Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT0R12H)

DTT Name Neuron-specific vesicular protein calcyon (CALY)
Synonyms Neuronspecific vesicular protein calcyon; CALY
Gene Name CALY
DTT Type
Discontinued target
 [1]
UniProt ID
CALY_HUMAN
TTD ID
T30802
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVKLGCSFSGKPGKDPGDQDGAAMDSVPLISPLDISQLQPPLPDQVVIKTQTEYQLSSPD
QQNFPDLEGQRLNCSHPEEGRRLPTARMIAFAMALLGCVLIMYKAIWYDQFTCPDGFLLR
HKICTPLTLEMYYTEMDPERHRSILAAIGAYPLSRKHGTETPAAWGDGYRAAKEERKGPT
QAGAAAAATEPPGKPSAKAEKEAARKAAGSAAPPPAQ
Function Interacts with clathrin light chain A and stimulates clathrin self-assembly and clathrin-mediated endocytosis.
KEGG Pathway
Dopaminergic synapse (hsa04728 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
1 Discontinued Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
CY-208243 DMP8TKA Pain MG30-MG3Z Discontinued in Phase 2 [1]
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1 Investigative Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
Apomorphine SL DMPH7EO Discovery agent N.A. Investigative [2]
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References

1 Dopamine D1 receptor agonists induce penile erections in rats. Eur J Pharmacol. 2003 Jan 26;460(1):71-4.
2 Dopamine and sexual function. Int J Impot Res. 2001 Aug;13 Suppl 3:S18-28.