Details of the Drug

General Information of Drug (ID: DMR5RHG)

Drug Name
JNJ-75276617
Synonyms JNJ-6617
Indication
Disease Entry ICD 11 Status REF
Haematological malignancy 2B33.Y Phase 1 [1]
Drug Type
Small molecule
Cross-matching ID
PubChem CID
156498110
DrugBank ID
DB17574
TTD ID
DYJ76M
Drug-Molecule Activity Atlas (DMA)NEW Click to Jump to the Detailed DMA Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Menin-MLL1 interaction (MEN1-KMT2A PPI) TT0CZBQ MEN1_HUMAN-KMT2A_HUMAN Inhibitor [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

References

1 ClinicalTrials.gov (NCT04811560) A First in Human Study of the Menin-KMT2A (MLL1) Inhibitor JNJ-75276617 in Participants With Acute Leukemia. U.S.National Institutes of Health.
2 Targeting the undruggable: menin inhibitors ante portas. J Cancer Res Clin Oncol. 2023 Sep;149(11):9451-9459.