Details of the Drug

General Information of Drug (ID: DMRSX53)

Drug Name
nusinersen
Synonyms BIIB 058; IONIS-SMNRx; ISIS-396443; Spinraza
Indication
Disease Entry ICD 11 Status REF
Spinal muscular atrophy 8B61 Approved [1]
Affected Organisms
Humans and other mammals
ATC Code
M09AX07: nusinersen
M09AX: Other drugs for disorders of the musculo-skeletal system
M09A: OTHER DRUGS FOR DISORDERS OF THE MUSCULO-SKELETAL SYSTEM
M09: OTHER DRUGS FOR DISORDERS OF THE MUSCULO-SKELETAL SYSTEM
M: MUSCULO-SKELETAL SYSTEM
Drug Type
Antisense drug
Sequence
UCACUUUCAUAAUGCUGG
Structure
3D MOL is unavailable 2D MOL
ADMET Property
Clearance
The drug is slowly cleared []
Half-life
The concentration or amount of drug in body reduced by one-half in 135 - 177 days []
Metabolism
The drug is metabolized via the exonuclease (3- and 5)-mediated hydrolysis primarily at the 3' end of the oligonucleotide [2]
Vd
The volume of distribution (Vd) of drug is 29 L []
Cross-matching ID
PubChem CID
131801471
UNII
5Z9SP3X666
DrugBank ID
DB13161
TTD ID
D05MZI

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
SMN1 messenger RNA (SMN1 mRNA) TTSVGQ5 SMN_HUMAN Modulator [1]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

References

1 2016 FDA drug approvals. Nat Rev Drug Discov. 2017 Feb 2;16(2):73-76.
2 CENTER FOR DRUG EVALUATION AND RESEARCH