Details of the Drug

General Information of Drug (ID: DMTSRI6)

Drug Name
Oprelvekin
Synonyms Neumega; Neumega (TN); Oprelvekin (genetical recombination); Oprelvekin (USAN/INN); Oprelvekin (genetical recombination) (JAN)
Indication
Disease Entry ICD 11 Status REF
Inflammatory bowel disease DD72 Approved [1]
MALT lymphoma N.A. Approved [2]
Nodal marginal zone lymphoma 2A85.0 Approved [2]
Splenic marginal zone lymphoma N.A. Approved [2]
Thrombocytopenia 3B64 Approved [3]
Ulcerative colitis DD71 Approved [2]
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Therapeutic Class
Anticoagulants
Affected Organisms
Humans and other mammals
ATC Code
L03AC02: Oprelvekin
L03AC: Interleukins
L03A: IMMUNOSTIMULANTS
L03: IMMUNOSTIMULANTS
L: ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
Sequence
GPPPGPPRVSPDPRAELDSTVLLTRSLLADTRQLAAQLRDKFPADGDHNLDSLPTLAMSA
GALGALQLPGVLTRLRADLLSYLRHVQWLRRAGGSSLKTLEPELGTLQARLDRLLRRLQL
LMSRLALPQPPPDPPAPPLAPPSSAWGGIRAAHAILGGLHLTLDWAVRGLLLLKTRL
ADMET Property
Bioavailability
The bioavailability of drug is over 80% []
Half-life
The concentration or amount of drug in body reduced by one-half in 6.9 +/- 1.7 hours [4]
Cross-matching ID
UNII
HM5641GA6F
DrugBank ID
DB00038
TTD ID
D0T1IJ
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Interleukin 11 receptor alpha (IL11RA) TTZPLJS I11RA_HUMAN Binder [5]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Disease Different from Oprelvekin (Comorbidity)
DDI Drug Name DDI Drug ID Severity Mechanism Comorbidity REF
Carfilzomib DM48K0X Major Additive thrombogenic effects by the combination of Oprelvekin and Carfilzomib. Multiple myeloma [2A83] [6]

References

1 Interleukin-11. BioDrugs. 1997 Dec;8(6):418-29.
2 A standard database for drug repositioning. Sci Data. 2017 Mar 14;4:170029.
3 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6971).
4 Trend Analysis of a Database of Intravenous Pharmacokinetic Parameters in Humans for 1352 Drug Compounds
5 Oprelvekin: a review of its pharmacology and therapeutic potential in chemotherapy-induced thrombocytopenia. BioDrugs. 1998 Aug;10(2):159-71.
6 Cerner Multum, Inc. "Australian Product Information.".