619050-00005.
5	Betamethasone does not prevent nausea and vomiting induced by the dopamine-agonist apomorphine. Can J Anaesth. 2006 Apr;53(4):370-4. doi: 10.1007/BF03022501.