Details of the Drug

General Information of Drug (ID: DMTSRI6)

Drug Name

Oprelvekin

Synonyms

Neumega; Neumega (TN); Oprelvekin (genetical recombination); Oprelvekin (USAN/INN); Oprelvekin (genetical recombination) (JAN)

Indication

Disease Entry	ICD 11	Status	REF
Inflammatory bowel disease	DD72	Approved	[1]
MALT lymphoma	N.A.	Approved	[2]
Nodal marginal zone lymphoma	2A85.0	Approved	[2]
Splenic marginal zone lymphoma	N.A.	Approved	[2]
Thrombocytopenia	3B64	Approved	[3]
Ulcerative colitis	DD71	Approved	[2]
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Therapeutic Class

Anticoagulants

Affected Organisms

Humans and other mammals

ATC Code

L03AC02: Oprelvekin

L03AC: Interleukins

L03A: IMMUNOSTIMULANTS

L03: IMMUNOSTIMULANTS

L: ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS

Sequence

GPPPGPPRVSPDPRAELDSTVLLTRSLLADTRQLAAQLRDKFPADGDHNLDSLPTLAMSA
GALGALQLPGVLTRLRADLLSYLRHVQWLRRAGGSSLKTLEPELGTLQARLDRLLRRLQL
LMSRLALPQPPPDPPAPPLAPPSSAWGGIRAAHAILGGLHLTLDWAVRGLLLLKTRL

ADMET Property

Bioavailability: The bioavailability of drug is over 80% []
Half-life: The concentration or amount of drug in body reduced by one-half in 6.9 +/- 1.7 hours [4]

Cross-matching ID

UNII: HM5641GA6F
DrugBank ID: DB00038
TTD ID: D0T1IJ

Repurposed Drugs (RPD)

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Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Interleukin 11 receptor alpha (IL11RA)	TTZPLJS	I11RA_HUMAN	Binder	[5]

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Molecular Interaction Atlas (MIA)

MIA Detail

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Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Disease Different from Oprelvekin (Comorbidity)

DDI Drug Name	DDI Drug ID	Severity	Mechanism	Comorbidity	REF
Carfilzomib	DM48K0X	Major	Additive thrombogenic effects by the combination of Oprelvekin and Carfilzomib.	Multiple myeloma [2A83]	[6]
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References

1	Interleukin-11. BioDrugs. 1997 Dec;8(6):418-29.
2	A standard database for drug repositioning. Sci Data. 2017 Mar 14;4:170029.
3	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6971).
4	Trend Analysis of a Database of Intravenous Pharmacokinetic Parameters in Humans for 1352 Drug Compounds
5	Oprelvekin: a review of its pharmacology and therapeutic potential in chemotherapy-induced thrombocytopenia. BioDrugs. 1998 Aug;10(2):159-71.
6	Cerner Multum, Inc. "Australian Product Information.".