Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT0CZBQ)

DTT Name	Menin-MLL1 interaction (MEN1-KMT2A PPI)
Gene Name	MEN1-KMT2A
DTT Type	Clinical trial target	[1]
UniProt ID	MEN1_HUMAN-KMT2A_HUMAN
TTD ID	T17485
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DTT

3 Clinical Trial Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
KO-539	DM0NZYC	Acute myeloid leukaemia	2A60	Phase 1/2	[1]
SNDX-5613	DMCGX9Y	T lymphoblastic leukaemia	2B33.4	Phase 1/2	[2]
JNJ-75276617	DMR5RHG	Haematological malignancy	2B33.Y	Phase 1	[3]
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References

1	Clinical pipeline report, company report or official report of Kura Oncology.
2	Clinical pipeline report, company report or official report of Syndax Pharmaceuticals.
3	Targeting the undruggable: menin inhibitors ante portas. J Cancer Res Clin Oncol. 2023 Sep;149(11):9451-9459.